Search

This study reveals that transcription factors DAF-16/FOXO and HLH-30/TFEB promote healthy aging in C. elegans, in part, by activating lipid metabolism genes that remodel lysosomes into tubular networks.

Using a cryogenic 300-mm wafer prober, a new approach for the testing of hundreds of industry-manufactured spin qubit devices at 1.6 K provides high-volume data on performance, allowing optimization of the complementary metal–oxide–semiconductor (CMOS)-compatible fabrication process.

Thin samples CrI₃ exhibit a phase transition under an applied magnetic field from layered antiferromagnetism to ferromagnetism. Here the authors observe an associated abrupt change in the magneto-Raman spectra, illustrating the sensitivity of Raman spectra to magnetic ordering.

The authors show that an out-of-plane antidamping spin–orbit torque can produce a sizeable change in the switching dynamics of a magnetic layer with perpendicular anisotropy.

Spin-charge interactions are at the core of electronic correlation phenomena in Mott insulators. Here, the authors observe a positive anomalous magnetoresistance in a SrIrO₃/SrTiO₃ superlattice, indicative of strong spin-charge fluctuations in this pseudospin-half square-lattice Mott insulator.

Gap junctions close in response to intracellular acidification. Using cryo-EM, the authors reveal a reversible gating mechanism in Cx46/50, where lipid entry into the pore displaces a gating helix and induces pH-dependent conformational closure.

Spin-ice physics in frustrated magnets is constrained by the energy scale of magnetic interactions, which typically translates to temperatures of a few Kelvin. Here, the authors demonstrate that similar physics can be observed in the system of frustrated electric dipoles in Cd(CN)₂ even at room temperature.

The authors present BARASA, an approach to assign backbone triple resonance spectra of proteins that augments traditional approaches with a Bayesian statistical analysis of the observed chemical shifts. The algorithm employs a simulated annealing engine to establish a consensus set of resonance assignments and is tested against systems ranging in size to over 450 amino acids including examples of intrinsically disordered proteins.

Graphene is expected to possess characteristics that are particularly useful for transporting and manipulating electronic spin. The discovery of spin-dependent interference features in its electrical characteristics could be useful in the development of graphene spintronics.

For most binary stars, the theoretical and observed precession rates are in agreement, but the observed precession rate for the DI Herculis system is a factor of four slower than the theoretical rate, a disagreement that once was interpreted as evidence for a failure of general relativity. Here, both stars of DI Herculis are reported to rotate with their spin axes nearly perpendicular to the orbital axis, an observation that leads to the reconciliation of the theoretical and observed precession rates.

To enable the development of devices based on the electrical manipulation of magnetic molecules, their magnetic state needs to be conserved when electrical contacts are applied. N@C₆₀ molecules have now been integrated as part of single-molecule transistors, and their spin states retained. This achievement may lead towards their use in high-density information storage and quantum-state control.

Spin-polarized defects in 2D materials are attracting attention for future quantum technology applications, but their controlled fabrication is still challenging. Here, the authors report the creation and characterization of effective spin 1/2 defects via the atomically-precise generation of magnetic carbon radical ions in 2D WS₂.

An analysis of transits of planets over starspots on the Sun-like star Kepler-30 shows that the orbits of the three planets are aligned with the stellar equator; this configuration is similar to that of our Solar System, and suggests that high obliquities are confined to systems that experienced disruptive dynamical interactions.

Here, the authors report the characterization of stable few-layer PdSe₂ transistors encapsulated in hexagonal boron nitride, showing field effect mobilities up to 700 cm²/Vs at room temperature and signatures of an 8-fold spin-valley degeneracy of the magnetotransport quantum oscillations at cryogenic temperatures.

Parallel operation of two exchange-only qubits consisting of six quantum dots arranged linearly is shown to be achievable and maintains qubit control quality compared with sequential operation, with potential for use in scaled quantum computing.

A long-period radio transient with coincident radio and X-ray emission and observational properties unlike any known Galactic object has been observed by the Australian Square Kilometre Array Pathfinder.

When lanthanum aluminate and strontium titanate are brought together, a 2D electron gas with many interesting properties forms at the interface. Magnetotransport results obtained by Joshuaet al. suggest that the behaviour of this interface is governed by a small but fundamental set of electronic bands.

Here, the authors show that methylphenidate alters brain organization by compressing the hierarchy between sensory and association areas. This dopamine-driven shift predicts improved attention, revealing how stimulants reorganize brain networks to enhance cognitive function.

Gating dependent laser induced spin dynamics in an antiferromagnetic bilayer are observed and explained, with implications for future spintronic applications.

Twisted double bilayer graphene (tDBG) comprises two Bernal-stacked bilayer graphene sheets with a twist between them. Here, the authors report a strong anomalous Hall effect in the correlated-metal regime of tDBG, indicating time reversal symmetry breaking from orbital ferromagnetism, likely associated with valley polarization.

Individually addressable ‘T centre’ photon-spin qubits are integrated in silicon photonic structures and their spin-dependent telecommunications-band optical transitions characterized, creating opportunities to construct silicon-integrated, telecommunications-band quantum information networks.

