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Showing 1–50 of 64 results

Advanced filters: Author: Hai-yan He Clear advanced filters

Neutralizing antibody durability and SARS-CoV-2 infection in older adults six months after XBB-containing vaccine booster

Rui-Rui Chen
Guo-Ping Cao
Mai-Juan Ma
ResearchOpen Access09 Oct 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-13
Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets

Follicle-stimulating hormone (FSH) is involved in mammalian reproduction, but several studies have suggested a role of FSH and its receptor in extragonadal tissue. Here, the authors show that FSH orchestrates glucose-stimulated insulin secretion (GSIS) via its receptor on pancreatic β-cells, with pre-menopausal FSH levels dose-dependently promoting GSIS and postmenopausal FSH levels inhibiting this effect.

Yi Cheng
Hong Zhu
He-Feng Huang
ResearchOpen Access01 Nov 2023
Nature Communications

Volume: 14, P: 1-11
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma

Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERTp^WT-IDH^WT glioblastoma). Here, the authors present a genetic landscape of TERTp^WT-IDH^WT glioblastoma, identifying a telomerase-positive subgroup driven by TERT-structural rearrangements and an ALT-positive subgroup with mutations in ATRX or SMARCAL1.

Bill H. Diplas
Xujun He
Hai Yan
ResearchOpen Access25 May 2018
Nature Communications

Volume: 9, P: 1-11
Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors

Yu-fang Shi
Hai-yan Zhang
Xu-chang He
Research06 Jul 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1195-1203
Immunostimulatory and anti-neoplasm effects of a novel palindrome CpG oligodeoxynucleotide in mice

Hai-yan Du
Li-hou Dong
Hai-feng Song
Research25 Jun 2012
Acta Pharmacologica Sinica

Volume: 33, P: 1047-1054
Propofol attenuation of renal ischemia/reperfusion injury involves heme oxygenase-1

Hui-hua Wang
Hai-yan Zhou
Gang Cheng
Research01 Aug 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1175-1180
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas

Hai Yan, Zachary Reitman and colleagues report exome sequencing of resected tumor tissue from brainstem gliomas and thalamic gliomas and identify mutations in PPM1D in brainstem gliomas.

Liwei Zhang
Lee H Chen
Hai Yan
Research01 Jun 2014
Nature Genetics

Volume: 46, P: 726-730
Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids

Yi-ping Zhu
Kun Xiao
Jing-kang Shen
Research26 Jan 2009
Acta Pharmacologica Sinica

Volume: 30, P: 259-269
Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer

In a prospective international cohort of 1,127 patients with non-small-cell lung cancer and ctDNA-guided therapy, ctDNA detection was associated with shorter survival, independently of clinicopathologic features and metabolic tumor volume.

Justin Jee
Emily S. Lebow
Bob T. Li
Research10 Nov 2022
Nature Medicine

Volume: 28, P: 2353-2363
Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity

Both inhibitory and excitatory input development are shaped by activity, but one may be dependent on the other. Here, the authors examine plasticity of inhibitory inputs in vivo, as well as behavioral consequences in tadpoles where excitatory transmission has been impaired.

Hai-yan He
Wanhua Shen
Hollis T. Cline
ResearchOpen Access24 Jul 2018
Nature Communications

Volume: 9, P: 1-14
BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16

Ma et al. show that acetylation of PRDM16 via acetyl-CoA, derived from branched-chain keto acids, impairs PRDM16–PPAR interaction, thus linking the BCAA–BCKA axis to the regulation of white adipose tissue browning.

Qi-Xiang Ma
Wen-Ying Zhu
Qun-Ying Lei
Research24 Jan 2022
Nature Metabolism

Volume: 4, P: 106-122
Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis

Peng Xiang
Liwen Wang
Hai-Yan Zhou
Research14 May 2025
Cellular & Molecular Immunology

Volume: 22, P: 743-759
The integrated genomic and epigenomic landscape of brainstem glioma

Brainstem gliomas are heterogenous in terms of clinical outcome and disease etiology. Here, the authors present a genetic and epigenetic landscape of brainstem gliomas, finding distinct epigenetic clusters associated with unique genetic and clinical profiles.

