Nature Search

Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism

Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detectable in blood samples from unaffected individuals, and may therefore represent disease biomarkers.

Rianne E. van Outersterp
Sam J. Moons
Jonathan Martens
ResearchOpen Access19 Mar 2021
Communications Biology

Volume: 4, P: 1-8
Genomically matched therapy in advanced solid tumors: the randomized phase 2 ROME trial

In the proof-of-concept phase 2 ROME trial, comprehensive genomic profiling followed by molecular tumor board evaluation and randomization of patients with metastatic solid cancer to receive personalized therapy or standard of care led to a significantly higher objective response rate and longer progression-free survival in patients who received personalized therapy.

Paolo Marchetti
Giuseppe Curigliano
Francesca Mannozzi
ResearchOpen Access29 Sept 2025
Nature Medicine

Volume: 31, P: 3514-3523
HCS-3DX, a next-generation AI-driven automated 3D-oid high-content screening system

Standardisation of working with 3D cell cultures in high-content screening (HCS) approaches remains difficult. Here, the authors propose HCS-3DX, a system for HCS of 3D tumour models at single-cell resolution by combining micromanipulation, custom multi-well plates, advanced imaging and AI-based analysis.

Akos Diosdi
Timea Toth
Peter Horvath
ResearchOpen Access07 Oct 2025
Nature Communications

Volume: 16, P: 1-16
An agent cleaving glucose-derived protein crosslinks in vitro and in vivo

Sara Vasan
Xin Zhang
Peter Ulrich
Research18 Jul 1996
Nature

Volume: 382, P: 275-278
Linkage of Carbohydrate to Protein in Ovalbumin

F. R. JEVONS
Research10 May 1958
Nature

Volume: 181, P: 1346-1347
Carbamylation and glycation compete for collagen molecular aging in vivo

Camille Nicolas
Stéphane Jaisson
Philippe Gillery
ResearchOpen Access04 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Docetaxel and gemcitabine activity in NSCLC cell lines and in primary cultures from human lung cancer

W Zoli
L Ricotti
D Amadori
ResearchOpen Access24 Sept 1999
British Journal of Cancer

Volume: 81, P: 609-615
Directed evolution of new catalytic activity using the α/β-barrel scaffold

Myriam M. Altamirano
Jonathan M. Blackburn
Alan R. Fersht
Research10 Feb 2000
Nature

Volume: 403, P: 617-622
Mutational and low-coverage whole genome sequencing identifies actionable DNA repair alterations in prostate cancer plasma DNA

Alessandra Virga
Milena Urbini
Paola Ulivi
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-14
Minimally differentiated acute myeloid leukemia in Taiwan: predominantly occurs in children less than 3 years and adults between 51 and 70 years

S-Y Huang
J-L Tang
H-F Tien
Research07 Oct 1999
Leukemia

Volume: 13, P: 1506-1512
Absorption Spectrum of Deeply Coloured Cyclopentadiene Polymers

C. F. BLAKELY
A. WASSERMANN
Research29 Jan 1955
Nature

Volume: 175, P: 219-220
Structure of the Oxygen-carrying Cobalt (II) Histidine Complex

A. EARNSHAW
L. F. LARKWORTHY
Research16 Dec 1961
Nature

Volume: 192, P: 1068-1069
B procyanidins of Annona crassiflora fruit peel inhibited glycation, lipid peroxidation and protein-bound carbonyls, with protective effects on glycated catalase

Allisson B. Justino
Rodrigo R. Franco
Foued S. Espindola
ResearchOpen Access16 Dec 2019
Scientific Reports

Volume: 9, P: 1-15
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

Kidney metabolism in disease is important but not well understood. Here, using isotope-guided metabolomics, the authors show that lysine’s metabolic activity conveys kidney protection in hypertension through accelerated metabolism and physiological effects on tubular function.

Markus M. Rinschen
Oleg Palygin
Alexander Staruschenko
ResearchOpen Access14 Jul 2022
Nature Communications

Volume: 13, P: 1-17
A climatological baseline for understanding patterns of seasonal lake dynamics across sub-Sahelian Africa

The seasonal lake dynamics in sub-Sahelian Africa are shaped by climate and human activities, revealing shared ecological vulnerabilities, according to a climatological analysis of 137 lakes.

M. Amadori
A. J. Greife
R. I. Woolway
ResearchOpen Access20 Aug 2025
Communications Earth & Environment

Volume: 6, P: 1-16
Gastroesophageal circulating tumor cell crosstalk with peripheral immune system guides CTC survival and proliferation

Tania Rossi
Martina Valgiusti
Giulia Gallerani
ResearchOpen Access29 Mar 2025
Cell Death & Disease

Volume: 16, P: 1-15
Formation of Advanced Glycosylation End Products and Oxidative Stress in Young Patients with Type 1 Diabetes

Hirokazu Tsukahara
Kyouichi Sekine
Mitsufumi Mayumi
Research01 Sept 2003
Pediatric Research

Volume: 54, P: 419-424
Comparative analysis of library preparation approaches for FFPE gene expression profiling and related recommendations

Sara Pignatta
Marcella Tazzari
Jenny Bulgarelli
ResearchOpen Access12 Aug 2025
Scientific Reports

Volume: 15, P: 1-9
Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture

The role of alphavirus nsP3 protein is not entirely clear. Here, through structural analysis the authors show that CHIKV nsP3 polymerizes to form tubular scaffolds in both replication complexes and alpha-granules and that these scaffolds are important for virus RNA synthesis and infectivity.