T cells contribute to protection and pathogenesis in tuberculosis. Here the authors sequence T cell receptor repertoires in human skin biopsies from the site of the tuberculin skin test and show enrichment of clonotypes reactive to Mycobacterium tuberculosis using a computational pipeline metaclonotypist to identify distinct TCRs predicted to share peptide-MHC reactivity across participants, as an approach to explore T cell correlates of tuberculosis disease-risk stratification and vaccine efficacy.

Directly observing ultrafast single electron dynamics at the atomic scale remains a challenge. Here, the authors demonstrate ultrafast Coulomb blockade at selenium vacancies in WSe2/graphene heterostructures using lightwave-driven scanning tunneling microscopy.

Tomonaga-Luttinger liquid behavior has been observed within 1D defects in transition metal dichalcogenides. Here, using complementary experiments and engineered defects, the authors demonstrate the importance of graphene as a substrate and its role in the formation of this quasiparticle excitation in 2D WS₂.

Chemical doping allows for boosting the conductivity in conjugated polymers but the relationship between doping and the polymers’ complex, multiscale morphology remains elusive. Here the authors report that supramolecular chirality, which up to now had not been considered a parameter relevant to doping, significantly boosts the underpinning redox reaction in conjugated polymer thin films.

Paul and colleagues report the development and characterization of an antibody–drug conjugate targeting TRBC2 for the treatment of T cell malignancies.

An Fe^III/V redox mechanism in Li₄FeSbO₆ on delithiation without Fe^IV or oxygen formation with resistance to aging, high operating potential and low voltage hysteresis is demonstrated, with implications for Fe-based high-voltage applications.

Using molecular-beam epitaxy, we synthesize heterostructures of topological insulator Bi₂Se₃ and the Ising superconductor monolayer NbSe₂. By changing the Bi₂Se₃ thickness, they demonstrate a crossover from Ising- to Rashba-type superconducting pairing.

A long-lived photoinduced metastable state in a quasi-one-dimensional cuprate, Sr₁₄Cu₂₄O₄₁, is reported.

Central nervous system lesions are reduced following focused ultrasound treatment in a mouse model.

Ising anyons are a promising platform for topological quantum computation, but braiding alone is not universal. Here, authors show that extending to non-semi simple TQFTs introduces new anyon types that enable universal quantum computation with Ising anyons.

FeSe does not exhibit magnetic order and lacks a nematic quantum critical point coinciding with optimal superconductivity, suggesting that an orbital mechanism drives nematicity, but direct evidence is lacking. Here, combining X-ray linear dichroism with in situ uniaxial stress, the role of spontaneous orbital polarization in nematic-phase FeSe is determined.

HTLV-1 type-C causes more severe disease than type-A, but the underlying reason is unclear. Here the authors show in a macaque model how type-C orf-I affects lung pathogenesis and the immune response to HTLV-1, providing a model to test viral targets for disease prevention.

A flexible micro-electrocorticography brain–computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal–oxide–semiconductor substrate can provide stable, chronic in vivo recordings.

After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.

Differentiating DCs express ALDH1A2, which produces retinoic acid and suppresses DC activity. Blocking this pathway with a new inhibitor, KyA33, enhances immune responses and boosts the effectiveness of DC cancer vaccines in mouse models.

We report superconductivity, in a limited region of displacement field and density, in 5.0° twisted bilayer WSe₂ with a maximum critical temperature of 426 mK, establishing that moiré flat-band superconductivity extends beyond graphene structures.

Observations from the Lucy spacecraft of the small main-belt asteroid (152830) Dinkinesh reveals unexpected complexity, with a longitudinal trough and equatorial ridge, as well as the discovery of the first contact binary satellite.

Magnetic brightening enables direct observation of spin-forbidden dark excitons in a monolayer WSe₂.

Analysis of experimental data in condensed matter is often challenging due to system complexity and slow character of physical simulations. The authors propose a framework that combines machine learning with theoretical calculations to enable real-time analysis for electron, neutron, and x-ray spectroscopies.

Healthy adults were tracked before, during and after high doses of psilocybin and methylphenidate to assess how psychedelics can change human brain networks, and psilocybin was found to massively disrupt functional connectivity in cortex and subcortex with some changes persisting for weeks.

Gram-negative bacteria use a multiprotein complex, LptB₂FGC, to transport lipopolysaccharides (LPS) to the outer membrane. Here, Fiorentino et al. present cryo-EM structures of the complex from Pseudomonas aeruginosa, revealing species-specific features and providing insights into LPS transport mechanisms.

Point defects in 2D semiconductors have potential for quantum computing applications, but their controlled design and synthesis remains challenging. Here, the authors identify and fabricate a promising quantum defect in 2D WS₂ via high-throughput computational screening and scanning tunnelling microscopy.

Strong acoustic fields applied to solutions of linear polymers typically result in mid-chain scission, yielding products half the molecular weight of the original. Now it has been shown that poly(o-phthalaldehyde), a polymer with a ceiling temperature below room temperature, undergoes chain scission and subsequent depolymerization to monomers. Introduction of an appropriate initiator to the monomer regenerates poly(o-phthaladehyde) macromolecules.

Twisted multilayer graphene structures composed of Bernal-stacked constituents are predicted to host flat moiré bands for several layer-number combinations. Here, the authors find an array of band insulators, correlated insulators, and topological states with notable similarities across different constructions.