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Showing 1–50 of 96 results

Advanced filters: Author: Huiling Xu Clear advanced filters

A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2

A screen for protein degraders discovers hits by imaging cell survival.

Yankai Chu
Shishuang Chen
Hai Jiang
Research10 Sept 2025
Nature Biotechnology

P: 1-12
LdIL-2 treatment in ASD: a novel immunotherapeutic approach targeting Th/Treg dysfunction and neuroinflammation

Meng Li
Xiuying Kui
Xia Cao
ResearchOpen Access06 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-9
Flexible high-entropy functional ceramics

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

Lvye Dou
Bingbing Yang
Yuan-Hua Lin
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-10
PI3K/AKT Mediated P53 Down-Regulation Participates in CpG DNA Inhibition of Spontaneous B Cell Apoptosis

Yongxin Zhou
Huiling Zhen
Xiaoying Fu
Research01 Jun 2009
Cellular & Molecular Immunology

Volume: 6, P: 175-180
The gut–brain axis underlying hepatic encephalopathy in liver cirrhosis

The gut microbiota bacterium Ruminococcus gnavus is implicated in the development of cirrhotic liver encephalopathy through the production of neurotoxins.

Xiaolong He
Mengyao Hu
Hongwei Zhou
Research08 Jan 2025
Nature Medicine

Volume: 31, P: 627-638
Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary

Patients with metastatic cancers of unknown primary (CUP) are currently unable to gain access to drugs through standard of care or clinical trials. Here, the authors perform whole-genome and transcriptome sequencing (WGTS) on 72 patients with CUP and demonstrate the feasibility of using WGTS to determine the specific cancer types of CUP, thereby clinically benefiting patients with CUP.

Richard J. Rebello
Atara Posner
Richard W. Tothill
ResearchOpen Access20 May 2025
Nature Communications

Volume: 16, P: 1-15
Thin, soft, wearable system for continuous wireless monitoring of artery blood pressure

Continuous monitoring of arterial blood pressure is limited by bulky connecting systems and poor interfacial contact. Here, Li et al. report a wearable thin, soft, miniaturized system that integrates sensing, active pressure adaptation, and signal processing for improved performance and accuracy.

Jian Li
Huiling Jia
Xinge Yu
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-12
Author Correction: Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning

Naixin Liang
Bingsi Li
Zhihong Zhang
Amendments and Corrections30 Sept 2021
Nature Biomedical Engineering

Volume: 5, P: 1402
Transcriptome-wide Mendelian randomization during CD4⁺ T cell activation reveals immune-related drug targets for cardiometabolic diseases

Here, the authors identify genes and drug targets that show immune cell-specific and activation time point-specific effects on type 2 diabetes and coronary heart disease and find strong immune-to-metabolic disease connections.

Xueyan Wu
Hui Ying
Jieli Lu
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Erratum: Can corruption of chromosome cohesion create a conduit to cancer?

Huiling Xu
Jonathan M. Tomaszewski
Michael J. McKay
Amendments and Corrections01 Mar 2011
Nature Reviews Cancer

Volume: 11, P: 309
FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy

Aberrant protein O-GlcNAcylation has been linked with endometrial cancer (EC). Here the authors report that cellular O-GlcNAcylation level is positively correlated with EC histologic grade, and FBXO31 regulates O-GlcNAcylation homeostasis in EC by ubiquitinating the O-GlcNAc transferase OGT.

Na Zhang
Yang Meng
Kai Yuan
ResearchOpen Access02 Feb 2025
Nature Communications

Volume: 16, P: 1-22
Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation

The SARS-CoV-2 pandemic highlighted our need for methods that allow rapid viral surveillance. Here, authors report a wireless, battery-free and wearable self-diagnosis platform that can continuously capture viral particles, diagnose infection status and evaluate symptom severity via breath and blow.

