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The authors conducted a genome-wide association study of educational attainment in an East Asian ancestry cohort, and a cross-ancestry meta-analysis with earlier genome-wide association studies from European ancestry populations, providing new insights into correlations and transferability between ancestries.

Electrocatalytic CO₂ reduction has largely been limited to C₁ and C₂ products, especially at high current densities. Here, a Faradaic efficiency of 67% is reported for C₃₊ products from CO₂ at 1.1 A cm⁻² via a formaldehyde condensation mechanism on a phosphorus-rich copper catalyst.

Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.

Eukaryotic algae and cyanobacteria can produce hydrogen in the presence of little or no oxygen. Here, the authors show that two microalgal strains are capable of producing hydrogen under aerobic conditions, and provide new insights into the natural evolution of oxygen-tolerant hydrogenase.

Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis. Here, the authors study the roles played by 129 putative kinases in the growth and virulence of C. neoformans, identifying potential targets for development of anticryptococcal drugs.

A cross-ancestry GWAS meta-analysis of β-amyloid deposition in East Asian and European populations identifies a novel SORL1 locus and highlights its differential expression in microglia associated with β-amyloid positivity.

Cryptococcus neoformans is a fungal pathogen that causes meningoencephalitis. Here the authors describe the production of a gene-deletion mutant collection representing most C. neoformansnon-essential transcription factors, providing insight into the signalling networks that govern the biology and pathogenicity of this fungus.

While emission and stability of metal–halide perovskites can be enhanced through heterostructural encapsulation, a controlled synthesis route to such structures is not trivial to realize. Here, the authors design a mechanochemistry-driven protocol for synthesizing highly luminescent CsPbBr₃/Cs₄PbBr₆ heterostructures.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Here, the authors show that genetic risk for hypertensive disorders of pregnancy increases cardiovascular risk, and present evidence suggesting that maintaining a healthy lifestyle and ideal metabolic status significantly reduces this risk.

Changes in FSIN physiology and cortical E–I balance underlying pHFO generation are not fully understood. Here authors show net synaptic drive at FSINs from excitation to inhibition represents the major epileptogenic mechanism of FCD I epilepsy.

Diversity-oriented synthesis is useful for generating complex molecular structures occupying diverse molecular space. Here the authors report a strategy to access libraries of privileged heterocyclic structures, and furthermore identify an inhibitor of LRS–RagD protein–protein interaction.

A metastable palladium hydride is synthesized where the unique environment in the liquid cell, namely the limited quantity of Pd precursors and the continuous supply of H, resulted in the formation of the hcp phase.

Doil Choi and colleagues report the genome sequence of the hot pepper, Capsicum annuum, as well as the resequencing of two cultivated peppers and a wild species, Capsicum chinense. Comparative genomic analysis across Solanaceae provides insights into genome expansion, pungency, ripening and disease resistance in hot peppers.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

The quantitative relationship between the fluctuation of specific extrinsic and intrinsic factors, and stochastic fluctuations in gene expression - or noise - has not been clearly established. Here, Yang et al.demonstrate that intrinsic noise is independent of - while extrinsic noise scales linearly with - variation in RNA polymerase abundance.

In situ vibrational spectroscopy affords a powerful tool for probing elementary chemical processes on catalytic surfaces. Using surface enhanced Raman scattering, authors identify an array of multicarbon species formed on a Ag nanoparticle catalyst in plasmon-driven reduction of CO₂ in water.

Large-scale multivariate analyses across populations of European ancestry identify risk loci for the metabolic syndrome, improving polygenic prediction models and highlighting associations with diverse traits beyond cardiometabolic diseases.

Water contaminants are detected with freeze-dried, regulated in vitro transcription reactions.

In situ studies under working conditions are important in atomic-level elucidation, design, and optimization of industrially relevant catalysts. Here, the authors report an in situ study of an Ag ethylene photo-epoxidation catalyst using surface enhanced Raman scattering, which uncovers an unconventional mechanism.

The Verwey transition in magnetite has been studied for nearly eight decades since its discovery in the 1940s. Here, Kim et al. elucidate the influence of chemical doping by extremely slow oxidization process with magnetite nanoparticles, revealing why first- and second-order regimes of the Verwey transition are observed.

Plant pathogens secrete various effectors to manipulate host immunity. Here, Kim et al. describe two Magnaporthe oryzae effectors that translocate into the nuclei of infected rice cells and reprogram expression of immunity-associated genes, increasing susceptibility to hemibiotrophic pathogens.

Achieving stable production by co-culturing multiple microorganisms is often challenging due to difficulties in controlling its population. Here, the authors develop a “population guider” that can acclimate a population to higher production.

Despite significant efforts to improve the thermoelectric properties of polycrystalline SnSe, precise control of texturing and doping is a challenge. Here, the authors report hole doped and highly textured SnSe thin films prepared by low cost, scalable solution processing.

Soluble fumarate reductases are essential for eukaryotic cell survival under anaerobic conditions but their mechanism is not fully understood. Here, the authors present structural and enzymatic analyses of yeast fumarate reductase Osm1, elucidating the molecular basis of maintaining redox balance during anaerobiosis.

Optimizing the retention of drug delivery nanocarriers for improved cancer therapy has the potential to improve clinical outcomes. Here the authors screen 20 renal-clearable zwitterionic cyclodextrin-based nanocarriers for optimized biodistribution and tumour retention, demonstrating application in colorectal cancer models.

Richard O'Connell and colleagues report the genomes and transcriptomes of two Colletotrichum plant fungal pathogens. C. higginsianum infects Arabidopsis thaliana, and C. graminicola infects maize (Zea mays); comparative genomics in both species lead to molecular insights into the transition from biotrophic to necrotrophic life stages.