The study reveals the novel role of B7H3, a co-stimulator molecule of the cell surface B7 protein superfamily, in glioblastoma multiforme (GBM). B7H3 is synchronously upregulated with glioma self-renewing cell (GSC)-related genes. B7H3 regulates GBM differentiation through activation of the TGF-β pathway and modulation of MYC. The study provides a new paradigm of B7H3 as a prognostic and therapeutic target in GBM.
- Jingwen Zhang
- Jinhua Wang
- Ying Mao