Hu Li
Huarui Gong
Xinge Yu
ResearchOpen Access20 Nov 2023
Nature Communications

Volume: 14, P: 1-13
Molecular epidemiology and population immunity of SARS-CoV-2 in Guangdong (2022–2023) following a pivotal shift in the pandemic

Release of the zero-COVID policy in China in late 2022 led to two large Omicron-driven waves of infection in 2023. Here, the authors analyze virus genomes and serology data from before and after the two waves and describe changes in virus lineage distribution and age-specific antibody responses.

Zhencui Li
Pei Hu
Jing Lu
ResearchOpen Access15 Aug 2024
Nature Communications

Volume: 15, P: 1-12
Cell-free biosynthesis and engineering of ribosomally synthesized lanthipeptides

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major class of natural products with potent biological activities but a vast majority of RiPP gene clusters remain unexplored in microbial genomes. Here, the authors report a unified biocatalysis (UniBioCat) system based on cell-free gene expression for rapid biosynthesis and engineering of RiPPs.

Wan-Qiu Liu
Xiangyang Ji
Jian Li
ResearchOpen Access21 May 2024
Nature Communications

Volume: 15, P: 1-13
CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

The mechanistic details of fatty acid uptake into cells remains poorly understood. Here, the authors identify CD36 internalization via cavaeolae and demonstrate dynamic palmitoylationof CD36 is required for endocytic uptake of fatty acids.

Jian-Wei Hao
Juan Wang
Tong-Jin Zhao
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Facile engineering of interactive double network hydrogels for heart valve regeneration

Regenerative heart valve prostheses rely on interactive materials that can adapt to the remodeling process, but these materials are often based on complex designs. Using 1,1’-thiocarbonyldiimidazole chemistry, the authors propose a double network hydrogel formulation for heart valve regeneration.

Jinsheng Li
Weihua Qiao
Yuzhou Wu
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-20
N6-methyladenosine-modified GPX2 impacts cancer cell stemness and TKI resistance through regulating of redox metabolism

Xu Yang
Long Yu
Lan Wang
ResearchOpen Access18 Jun 2025
Cell Death & Disease

Volume: 16, P: 1-12
Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning

Deep methylation sequencing aided by a machine-learning classifier of methylation patterns enables the detection of early cancers from plasma samples at dilution factors as low as 1/10,000.

Naixin Liang
Bingsi Li
Zhihong Zhang
Research15 Jun 2021
Nature Biomedical Engineering

Volume: 5, P: 586-599
Algorithm for optimized mRNA design improves stability and immunogenicity

An algorithm based on concepts established in computational linguistics enables rapid principled design of mRNA vaccines optimizing both structural stability and codon usage, resulting in improved half-life, protein expression and immune responses.

He Zhang
Liang Zhang
Liang Huang
ResearchOpen Access02 May 2023
Nature

Volume: 621, P: 396-403
An SHR–SCR module specifies legume cortical cell fate to enable nodulation

Repurposing of an SHR–SCR stem cell program in the legume root cortex enables rhizobial symbiosis.

Wentao Dong
Yayun Zhu
Ertao Wang
Research09 Dec 2020
Nature

Volume: 589, P: 586-590
Encoding of tactile information in hand via skin-integrated wireless haptic interface

The haptic interface is an essential part of human–machine interfaces where tactile information is delivered between human and machine. Yao et al. develop a soft, ultrathin, miniaturized and wireless electrotactile system that allows virtual tactile information to be reproduced over the hand.

Kuanming Yao
Jingkun Zhou
Xinge Yu
Research17 Oct 2022
Nature Machine Intelligence

Volume: 4, P: 893-903
High-performance piezoelectric composites via β phase programming

The piezoelectricity of PVDF composites is mainly determined by the crystalline phases and spontaneous polarization. Here, the authors propose a Ti₃C₂T_x anchoring method to modulate the molecular interactions and conformation of polymer matrix.

