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Computational analysis and pairwise assays reveal that bacterial topoisomerase IV is a target of microbially produced phenazines, which informs synthetic-community design to treat fungal crop infection.

This study shows that anthropogenic forcing has driven an equatorward migration of heatwave locations in both hemispheres in the past 40 years. Projections of future climate show even larger migration rates, suggesting a ‘warm-get-warmer’ tendency.

Gasdermin E (GSDME) is abundantly expressed, but its physiological function remains unclear. Here, the authors show a non-pyroptotic function of GSDME in limiting renal inflammation during cisplatin nephrotoxicity by regulating O-GlcNAcylation and STAT3-S100A7A-RAGE signaling.

Chen, Hu, Zhao, Fang and colleagues show that the ribosomal large subunit protein Rpl12 functions as a conserved ribophagy receptor in multiple organisms.

Interfacial water consists of hydrogen-bonded water and Na·H₂O, its structure changes at hydrogen evolution reaction (HER) potentials, and when structurally ordered it aids interfacial electron transfer, resulting in higher HER rates.

Existing isokinetic training devices are often heavy, bulky, and energy-consuming, which limits the rehabilitation opportunities only at designated hospitals. Here, the authors show a highly integrated and power-free knee rehabilitation robot that can provide home-based isokinetic training

Design strategies for non-fullerene acceptors are important for achieving high-efficiency organic solar cells. Here the authors design asymmetrically branched alkyl chains on the thiophene unit of the L8-BO acceptor to achieve high crystallinity and photoluminescence quantum yield, yielding over 20% efficiency in single-junction organic solar cells.

The authors present a reference genome for Hordeum I-genome species. This work unravels genomic features that drive adaptation to salt and alkali environments and could aid in improving crop resilience.

TPP endows TPP₃Cu₂Br₂ with both excellent water resistance and sensitive temperature-dependent luminescence lifetime, achieving a S_r up to 12.82% K⁻¹.

This study conducted a comprehensive scRNA-seq of ovarian clear cell carcinoma (OCCC), identifying a malignant epithelial subcluster and 173 associated factors. Analysis highlighted crucial roles of STAT3, KLF5, and TRIM28, as a valuable resource for understanding OCCC.

Two divergent haplotypes from a highly heterozygous lychee genome of the cultivar ‘Feizixiao’ and resequencing of 72 lychee accessions provide insights into the genome evolution and domestication history of lychee.

Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV induce ALS-like phenotypes in rats and highlight CIV deficiency as a potential risk factor and therapeutic target for ALS.

Targeting the TGF-β signaling pathway has been exploited to relieve immunosuppression in the tumor microenvironment. Here the authors describe the design of a nanoplatform integrating the TGF-β receptor 1 inhibitor LY2157299 and the ROS-responsive JQ1 pro-drug, promoting anti-tumor immune responses in preclinical cancer models.

Non-fused ring electron acceptors may have low synthetic costs but also exhibit poor crystallinity in organic solar cells. Zeng et al. use a binary solvent system to control the crystallization and phase separation of donor and acceptor materials, achieving over 19% efficiency.

Direct seawater electrolysis is an approach to produce hydrogen from an abundant water source, but current catalysts face performance and durability challenges. Here Guo et al. introduce a hard Lewis acid layer on the catalyst surface that generates local alkalinity, facilitating water splitting and minimizing degradation.

The use of time modulation to break reciprocity is well understood for light, sound or charge diffusion, but it’s unclear whether it can work for thermal diffusion. Here, the authors answer in the negative by analysing diffusive processes under time modulation, and giving numerical and experimental evidence.

Nonlinear optical parametric polaritons are observed in a WS₂ monolayer microcavity, opening the way for all-optical valley polariton nonlinear devices.

Conventional spectroscopic techniques are not sufficiently selective to follow the dynamics of trapped carriers in working perovskite solar cells. Here, authors use infrared optical activation spectroscopy to observe real time evolution of trapped carriers and compare the behaviour of trapped holes.

The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.

Fast and scalable synthesis of a variety of transition metal telluride nanosheets by solid lithiation and hydrolysis is demonstrated and several interesting quantum phenomena were observed, such as quantum oscillations and giant magnetoresistance.

An integrative network map of maize (Zea mays L.) that contains genomic, transcriptomic, translatomic and proteomic networks illustrates the landscape of molecular interactions of different functional elements and potential pathway modules in maize.

SEAM is a platform for the analysis of high-resolution secondary ion mass spectrometry imaging that allows spatially resolved nuclear metabolomic profiling at the single-cell level.

A graphene/mesoporous carbon composite presents rapid and efficient H2O2 electrosynthesis capability by two-electron oxygen reduction catalysis which is facilitated by the presence of multiple pyrrolic nitrogen dopants within the material.

The fungal pathogen Candida albicans is diploid, which hinders genome-wide studies. Here, Gao et al. present a piggyBac transposon-mediated mutagenesis system using stable haploid C. albicans strains, and use it to identify genes and mechanisms underlying azole resistance.

Coupling photochemical derivatization with tandem mass spectrometry enables C=C-isomer resolved lipidomics. Here, the authors further develop this approach into a shotgun lipidomics workflow that allows simultaneous characterization of lipid C=C locations and sn-positions in complex biological samples.

Diffractive imaging of an important class of battery electrodes during cycling shows that lattice strain is a crucial yet overlooked factor that contributes to voltage fade over time.

A thermal analogue of coherent perfect absorption would allow to control heat transfer using heat, but the lack of momentum propagation in a thermal field seems to prevent any role for coherence. Here, the authors allow this by introducing an imitated momentum for steady-state heat diffusion.

The collinear antiferromagnet ruthenium dioxide (RuO₂) can generate an electric-field-induced spin current with a well-defined tilted spin orientation that is approximately parallel to the Néel vector.

Defect modulation and understanding its impact on electrode materials remain challenging. Here, authors introduce twin boundaries into spinel cathode and demonstrate that their presence enables fast lithium ion diffusion.

Reduction on cobalt reliance is an urgent requirement in the development of sustainable cathode materials for Li-ion batteries. Here the authors analyse the roles of cobalt and its interplay with other ions in high-nickel layered oxides, and deduce a material formula for promising cobalt-free cathodes.

To unlock the potential of Mn-based cathode materials, the fast capacity fading process has to be first understood. Here the authors utilize advanced characterization techniques to look at a spinel LiMn₂O₄ system, revealing that a combination of irreversible structural transformations and Mn dissolution takes responsibility.

Wollastonite (W)/carbon black (CB)/chlorinated polyethylene (CPE) conductive composites were prepared via melt compounding using CB and wollastonite as fillers and CPE as the matrix. The results indicated that the room temperature resistivity of CPE/CB/wollastonite composites decreased to 1.66Ω·cm after 1 hour of heat treatment, and the PTC strength reached 4.7. Subsequently, the relationship between the internal structure of the materials, changes in crystallinity, and PTC properties was analyzed using X-ray diffractometry and DSC differential scanning calorimetry.

Amide-bearing organic compounds are important building blocks in organic synthesis, however, the ambident reactivities of the nitrogen and oxygen atoms in the amide moiety requires catalysts and reagents that are able to control the reaction selectivity. Here, hypervalent iodine reagents are shown to mediate the intramolecular cycloisomerization of O-alkenylbenzamides to selectively generate isoquinolinone and iminoisocoumarin derivatives.