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Showing 1–50 of 580 results
Advanced filters: Author: Jia Kim Clear advanced filters
  • Patients with myelodysplastic syndromes (MDS) have limited therapeutic options. Here the authors show that functionally impaired NK cells contribute to immune escape of pre-malignant clones in early stage MDS and that NK adoptive cell therapy can be considered to prevent or delay the development of MDS.

    • Juan Jose Rodriguez-Sevilla
    • Irene Ganan-Gomez
    • Simona Colla
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Owing to electron localization, two-dimensional materials are not expected to be metallic at low temperatures, but a field-induced quantum metal phase emerges in NbSe2, whose behaviour is consistent with the Bose-metal model.

    • A. W. Tsen
    • B. Hunt
    • A. N. Pasupathy
    Research
    Nature Physics
    Volume: 12, P: 208-212
  • A low-cost robotic platform using mainly optical detection to quantify yields of products and by-products allows the analysis of multidimensional chemical reaction hyperspaces and networks much faster than is possible by human chemists.

    • Yankai Jia
    • Rafał Frydrych
    • Bartosz A. Grzybowski
    ResearchOpen Access
    Nature
    Volume: 645, P: 922-931
  • Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.

    • B. E. Aboona
    • J. Adam
    • M. Zyzak
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • An in-built fluoropolyether-based quasi-solid-state polymer electrolyte enables high-capacity lithium-rich manganese-based layered oxide cathodes with stable interfaces, achieving 604 Wh kg−1 pouch-cell energy density.

    • Xue-Yan Huang
    • Chen-Zi Zhao
    • Qiang Zhang
    Research
    Nature
    Volume: 646, P: 343-350
  • Fabricating wide-bandgap perovskite films with a thickness of 1 μm on nano-textured silicon substrates remains a formidable challenge. Here, authors design an amphoteric coplanar conjugated molecule for improve bulk and interfacial properties of perovskites for high-efficiency tandem solar cells.

    • Dan Yang
    • Bita Fahadi
    • Shengzhong Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Cooperative paramagnetism refers to a strongly correlated state without long range magnetic order that occurs in frustrated magnetic systems between the Neel temperature and Curie-Weiss temperature. Here, using resonant elastic magnetic and inelastic x-ray scattering, Terilli et al find a spectrally sharp gapped magnetic excitations that persists above the Neel temperature in Y2Ir2O7, implying a cooperative paramagnetic phase.

    • Michael Terilli
    • Xun Jia
    • Jak Chakhalian
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

    • Esther Rheinbay
    • Morten Muhlig Nielsen
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 102-111
  • Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

    • Zhishan Chen
    • Xingyi Guo
    • Wei Zheng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17
  • Spin excitations are implicated in the emergence of high-temperature superconductivity in the cuprates but the details are unclear. Calculations performed by Jia et al.resolve a seeming contradiction presented by recent X-ray measurements and suggest that the role played by high-energy spin excitations is nominal for pairing.

    • C. J. Jia
    • E. A. Nowadnick
    • T. P. Devereaux
    Research
    Nature Communications
    Volume: 5, P: 1-7
  • Experimental systems in which non-trivial topology is driven by spontaneous symmetry breaking are rare. Now, topological gaps resulting from two excitonic condensates have been demonstrated in a three-dimensional material.

    • Md Shafayat Hossain
    • Zi-Jia Cheng
    • M. Zahid Hasan
    Research
    Nature Physics
    Volume: 21, P: 1250-1259
  • Nine researchers, editors and science communicators share their views about the barriers that Asian scientists encounter in publishing their work and becoming more visible on the international level.

    • Shravan Hanasoge
    • Noriaki Horiuchi
    • Jens Wilkinson
    Reviews
    Nature Reviews Physics
    Volume: 2, P: 178-180
  • Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

    • Antoine de Morree
    • Iwijn De Vlaminck
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 173-184
  • Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

    • Jin Zhou
    • Austin Hepperla
    • Qing Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • CO2 reduction to value-added products is an attractive strategy in sustainable chemistry. Now a photochemical diode simultaneously drives biophotocathodic CO2-to-multicarbon conversion and photoanodic glycerol oxidation under red light with a photocurrent density of ~1.2 mA cm−2 and a Faradaic efficiency of ~80%.

    • Jimin Kim
    • Jia-An Lin
    • Peidong Yang
    Research
    Nature Catalysis
    Volume: 7, P: 977-986
  • Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

    • Jianxin Shi
    • Kouya Shiraishi
    • Qing Lan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

    • Camille Ezran
    • Shixuan Liu
    • Mark A. Krasnow
    ResearchOpen Access
    Nature
    Volume: 644, P: 185-196
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

    • Shimin Shuai
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

    • Marta Paczkowska
    • Jonathan Barenboim
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • Dickkopf-related protein 1 (DKK1) is a secreted protein associated with poorer outcomes in patients with gastric cancer. Here, the authors report part B of the DisTinGuish phase II trial reporting the safety and efficacy of DKN-01 (DKK1 neutralising antibody) in combination with tislelizumab (anti-PD-1) in patients with advanced gastric/gastoesophageal junction cancer and elevated DKK1 expression.

    • Keun-Wook Lee
    • Devalingam Mahalingam
    • Samuel J. Klempner
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • The symmetry and mechanism underlying unconventional charge orders in Kagome materials are under debate. Here, the authors uncover a longitudinal and helicity-dependent photocurrent in KV3Sb5 that indicates broken symmetries and intrinsic chirality.

    • Zi-Jia Cheng
    • Md Shafayat Hossain
    • M. Zahid Hasan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • The methanol oxidation reaction is crucial for direct methanol fuel cells but is hindered by CO poisoning of Pt-based catalysts. Here, the authors report high-entropy alloyed single-atom Pt catalysts that resist CO poisoning, achieving a mass activity of 35.3 A mg-1 and maintaining high durability.

    • Mingda Liu
    • Zhichao Zhang
    • Kai Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

    • Constance H. Li
    • Stephenie D. Prokopec
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-24
  • In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

    • Lina Sieverling
    • Chen Hong
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136
  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121
  • Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

    • Marc Zapatka
    • Ivan Borozan
    • Christian von Mering
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 320-330
  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128
  • Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

    • Wei Jiao
    • Gurnit Atwal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

    • Marek Cmero
    • Ke Yuan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

    • Vinayak Bhandari
    • Constance H. Li
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10
  • In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

    • Yiqun Zhang
    • Fengju Chen
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

    • Yulia Rubanova
    • Ruian Shi
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712