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Showing 1–50 of 71 results

Advanced filters: Author: Jae-won Do Clear advanced filters

Tri-visualization feature extraction for light field angular super-resolution

Ebrahem Elkady
Ahmed Salem
Jae-Won Suh
ResearchOpen Access23 Sept 2025
Scientific Reports

Volume: 15, P: 1-16
Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease

The naïve CD4 T cell compartment is traditionally deemed as homogenous. Here, by leveraging scRNA-seq analysis, the authors reveal the role of naive CD4 T cell heterogeneity in disease states and therapeutic outcomes by characterizing a Th1-poised naive CD4 T cell subpopulation, linked to anti-tumor immunity in mice and responsiveness to anti-PD-1 therapy in humans.

Jae-Won Yoon
Kyung Min Kim
Je-Min Choi
ResearchOpen Access25 Feb 2025
Nature Communications

Volume: 16, P: 1-16
Major house dust mite allergen, Der p I, activates phospholipase D in human peripheral blood mononuclear cells from allergic patients: involvement of protein kinase C

Jae-Won Oh
Jong-Hoon Kim
Joong-Soo Han
ResearchOpen Access01 Jun 2000
Experimental & Molecular Medicine

Volume: 32, P: 67-71
Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans

Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.

Jae-Hyung Jin
Kyung-Tae Lee
Yong-Sun Bahn
ResearchOpen Access24 Aug 2020
Nature Communications

Volume: 11, P: 1-17
Cell membrane cholesterol affects serotonin transporter efflux due to altered transporter oligomerization

Deborah Rudin
Dino Luethi
Harald H. Sitte
ResearchOpen Access02 Sept 2025
Molecular Psychiatry

P: 1-13
Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification

Bo-Hyun Lim
Bok-Im Cho
Chang-Won Lee
ResearchOpen Access01 Oct 2006
Experimental & Molecular Medicine

Volume: 38, P: 455-465
Microsecond triplet emission from organic chromophore-transition metal dichalcogenide hybrids via through-space spin orbit proximity effect

Metal-organic charge transfer has been the inevitable core of microsecond triplet emitters. Here the authors hybridize organic chromophores with transition-metal dichalcogenides to realize microsecond phosphorescence without metal-organic ligand bonding.

Jinho Choi
Healin Im
Jinsang Kim
ResearchOpen Access02 Dec 2024
Nature Communications

Volume: 15, P: 1-11
Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

Here the authors characterise the cellular and molecular progression of lung alveolar damage in severe COVID-19 patients using integrated histopathology and cell atlassing, pinpointing a role for macrophage SPP1 signalling to vasculature in this process.

Jimmy Tsz Hang Lee
Sam N. Barnett
Omer Ali Bayraktar
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Molecular identification and diversity of gastrointestinal apicomplexan protozoa in pigs in the Republic of Korea

Subin Lee
Sang-Hyup Lee
Seung-Hun Lee
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment

Spatial molecular imaging analysis of human pancreatic adenocarcinomas describes multicellular neighborhoods in the tumor microenvironment. Ligand–receptor analysis using optimal transport-based SCOTIA identifies interleukin-6 as a mediator of chemoresistance.

Carina Shiau
Jingyi Cao
William L. Hwang
Research03 Sept 2024
Nature Genetics

Volume: 56, P: 2466-2478
Structural basis of organic cation transporter-3 inhibition

The current work reports the structure of the human organic cation transporter 3 (OCT3 / SLC22A3) and provides the structural basis of its inhibition by two specific inhibitors, decynium-22 and corticosterone.

Basavraj Khanppnavar
Julian Maier
Harald H. Sitte
ResearchOpen Access07 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Dysregulation of T_FH-B-T_RM lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer

EGFR mutant lung tumours do not respond favourably to immunotherapy. Here, using single cell sequencing, the authors find that tissue resident memory CD8⁺ T like cells are reduced in the immune landscape of EGFR mutant tumours in comparison to wild type tumours and the presence of these cells may predict response to immunotherapy.

