Nature Search

Mass Ejection by Highly Evolved Stars

HOWARD D. GREYBER
Research30 Apr 1966
Nature

Volume: 210, P: 510-511
Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor

Gao et al. report that leptin receptor⁺ stromal cells sustain nerves in the bone marrow by producing nerve growth factor. After myeloablation, nerves promote marrow regeneration by increasing the production of multiple growth factors by leptin receptor⁺ cells.

Xiang Gao
Malea M. Murphy
Sean J. Morrison
ResearchOpen Access27 Nov 2023
Nature Cell Biology

Volume: 25, P: 1746-1757
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

Calvin J. Kuo
Jongkyeong Chung
Gerald R. Crabtree
Research02 Jul 1992
Nature

Volume: 358, P: 70-73
Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction

Schneeberger et al. show that glutamatergic neurons within the dorsal raphe nucleus of the brainstem are enriched with the orexin 1 receptor Hcrtr1, which can be pharmacologically targeted to treat obesity in mice.

Marc Schneeberger
Nicola L. Brice
Jeffrey M. Friedman
ResearchOpen Access21 Nov 2022
Nature Metabolism

Volume: 4, P: 1495-1513
Activation of Raf by ionizing radiation

Usha Kasid
Simeng Suy
Thomas W. Sturgill
Research29 Aug 1996
Nature

Volume: 382, P: 813-816
Metal ion catalysis in the Tetrahymena ribozyme reaction

Joseph A. Piccirilli
Joseph S. Vyle
Thomas R. Cech
Research07 Jan 1993
Nature

Volume: 361, P: 85-88
Disruption of the cerebrospinal fluid–plasma protein balance in cognitive impairment and aging

Proteomic analysis of paired cerebrospinal fluid and plasma samples from 2,171 individuals drawn from multiple cohorts, including the Global Neurodegeneration Proteomics Consortium, reveals age-related changes in the ratios of proteins in the cerebrospinal fluid and plasma that are associated with cognitive function, enhancing understanding of blood–brain barrier dynamics in aging.

Amelia Farinas
Jarod Rutledge
Tony Wyss-Coray
ResearchOpen Access15 Jul 2025
Nature Medicine

Volume: 31, P: 2578-2589
Transformations of neural representations in a social behaviour network

BNSTpr^Esr1 activity is required to gate the transition from appetitive to consummatory male social behaviours towards both sexes, by controlling sex- and behaviour-specific representations in VMHvl and MPOA, respectively.

Bin Yang
Tomomi Karigo
David J. Anderson
Research03 Aug 2022
Nature

Volume: 608, P: 741-749
Causal evidence of a line attractor encoding an affective state

Single-cell optogenetic stimulation and calcium imaging experiments provide direct evidence of line-attractor dynamics, including functional network connectivity, in the mammalian hypothalamus.

Amit Vinograd
Aditya Nair
David J. Anderson
ResearchOpen Access14 Aug 2024
Nature

Volume: 634, P: 910-918
Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins

Stefano Stifani
Christine M. Blaumueller
Spyros Artavanis-Tsakonas
Research01 Oct 1992
Nature Genetics

Volume: 2, P: 119-127
The 2.2 Å crystal structure of transducin-α complexed with GTP_γS

Joseph P. Noel
Heidi E. Hamm
Paul B. Sigler
Research16 Dec 1993
Nature

Volume: 366, P: 654-663
The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma–associated herpesvirus): Distribution of infection in KS risk groups and evidence for sexual transmission

Dean H. Kedes
Eva Operskalski
Don Ganem
Research01 Aug 1996
Nature Medicine

Volume: 2, P: 918-924
Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences

Eiríkur Steingrímsson
Karen J. Moore
Nancy A. Jenkins
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 256-263
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

Mark W. Sornson
Wei Wu
Michael G. Rosenfeld
Research28 Nov 1996
Nature

Volume: 384, P: 327-333
Rim4-seeded stress granules connect temperature sensing to meiotic regulation

In S. Cerevisiae, meiotic stress granules (SGs) form at temperatures ~10°C lower than those in mitosis, seeded by the meiosis-specific RNA-binding protein Rim4. These SGs halt meiosis and facilitate its resumption under heat and after heat relief, respectively.

Rudian Zhang
Shunjin Li
Fei Wang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state

Astrocyte calcium increases can alter brain state, but their dynamics during different behaviors have not been fully described. Here, the authors use multicore fiber optic imaging in freely moving mice to show that astrocyte engagement in behavior is influenced by the motivational state.

