Nature Search

Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial

A phase 3 trial found that VER-01, a full-spectrum cannabis extract, reduces chronic low back pain, improves physical function and sleep and shows no signs of dependence or withdrawal.

Matthias Karst
Winfried Meissner
Winfried Häuser
ResearchOpen Access29 Sept 2025
Nature Medicine

P: 1-8
Crystallographic structure and functional implications of the nitrogenase molybdenum–iron protein from Azotobacter vinelandii

Jongsun Kirn
D. C. Rees
Research10 Dec 1992
Nature

Volume: 360, P: 553-560
Two-electron quantization of the charge on a superconductor

P. Lafarge
P. Joyez
M. H. Devoret
Research30 Sept 1993
Nature

Volume: 365, P: 422-424
Catastrophic disruption of asteroid 2023 CX1 and implications for planetary defence

2023 CX1 is the only L-chondrite-like asteroid analysed from space to ground. It catastrophically fragmented in the atmosphere, depositing 98% of its energy in one burst—an unusual, high-risk fragmentation mode with implications for planetary defence.

Auriane Egal
Denis Vida
Peter Jenniskens
Research17 Sept 2025
Nature Astronomy

P: 1-14
The genomic history of Iberian horses since the last Ice Age

Horses have lived in Iberia since the Ice Age. Using ancient genomes to study their history, Lira Garrido et al. reveal a local wild lineage lasting until Late Iron Age, and highlight the far-reaching influence of Iberian bloodlines across Europe and north Africa during the Iron Age and beyond.

Jaime Lira Garrido
Gaétan Tressières
Ludovic Orlando
ResearchOpen Access02 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Evolution of avian foot morphology through anatomical network analysis

Birds have evolved a large diversity of foot morphologies in the past 100 million years. Here, the authors use anatomical network analysis to find a constrained foot organization, a trend toward simplification, and no association between foot complexity and foot specialization.

Julieta Carril
Ricardo S. De Mendoza
Claudia P. Tambussi
ResearchOpen Access14 Nov 2024
Nature Communications

Volume: 15, P: 1-9
Plasma proteomic associations with Alzheimer’s disease endophenotypes

Afshar, Dammer et al. identify plasma proteins associated with Alzheimer’s disease brain pathologies and find that many plasma proteins related to cognitive function are not associated with these pathologies.

Shiva Afshar
Eric B. Dammer
Erik C. B. Johnson
ResearchOpen Access10 Sept 2025
Nature Aging

P: 1-21
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are key contributors to tau PET positivity, which should aid clinical decision-making and trial designs.

Rik Ossenkoppele
Emma M. Coomans
Oskar Hansson
ResearchOpen Access16 Jul 2025
Nature Neuroscience

Volume: 28, P: 1610-1621
Nivolumab plus platinum-doublet chemotherapy in treatment-naive patients with advanced grade 3 Neuroendocrine Neoplasms of gastroenteropancreatic or unknown origin: The multicenter phase 2 NICE-NEC trial (GETNE-T1913)

Immune checkpoint inhibitors have been incorporated as the standard of care for some high-grade neuroendocrine neoplasms (NEN), but their efficacy in digestive NEN is still unclear. Here the authors report the results of a phase II trial of nivolumab (anti-PD1) in combination with platinum-doublet chemotherapy (carboplatin-etoposide) as first-line treatment in patients with unresectable or metastatic advanced grade 3 NENs of gastro-enteropancreatic or unknown origin.

Maria Carmen Riesco-Martinez
Jaume Capdevila
Rocio Garcia-Carbonero
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-10
Near-quantum-limited amplification from inelastic Cooper-pair tunnelling

DC-powered microwave amplifiers approach the quantum noise limit by using the interaction between microwave radiation and inelastic Cooper-pair tunnelling across a voltage-biased Josephson junction.

S. Jebari
F. Blanchet
M. Hofheinz
Research17 Apr 2018
Nature Electronics

Volume: 1, P: 223-227
The Solve-RD Solvathons as a pan-European interdisciplinary collaboration to diagnose patients with rare disease

This Perspective presents the Solve-RD Solvathon model, an innovative, pan-European framework uniting clinical and bioinformatics experts to diagnose rare diseases through integrative multiomics analysis and structured collaboration.