Jae-Won Cho
Seyeon Park
Hye Ryun Kim
ResearchOpen Access18 Oct 2021
Nature Communications

Volume: 12, P: 1-16
Soft gels select tumorigenic cells

Pliable gels of fibrin, a fibrous protein involved in blood clotting and linked to cancer, select cells with high in vivo aggressiveness and 'stemness' from a pool of cancer cells.

Jae-Won Shin
Dennis E. Discher
News & Views24 Jul 2012
Nature Materials

Volume: 11, P: 662-663
Three-dimensional nanopillar-array photovoltaics on low-cost and flexible substrates

Solar power is an important part of the strategy towards using more renewable energy. The development of low-cost photovoltaic nanopillar structures fabricated on thin aluminium substrates will contribute to this effort, as it promises new applications for flexible, mass-produced solar cells.

Zhiyong Fan
Haleh Razavi
Ali Javey
Research05 Jul 2009
Nature Materials

Volume: 8, P: 648-653
Structural basis for the role of inhibition in facilitating adult brain plasticity

Chen and colleagues show that visual deprivation drives structural remodeling of the dendritic branch tips of cortical layer 2/3 interneurons in an input-specific manner. Neighboring pyramidal cells show a corresponding loss of inhibitory inputs. This decreased inhibition seems to be permissive for the subsequent addition of new synapse-bearing branch tips.

Jerry L Chen
Walter C Lin
Elly Nedivi
Research10 Apr 2011
Nature Neuroscience

Volume: 14, P: 587-594
Automated 3D liver segmentation from hepatobiliary phase MRI for enhanced preoperative planning

Namkee Oh
Jae-Hun Kim
Jae-Won Joh
ResearchOpen Access17 Oct 2023
Scientific Reports

Volume: 13, P: 1-7
Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

Malignant phenotypes in the mammary epithelium have been correlated to increases in extracellular matrix stiffness. It is now shown that the effect of matrix stiffness in normal mammary epithelial cells can be offset by an increase in basement-membrane ligands and that both the stiffness and composition of the matrix are sensed by the β4 integrin. The results suggest that the relationship between matrix stiffness and composition is a more relevant predictor of breast-cancer progression.

Ovijit Chaudhuri
Sandeep T. Koshy
David J. Mooney
Research15 Jun 2014
Nature Materials

Volume: 13, P: 970-978
PKCα induces differentiation through ERK1/2 phosphorylation in mouse keratinocytes

Haeng Ran Seo
Yoo-Wook Kwan
Yun-Sil Lee
ResearchOpen Access01 Aug 2004
Experimental & Molecular Medicine

Volume: 36, P: 292-299
Bias and sensitivity in numerosity perception of negative emotions among individuals with high social anxiety

Jae-Won Yang
Jongsoo Baek
ResearchOpen Access04 Jul 2022
Scientific Reports

Volume: 12, P: 1-8
Transient fixation of L4 vertebra preserves lumbar motion and function in Lenke Type 5C and 6C scoliosis

Jae-Ho Yang
Jae-Won Shin
Hak-Sun Kim
ResearchOpen Access13 May 2021
Scientific Reports

Volume: 11, P: 1-9
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice

ADHD is characterized by hyperactivity and deficits in learning and memory. Now, Eunjoon Kim and colleagues report that a polymorphism in the gene that encodes the adaptor protein GIT1 is linked to ADHD in humans. This polymorphism reduces GIT1 expression, and GIT1-deficient mice show ADHD-like behaviors that can be alleviated with the psychostimulant drugs used to treat human ADHD.

Hyejung Won
Won Mah
Eunjoon Kim
Research17 Apr 2011
Nature Medicine

Volume: 17, P: 566-572
Systematic identification of genomic markers of drug sensitivity in cancer cells

Human cancer cell lines are screened with drugs, undergoing clinical or preclinical investigation, to determine specific genomic alterations associated with response to therapeutic agents.