Yuanjie Su
Weixiong Li
Jun Chen
ResearchOpen Access18 Aug 2022
Nature Communications

Volume: 13, P: 1-12
RETRACTED ARTICLE: HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development

Zhaoliang Su
Pan Zhang
Huaxi Xu
ResearchOpen Access22 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Comparable immune escape capacity between KP.2 and other SARS-CoV-2 variants in the central Chinese population after the first COVID-19 booster

Youhua Yuan
Junhong Xu
Rong Wang
ResearchOpen Access22 May 2025
Scientific Reports

Volume: 15, P: 1-10
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. Here, the authors conduct a GWAS and suggest protective effect of higher TSH on risk of thyroid cancer and goitre.

Wei Zhou
Ben Brumpton
Bjørn Olav Åsvold
ResearchOpen Access07 Aug 2020
Nature Communications

Volume: 11, P: 1-13
piRNAs and circRNAs acting as diagnostic biomarkers in clear cell renal cell carcinoma

Yin Xu
Huiling Liu
Baoli Heng
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-14
DELLA proteins are common components of symbiotic rhizobial and mycorrhizal signalling pathways

Symbiotic associations between legumes and nitrogen-fixing bacteria are regulated by a CCaMK-IPD3 protein complex which promotes nodule initiation. Here, Jin et al. propose that DELLA proteins positively regulate nodulation by enhancing phosphorylation of IPD3 and acting as a positive regulator of transcription.

Yue Jin
Huan Liu
Ertao Wang
ResearchOpen Access12 Aug 2016
Nature Communications

Volume: 7, P: 1-14
A genome-wide association study yields five novel thyroid cancer risk loci

Non-medullary thyroid cancers include papillary and follicular subtypes, and are the most common type of thyroid cancer. Here, the authors extend previous work by performing a large genome-wide association study and find five novel loci associated with this disease.

Julius Gudmundsson
Gudmar Thorleifsson
Kari Stefansson
ResearchOpen Access14 Feb 2017
Nature Communications

Volume: 8, P: 1-8
Can corruption of chromosome cohesion create a conduit to cancer?

Cohesin is a conserved multisubunit protein complex with diverse cellular roles. Much has been learned in recent years about the roles of cohesin in a physiological context, whereas its potential and emerging role in tumorigenesis has received relatively little attention. Are alterations in cohesin proteins drivers or passengers in cancer?

Huiling Xu
Jonathan M. Tomaszewski
Michael J. McKay
Reviews17 Feb 2011
Nature Reviews Cancer

Volume: 11, P: 199-210
Polyoxometalate-based Supramolecular Gel

Peilei He
Biao Xu
Xun Wang
ResearchOpen Access13 May 2013
Scientific Reports

Volume: 3, P: 1-6
Cognitive impairment following maternal separation in rats mediated by the NAD⁺/SIRT3 axis via modulation of hippocampal synaptic plasticity

Keke Hao
Fashuai Chen
Huiling Wang
ResearchOpen Access30 Mar 2025
Translational Psychiatry

Volume: 15, P: 1-10
Development of machine learning-based differential diagnosis model and risk prediction model of organ damage for severe Mycoplasma pneumoniae pneumonia in children

Bing He
Xuewen Li
Jiancheng Xu
ResearchOpen Access19 Mar 2025
Scientific Reports

Volume: 15, P: 1-14
A neuroimaging biomarker for striatal dysfunction in schizophrenia

A new cross-validated neuroimaging biomarker that reflects striatal dysfunctioning can be used to distinguish patients with schizophrenia from healthy controls, and is associated with treatment response to antipsychotics.

