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A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

Linkers are traditionally seen as important for PROTAC activity. Here, the authors demonstrate that linker-free PROTACs can outperform traditional designs, marking a paradigm shift in PROTAC development for targeted protein degradation.

This study reports the horizontal gene transfer of CSP genes from bacteria to Triticeae, promoting the adaptation and spread of wheat through enhanced drought tolerance and photosynthetic efficiency.

Ischemic injury induces a partial mesenchymal shift in endothelial cells. Here, the authors show that circATXN1 regulates angiogenesis and partial endothelial-to-mesenchymal transition by controlling SLUG mRNA methylation via ALKBH5, offering a potential therapeutic target for ischemic diseases.

PPEFs are highly conserved phosphatases. Here, authors use cryo-EM to solve the holoenzyme structures of the initially characterized PPEF family member, Drosophila RDGC, with/without Ca²⁺, uncovering a dual Ca²⁺-sensor-mediated activation mechanism.

This Perspective highlights membrane–catalyst systems as a promising approach for difficult large-scale chemical transformations. The authors emphasize the need for integrated design and co-optimization of the membrane and catalysts, especially in the context of oxidative and non-oxidative shale-gas conversion chemistries.

Potent pan-Atg8 or GABARAP-selective inhibitory peptides derived from giant neuronal ankyrin-B and -G effectively block autophagy in cell cultures and in C. elegans spatiotemporally.

A multivalent immobilization strategy uses hydrogen, ionic and coordination bonds that interact with perovskite, enabling deep-blue perovskite LEDs to achieve an external quantum efficiency of 15.36% at 459 nm.

While light-driven CO₂ methanation provides a renewable means to upgrade waste emissions, the sunlight is insufficient to drive high temperature CO₂ methanation. Here, authors prepare single-atom Ni on Y₂O₃ with a selective light absorber for ambient-sunlight-driven photothermal CO₂ methanation.

Lysosomal biogenesis errors often result in diseases including mucolipidosis. Here Zhang and Yang et al. identify TMEM251/GCAF as a mannose-6-phosphate modification regulator that is necessary for correct lysosomal targeting, and classify Mucolipidosis Type V as resulting from GCAF mutations.

The maintenance of cell polarity depends on adhesion complexes that tether to the cytoskeleton. Here the authors show the dynamic nature of E-cadherin–Ankyrin-G complex formation and investigate its functional role in epithelial cell polarity maintenance.

Methanosuratincola petrocarbonis LWZ-6 is a strict hydrogen-dependent methylotrophic methanogen that does not ferment sugars, peptides or amino acids.

Little is known about the regulation of mitofusin proteins that are involved in the fusion of mitochondrial membranes. In this study, the authors report that a heterotrimeric G protein, Gβ-subunit 2, can interact with mitofusin 1, and is involved in the regulation of mitochondrial fusion.

The scaffold protein Miranda is required for the asymmetric segregation of the RNA binding protein Staufen to ganglion mother cells during Drosophila neuroblast division. Jia et al. map the interaction between these proteins and present a crystal structure of the interacting domains.

The study assembled a chromosome-level genome of Cycas panzhihuaensis, the last major lineage of seed plants for which a high-quality genome assembly was lacking. The study closes an important gap in our understanding of genome structure and evolution in seed plants.

Myo1c is a monomeric, unconventional myosin that can sense mechanical force in the cell. The structure of Myo1c's entire tail and neck domains in complex with apocalmodulin reveals a new mode of calmodulin interaction.

An introgression platform for transferring genetic variations of Aegilops tauschii to hexaploid wheat is established based on synthetic octoploid wheat. Combined with newly generated genome resources of A. tauschii, it represents a powerful tool for wheat gene discovery and breeding.

Accurate haplotypes with abundant genomic variations benefit genetic research. Here, the authors accurately construct 1,874 pig haplotypes and demonstrate their applications in genome-wide association studies, prediction of breeding values and analyses of evolutionary selection.

Barocaloric effect, previously reported in solid-solid phase transition materials, offers a green alternative to current cooling technology. Here the authors report colossal BCE in n-alkanes associated with liquid–solid transition.

Heart contraction, which is decreased in disease, is determined by Ca²⁺binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin C variants, suggesting a new therapy for diseased hearts.

Red-emitting perovskite LEDs were fabricated by stabilizing their octahedral structure with a ligand to yield devices with enhanced efficiency, spectral stability and lifetime.

The GABARAP protein is known to support the stability of GABA_A receptors (GABA_ARs) in synapses, but the underlying molecular mechanisms remained to be elucidated. Here authors use biochemistry, X-ray crystallography and electrophsyiology and show that GABARAP directly binds to a previously unappreciated region in the γ2 subunit of GABA_AR.

Producing in situ composite materials with superior strength and ductility has long been a challenge. Here, the authors use lamellar microstructure inherited from casting, rolling, and annealing to produce an ultrafine duplex eutectic high entropy alloy with outstanding properties.

Antibodies capable of neutralizing a wide array of HIV isolates are rarely elicited by the adaptive immune response during HIV infection, and it is not known how to elicit such protective antibodies by vaccination. Philip Johnson and his colleagues have circumvented this hurdle through gene transfer technology. They show that it is possible to protect monkeys from SIV infection by administering intramuscular injections of adeno-associated virus vectors that express broadly neutralizing antibodies that can access the circulation (841–842 pages 951–954).

Inert mineral kaolinite and the energy/nutrient-rich olivine change microbial community structure, stimulate the antibiotic resistance genes, and regulate the degradation of complex organic matter, according to a serial passage evolution experiment in nutrient and energy-rich media.

3D-printed steels with hierarchically heterogeneous microstructures demonstrate high strength and ductility.

We demonstrate theoretically and experimentally that the stepwise phase dispersion compensation layer releases the numerical aperture, operation bandwidth, and aperture size from the tradeoffs of achromatic flat lens, allowing their flexible design.

A semantic redundancy based implicit neural compression guided with saliency map approach can compress arbitrary-dimensional biomedical images of diverse targets ranging from single virus to entire human organs, and ensures reliable downstream tasks, such as object segmentation and quantitative analyses, to be conducted at high efficiency.