Mathew J. Garnett
Elena J. Edelman
Cyril H. Benes
Research28 Mar 2012
Nature

Volume: 483, P: 570-575
Photoluminescent carbon nanotags from harmful cyanobacteria for drug delivery and imaging in cancer cells

Hyun Uk Lee
So Young Park
Jouhahn Lee
ResearchOpen Access11 Apr 2014
Scientific Reports

Volume: 4, P: 1-7
Two-signal blockade with anti-CD45RB and anti-CD154 monoclonal antibodies inhibits graft rejection via CD4-dependent mechanisms in allogeneic skin transplantation

Eun-Young Kim
Eun-Na Lee
Sung-Joo Kim
ResearchOpen Access01 Jun 2006
Experimental & Molecular Medicine

Volume: 38, P: 284-294
Prediction model for early graft failure after liver transplantation using aspartate aminotransferase, total bilirubin and coagulation factor

Jinsoo Rhu
Jong Man Kim
Jae-Won Joh
ResearchOpen Access18 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Phenotypic screening for serine hydrolase inhibitors capable of modulating lipid storage coupled with target deconvolution identifies carboxylesterase 3 as having a role in regulating adipocyte function, with enzyme inhibition causing positive outcomes in mouse models of obesity and diabetes.

Eduardo Dominguez
Andrea Galmozzi
Enrique Saez
Research22 Dec 2013
Nature Chemical Biology

Volume: 10, P: 113-121
Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

Withaferin A is a naturally occurring compound that has potent antidiabetic and anti-obesity properties in mice.

Jaemin Lee
Junli Liu
Umut Ozcan
Research01 Aug 2016
Nature Medicine

Volume: 22, P: 1023-1032
Diffracted X-ray Blinking Tracks Single Protein Motions

Hiroshi Sekiguchi
Masahiro Kuramochi
Yuji C. Sasaki
ResearchOpen Access30 Nov 2018
Scientific Reports

Volume: 8, P: 1-8
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

A new strategy for derivation of human midbrain dopamine neurons from pluripotent cells was developed; transplantation of the neurons in mice, rats and parkinsonian monkeys show they are a promising source of cells for applications in regenerative medicine.

Sonja Kriks
Jae-Won Shim
Lorenz Studer
Research06 Nov 2011
Nature

Volume: 480, P: 547-551
Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation

Myung-Hee Moon
Jae-Kyo Jeong
Sang-Youel Park
ResearchOpen Access07 Feb 2011
Experimental & Molecular Medicine

Volume: 43, P: 138-145
Glucocorticoid-induced tumor necrosis factor receptor–related protein co-stimulation facilitates tumor regression by inducing IL-9–producing helper T cells

GITR signaling inhibits tumor growth by inducing T_H9 cell differentiation, increasing IL-9–dependent dendritic cell function and enhancing cytotoxic T cell responses.

Il-Kyu Kim
Byung-Seok Kim
Chang-Yuil Kang
Research17 Aug 2015
Nature Medicine

Volume: 21, P: 1010-1017
Importance of dialysis specialists in early mortality in elderly hemodialysis patients: a multicenter retrospective cohort study

Yohan Park
Ji Won Lee
Won Min Hwang
ResearchOpen Access22 Jan 2024
Scientific Reports

Volume: 14, P: 1-11
Matrix mechanics and water permeation regulate extracellular vesicle transport

Stress relaxation properties of the matrix as well as water transport through aquaporin-1 enable extracellular vesicles to deform and travel through the dense mesh of the extracellular matrix between cells.

Stephen Lenzini
Raymond Bargi
Jae-Won Shin
Research17 Feb 2020
Nature Nanotechnology

Volume: 15, P: 217-223
Increased risk of depression and anxiety in patients with chronic back pain following COVID-19 infection based on a nationwide population-based study

Joonoh Seo
Namhoo Kim
Ji-Won Kwon
ResearchOpen Access17 Apr 2025
Scientific Reports

Volume: 15, P: 1-11
Extracellular vesicle–matrix interactions

Extracellular vesicles (EVs) are lipid-bound nanoscale mediators of intercellular communication. This Review discusses EVs in the context of the extracellular matrix, highlighting how the understanding of their interactions inspires materials design to control the release, retention and production of EVs for various biological and therapeutic applications.

