Search

Antiferromagnets have negligible stray magnetic fields and are robust against magnetic perturbations, making them ideal for high-density magnetic memory. However, these features make electrically switching the Néel vector challenging. Here, Guo, Lin and coauthors demonstrate layer-dependent electrical switching of a van der Waals antiferromagnet.

Innate lymphoid cells (ILC) have been shown to be involved in a range of inflammatory contexts but how their cellular lineage is regulated is not fully established. Here the authors show a role for circular RNA circTmem241 in the differentiation of ILC3 via initiation of Elk3 transcription.

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

Striatal neural circuits control reward-associated behaviors but the role of astrocytes is still unclear. Here, the authors show that chemogenetic manipulation of striatal astrocyte in mice restore obesity-associated cognitive defect and exert a control on whole-body metabolism.

This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Pancreatic cancer detection can be challenging, and is often diagnosed at a late stage. Here, the authors present a cfDNA-based liquid biopsy model that enables early detection and prognosis prediction of pancreatic cancer.

Here, Zhang et al. succeed in creating a heavily distorted oxygen deficient film of lanthanum cobaltite. The new phase of LaCoO_2.5 has several unique properties, most notably, a Curie temperature of 284 K, significantly larger than the films from which it was derived.

A template-free magnetization strategy for inverse programming of hard-magnetic domains embedded in solvent-responsive hydrogel is reported using a photodosage-based printing method, achieving shape morphing into 3D curved surfaces under the actuation of a magnetic field.

The suboptimal performance of perovskite solar cells based on non-fullerene acceptor as the electron-transporting layer underscores the need for their molecular engineering. Here, authors substitute the core of Y6 with phenanthroline and crown ether, achieving a certified efficiency of 25.59%.

High-speed electrostatic micromotors with low energy consumption are attractive for small-scale electromechanical systems, but applications are limited by power supplies. Here the authors use a triboelectric nanogenerator for actuation of a high-speed micromotor by low-frequency mechanical stimuli.

Semi-aquatic robots rely on surface tension for propulsion, which implies that breaking the water surface is a limitation. Here, the authors developed a soft robot with a superhydrophobic body, achieving high jumping height and take-off velocity.

Experimentally probing the orbital population is highly desirable to resolve the redox mechanism of cathodes materials. Here the authors quantify the orbital populations of Co and O in LiCoO₂ and identify the ligand-to-metal charge transfer.

Fan and colleagues show that circular RNA circPan3 controls expression of the cytokine receptor IL-13Rα1 on intestinal stem cells and, thus, the renewal of those cells in response to IL-13 derived from group 2 innate lymphoid cells.

A RuNi/NC catalyst with optimized interfacial water dynamics for alkaline H₂ evolution is reported. The designed strategy shows enhanced catalytic activity by achieving 12 mV overpotential at 10 mA cm^‒2 and 13.6-fold higher mass activity than Pt/C.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

Heterogeneous populations of basal cells in the prostate epithelium contain stem cells. Here the authors show that Zeb1 marks a pool of prostate epithelial stem cells that self-renew, generate prostate glandular structures with all 3 epithelial cell types and are required for prostate basal cell development.

Propulsive motion in soft robotic systems requires the power amplification of stored energy. An accumulated strain energy-fracture power-amplification method is used to create light-driven soft robotic systems with a controlled launching ability.

To date the performance of molecular electronics compared to silicon limits their applications. Yang et al. develop the first mechano-optoelectronic switch based on mechanically controlled aggregation-induced emission of the self-assembled molecules, which can be reversibly switched at high speed.

The dynamic transformation in soft architected materials often brings in unusual properties. Here, Zhang et al. present magneto-elastomers with 3D heterogeneous magnetization profiles encoded by buckling instability to achieve the dynamic regulation.

Lymphatic metastases are closely associated with tumor relapse and reduced survival in colorectal cancer (CRC). Here, the authors analysed the primary tumours, lymph node metastasis and liver metastasis of ten CRC patients and reveal co-existence of diverse modes of metastasis in the same patient.

Varying growth temperatures enables the tuning of the degree of disorder, which is fully described by the absence/presence of medium-range order and temperature-dependent densities of nanocrystallites, and electrical conductivity in amorphous monolayer carbon films.

Relocating rivers in the path of historic river channels most effectively limits ecological destruction by accelerating sediment deposition and mitigating coastal wetland loss, according to simulations of a river-dominated delta.

Designing efficient selector devices remains a challenge. Here, the authors propose a CuAg alloy-based selector with excellent ON/OFF ratio and thermal stability. It can effectively suppress the sneak-path current in 1S1R arrays, making it suitable for storage class memory and neuromorphic computing applications.

The structure of nanoparticles strongly influences their properties. Here, the authors use single crystal X-ray diffraction to resolve the crystal structures of Ag₁₃₆ and Ag₃₇₄nanoparticles, enabling the observation of local structure distortion and the lower size limit of surface plasmon resonance.

Polo-like kinase 1 (Plk1) is a key regulator of mitosis. Here, the authors show that Plk1 activates the pentose phosphate pathway in cancer cells by directly phosphorylating glucose-6-phosphate dehydrogenase (G6PD) and that such activation is critical for cell cycle progression and cancer cell growth.

De novo DNA methylation has been associated with T cell exhaustion in cancer immunotherapy. Here the authors show that the pre-treatment of CD19 CAR-T cells with the DNA methyltransferase inhibitor decitabine limits exhaustion and confers enhanced proliferative, effector and memory properties upon antigen exposure, with improved tumor control.

Aqueous solutions under nanoscale confinement exhibit interesting physicochemical properties. This work reports evidence on the spontaneous formation of two-dimensional alkali chloride crystalline/non-crystalline nanostructures in dilute aqueous solution under nanoscale confinement by computer simulations.

Favoured cathodes for batteries should include abundant and redox-active elements, such as manganese. Here the authors report a Na_0.6Li_0.2Mn_0.8O₂ cathode design featuring a unique layer stacking sequence that provides topological protection to oxygen redox to overcome the performance fading.

Li and colleagues show how cMyc promotes tumourigenesis by promoting succinate dehydrogenase complex subunit A acetylation by activating SKP2-mediated degradation of SIRT3. This leads to succinate accumulation and consequent tumour-specific gene expression.

The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.

Hydrogen production from water electrolysis requires high working voltages and produces H₂ only at the cathode. Now, H₂ generation during the oxidation of biomass-derived aldehydes is combined with the hydrogen evolution reaction on the cathode for low-voltage H₂ production.

Cognitive impairment is a feature of many psychiatric diseases. Here the authors aimed to identify multimodal neuromarkers that can be used to quantify and predict cognitive performance in individuals with schizophrenia using three different features of MRI and three independent cohorts.