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Showing 401–450 of 495 results

Advanced filters: Author: David G. Lowe Clear advanced filters

Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer

Mónica Álvarez-Fernández
María Sanz-Flores
Marcos Malumbres
ResearchOpen Access11 Dec 2017
Cell Death & Differentiation

P: 1-13
De novo mutations in epileptic encephalopathies

Exome sequencing has found an excess of de novo mutations in the ∼4,000 most intolerant genes in patients with two classical epileptic encephalopathies (infantile spasms and Lennox–Gastaut syndrome); among them are multiple de novo mutations in GABRB3 and ALG13.

Andrew S. Allen
Samuel F. Berkovic
Melodie R. Winawer
Research11 Aug 2013
Nature

Volume: 501, P: 217-221
Genome-wide association studies identify genetic loci for low von Willebrand factor levels

Janine van Loon
Abbas Dehghan
Christopher O'Donnell
Research21 Oct 2015
European Journal of Human Genetics

Volume: 24, P: 1035-1040
HPV-18 E6*I protein modulates the E6-directed degradation of p53 by binding to full-length HPV-18 E6

David Pim
Lawrence Banks
Research09 Dec 1999
Oncogene

Volume: 18, P: 7403-7408
The antimicrobial potential of cannabidiol

Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae. This article highlights the potential for cannabidiol in the age of antimicrobial resistance.

Mark A. T. Blaskovich
Angela M. Kavanagh
Michael Thurn
ResearchOpen Access19 Jan 2021
Communications Biology

Volume: 4, P: 1-18
Regulation of PML-dependent transcriptional repression by pRB and low penetrance pRB mutants

Weizhao Fang
Takahiro Mori
David Cobrinik
Research15 Aug 2002
Oncogene

Volume: 21, P: 5557-5565
A Chromosome Integration System for Stable Gene Transfer into Thermus flavus

J. Mark Weber
Scot P. Johnson
David C. Demirjian
Research01 Mar 1995
Bio/Technology

Volume: 13, P: 271-275
p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding

Carol A Midgley
David P Lane
Research04 Sept 1997
Oncogene

Volume: 15, P: 1179-1189
The skin is no barrier to mixtures: Air pollutant mixtures and reported psoriasis or eczema in the Personalized Environment and Genes Study (PEGS)

Melissa E. Lowe
Farida S. Akhtari
Kyle P. Messier
ResearchOpen Access02 Dec 2022
Journal of Exposure Science & Environmental Epidemiology

Volume: 33, P: 474-481
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

Elizabeth England
D. Gareth Rees
E. Suzanne Cohen
ResearchOpen Access17 Jun 2023
Scientific Reports

Volume: 13, P: 1-15
Should mentoring be routinely introduced into general dental practice to reduce the risk of occupational stress?

Robert J. G. Seath
David R. Radford
Debbie P. Reed
Research26 Jul 2019
British Dental Journal

Volume: 227, P: 121-125
Enzyme engineering for rare genetic diseases and cancer

Aeglea BioTherapeutics is engineering human enzymes for the treatment of both rare genetic diseases and cancer.

Aeglea BioTherapeutics
Advertorial02 Jun 2017
Biopharma Dealmakers
Improved Wool Production in Transgenic Sheep Expressing Insulin-like Growth Factor 1

Sami Damak
Hung-yi Su
David W. Bullock
Research01 Feb 1996
Bio/Technology

Volume: 14, P: 185-188
Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis

David J Askew
Unsal Kuscuoglu
Roger L Miesfeld
Research27 Aug 1999
Cell Death & Differentiation

Volume: 6, P: 796-804
Large Scale, In Situ Isolation of Periplasmic IGF–I from E. coli

Roger A. Hart
Philip M. Lester
Stuart E. Builder
Research01 Nov 1994
Bio/Technology

Volume: 12, P: 1113-1117
Multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma

A large multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma, providing insight into the genetic basis of these serious forms of cancer.