Ang Li
Andrew Zalesky
Bing Liu
Research23 Mar 2020
Nature Medicine

Volume: 26, P: 558-565
Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis

Huan Huang
Xiaowei Wang
Lena Palaniyappan
Research28 May 2025
Neuropsychopharmacology

P: 1-10
TNF-α inhibits Epstein Barr virus reactivation through the GPX4 mediated glutathione pathway

Youyu Zhang
Yilin Wu
Yongguo Li
ResearchOpen Access12 May 2025
Scientific Reports

Volume: 15, P: 1-15
A large-scale screen for coding variants predisposing to psoriasis

Xuejun Zhang, Jun Wang and colleagues report the application of exome sequencing to a large collection of psoriasis cases and controls. They identify seven common and low-frequency nonsynonymous variants within known psoriasis susceptibility genes that are associated with psoriasis risk.

Huayang Tang
Xin Jin
Xuejun Zhang
Research10 Nov 2013
Nature Genetics

Volume: 46, P: 45-50
Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer

Wei Zhou
Ben Brumpton
Bjørn Olav Åsvold
Amendments and CorrectionsOpen Access16 Dec 2021
Nature Communications

Volume: 12, P: 1-2
Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty

Luo et al. report a single-cell landscape of human blood from newborn to frailty. Comprehensive profiling uncovers frailty-specific immune cells and gene expression signatures useful for formulating a clinically relevant screen for unhealthy aging.

Oscar Junhong Luo
Wen Lei
Guobing Chen
Research18 Apr 2022
Nature Aging

Volume: 2, P: 348-364
A modified particle swarm optimization algorithm for a vehicle scheduling problem with soft time windows

Jinwei Qiao
Shuzan Li
Chi Ma
ResearchOpen Access26 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
An adaptive and lightweight YOLOv5 detection model for lung tumor in PET/CT images

Tao Zhou
Xinyu Ye
Yang Liu
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-19
Frontal-posterior functional imbalance and aberrant function developmental patterns in schizophrenia

Dandan Sun
Huiling Guo
Fei Wang
ResearchOpen Access27 Sept 2021
Translational Psychiatry

Volume: 11, P: 1-9
Retraction Note: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7

Kaixuan Zeng
Xiaoxiang Chen
Shukui Wang
Amendments and CorrectionsOpen Access29 May 2024
Cell Death & Disease

Volume: 15, P: 1
Dynamic analysis and application of network structure control in risk conduction in the industrial chain

Xian Xi
Xiangyun Gao
Congcong Wu
ResearchOpen Access05 Nov 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-13
Identification of UBE2N as a biomarker of Alzheimer’s disease by combining WGCNA with machine learning algorithms

Gangyi Feng
Manli Zhong
He Xu
ResearchOpen Access22 Feb 2025
Scientific Reports

Volume: 15, P: 1-19
Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription

Tao Xu
Mengqiu Xiong
Bangshun He
ResearchOpen Access20 Feb 2024
Cell Death & Disease

Volume: 15, P: 1-12
Capsaicin alleviates neuronal apoptosis and schizophrenia-like behavioral abnormalities induced by early life stress

Shilin Xu
Keke Hao
Huiling Wang
ResearchOpen Access07 Nov 2023
Schizophrenia

Volume: 9, P: 1-12
Environment random interaction of rime optimization with Nelder-Mead simplex for parameter estimation of photovoltaic models

Jinge Shi
Yi Chen
Guoxi Liang
ResearchOpen Access08 Jul 2024
Scientific Reports

Volume: 14, P: 1-37
Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo

Rumin Zhang
Dandan Li
Jing Chen
ResearchOpen Access25 Mar 2022
Translational Psychiatry

Volume: 12, P: 1-12
Retraction Note: HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development

Zhaoliang Su
Pan Zhang
Huaxi Xu
Amendments and CorrectionsOpen Access08 Apr 2022
Scientific Reports

Volume: 12, P: 1
Fractal features of soil particle size distributions and their potential as an indicator of Robinia pseudoacacia invasion¹

Kun Li
Huanxiang Yang
Yikun Zhang
ResearchOpen Access04 May 2018
Scientific Reports

Volume: 8, P: 1-13

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