Lee H. Chen
Changcun Pan
Liwei Zhang
ResearchOpen Access17 Jun 2020
Nature Communications

Volume: 11, P: 1-11
A linear and circular dual-conformation noncoding RNA involved in oxidative stress tolerance in Bacillus altitudinis

The presence and/or biological functionality of circular RNAs in bacteria are unclear. Here, the authors identify a dual-conformation (linear and circular) noncoding RNA that promotes tolerance to oxidative stress in Bacillus altitutidinis, and provide evidence for the existence of other circular RNAs in diverse bacterial species.

Ting-Ting He
Yun-Fan Xu
Hai-Yan Wang
ResearchOpen Access15 Sept 2023
Nature Communications

Volume: 14, P: 1-14
Glycine-derived nitronates bifurcate to O-methylation or denitrification in bacteria

O-methyl nitronate is a rare functional group in natural products. Now, the biosynthetic pathway to O-methyl nitronate, which involves O-methylation of a peptidyl carrier protein (PCP)-tethered nitronate, has been revealed. In some bacteria, the same PCP-tethered nitronate is shown to be oxidized by nitronate monooxygenases to provide nitrite and a PCP-tethered glyoxylate.

Hai-Yan He
Katherine S. Ryan
Research29 Mar 2021
Nature Chemistry

Volume: 13, P: 599-606
A general supramolecular strategy for fabricating full-color-tunable thermally activated delayed fluorescence materials

Thermally activated delayed fluorescence materials with full-colour tunability are desirable but challenging to prepare. Here, the authors report a method for preparing such materials through the design of host-guest cocrystals with through-space charge transfer.

Nan Xue
He-Ye Zhou
Chuan-Feng Chen
ResearchOpen Access16 Feb 2024
Nature Communications

Volume: 15, P: 1-9
Bacterial outer membrane vesicle based versatile nanosystem boosts the efferocytosis blockade triggered tumor-specific immunity

Efferocytosis inhibition leads to the release of immunogenic contents into the tumor microenvironment. Here the authors developed a nanosystem that inhibits MerTK-mediated efferocytosis and captures tumor-associated agents to enhance antitumour immunity.

Wan-Ru Zhuang
Yunfeng Wang
Hai-Yan Xie
ResearchOpen Access25 Mar 2023
Nature Communications

Volume: 14, P: 1-15
Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice

Hai-yan Cai
Ting Wang
Kai-xian Chen
Research30 Sept 2013
Acta Pharmacologica Sinica

Volume: 34, P: 1397-1402
Experience-dependent recovery of vision following chronic deprivation amblyopia

Hai-Yan He
Baisali Ray
Elizabeth M Quinlan
Research12 Aug 2007
Nature Neuroscience

Volume: 10, P: 1134-1136
A heme-dependent enzyme forms the nitrogen–nitrogen bond in piperazate

Characterization of the heme-dependent enzyme KtzT reveals it to be the elusive enzyme responsible for nitrogen–nitrogen bond formation during the biosynthesis of piperazate, a building block for some nonribosomal peptide natural products.

Yi-Ling Du
Hai-Yan He
Katherine S Ryan
Research19 Jun 2017
Nature Chemical Biology

Volume: 13, P: 836-838
Raman response and transport properties of tellurium atomic chains encapsulated in nanotubes

By isolating one-dimensional tellurium nanowires in boron nitride nanotubes, the electronic properties of the atomic chains can be measured and the structures used to create field-effect transistors.