Yung-Tian A. Gau
Eric T. Hsu
Dwight E. Bergles
ResearchOpen Access08 Apr 2024
Nature Communications

Volume: 15, P: 1-21
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle

Anita G. Seto
Arthur J. Zaug
Thomas R. Cech
Research09 Sept 1999
Nature

Volume: 401, P: 177-180
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform

Peptides that bind MHC class I are readily identified with a programmable, high-throughput method.

Peter M. Bruno
Richard T. Timms
Stephen J. Elledge
Research02 Jan 2023
Nature Biotechnology

Volume: 41, P: 980-992
A mouse model for the learning and memory deficits associated with neurofibromatosis type I

Alcino J. Silva
Paul W. Frankland
Roussoudan Bourtchuladze
Research01 Mar 1997
Nature Genetics

Volume: 15, P: 281-284
Afocal apposition optics in butterfly eyes

D.-E. Nilsson
M. F. Land
J. Howard
Research06 Dec 1984
Nature

Volume: 312, P: 561-563
Genetic transfer of nitrogenase–hydrogenase activity in Rhodopseudomonas capsulata

JUDY D. WALL
PAUL F. WEAVER
HOWARD GEST
Research01 Dec 1975
Nature

Volume: 258, P: 630-631
Brain-wide visual habituation networks in wild type and fmr1 zebrafish

Habituation is a process in which animals stop responding to repetitive stimuli, and habituation is altered in autism and other conditions. Here, the authors describe visual habituation networks across the zebrafish brain, and find that fmr1 mutants show slower brain-wide and behavioural habituation.

Emmanuel Marquez-Legorreta
Lena Constantin
Ethan K. Scott
ResearchOpen Access16 Feb 2022
Nature Communications

Volume: 13, P: 1-19
Molecular logic of cellular diversification in the mouse cerebral cortex

A single-cell atlas of the developing mouse cortex provides a temporal and spatial assessment of the molecular logic that drives the establishment and organization of cortical cell types.

Daniela J. Di Bella
Ehsan Habibi
Paola Arlotta
Research23 Jun 2021
Nature

Volume: 595, P: 554-559
Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice

Ultrasonic vocalizations of male mice distinguish aggressive, male-directed mounting from reproductive, female-directed mounting behaviours, which are represented by distinct ESR1-expressing populations of neurons in the ventromedial hypothalamus and medial preoptic area, respectively.

Tomomi Karigo
Ann Kennedy
David J. Anderson
Research02 Dec 2020
Nature

Volume: 589, P: 258-263
The thermosome: chaperonin with a built-in lid

Recent crystal structures of the Thermoplasma acidophilum thermosome and its isolated apical domain suggest that an integral extension of the apical domain encloses the folding-active chaperonin central cavity.

Arthur L. Horwich
Helen R. Saibil
News & Views01 May 1998
Nature Structural Biology

Volume: 5, P: 333-336
Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial

In this phase 1 trial, patients with locally advanced or metastatic solid tumors were treated with the individualized mRNA neoantigen-specific immunotherapy (iNeST) autogene cevumeran alone or in combination with the anti-PD-L1 agent atezolizumab, showing long-lasting neoantigen-specific immune responses and preliminary clinical activity, supporting further development of this therapeutic approach.

Juanita Lopez
Thomas Powles
D. Ross Camidge
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 152-164
Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function

Despite the known role of midbrain dopaminergic (mDA) signaling in the homeostatic control of mood and motor functions, little is known about how gene expression in these neurons is regulated. Here, authors develop an in vivo nuclear tagging and capture technique for low-input chromatin accessibility and transcriptome profiling of genetically-defined neuron populations to identify Gmeb1 as a novel transcriptional regulator of mDA neurons, whose loss of function impairs motor control in mice.

Luis M. Tuesta
Mohamed N. Djekidel
Yi Zhang
ResearchOpen Access07 Jun 2019
Nature Communications

Volume: 10, P: 1-12
Neural ensemble dynamics underlying a long-term associative memory

Use of a head-mounted miniature microscope in awake, behaving mice reveals that neural ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli in a way that matches models of supervised learning.

Benjamin F. Grewe
Jan Gründemann
Mark J. Schnitzer
Research22 Mar 2017
Nature

Volume: 543, P: 670-675
Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster

Steven F. Bellon
Karla K. Rodgers
Thomas A. Steitz
Research01 Jul 1997
Nature Structural Biology

Volume: 4, P: 586-591
LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment

Immunoengineering-based cancer therapies have huge potential. Here the authors report on the lipid nanoparticle delivery, to cancer cells, of self-amplifying RNA encoding SARS-CoV-2 spike epitope-loaded MHC I molecules to take advantage of anti-SARS-CoV-2 immunity from a vaccinated population to treat cancer.

