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Various cell-penetrating peptides (CPPs) can trigger endocytosis independently of specific lysosome-targeting receptors (LTRs). Here, the authors present CPP-mediated lysosome-targeting chimeras (CPPTACs), a versatile platform that enables the efficient degradation of cell surface proteins without dependence on specific LTRs.

Legionella effector LnaB, a recently identified actin-activated AMPylase, mediates phosphoryl-AMPylation in a yet-unknown manner. Here the authors unveil a two-step catalytic process involving dual ATPase–AMPylase activity based on structural studies, providing a biochemical basis for AMPylation.

Heterogeneous single-atom catalysts (SACs) offer high atom utilization and well-defined active sites but face challenges in multi-stage cross-couplings due to limited coordination and reactivity. Here, the authors introduce SACs on reducible carriers, enabling adaptive coordination to bypass oxidative addition in cross-couplings.

Cycling positive electrodes at high voltages leads to structural instability and capacity decay. Here, authors report a cationic defective electrode, Na_3.2□_0.8Co_0.5Fe_0.5V(PO_3.9F_0.1)₃, through fluorine doping with enhanced stability, reversible capacity, and fast Na⁺ (de)intercalation.

Fan, Shang, Song, Chen et al. identify the Integrator–PP2A complex (INTAC) as a key regulator of cancer cell sensitivity to BET inhibitors through directly interacting with the RACK7–KDM5 complex to orchestrate epigenetic silencing in a catalytic-independent manner.

Comparing to Gossypium hirsutum, G. barbadense cotton lines have superior fiber quality but lower fiber yield. Here, the authors construct pangenome using 12 newly assembled G. barbadense genomes and 17 publicly tetraploid cotton genomes and reveal yield- and fiber-related diversity and interspecific gene flow.

Our understanding of reaction dynamics has developed as more accurate measurements of product state-resolved angular distributions have become available. Now, fast forward-scattering oscillations in the product angular distribution of the benchmark chemical reaction H + HD → H₂ + D have been observed and are in excellent agreement with quantum-mechanical dynamics calculations.

The authors make multi-oriented nanodomain in BiFeO3-based ceramics via the strategic design of a dipolar region with high resilience to electric fields, achieving high energy storage density of 12.2 J cm−3 and energy storage efficiency of 90.1%.

SOSS–INTAC stimulates promoter-proximal termination of transcription and attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced genome instability.

The authors construct a nanostructure consisting of defect dipole polarization and polymorphic relaxor phases. The high-entropy ceramic achieves an energy density of 11.23 J cm⁻³, an efficiency of 90.87%, along with temperature sensing feature.

In laser-driven inertial fusion, finding optimal driving pressure is a major challenge. Here, the authors use a 100 kJ SG laser and a hybrid-drive scheme to demonstrate such driving pressure with the help of the direct-drive laser such that the indirect-drive radiation ablation pressure is turned into a well-smoothed hybrid-drive pressure much greater than the radiation ablation pressure.

Here the authors describe the catalytic-independent role of LSD1 in regulating gene expression and cellular differentiation and a mechanism by which the LSD1-P300 axis contributes to the regulation of enhancers and cell fate.

The development of superior and cost-effective catalysts for the oxygen reduction and evolution reactions is pivotal for the future hydrogen economy. Now a series of Ru-modified Li₂MnO₃ catalysts have been designed to optimize the electronic structure and achieve a high performance in both oxygen reduction and evolution reactions, as demonstrated in practical anion exchange membrane fuel cell and water electrolyser tests.

Lai and colleagues show that the RNA helicase DDX5 mediates the alternative splicing of the IL-36R mRNA in keratinocytes and modulates skin inflammation downstream of IL-17D signaling.

Zhou et. al. report the interim results of the randomized phase III GEMSTONE-302 trial, showing the overall survival benefits of first-line treatment with the PD-L1 inhibitor sugemalimab versus placebo in combination with chemotherapy, in patients with NSCLC.