Vasiliya Kril
Michael Hons
Juan Reguera
ResearchOpen Access16 Sept 2024
Nature Communications

Volume: 15, P: 1-16
Pelabresib plus ruxolitinib for JAK inhibitor-naive myelofibrosis: a randomized phase 3 trial

In a randomized phase 3 trial, the combination of the BET inhibitor pelabresib with the JAK inhibitor ruxolitinib resulted in a significantly higher spleen volume reduction from baseline versus placebo with ruxolitinib in patients with JAK inhibitor-naive myelofibrosis.

Raajit K. Rampal
Sebastian Grosicki
John Mascarenhas
ResearchOpen Access10 Mar 2025
Nature Medicine

Volume: 31, P: 1531-1538
Analytical performance evaluation of the Mindray enzymatic assay for hemoglobin A_1c measurement

Mingyang Li
Xiongjun Wu
Ling Ji
ResearchOpen Access29 May 2024
Scientific Reports

Volume: 14, P: 1-7
Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia

The role of metabolism in acute myeloid leukaemia (AML) onset remains to be explored. Here, the authors explore the metabolic landscape of AML cells and the signature of extracellular vesicles (EVs) in peripheral blood and show that circulating EVs regulate leukaemia (stem) cell metabolic reprogramming.

Dorian Forte
Roberto Maria Pellegrino
Antonio Curti
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-19
Network pharmacology-based study in polymetformin’s new function of blocking ages/rage pathway curing diabetic complications

Linghong Kong
Hui Wang
Hanping Liu
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-11
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes, highlighting roles in synaptic transmission and neuronal excitability.

Siwei Chen
Bassel W. Abou-Khalil
Samuel F. Berkovic
Research03 Oct 2024
Nature Neuroscience

Volume: 27, P: 1864-1879
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy

Maximilian Jonathan Herzog
Patrick Müller
Ruediger C. Braun-Dullaeus
ReviewsOpen Access01 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-33
Prognostic relevance of the expression of Tdt and CD7 in 335 cases of acute myeloid leukemia

A Venditti
G Del Poeta
S Amadori
Research24 Jul 1998
Leukemia

Volume: 12, P: 1056-1063
A mechanistic framework for cardiometabolic and coronary artery diseases

Koplev et al. apply interactive system analyses to infer and characterize gene-regulatory networks (GRNs) active within and across tissues that cause cardiometabolic disease and coronary artery disease (CAD). By including GWAS in the integrative analysis, the provided multiorgan framework of GRNs is suggested to explain significantly more heritability of CAD than what has been achieved by analyzing GWAS alone.

Simon Koplev
Marcus Seldin
Johan L. M. Björkegren
Research12 Jan 2022
Nature Cardiovascular Research

Volume: 1, P: 85-100
Single-cell immune landscape of human atherosclerotic plaques

Single-cell proteomic and transcriptional profiling of atherosclerotic lesions from human carotid arteries reveals specific features of lesional T cells and macrophages associated with symptomatic disease.

Dawn M. Fernandez
Adeeb H. Rahman
Chiara Giannarelli
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1576-1588
Academic standards in Italy

F. Persico
Correspondence30 Jul 1992
Nature

Volume: 358, P: 364
Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition

Hajar Estiri
Shapla Bhattacharya
Alfonso Gautieri
ResearchOpen Access30 Oct 2023
Scientific Reports

Volume: 13, P: 1-12
Dynamic changes of live/apoptotic circulating tumour cells as predictive marker of response to Sunitinib in metastatic renal cancer

E Rossi
M Fassan
R Zamarchi
ResearchOpen Access06 Sept 2012
British Journal of Cancer

Volume: 107, P: 1286-1294
Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs

T-UCRs encode long non-coding RNAs implicated in human carcinogenesis, but the underlying mechanisms are poorly understood. Here, the authors identify uc.339 as an oncogene in lung cancer that is upregulated through the loss of TP53 and promotes Cyclin E activation by entrapping regulatory miRNAs.

