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The spatial and temporal control of material properties at a distance have been so far achieved with light, heat, or sound. Here, the authors control chemical reactions and further polymerization of composites with an electric field via inverse piezo-effect resulting in multi-stiffness gels.

The mechanisms that determine whether fibrosis occurs during chronic skin inflammation are poorly understood. Here, the authors show that chronic inflammatory skin diseases characterized by skin fibrosis share activation of EGFR-STAT1 signaling in pathologic fibroblasts as a disease defining signaling mechanism.

The existence of Bragg glasses—featuring nearly perfect crystalline order and glassy features—has yet to be experimentally confirmed for disordered charge-density-wave systems. A machine-learning-based experimental study now provides evidence for a Bragg glass phase in the charge density waves of Pd_xErTe₃.

Adaptive optical vision Fourier transformer (AOViFT) is a machine learning-based framework for accurately inferring aberrations and restoring diffraction-limited performance in diverse biological specimens.

NSF hydrolyzes ATP to disassemble SNARE complexes. Here, the authors find NSF colocalizes with syntaxin nanodomains, reveal disassembly of syntaxin oligomers and other pre-fusion cis-SNARE complexes by NSF, and show how sequential hydrolysis drives disassembly.

The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth syndrome.

The dorsal peduncular area of the mouse brain functions as a network hub that integrates diverse cortical and thalamic inputs to regulate neuroendocrine and autonomic responses.

The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—two key adaptations that underlie bipedalism.

The simultaneous recording of fast-scan cyclic voltammetry and functional magnetic resonance imaging signals enable the coupling of local tissue oxygen and neurotransmitter dynamics for measuring changes in the brain

Thermoelectric materials are required to be electrically conducting while thermally insulating, which can be challenging to achieve. Here, the authors report a thermoelectric transport regime with defect tolerant charge transport but defect intolerant heat propagation in two-dimensional coordination polymer films.

PIEZO1 is critical in numerous physiological processes, but monitoring its activity and localization in cells can be challenging. Here, the authors present a chemogenetic platform to visualize endogenous human PIEZO1 localization and activity in native cellular conditions, expanding the knowledge on mechanotransduction across single cells and tissue organoids.

Determinants of Vibrio cholerae transmission are incompletely understood. Here, the authors use an infant mouse model to show that events in the intestine govern inter-animal transmission and that bacterial motility along with cholera toxin-driven diarrhea are critical for pathogen spread.

Volcanic eruptions at ocean ridges produce large volumes of glass that is rapidly leached by seawater. Geochemical calculations suggest that this process helps to explain the deposition of carbonates at the end of extreme ice ages.

Neural networks fundamentally dictate function. Here, the authors show thirteen uniquely connected neuron populations within the anterior thalamic nuclei, suggesting multiple parallel subnetworks support its emotional and cognitive functions.

Khan et al. report a non-catalytic function of the methyltransferase SETD2 in regulating nuclear morphology and genome integrity. The SETD2 amino terminus functions as a scaffold helping CDK1 associate with lamins during nuclear-envelope disassembly

Molten glass is made viscous by oxygen atoms that form bridges between silicon or aluminium. Non-bridging oxygens make for a runnier melt, affecting, for example, the rate of mixing of melt batches in industrial glass making, and the explosiveness of volcanic magmas. Now non-bridging oxygens have been discovered in an aluminosilicate that, by conventional theory, should not have them.

Seeded growth methods are used to prepare highly ordered, crystalline semiconducting poly(di-n-hexylfluorene) platelet micelles, which exhibit long-range anisotropic exciton diffusion, particularly along the π–π-stacking direction.

Spin relaxation in organic semiconductors is normally strongly correlated with temperature, varying over many orders of magnitude from 4 K to 300 K. Here, the authors report stable, microsecond-long spin lifetimes in rubrene single crystals due to the rapid transient localization of charge carriers.

Unlike squalene, peplusol is only synthesized in a few species of the Euporbia genus and its biosynthetic pathway is unclear. Here, the authors report the discovery and characterization of two peplusol synthases and demonstrate the feasibility of the evolution of peplusol synthase from the ancient squalene synthase.

Current first-line treatments of pediatric UC maintain a 6-month remission in only half of the patients. Here, applying multi-omics on intestinal biopsies from treatment-naïve children, the authors show that relapse-prediction using separate omics data is outperformed by a robust machine learning approach combining microbiomes and epigenomes.

Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.

Non-uniform noise introduces bias in multivariate analysis of mass spectrometry data. Here, the authors study the noise structure of the widely used Orbitrap to develop a data scaling method that reduces this bias resulting in clearer separation of chemical information from noise in biological data.

Here the authors found that brown planthopper gravid females, but not nymphs and non-gravid females, strongly induce rice defenses. Aggregation of nymphs with female adults benefits the herbivore by disarming plants’ indirect defenses.

Chemotherapy-induced cardiotoxicity (CIC) is an adverse condition associated with several DNA damaging chemotherapeutics. Here, the authors discover that tumour ZNF281-mediated increase of purinergic signalling factors inosine and hypoxanthine promotes RBFOX1 degradation in cardiomyocytes, increasing the risk for developing CIC.

Ex vivo normothermic machine perfusion has been proposed to protect donor kidneys. Here, the authors show that red blood cell-based human kidney perfusion and associated hemolysis contribute to iron accumulation, ferroptosis, and kidney injury.

The supraglacial meltwater ponds of the McMurdo Ice Shelf, analogues for proposed Cryogenian period eukaryotic refugia, are shown to host diverse and varied eukaryotic communities.

Confinement is encountered in systems varying from simple liquids to biological cells. Williams et al. introduce an adaptive confinement with an elastic wall composed of colloidal particles, whereby the osmotic pressure of the confined system can be directly obtained from the displacement of the wall.

Lipoprotein uptake dependent on sulfated glycosaminoglycans linked to cell-surface proteoglycans is a key determinant of ferroptosis sensitivity in cancer.

Khan et al. show that Sec18 uses both D1 and D2 AAA+ rings cooperatively, opening them laterally for SNARE substrate loading and for subsequent release of SNAREs.

This Article provides evidence for apatite in a ferroan anorthosite clast in a lunar meteorite, allowing direct measurement of the volatile systematics of the primary products of the lunar magma ocean and the earliest lunar crust.

Hollow core fibers have low light attenuation because the light travels through air rather than glass, but other sources of loss have limited the performance so far. Here the authors design and demonstrate a Nested Antiresonant Nodeless hollow core fiber that has losses competitive with standard solid-core fiber at several important wavelengths.

Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour distances from experimental single-protein position data with those obtained from simulations based on a model of protein oligomerisation.

The role of cohesion is vital to our understanding of how sedimentary bedforms evolve. Here, the authors show that microorganisms within the sediment affect cohesion and demonstrate that ripples can take up to one hundred times as long to develop when extracellular polymeric substances are present.

Mixed ionic–electronic transport in conducting polymers remains poorly understood. Here the authors observe non-equilibrium electronic transport when counterions are unable to equilibrate in response to gate-injected electronic carriers.