Jing-Kai Qin
Pai-Ying Liao
Peide D. Ye
Research10 Feb 2020
Nature Electronics

Volume: 3, P: 141-147
Bifidobacterium boosts anti-PD-1 effectiveness through JAK pathway in hepatocellular carcinoma

Ran Huo
Quan-guo Xu
Yan Chen
ResearchOpen Access23 Jul 2025
npj Precision Oncology

Volume: 9, P: 1-15
Author Correction: BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

Linus Manubens-Gil
Zhi Zhou
Hanchuan Peng
Amendments and Corrections02 Aug 2024
Nature Methods

Volume: 21, P: 1959
Value of TIRADS, BSRTC and FNA-BRAF^V600E mutation analysis in differentiating high-risk thyroid nodules

Yu-zhi Zhang
Ting Xu
Xiao-hong Wu
ResearchOpen Access24 Nov 2015
Scientific Reports

Volume: 5, P: 1-8
Inhibiting the CD8⁺ T cell infiltration in the tumor microenvironment after radiotherapy is an important mechanism of radioresistance

Hai-yan Chen
Lei Xu
Yong-rui Bai
ResearchOpen Access09 Aug 2018
Scientific Reports

Volume: 8, P: 1-10
Corrigendum: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54

Li-Dong Wang
Fu-You Zhou
Xue-Jun Zhang
Amendments and Corrections01 Sept 2014
Nature Genetics

Volume: 46, P: 1041
Liposome-mediated IL-28 and IL-29 expression in A549 cells and antiviral effect of IL-28 and IL-29 on WISH cells

Ming-cai Li
Hao-yang Wang
Shao-heng He
Research01 Apr 2006
Acta Pharmacologica Sinica

Volume: 27, P: 453-459
A pyridoxal phosphate–dependent enzyme that oxidizes an unactivated carbon-carbon bond

Pyridoxal 5-phosphate (PLP) is an essential coenzyme involved in diverse amino acid transformations. The discovery that Ind4 catalyzes the PLP-dependent oxidation of an unactivated carbon of L-arginine, as a part of the indolmycin biosynthetic pathway, expands the scope of reactions facilitated by PLP-dependent enzymes.

Yi-Ling Du
Rahul Singh
Katherine S Ryan
Research25 Jan 2016
Nature Chemical Biology

Volume: 12, P: 194-199
From pluripotent stem cell to adipocyte

Qi-qun Tang
Xi Li
Hai-yan Huang
Research04 Aug 2008
Cell Research

Volume: 18, P: S96
In situ 3D topographic and shape analysis by synchrotron radiation X-ray microtomography for crystal form identification in polymorphic mixtures

Xian-Zhen Yin
Ti-Qiao Xiao
Ji-Wen Zhang
ResearchOpen Access21 Apr 2016
Scientific Reports

Volume: 6, P: 1-10
The essential role for aromatic cluster in the β3 adrenergic receptor

Hai-yan Cai
Zhi-jian Xu
Wei-liang Zhu
Research25 Jun 2012
Acta Pharmacologica Sinica

Volume: 33, P: 1062-1068
Classification of 5-HT_1A receptor agonists and antagonists using GA-SVM method

Xue-lian Zhu
Hai-yan Cai
Wei-liang Zhu
Research03 Oct 2011
Acta Pharmacologica Sinica

Volume: 32, P: 1424-1430
IR-780-loaded polymeric micelles enhance the efficacy of photothermal therapy in treating breast cancer lymphatic metastasis in mice

Bin He
Hai-yan Hu
Zhi-wen Zhang
Research10 Aug 2017
Acta Pharmacologica Sinica

Volume: 39, P: 132-139
Focal neuropathologies in the brain of COVID-19-infected humans: inflammation, primary gliovascular failure and microglial dysfunction

Peter Illes
Hai-Yan Yin
Yong Tang
Research HighlightsOpen Access25 Aug 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-3
Effect of baicalin and berberine on transport of nimodipine on primary-cultured, rat brain microvascular endothelial cells

Dong-mei Zhang
Hai-yan Liu
Xiao-dong Liu
Research01 Apr 2007
Acta Pharmacologica Sinica

Volume: 28, P: 573-578
Biotransformation of indomethacin by the fungus Cunninghamella blakesleeana

Peng Zhang
Li-hong Lin
Da-fang Zhong
Research01 Aug 2006
Acta Pharmacologica Sinica

Volume: 27, P: 1097-1102
Improvement of chronic heart failure by dexamethasone is not associated with downregulation of leptin in rats

Qin-gui Xia
Tao Na
De-zai Dai
Research01 Feb 2007
Acta Pharmacologica Sinica

Volume: 28, P: 202-210
BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

This resource describes a collection of neurons from a variety of light microscopy-based datasets, which can serve as a gold standard for testing automated tracing algorithms, as shown by comparison of the performance of 35 algorithms.