Ivan Vannini
Petra M. Wise
Muller Fabbri
ResearchOpen Access27 Nov 2017
Nature Communications

Volume: 8, P: 1-19
A climatically significant abiotic mechanism driving carbon loss and nitrogen limitation in peat bogs

Alexandra B. Cory
Rachel M. Wilson
Jeffrey P. Chanton
ResearchOpen Access20 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
Role of Carbonyl Modifications on Aging-Associated Protein Aggregation

Maya Tanase
Aleksandra M. Urbanska
Laura Santambrogio
ResearchOpen Access18 Jan 2016
Scientific Reports

Volume: 6, P: 1-14
Circulating genomic landscape following cyclin-dependent kinase 4/6 inhibitors exposure in HR + /HER2− metastatic breast cancer: a retrospective multi-institutional Consortium analysis

Letizia Pontolillo
Andrew A. Davis
Massimo Cristofanilli
ResearchOpen Access16 Aug 2025
npj Breast Cancer

Volume: 11, P: 1-10
Sequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II SECOMBIT trial

SECOMBIT was a clinical trial testing different sequences of immunotherapy (ipilimumab plus nivolumab) and targeted therapy (encorafenib plus binimetinib) for untreated BRAF-mutated metastatic melanoma. Here the authors report 4-year survival outcomes, confirming long-term benefit with first-line immunotherapy, and preliminary biomarkers evaluation.

Paolo A. Ascierto
Milena Casula
Giuseppe Palmieri
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-12
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial

In an arm of a phase 1b trial, the combination of divarasib, a KRAS G12C inhibitor, and cetuximab, an epidermal growth factor receptor inhibitor, was well tolerated with an encouraging overall response rate of 62.5% in patients with KRAS G12C-positive colorectal cancer.

Jayesh Desai
Guzman Alonso
Sae-Won Han
ResearchOpen Access05 Dec 2023
Nature Medicine

Volume: 30, P: 271-278
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Here, the authors perform a meta-analysis in 26,699 people with seizures and 492,324 controls to identify 25 genome-wide significant copy-number variants. The discovered loci point to known disease genes and associations with clinical annotations.

Ludovica Montanucci
David Lewis-Smith
Dennis Lal
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Selected medical conditions and risk of breast cancer

R Talamini
S Franceschi
C La Vecchia
Research01 Jun 1997
British Journal of Cancer

Volume: 75, P: 1699-1703
The role of Gemtuzumab Ozogamicin in the treatment of acute myeloid leukemia patients

L Pagano
L Fianchi
G Leone
Reviews28 May 2007
Oncogene

Volume: 26, P: 3679-3690
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.

Wei-Yu Lin
Sarah E. Fordham
James M. Allan
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-10
Fluorescence in situ hybridization for the detection and monitoring of the Ph-positive clone in chronic myelogenous leukemia: comparison with metaphase banding analysis

A Cuneo
R Bigoni
A Hagemeijer
Research22 Oct 1998
Leukemia

Volume: 12, P: 1718-1723
Oxidative stress in early diabetic nephropathy: fueling the fire

This Review summarizes the role of reactive oxygen species and oxidative stress in diabetes mellitus and in the pathogenesis of endothelial cell dysfunction and diabetic nephropathy. Furthermore, the authors explore possible therapeutic interventions to reduce oxidative stress and endothelial cell dysfunction and retard the progression of diabetic nephropathy.

Dhruv K. Singh
Peter Winocour
Ken Farrington
Reviews14 Dec 2010
Nature Reviews Endocrinology

Volume: 7, P: 176-184
Loop dynamics and the evolution of enzyme activity

Enzyme conformational plasticity plays an important part in expanding the functional diversity of a limited repertoire of sequences. This Review discusses the role of flexible loops in enzyme evolution, focusing on both examples from natural evolution and engineering success stories.

Marina Corbella
Gaspar P. Pinto
Shina C. L. Kamerlin
Reviews24 May 2023
Nature Reviews Chemistry

Volume: 7, P: 536-547
THE EFFECT OF RH FETO-MATERNAL INCOMPATIBILITY ON ABO INCOMPATIBILITY

G Jovenitti
F Gloria
E Bottini
Research01 Nov 1975
Pediatric Research

Volume: 9, P: 867
EFFECT OF D-XYLOSE ON ACTIVE SODIUM TRANSPORT IN ISOLATED RABBIT INTESTINE

Nicole Bertrand
Monique Chevrot
J F Desjeux
Research01 Nov 1975
Pediatric Research

Volume: 9, P: 867
POSSIBLE COUPLING BETWEEN NA AND GLUCOSE ABSORPTIONS IN JEJUNAL MUCOSA OF CHILDREN

J F Desjeux
Research01 Nov 1975
Pediatric Research

Volume: 9, P: 867
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

Genetic variants in ionotropic glutamate receptors have been implicated in neurodevelopmental disorders. Here, the authors report heterozygous de novo mutations in the GRIA2 gene in 28 individuals with intellectual disability and neurodevelopmental abnormalities associated with reduced Ca²⁺ transport and AMPAR currents.”

Vincenzo Salpietro
Christine L. Dixon
Henry Houlden
ResearchOpen Access12 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Role of cytokines in the treatment of acute leukemias: a review

F Ravandi
Reviews23 Feb 2006
Leukemia

Volume: 20, P: 563-571

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