Hélène Choquet
Chen Jiang
Maryam M. Asgari
ResearchOpen Access05 Jan 2024
Communications Biology

Volume: 7, P: 1-10
The size and culturability of patient-generated SARS-CoV-2 aerosol

Joshua L. Santarpia
Vicki L. Herrera
John J. Lowe
ResearchOpen Access18 Aug 2021
Journal of Exposure Science & Environmental Epidemiology

Volume: 32, P: 706-711
Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia

Karolina Kozak Bidzinski
Darby J. E. Lowe
Tony P. George
ResearchOpen Access24 Feb 2022
Schizophrenia

Volume: 8, P: 1-11
The effect of microbial colonization on the host proteome varies by gastrointestinal location

Joshua S Lichtman
Emily Alsentzer
Joshua E Elias
Research17 Nov 2015
The ISME Journal

Volume: 10, P: 1170-1181
A global database for metacommunity ecology, integrating species, traits, environment and space

Alienor Jeliazkov
Darko Mijatovic
Jonathan M. Chase
ResearchOpen Access08 Jan 2020
Scientific Data

Volume: 7, P: 1-15
Strategies for the successful implementation of plasma-based NSCLC genotyping in clinical practice

Genotyping is recommended for all patients with metastatic non-squamous non-small-cell lung cancers (NSCLC), both to enable patients to receive targeted therapies and to avoid therapies they are unlikely to benefit from. However, obtaining tumour biopsy material for genotyping is often challenging and is unfeasible in some patients, indicating the need to incorporate liquid biopsy approaches. In this Perspective, the authors provide guidance on how analysis of ctDNA from liquid biopsy samples in patients with metastatic NSCLC prior to first-line therapy has the potential to extend the benefits of genotyping to virtually all patients.

Charu Aggarwal
Christian D. Rolfo
David R. Gandara
Reviews11 Sept 2020
Nature Reviews Clinical Oncology

Volume: 18, P: 56-62
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Executable network of SARS-CoV-2-host interaction predicts drug combination treatments

Rowan Howell
Matthew A. Clarke
Jasmin Fisher
ResearchOpen Access14 Feb 2022
npj Digital Medicine

Volume: 5, P: 1-13
A cocktail of human monoclonal antibodies broadly neutralizes North American rabies virus variants as a promising candidate for rabies post-exposure prophylaxis

Monir Ejemel
Todd G. Smith
Yang Wang
ResearchOpen Access07 Jun 2022
Scientific Reports

Volume: 12, P: 1-11
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

Claire L. Dobson
Paul W. A. Devine
David C. Lowe
ResearchOpen Access20 Dec 2016
Scientific Reports

Volume: 6, P: 1-14
RETRACTED ARTICLE: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus

David Bernard
Juan F Martinez-Leal
Jesus Gil
Research09 May 2005
Oncogene

Volume: 24, P: 5543-5551
Variation in the colour of the keel petals in Lotus corniculatus L. 4. Morph distribution in the British Isles

Terence J Crawford
David A Jones
Research01 Oct 1988
Heredity

Volume: 61, P: 175-188
Transmission dynamics of SARS-CoV-2 in a strictly-Orthodox Jewish community in the UK

William Waites
Carl A. B. Pearson
Rosalind M. Eggo
ResearchOpen Access20 May 2022
Scientific Reports

Volume: 12, P: 1-12
The UCSC SARS-CoV-2 Genome Browser

The UCSC SARS-CoV-2 Genome Browser (https://genome.ucsc.edu/covid19.html) is an adaptation of our popular genome-browser visualization tool for this virus, containing many annotation tracks and new features, including conservation with similar viruses, immune epitopes, RT–PCR and sequencing primers and CRISPR guides. We invite all investigators to contribute to this resource to accelerate research and development activities globally.

Jason D. Fernandes
Angie S. Hinrichs
Maximilian Haeussler
Comments & Opinion09 Sept 2020
Nature Genetics

Volume: 52, P: 991-998
Analysis of rare Parkinson’s disease variants in millions of people

Vanessa Pitz
Mary B. Makarious
Cornelis Blauwendraat
ResearchOpen Access08 Jan 2024
npj Parkinson's Disease

Volume: 10, P: 1-10
Characterizing mood disorders in the AFFECT study: a large, longitudinal, and phenotypically rich genetic cohort in the US

Maria Dalby
Morana Vitezic
Jordan W. Smoller
ResearchOpen Access25 Mar 2022
Translational Psychiatry

Volume: 12, P: 1-10
Modeling the functional genomics of autism using human neurons

G Konopka
E Wexler
D H Geschwind
Research07 Jun 2011
Molecular Psychiatry

Volume: 17, P: 202-214
Cocaine-mediated impact on HIV infection in humanized BLT mice

Sohn G. Kim
Emily L. Lowe
Dimitrios N. Vatakis
ResearchOpen Access18 Jun 2015
Scientific Reports

Volume: 5, P: 1-11
A comparison of experience sampled hay fever symptom severity across rural and urban areas of the UK

Ann Gledson
Douglas Lowe
Caroline Jay
ResearchOpen Access21 Feb 2023
Scientific Reports

Volume: 13, P: 1-15
X-ray computed tomography

This Primer on X-ray computed tomography explores the different experimental configurations for three-dimensional data acquisition as well as the fundamentals of three-dimensional data reconstruction, segmentation and analysis with examples across the physical and life sciences.