Yonger Xue
Xucheng Hou
Yizhou Dong
ResearchOpen Access04 Mar 2025
Nature Communications

Volume: 16, P: 1-13
Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain

Dara S. Friedman
Ronald D. Vale
Research11 Aug 1999
Nature Cell Biology

Volume: 1, P: 293-297
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome

The molecular mechanisms underlying deficits in Down syndrome remain unclear. Here, the authors show that copy number restoration of a chromatin remodeler in trisomic mice is sufficient to rescue epigenomic, physiological and cognitive deficits.

Sasha L. Fulton
Wendy Wenderski
Ian Maze
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-17
Specific expression of an elastase–human growth hormone fusion gene in pancreatic acinar cells of transgenic mice

David M. Ornitz
Richard D. Palmiter
Raymond J. MacDonald
Research14 Feb 1985
Nature

Volume: 313, P: 600-602
Primary structure of porcine relaxin: homology with insulin and related growth factors

ROBERT JAMES
HUGH NIALL
GILLIAN BRYANT-GREENWOOD
Research09 Jun 1977
Nature

Volume: 267, P: 544-546
Influence of dendritic structure on firing pattern in model neocortical neurons

Zachary F. Mainen
Terrence J. Sejnowski
Research25 Jul 1996
Nature

Volume: 382, P: 363-366
Homology-dependent interactions in phage λ site-specific recombination

Paul A. Kitts
Howard A. Nash
Research24 Sept 1987
Nature

Volume: 329, P: 346-348
GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF⁻₄

John Sondek
David G. Lambright
Paul B. Sigler
Research17 Nov 1994
Nature

Volume: 372, P: 276-279
Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids

Lisa J. Hager
Richard D. Palmiter
Research28 May 1981
Nature

Volume: 291, P: 340-342
Ancestral lysozymes reconstructed, neutrality tested, and thermostability linked to hydrocarbon packing

Bruce A. Malcolm
Keith P. Wilson
Allan C. Wilson
Research03 May 1990
Nature

Volume: 345, P: 86-89
A maternally inherited superantigen encoded by a mammary tumour virus

Philippa Marrack
Elenora Kushnir
John Kappler
Research07 Feb 1991
Nature

Volume: 349, P: 524-526
Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo

Elizabeth G. Nabel
Zhi-yong Yang
Gary J. Nabel
Research29 Apr 1993
Nature

Volume: 362, P: 844-846
Sequence specificity of methylation in higher plant DNA

Yosef Gruenbaum
Tally Naveh-Many
Aharon Razin
Research27 Aug 1981
Nature

Volume: 292, P: 860-862
Peripheral deletion of antigen-reactive T cells in oral tolerance

Youhai Chen
Jun-ichi Inobe
Howard L. Weiner
Research13 Jul 1995
Nature

Volume: 376, P: 177-180
Structure of Taq polymerase with DNA at the polymerase active site

Soo Hyun Eom
Jimin Wang
Thomas A. Steitz
Research18 Jul 1996
Nature

Volume: 382, P: 278-281
Localization of pre-mRNA splicing in mammalian nuclei

Guohong Zhang
Krishan L. Taneja
Michael R. Green
Research29 Dec 1994
Nature

Volume: 372, P: 809-812
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca²⁺ flux but not mitogenesis

Kevin G. Peters
Jacky Marie
Lewis T. Williams
Research20 Aug 1992
Nature

Volume: 358, P: 678-681
One-step nanoscale expansion microscopy reveals individual protein shapes

Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins.

Ali H. Shaib
Abed Alrahman Chouaib
Silvio O. Rizzoli
ResearchOpen Access09 Oct 2024
Nature Biotechnology

Volume: 43, P: 1539-1547
A subcortical feeding circuit linking an interoceptive node to jaw movement

A subcortical circuit that regulates food consumption in mice is described, involving neurons in the ventromedial hypothalamus that are directly linked to motor centres that regulate feeding and jaw movements.

Christin Kosse
Jessica Ivanov
Jeffrey Friedman
ResearchOpen Access23 Oct 2024
Nature

Volume: 636, P: 151-161
Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

Daru Sharp
Laura Blinderman
John R. Wetterau
Research02 Sept 1993
Nature

Volume: 365, P: 65-69

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