Vicente A. Yépez
German Demidov
Holm Graessner
Reviews09 Sept 2025
Nature Genetics

Volume: 57, P: 2361-2370
Effect of the slimming agent oleoyl-estrone in liposomes on the body weight of Zucker obese rats

F Balada
D Sanchis
M Alemany
Research01 Sept 1997
International Journal of Obesity

Volume: 21, P: 789-795
Influence of stage at diagnosis on survival differences for rectal cancer in three European populations

E Monnet
J Faivre
I Garau
ResearchOpen Access10 Sept 1999
British Journal of Cancer

Volume: 81, P: 463-468
Reply to: Challenges to identifying risk versus protective factors in Alzheimer’s disease

Juan Fortea
Lídia Vaqué-Alcázar
Víctor Montal
Research18 Jul 2024
Nature Medicine

Volume: 30, P: 3096-3097
Nanopatterning Si(111) surfaces as a selective surface-chemistry route

The ability to control the surface chemistry of silicon is important for microelectronic applications. Chemical species can now be stabilized on Si(111) surfaces using a partially alkoxylated surface as a nanopatterning template.

David J. Michalak
Sandrine Rivillon Amy
Yves J. Chabal
Research10 Jan 2010
Nature Materials

Volume: 9, P: 266-271
USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder

This study uncovers the role of epigenetic H2A monoubiquitination in the mouse brain’s response to chronic cocaine use. It also identifies genetic variations in humans linked to H2A monoubiquitination, modifying susceptibility to cocaine addiction and aggression, and paving the way for tailored treatments.

Julian Cheron
Leonardo Beccari
Alban de Kerchove d’Exaerde
ResearchOpen Access20 Dec 2023
Nature Communications

Volume: 14, P: 1-18
A new high-resolution 3-D quantitative method for analysing small morphological features: an example using a Cambrian trilobite

Jorge Esteve
Yuan-Long Zhao
Jin Peng
ResearchOpen Access12 Feb 2018
Scientific Reports

Volume: 8, P: 1-10
APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease

The study on APOE4 homozygosity indicates a genetic variant of Alzheimer’s disease with early symptom onset and distinct biomarker progression, highlighting the need for specialized treatment approaches.

Juan Fortea
Jordi Pegueroles
Víctor Montal
Research06 May 2024
Nature Medicine

Volume: 30, P: 1284-1291
Understanding energy performance in drinking water treatment plants using the efficiency analysis tree approach

Alexandros Maziotis
Maria Molinos-Senante
ResearchOpen Access29 Feb 2024
npj Clean Water

Volume: 7, P: 1-8
Sulphonamides and the Thyroid Gland

D. LIBERMANN
Research19 Oct 1946
Nature

Volume: 158, P: 557
Angiogenic factors versus fetomaternal Doppler for fetal growth restriction at term: an open-label, randomized controlled trial

In 1,088 pregnant individuals, assessment of abnormal serum angiogenic factors is demonstrated to be noninferior to the standard clinical approach based on estimated fetal weight and Doppler percentiles for the identification of fetuses at a higher risk of neonatal acidosis or Cesarean delivery, thus offering a beneficial option in settings where Doppler or experienced sonographers are not readily available.

Pablo Garcia-Manau
Erika Bonacina
Manel Mendoza
Research07 Jan 2025
Nature Medicine

Volume: 31, P: 1008-1015
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis

Secreted frizzled-related proteins (SFRPs) are putative Wnt antagonists. Here, Esteve et al. show that SFRPs during eye development can also serve as inhibitors of Notch signaling by acting on ADAM10 metalloprotease activity.

Pilar Esteve
Africa Sandonìs
Paola Bovolenta
Research10 Apr 2011
Nature Neuroscience

Volume: 14, P: 562-569
KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain

Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene expression, circuit activity, and behavior in mice.

Michal Lipinski
Rafael Muñoz-Viana
Angel Barco
ResearchOpen Access22 May 2020
Nature Communications

Volume: 11, P: 1-18
The a.c. Josephson effect in constrictions engraved in bulk YBa²Cu³O^7–δ and d.c. SQUID operation at 77 K

D. Robbes
Y. Monfort
R. Stephant
Research01 Jan 1988
Nature

Volume: 331, P: 151-153
Is neuroblastoma screening evaluation needed and feasible?