Linus Manubens-Gil
Zhi Zhou
Hanchuan Peng
Research17 Apr 2023
Nature Methods

Volume: 20, P: 824-835
Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling

Yi-Shang Yan
Jia-Ying Mo
He-Feng Huang
ResearchOpen Access23 Jul 2024
Nutrition & Diabetes

Volume: 14, P: 1-13
IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients

Mou-ze Liu
Hai-yan He
Wei Zhang
Research23 Jan 2017
Acta Pharmacologica Sinica

Volume: 38, P: 415-423
Improved grading of IDH-mutated astrocytic gliomas

The WHO’s revised classification system for CNS tumours now incorporates genetic features, including the mutation status of isocitrate dehydrogenase (IDH) genes. A new article proposes that mutational status of CDKN2A and CDKN2B should also be included to facilitate grading of IDH-mutated gliomas with both prognostic and clinical relevance.

Christopher J. Pirozzi
Hai Yan
News & Views31 May 2018
Nature Reviews Neurology

Volume: 14, P: 383-384
Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro

Bing Zhang
Xian-xi Liu
Lei Gong
Research01 Mar 2006
Acta Pharmacologica Sinica

Volume: 27, P: 353-359
Ground-to-satellite quantum teleportation

Quantum teleportation of single-photon qubits from a ground observatory to a satellite in low-Earth orbit via an uplink channel is achieved with a fidelity that is well above the classical limit.

Ji-Gang Ren
Ping Xu
Jian-Wei Pan
Research09 Aug 2017
Nature

Volume: 549, P: 70-73
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies a susceptibility locus at PLCE1

Li Dong Wang and colleagues report a genome wide association study for esophageal squamous cell carcinoma in the Chinese population. They identify two risk loci at PLCE1 and C20orf54.

Li-Dong Wang
Fu-You Zhou
Xue-Jun Zhang
Research22 Aug 2010
Nature Genetics

Volume: 42, P: 759-763
Xiaoshuan enteric-coated capsule alleviates cognitive impairment by enhancing hippocampal glucose metabolism, hemodynamics and neuroplasticity of rat with chronic cerebral hypoperfusion

Man-zhong Li
Yi Zhang
Hui Zhao
ResearchOpen Access10 May 2018
Scientific Reports

Volume: 8, P: 1-14
Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line

Xiao-Lin Lin
Jin-Hua Lin
Xu-Feng Qi
ResearchOpen Access19 Dec 2024
npj Regenerative Medicine

Volume: 9, P: 1-11
The temporal progression of retinal degeneration and early-stage idebenone treatment in the Pde6b^rd1/rd1 mouse model of retinal dystrophy

Lei Zhang
Wei Liu
Zuo-Ming Zhang
ResearchOpen Access23 Jan 2024
Scientific Reports

Volume: 14, P: 1-14
Author Correction: Bufalin suppresses the migration and invasion of prostate cancer cells through HOTAIR, the sponge of miR-520b

Jian-jun Zhang
Xiao-hui Zhou
Yang Yao
Amendments and Corrections29 Jul 2024
Acta Pharmacologica Sinica

Volume: 46, P: 234
Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages

Yi-ping You
Liang Yan
Xian-hui He
Research02 Sept 2024
Acta Pharmacologica Sinica

Volume: 46, P: 430-447
Prime editing-based gene correction alleviates the hyperexcitable phenotype and seizures of a genetic epilepsy mouse model

Bi-rong Cao
Yi-ming Huang
Chang-yang Zhou
Correspondence04 Jul 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2342-2345

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