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Genotype-phenotype data from over 450,000 individuals was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual.

We report direct measurement of repulsive van der Waals forces on suspended graphene using atomic force microscopy. The strong repulsive forces substantially lower the wettability of suspended graphene.

Using a virtual reality apparatus in rats that dissociates external landmarks from self-motion cues, the authors describe how the two modes of theta phase coding in the hippocampus during navigation are controlled via distinct computations.

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

The axial Higgs mode is theoretically attributed to a hidden ferroaxial component of charge order. In rare-earth tritellurides, this ferroaxial order is now shown to be induced by intertwined orbital and charge orders.

Bull et al. developed a mathematical model for how bacteria colonise urinary catheters. The model reveals that different strategies may be needed to reduce catheter associated infection for long-term vs short-term catherised patients

Surprisingly consistent replication failure of gray matter correlates of childhood maltreatment raises questions about publication bias in prior literature and about prevailing models linking maltreatment to brain structure in adult populations.

Using experimental and modelling evidence, this study reveals that small coral populations face fertilization failure due to Allee effects. The findings identify critical population thresholds needed to maintain reproductive success.

The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesting potential causal relationships through Mendelian randomization analysis.

The protein corona formed on nanoparticles can impact bioactivity. Here the authors show that the protein corona on lipid nanoparticles alters their function and reduces transfection efficiency, showing the importance of considering the protein corona in designing lipid nanoparticle-based therapeutics.

Altered pre-mRNA splicing frequently causes disease, yet how sequence variants alter splicing remains enigmatic. Here the authors use deep indel mutagenesis and deep learning tools to reveal the regulatory architecture of human exons and identify splicing-modulating antisense oligonucleotides.

Cooperative paramagnetism refers to a strongly correlated state without long range magnetic order that occurs in frustrated magnetic systems between the Neel temperature and Curie-Weiss temperature. Here, using resonant elastic magnetic and inelastic x-ray scattering, Terilli et al find a spectrally sharp gapped magnetic excitations that persists above the Neel temperature in Y₂Ir₂O₇, implying a cooperative paramagnetic phase.

A novel multistep strategy reveals how parent-of-origin effects shape complex traits in large-scale biobanks.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Aging is a risk factor for Parkinson’s disease; however, how DNA damage accumulation, a hallmark of aging, contributes to its pathophysiology remains incompletely understood. Here, the authors identify a blood-based DNA damage signature that is associated with disease progression in patients with Parkinson’s disease.

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Here the authors use sex-stratified genetic analyses in mice and humans to uncover hidden trait influences, revealing many undetected loci and cautioning against misleading genetic interactions from widespread effects.

STING is a promising drug target, but selective activation is necessary for safety and efficacy. Researchers have developed a two-component prodrug system for potent pharmacological activation of STING that offers excellent tumour targeting.

The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—two key adaptations that underlie bipedalism.

CD123 expression on leukemic stem and progenitor cells (LSPCs) and leukemic blasts representing a promising therapeutic target. However previous CD123-targeting approaches had limited efficacy and safety concerns. The authors here evaluate the bispecific CD123/CD16A innate cell engager AFM28 and manifest its efficacy both in vitro and in vivo, which is mediated by NK cells.

By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding interdomain misfolding.

A global land surface phenology map predicts complex geographical discontinuities in flowering phenology, genetic divergence and harvest seasonality across a range of taxa.

A topological phase of light emerges in dynamically driven nonlinear photonic crystals.

Scaffolding protein ankyrin-B, implicated in cardiometabolic syndrome, enables mitochondrial fission and flexibility of nutrient utilization under energetic stress in skeletal muscle to support energy production and optimal exercise capacity.

Real-space nanoimaging and theoretical analyses show the emergence of hyperbolic phonon polaritons on the surface of a non-hyperbolic material and that the polariton dispersions can be manipulated by varying the temperature.

Joint profiling of chromatin and splicing in the brain uncovers shared and distinct patterns.

This Expert Recommendation provides tools to help researchers in 2D materials improve reproducibility in their work and practical guidance on how to engage constructively with funders, publishers and industry to create a stronger basis for reproducibility, transparency and trust in the field.

A summary of CAR T-cell engineering approaches, including functional screening methods, gene editing and delivery advances, and optimization of metabolic fitness.

Neuromorphic computing mimics brain efficiency but lacks theoretical guidance. Here, authors develop a computational foundation for processing signals in space and time in spiking neural networks that can outperform standard neural networks in event-based vision.

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present DNAscent, an AI supported assay for DNA replication stress in human cells using Nanopore sequencing data.

Here the authors show that mutations in V-ATPase genes in follicular lymphoma trigger V-ATPase-dependent autophagy. This process, linked to tryptophan metabolism and ribosome biogenesis, may help tumor cells thrive under stress conditions.

Studies of Bloch oscillations in many-body systems remain limited due to their interaction-induced damping. Now, such oscillations have been observed in a solitonic wave packet of atoms in a Bose gas at the mesoscopic scale.

Genetic background, plasma metabolome and dietary data from 4,215 women and 1,490 men reveal 57 metabolites whose associations with dementia risk vary by APOE4 genotype and other risk variants.

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.

A PICALM allele associated with increased risk of late-onset Alzheimer’s disease has a microglial-specific role in lipid droplet accumulation.

The analysis of radial velocity variations of O-type stars in the Small Magellanic Cloud reveals a large fraction of close binaries, suggesting that binary physics also plays a prominent role in the low-metallicity environment of the distant Universe.

Using 7T resting-state functional MRI data, the authors investigate the effective connectivity of basal forebrain areas in a transdiagnostic sample of patients with anxiety and depression and healthy controls.

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capillary–venous networks contribute to age-related hypoperfusion and white matter damage in mice.

Biomolecular phase separation arises from collective molecular interactions and is emerging as a key theme for biological function. Here the authors propose a broadly applicable method to quantify these interactions based on compositional and energetic parameters.

Using a transposon-based approach to create a set of large genomic rearrangements, Dauban et al. demonstrate that interactions of lamina-associated domains with the nuclear lamina involve multiple contacts of varying strength.

Modulating deep brain structure can lead to therapies for neurological conditions. Here, the authors show a transcranial ultrasound stimulation (TUS) system featuring a 256-element helmet-shaped transducer array for modulation of the LGN and connected visual cortex regions

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Heme is an iron-containing molecule made in mitochondria. The study shows that FLVCR1b and TANGO2 proteins export mitochondrial heme to GAPDH in the cytosol and this allows heme to reach many proteins in cells that require it for their function.

Chaos causes interacting particles to rapidly thermalize and lose memory of their past. Here, the authors show that, despite thermalization, genuine quantum scarring can imprint structure and long-lived memory effects in the many-body wavefunction.

In a phase 1/2a umbrella trial in patients with glioblastoma matching targeted therapies according to tumor molecular profiling, temsirolimus plus radiotherapy improved PFS compared to standard of care in patients with phospho-mTOR activation.

Detailed mapping of the distribution of water and semiheavy water in the coma of Halley-type comet 12P implies a D/H ratio that is consistent with that of Earth’s water, indicating a common heritage.

Aggregates of misfolded proteins are sequestered in the aggresome via dynein transport in an aggregate size-dependent manner. Here, authors find episodic transport kinetics mediated by aggresome-dynein adapters are central to this size-filter effect.