J Estève
L Parker
T Philip
Reviews01 Jun 1995
British Journal of Cancer

Volume: 71, P: 1125-1131
First use of anatomical networks to study modularity and integration of heads, forelimbs and hindlimbs in abnormal anencephalic and cyclopic vs normal human development

Rui Diogo
Janine M. Ziermann
Andre Duerinckx
ResearchOpen Access24 May 2019
Scientific Reports

Volume: 9, P: 1-25
Personalised genomic strategies improve diagnostic yield in inherited retinal dystrophies: a stepwise, patient-centred approach

Anna Esteve-Garcia
Ariadna Padró-Miquel
Cinthia Aguilera
ResearchOpen Access09 Sept 2025
Eye

P: 1-13
Long COVID and the kidney

Here, the authors describe the effects of coronavirus disease (COVID) on the kidney, including long COVID in patients with chronic kidney disease. They also discuss potential associations between COVID-19 and glomerular diseases and the impact of severe acute respiratory syndrome coronavirus 2 vaccines on the risk of long COVID.

Vanja Ivković
Urmila Anandh
Annette Bruchfeld
Reviews04 Sept 2025
Nature Reviews Nephrology

P: 1-13
Completeness of cancer registration: a new method for routine use

J Bullard
M P Coleman
J Peto
ResearchOpen Access03 Feb 2000
British Journal of Cancer

Volume: 82, P: 1111-1116
Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells

In human adipose tissue (AT), adipocytes are organized into units of lobules. Here the authors identify distinct fibrous septal and stromal compartments within AT lobules that differ in composition and potential between subcutaneous and visceral regions and are disturbed in obesity and metabolic syndrome.

D. Estève
N. Boulet
J. Galitzky
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-16
A CMOS silicon spin qubit

Silicon is a promising material for realization of quantum processors, particularly as it could be naturally integrated with classical control hardware based on CMOS technology. Here the authors report a silicon qubit device made with an industry-standard fabrication process on a CMOS platform.

R. Maurand
X. Jehl
S. De Franceschi
ResearchOpen Access24 Nov 2016
Nature Communications

Volume: 7, P: 1-6
DNA methylation inhibits p53-mediated survivin repression

N H Nabilsi
R R Broaddus
D S Loose
Research13 Apr 2009
Oncogene

Volume: 28, P: 2046-2050
NADPH oxidase 1/4 dual inhibition impairs transforming growth factor-beta protumorigenic effects in cholangiocarcinoma cancer-associated fibroblasts

Josep Amengual
Ester Gonzalez-Sanchez
Javier Vaquero
ResearchOpen Access18 Aug 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-21
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment

DOPA decarboxylase (DDC) in cerebrospinal fluid has great diagnostic potential for Lewy body disorders. Here, the authors report limited diagnostic potential of plasma DDC and a strong association with dopaminergic treatment.

Katharina Bolsewig
Eline A. J. Willemse
Marta Del Campo Milán
ResearchOpen Access29 Jan 2025
Nature Communications

Volume: 16, P: 1-9
Sibling risks in cancer: clues to recessive or X-linked genes?

K Hemminki
P Vaittinen
D Easton
ResearchOpen Access30 Jan 2001
British Journal of Cancer

Volume: 84, P: 388-391
Antibunching of microwave-frequency photons observed in correlation measurements using linear detectors

Detecting and counting individual microwave photons is important for processing quantum information, but it is made challenging by an absence of detectors that are sensitive enough to radiation at this wavelength. Correlations between microwave photons have now been measured using a series of amplifiers and digital analysis.

D. Bozyigit
C. Lang
A. Wallraff
Research05 Dec 2010
Nature Physics

Volume: 7, P: 154-158
Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation

The immune suppression required for the resolution of acute inflammation is characterised by molecular and metabolic reprogramming of myeloid cells. Authors here show that the transcription factor ZEB1 is a key mediator of the pathway governing transition from inflammation to immunosuppression via regulating mitochondrial translation in macrophages.

