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In order to achieve net zeros in our urban areas, buildings need to adapt. This paper demonstrates a transferable building-scale model for net zero transitions in Nanjing. China.

Wang and colleagues show that an AI-assisted designed peptide obstructs GSDMD pores and inhibits IL-1β and IL-18 release and pyroptosis.

Conventional mechanoreceptors are limited by the trade-off between sensitivity and stability. Here, the authors present an artificial tactile neuromorphic device with a mechanical sensing unit based on a non-faradaic junction and a neuromorphic computing unit, enabling accurate object recognition.

Strategies to balance the emission wavelength and molecular weight of NIR-II dyes, particularly low molecular-weight (<500 Da) dyes, are missing. Here, the authors devise an approach that tunes NIR-II emissions by reducing Coulomb attraction interaction and use it to extend the emission wavelength of GFP chromophore-based dyes LS1-12 from the visible range into the NIR-II region.

Tandem catalysts are important in electrocatalysis but suffer from uncontrollable interfaces, limited crystal phases, and complex synthesis. Here, the authors report the facile synthesis of hetero-phase 4H/fcc Au–Cu tandem catalysts with tunable interfaces for ammonia electrosynthesis from nitrate.

Xiao, Dong, Xie, Feng et al. developed FRα-targeting chimeras (FRTACs) for targeted membrane protein degradation by conjugating multiple folate molecules to antibodies of targeted proteins. The folate polyvalency of FRTACs enables high affinity and potency of FRTACs in eliminating target proteins.

Tumor pericytes are located surrounding blood vessels, and can regulate tumor vascular structure. Here, the authors discover that a subpopulation of NKX2-3 high tumor pericytes modulates vasodilation and hemodynamics to promote metastasis.

A ligand oxidation structure-adaptive strategy creates an ultra-thin passivation nanolayer that enables copper and its alloys to resist corrosion and oxidation in harsh environments while retaining intrinsic electrical and thermal conductivities.

A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.

Global consumption drives freshwater overuse at production sites along supply chains, of which 24% is outsourced via trade. Agricultural demand is a key driver, while manufacturing exports exacerbate water stress in emerging economies.

A hybrid cathode interfacial layer (AZnO-F3N) is developed, delivering 21.0% efficiency along with excellent stability, mechanical robustness and broad versatility, highlighting its potential to advance organic solar cells.

Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N⁶-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

Bioproduction of steroids involves NADPH-dependent enzymes that mediate electron transfer reactions. Here, the author reveal the electron transfer mechanisms of NADPH-dependent enzymes and demonstrate the complete biosynthesis of steroids through electron transfer engineering.

Traditional silicon vision chips often challenge in emulating complex biological behaviors. This work reports birdlike broadband neuromorphic visual sensor arrays with 5 bits of in-memory sensing and computing. The built reservoir computing system achieves motion and UV grayscale information extraction, leading to fusion visual imaging.

The power conversion efficiency of wide-bandgap pure-sulfide kesterite is low. Wang et al. propose annealing in a hydrogen-containing atmosphere and report the underlying mechanism that enables a certified efficiency of 11.4%.

The unconventional hexagonal phase CuCo PBA with open structure, large pore size, and high specific surface area is synthesized, and it delivers much better small molecular gas adsorption performance than the traditional cubic counterpart.

Sodium-ion batteries face challenges due to electrode degradation and interphase instability. Here, authors develop a smart gel polymer electrolyte for hard carbon||NaNi_1/3Fe_1/3Mn_1/3O₂ batteries via in situ polymerization of specific monomers in conventional electrolytes.

Developing porous hemostatic sponges remains challenging. Here, authors proposed a temperature-assisted secondary network compaction strategy following the phase separation induced primary compaction to fabricate the superporous chitosan sponges.

The identification of post-translational modifications (N-glycosylation and phosphorylation) in GPR52, an orphan G-protein-coupled receptor, shapes the intrinsic signaling bias and can modulate GPR52-dependent accumulation of the huntingtin protein in brain cells.

How serine synthesis is regulated in cancer remains to be further explored. Here the authors identify FBXO7, an E3 ubiquitin ligase, inhibits serine synthesis in hepatocellular carcinoma by promoting ubiquitination and degradation of PRMT1 methyltransferase.

Pinoresinol–lariciresinol reductases (PLRs) are enzymes involved in the lignan biosynthesis. Here, crystal structures of three PLRs in the apo, substrate-bound and product-bound states, and accompanying mutagenesis provide insight into PLRs catalytic mechanism and suggest a strategy for PLR engineering.

A-to-I editing in animals is catalyzed by enzymes of the Adenosine Deaminase Acting on RNA family, orthologues of which do not exist in fungi. Here, Feng et al. characterise the enzymes involved in A-to-I mRNA editing in Fusarium graminearum.

Low-metallicity molecular clouds in the Milky Way and nearby galaxies exhibit a strong deficiency in turbulent support against their self-gravity, suggesting that the magnetic field may play a dominant role in supporting clouds under such conditions.

Available intrinsic magnetic topological insulators are rare. Here, the authors study the electronic and magnetic properties of Mn(Sb_xBi_(1-x))₂Te₄ bulks and thin flakes, revealing intrinsic magnetic topological insulator phase in the phase diagram.

Solid-state lithium batteries typically utilize heterogeneous composite cathodes with conductive additives, which limit energy density and cycle life. Here the authors present a cathode material that exhibits efficient mixed conduction and near-zero volume change during cycling, thereby improving battery performance.

An on-chip microcomb that provides reference clocks for all synthesized signals and electronics within the system can be used to unite time–frequency references in optoelectronics.

Hepatic expression of constitutively active glucagon receptor may have contributed to the glucose and lipid metabolism and the high metabolic rates that enabled the evolution of flight in birds.

Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signalling molecules in metabolic processes. Here, the author show 13-HODE produced by senescent hepatocytes and macrophages activates SREBP1 by directly inhibiting CAT activity and promotes age-related steatosis.

Understanding the structure-function relationship in Cu-catalyzed CO₂ reduction is challenging due to dynamic active sites. This study introduces stable coordination polymer catalysts with homogenized, single-site Cu, enabling the study and tuning of C–C coupling efficiency in CO₂ electroreduction.

PfENT1 is a promising antimalarial drug target. Here, authors report cryo-EM structures of PfENT1 that, together with biochemical work, suggests PfENT1 is an inosine transporter and describe the inhibitory mechanism of the endofacial inhibitor, GSK4.