Here the authors propose for the first time the concept of supervised-evolving learning (SEL) and a corresponding SEL-driven adaptive focusing (SELAF) system. This metasurface can adaptively realize focusing at any specified position for waves incident from any direction. This work demonstrates unprecedented potential for tasks involving real-time, fast and complex electromagnetic wave manipulation.

Designing active, stable and cost-effective catalysts for the acidic oxygen evolution reaction remains a challenge. Here, the authors report iridium single atoms incorporated cobalt oxides, showing distinctly enhanced performance in the acid.

A versatile hydrothermal approach in an operando acidic environment created ferromagnetic single-atom spin catalysts (SASCs). Ni-based SASC exhibits a giant magnetic field enhancement of OER activity, boosting both water and saline water electrolysis.

The study presents data from moorings in the Challenger Deep, the deepest known hadal trench in the world, showing a three-layer circulation structure, modulated by deep-water intrusion, topography and turbulent mixing.

Solid electrolytes play a crucial role as ion conductors and separator between electrodes in all-solid-state batteries. Here, the authors report a high-entropy halide solid electrolyte, which reveals the structure evolution with the increasing configurational entropy and improves the high-voltage stability.

How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat drug-resistant tumours lacking functional p53.

Structural degradation in manganese oxides leads to unstable activity during long-term cycles. Herein, authors demonstrated that reduced unstable O 2p holes and the short interlayer distance of layered lithium manganese oxide are favorable for excellent electrocatalytic stability and activity.

Exploring efficient electrocatalysts with fundamental understanding of the reaction mechanism is important for CO₂ electroreduction. Here, the authors report a strategy of promoting water dissociation to achieve high solar to chemical conversion and identify key surface species for the reaction.

Different deubiquitinases are associated to cancer development. Here, the authors show that PPARgamma is stabilized by USP22-mediated deubiquitination leading to lipid accumulation and promoting hepatocellular carcinoma.

Steam treatment transforms inactive Pd₁/CeO₂ catalyst into a highly reactive one by forming a Ce₂O₃-Pd nanoparticle interface. This domain interface is created by the coordinated migration of Ce and Pd atoms on the atom trapped Pd₁/CeO₂.

Postmortem analyses provide useful information for COVID-19 etiology. Here the authors profile 22 deceased severe COVID-19 patients with transcriptomic and histological approaches to find correlations between the presence of viral antigens with lymphocyte suppression yet myeloid activation, hinting distinct functions of these cells during pathogenesis.

Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP.

The use of a dimensionally graded 2D perovskite interface and passivation results in perovskite solar cells with very low photovoltage loss.

A small cluster of brainstem-projecting layer 5 neurons in primary motor cortex elicit contraction of the bladder muscle and trigger urination. These findings open new directions for treating urination-related disorders.

_L-3,4-Dihydroxyphenylalanine plays an important role in living system. Here, the authors investigated the effect of the molecular chirality of _L-3,4-dihydroxyphenylalanine on the improved structural and thermal stability of self-assembled films by tyrosinase-induced oxidative polymerization.

The mechanism and scaling of high harmonic generation in solids is a highly compelling ongoing area of research. Here the authors show a non-perturbative behavior of HHG in terahertz regime from 3D Dirac semimetal, Cd₃As₂, at room temperature, and reveal the underlying nonlinear kinetics.

Although termites are major human pests, they have an important role in maintaining ecosystem function and biodiversity. Here, the authors sequence the genome and transcriptomes of a dampwood termite and highlight genes that may be involved in the mechanisms underlying insect social behaviour.

Black carbon is a recalcitrant byproduct of biomass burning that ultimately accumulates in oceanic sinks. Here the authors assessed the sources and cycling of dissolved black carbon in rivers and oceans, finding that oceanic pools are cycled and aged on the same time scales as dissolved organic carbon.

A general strategy that allows a range of nanocrystals, microparticles and cells to be assembled into superstructures is reported.