Koushik Debnath
Kevin Las Heras
Jae-Won Shin
Reviews17 Mar 2023
Nature Reviews Materials

Volume: 8, P: 390-402
An increase of lysosomes through EGF-triggered endocytosis attenuated zinc-mediated lysosomal membrane permeabilization and neuronal cell death

Jae-Won Eom
Jin-Yeon Lee
Yang-Hee Kim
ResearchOpen Access13 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-16
Precipitation data in Seoul, Korea during 1778–1907

Jae-Won Lee
Ho-Jeong Shin
Jinkyu Hong
ResearchOpen Access31 May 2024
Scientific Data

Volume: 11, P: 1-8
TPMS-based auxetic structure for high-performance airless tires with variable stiffness depending on deformation

Do-Yeon Kim
Hong-Seok Kim
Sang-Hu Park
ResearchOpen Access19 May 2024
Scientific Reports

Volume: 14, P: 1-15
Prospective comparative analysis of three types of decompressive surgery for lumbar central stenosis: conventional, full-endoscopic, and biportal endoscopic laminectomy

Yoon Ha Hwang
Jin-Sung Kim
Jeong-Yoon Park
ResearchOpen Access27 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Alterations in sea urchin (Mesocentrotus nudus) microbiota and their potential contributions to host according to barren severity

Joon-Young Park
Jae-Won Jo
Bong-Soo Kim
ResearchOpen Access31 Oct 2023
npj Biofilms and Microbiomes

Volume: 9, P: 1-12
Risk factors of silent allograft fibrosis 10 years post-pediatric liver transplantation

Jinsoo Rhu
Sang Yun Ha
Suk-Koo Lee
ResearchOpen Access04 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
Reconstructing angular light field by learning spatial features from quadrilateral epipolar geometry

Ebrahem Elkady
Ahmed Salem
Jae-Won Suh
ResearchOpen Access30 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
Reassignment of Scattered Emission Photons in Multifocal Multiphoton Microscopy

Jae Won Cha
Vijay Raj Singh
Peter T. C. So
ResearchOpen Access05 Jun 2014
Scientific Reports

Volume: 4, P: 1-13
Combination of NTP with cetuximab inhibited invasion/migration of cetuximab-resistant OSCC cells: Involvement of NF-κB signaling

Jae Won Chang
Sung Un Kang
Chul-Ho Kim
ResearchOpen Access14 Dec 2015
Scientific Reports

Volume: 5, P: 1-12
Bacterial contamination of autologous blood salvaged during deceased donor liver transplantation: a prospective observational study

Doyeon Kim
Sangbin Han
Gaab Soo Kim
ResearchOpen Access05 Nov 2024
Scientific Reports

Volume: 14, P: 1-10
Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia

Seog Ju Kim
Yu Jin Lee
Do-Un Jeong
ResearchOpen Access02 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Multi-modality multi-task model for mRS prediction using diffusion-weighted resonance imaging

In-Seo Park
Seongheon Kim
Chulho Kim
ResearchOpen Access04 Sept 2024
Scientific Reports

Volume: 14, P: 1-11
Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality

Byung Lae Park
Hyoung Doo Shin
Sung-Il Woo
Research30 Oct 2009
Journal of Human Genetics

Volume: 54, P: 709-712
PKC-η mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways

Sean E Aeder
Patrick M Martin
Isa M Hussaini
Research18 Oct 2004
Oncogene

Volume: 23, P: 9062-9069
Phosphatidylinositol 4,5-bisphosphate (PIP₂) facilitates norepinephrine transporter dimerization and modulates substrate efflux

Phosphatidylinositol 4,5-bisphosphate (PIP₂) directly regulates norepinephrine transporter (NET) dimer stabilization at the plasma membrane. Furthermore, PIP₂ interaction with NET affects efflux.

Dino Luethi
Julian Maier
Harald H. Sitte
ResearchOpen Access17 Nov 2022
Communications Biology

Volume: 5, P: 1-11

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