Marlies Cortés
Agnese Brischetto
Antonio Postigo
ResearchOpen Access17 Nov 2023
Nature Communications

Volume: 14, P: 1-18
A primary quantum current standard based on the Josephson and the quantum Hall effects

Realizing the ampere, the unit of electrical current, involves controlling a flow of elementary charges with high accuracy. Here, the authors present the generation of sizeable currents at quantized values with relative uncertainties below 10⁻⁸.

Sophie Djordjevic
Ralf Behr
Wilfrid Poirier
ResearchOpen Access10 Feb 2025
Nature Communications

Volume: 16, P: 1-12
Regional associations between cerebrovascular disease and cholinergic white matter pathways in the Lewy body continuum

Anna Rennie
Milan Nemy
Daniel Ferreira
ResearchOpen Access21 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
Tropic origins, a dispersal model for saprotrophic mushrooms in Agaricus section Minores with descriptions of sixteen new species

Mao-Qiang He
Jie Chen
Rui-Lin Zhao
ResearchOpen Access11 Jul 2017
Scientific Reports

Volume: 7, P: 1-31
The Global Living Arrangements Database, 1960–2021

Juan Galeano
Albert Esteve
ResearchOpen Access26 Aug 2025
Scientific Data

Volume: 12, P: 1-13
Visual orientation in motion-blind flies is an operant behaviour

Reinhard Wolf
Martin Heisenberg
Research11 Sept 1986
Nature

Volume: 323, P: 154-156
Single-electron spin resonance detection by microwave photon counting

Spectroscopic measurements of individual rare-earth ion electron spins are performed by detecting their microwave fluorescence, with the method coming close to practical single-electron spin resonance at millikelvin temperatures.

Z. Wang
L. Balembois
E. Flurin
Research12 Jul 2023
Nature

Volume: 619, P: 276-281
A novel chimeric antigen receptor T-cell therapy targeting CD84 for the treatment of acute myeloid and T-cell lymphoblastic leukemias

Lorena Pérez-Amill
Mercedes Armand-Ugón
Nela Klein-González
ResearchOpen Access06 Aug 2025
Leukemia

Volume: 39, P: 2432-2441
Survival from breast cancer among South Asian and non-South Asian women resident in South East England

I dos Santos Silva
P Mangtani
D Mayer
ResearchOpen Access29 Jul 2003
British Journal of Cancer

Volume: 89, P: 508-512
Parental kinship coefficient but not paternal coloration predicts early offspring growth in lake char

Laura Garaud
David Nusbaumer
Claus Wedekind
ResearchOpen Access13 Mar 2024
Heredity

Volume: 132, P: 247-256
SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor

Josana Rodriguez
Pilar Esteve
Paola Bovolenta
Research18 Sept 2005
Nature Neuroscience

Volume: 8, P: 1301-1309
Sketching the spatial disparities in heatwave trends by changing atmospheric teleconnections in the Northern Hemisphere

This study uses complex networks to identify atmospheric teleconnections driving summer heatwaves in the Northern Hemisphere. The results show that changes in certain teleconnections drive the spatial differences in heatwave variability and trends.

Fenying Cai
Caihong Liu
Jürgen Kurths
ResearchOpen Access13 Sept 2024
Nature Communications

Volume: 15, P: 1-12
BRAF activation by metabolic stress promotes glycolysis sensitizing NRAS^Q61-mutated melanomas to targeted therapy

Targeted therapeutic options for NRAS-mutant melanoma are limited. Here, the authors show that under metabolic stress NRAS-mutant melanoma cells activate a BRAF-dependent glycolysis pathway for survival, leading to improve efficacy of sorafenib when combined with glycolysis inhibitors.

Kimberley McGrail
Paula Granado-Martínez
Juan A. Recio
ResearchOpen Access19 Nov 2022
Nature Communications

Volume: 13, P: 1-22
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

A randomized clinical trial reveals that the antidiabetic effects of metformin are at least partially due to beneficial changes in the microbiota.

Hao Wu
Eduardo Esteve
Fredrik Bäckhed
Research22 May 2017
Nature Medicine

Volume: 23, P: 850-858

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