Philip J. Withers
Charles Bouman
Stuart R. Stock
Reviews25 Feb 2021
Nature Reviews Methods Primers

Volume: 1, P: 1-21
Identification of genetic variants associated with tacrolimus metabolism in kidney transplant recipients by extreme phenotype sampling and next generation sequencing

Casey R. Dorr
Baolin Wu
David N. Rush
Research16 Nov 2018
The Pharmacogenomics Journal

Volume: 19, P: 375-389
EBV BCL-2 homologue BHRF1 drives chemoresistance and lymphomagenesis by inhibiting multiple cellular pro-apoptotic proteins

Leah Fitzsimmons
Rachel Cartlidge
Gemma L. Kelly
Research23 Oct 2019
Cell Death & Differentiation

Volume: 27, P: 1554-1568
Aerosol and surface contamination of SARS-CoV-2 observed in quarantine and isolation care

Joshua L. Santarpia
Danielle N. Rivera
John J. Lowe
ResearchOpen Access29 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Bite force in the horned frog (Ceratophrys cranwelli) with implications for extinct giant frogs

A. Kristopher Lappin
Sean C. Wilcox
Marc E. H. Jones
ResearchOpen Access20 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Rapid changes in Atlantic grey seal milk from birth to weaning – immune factors and indicators of metabolic strain

Amanda D. Lowe
Sami Bawazeer
Malcolm W. Kennedy
ResearchOpen Access23 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Charles E. Green
Jon E. Tyson
Kimberlee Weaver-Lewis
ResearchOpen Access04 Aug 2023
Journal of Perinatology

Volume: 43, P: 1398-1405
Correlations in sleeping patterns and circadian preference between spouses

Mendelian randomization analysis leveraging data from the UK Biobank and 23andMe, Inc., suggests that an individual’s sleep habits may impact those of their partner.

Rebecca C. Richmond
Laurence J. Howe
Céline Vetter
ResearchOpen Access13 Nov 2023
Communications Biology

Volume: 6, P: 1-14
Cellular manganese content is developmentally regulated in human dopaminergic neurons

Kevin K. Kumar
Edward W. Lowe, Jr.
Aaron B. Bowman
ResearchOpen Access28 Oct 2014
Scientific Reports

Volume: 4, P: 1-8
FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of the tetrasaccharide sLex on the surface of basophils, resulting in cells that are less sticky and therefore less able to form the necessary adhesions for exiting the blood vessel to drive the allergic reaction.

Kia Joo Puan
Boris San Luis
Olaf Rötzschke
ResearchOpen Access02 Jul 2021
Communications Biology

Volume: 4, P: 1-13
Long-term efficacy, tolerability and overall survival in patients with platinum-sensitive, recurrent high-grade serous ovarian cancer treated with maintenance olaparib capsules following response to chemotherapy

Michael Friedlander
Ursula Matulonis
Jonathan Ledermann
ResearchOpen Access24 Oct 2018
British Journal of Cancer

Volume: 119, P: 1075-1085
The promise and peril of chemical probes

Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

Cheryl H Arrowsmith
James E Audia
William J Zuercher
Comments & Opinion21 Jul 2015
Nature Chemical Biology

Volume: 11, P: 536-541
Selective digestive tract decontamination to prevent healthcare associated infections in critically ill children: the PICNIC multicentre randomised pilot clinical trial

Nazima Pathan
Kerry Woolfall
Francesca Moody
ResearchOpen Access07 Dec 2023
Scientific Reports

Volume: 13, P: 1-12
Anterior Cingulate and Frontal Lobe White Matter Spectroscopy in Early Childhood of Former Very LBW Premature Infants

John P Phillips
David Ruhl
Jean R Lowe
Research01 Mar 2011
Pediatric Research

Volume: 69, P: 224-229
Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer

M E Caldwell
G M DeNicola
D A Tuveson
Research22 Aug 2011
Oncogene

Volume: 31, P: 1599-1608

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