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The contribution of the extracellular matrix and its degradation to the aging process is not well understood. Here, the authors show that degraded elastin fragments, which increase in the circulation with age, promote aging, while counteracting elastin fragment signals alleviates inflammation, promotes healthy aging and extends lifespan.

Alpha-fetoprotein is a known biomarker for hepatocellular carcinoma. Here, the authors analyse differences between AFP positive and negative patients to identify alterations in androgen receptor signalling.

Through genetic and molecular analyses of interspecific stigma–pollen interactions, the authors show that Brassicaceae plants use an integrated pollen discrimination system and a shared pollen rejection pathway to reject conspecific self-pollen and heterospecific pollen. This establishes a mechanistic link between self-incompatibility and speciation in this clade.

During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent degradation.

NPF1 governs parthenocarpy by activating YUC4 expression in the ovules of cucumber. The selection of a single mutation in the NPF1 gene, along with a SNP in the YUC4 promoter, led to parthenocarpic fruit development during cucumber domestication.

Oligomers are among the various chemical contaminants that can derive from the breakdown of microplastics and that are challenging to detect. A purposely designed platform allows detection of a large number of oligomers, providing an important step towards their risk assessment.

Intracellular copper concentration has been linked to cell proliferation. Here, the authors demonstrate that copper binding to both Cyclin-dependent kinase 1 (CDK1) and CCNB1 is essential for activating CDK1 and promoting the G2/M transition in the cell cycle.

Guo et al. use two-sample Mendelian randomization analyses to reveal causal relationships between neuroimaging phenotypes and psychiatric disorders. This insight may be helpful in predicting psychiatric disorder risk at the neuroimaging level.

Cognitive impairment is a feature of many psychiatric diseases. Here the authors aimed to identify multimodal neuromarkers that can be used to quantify and predict cognitive performance in individuals with schizophrenia using three different features of MRI and three independent cohorts.

How excitatory neurons (EN) acquire senescence is unclear. Here, the authors show that GDF11 in ENs slows EN senescence, brain ageing, cognitive decline and maintains lifespan, revealing a mechanism underlying EN senescence and brain ageing.

Targeting metabolism is currently a promising approach for cancer treatment. Here, the authors show that the beta3 agonist mirabegron inhibits tumor progression by browning adipose tissues in preclinical murine models.

The interfaces in perovskite solar cells are critical to the device performance. Li et al. tune the bond strength of the interfacial molecule with the perovskite and the electron transport layer, increasing the power conversion efficiency of the cells.

Urinary proteomics offers sensitive, non-invasive biomarkers, but cross-platform LC-MS data comparability requires investigation. Here, the authors evaluate 20 LC-MS platforms, developing MSCohort, a QC system with 81 metrics, and a unified SOP, paving the way for precision medicine research.

High-resolution in situ protein structure can be solved by cryo-ET, which requires several days of data collection. Here Cheng et al. report GisSPA, a program that may enable determining sub-4 Å resolution structures on cellular lamellae within one day of data collection.

Identifying modifiable risk factors that could prevent depression is important. Here, the authors show increased risks of incident depression in pre-frail and frail individuals and highlight the mediating role of brain structure and inflammation.

Ytterbium oxide buffer layer for use in perovskite solar cells yields a certified power conversion efficiency of more than 25%, which enhances stability across a wide variety of perovskite compositions.

In this single-arm clinical trial, the authors show that treatment of COVID-19 patients with bevacizumab, an anti-vascular endothelial growth factor drug, can improve PaO₂/FiO₂ ratios and oxygen-support status. Relative to an external control group, bevacizumab shows clinical efficacy by improving oxygenation.

In situ structures of PBS–PSII–PSI–LHC megacomplexes from the alga P. purpureum at near-atomic resolution using cryogenic-electron tomography and in situ single-particle analysis are reported, providing interaction details between PBS, PSII and PSI.

Emerging SARS-CoV-2 variants with multiple mutations raise concerns on vaccine effectiveness. Here, Kang et al. report that a quadrivalent mosaic nanoparticle vaccine displaying spike proteins from the SARS-CoV-2 prototype and three different VOCs confer protection against SARS-CoV-2 variants in mice.

Schizophrenia is highly heritable and characterized by widespread brain abnormalities. Here, the authors identify schizophrenia polygenic risk associated multimodal frontotemporal network that can serve as a transdiagnostic brain signature specific to schizophrenia.

Analysis of brain functional connectivity cross-scan stability in a large-scale Adolescent Brain Cognitive Development dataset reveals that functional network connectivity can identify a given child from a large group with high accuracy and that variations across scans are associated with a range of health measures.

The east-west admixture profile in eastern China of Tang Dynasty inferred from ancient human genomes suggested that the intermarriage with Han Chinese involved the Sinicization process of the Hu people.

Systems where both time-reversal symmetry and inversion symmetry are broken can exhibit a magneto-chiral effect; however, this is usually weak. Here, Lan et al demonstrate a significantly enhanced excitonic magnetochiral effect in twisted bilayer tungsten disulphide on a ferromagnetic substrate.

Resistance to anti-HER2 therapy in breast cancer remains a major obstacle in the clinic. Here the authors performed a CRISPR-selective vulnerability screen to identify transaldoloase as a target that is synthetically lethal with HER2 inhibition in breast cancer cells.

Rigidity, as seen in crosslinked polymers, and plastic processability are mutually exclusive properties. Here, the authors prepare a solution-processable conjugated microporous thermoset with permanent pores and demonstrate its application as a two-dimensional molecular sieving membrane for hydrogen separation.

Exon–intron-fused RAB22A regulates metastasis of osteosarcoma. Liao et al. show that protein products resulting from chromosomal translocations involving RAB22A mediate release of GTP-bound RhoA, induce its activation and promote lung metastasis of osteosarcoma.

Zhu, He, Zhang et al. conduct a cross-sectional study examining the relationship between temperature and fluid intake in Chinese children. Findings reveal a 24 mL daily intake increase per 1 °C temperature rise and projections under climate change scenarios predict substantially higher hydration needs by 2099.