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Showing 1–50 of 452 results
Advanced filters: Author: Julia Bridge Clear advanced filters
  • Joint injury and disease are leading causes of disability, with mammalian joints exhibiting poor regenerative capacity. Here the authors showed that after loss of a whole joint, adult zebrafish regenerate de novo articular cartilage, ligament, and synovium into a complex joint organ.

    • Maria Blumenkrantz
    • Felicia Woron
    • Joanna Smeeton
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • The ultrafast and mode-specific infrared excitation of several donor–bridge–acceptor (DBA) assemblies in solution has been shown to modulate their light-induced electron transfer properties. New insights are afforded into the role of vibrational processes immediately following light absorption in charge-transfer molecules and a recipe for efficient ‘vibrational control’ of electron transfer is proposed.

    • Milan Delor
    • Theo Keane
    • Julia A. Weinstein
    Research
    Nature Chemistry
    Volume: 7, P: 689-695
  • Manipulating chemical reactions using laser pulses to control electron transfer is an attractive goal, however much of the underlying physics remains unexplored. Here the authors analyse and explain the intramolecular electronic transfer occurring during charge-separation in acetylene, a model donor-bridge-acceptor molecule.

    • Xunmo Yang
    • Theo Keane
    • Eric R. Bittner
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8
  • Single-molecule and biochemistry approaches are used to investigate how ultra-fine DNA bridges, which form between sister chromatids during anaphase, are recognized and processed by cellular factors PICH, BLM, TopoIIIα and RPA.

    • Kata Sarlós
    • Andreas S. Biebricher
    • Ian D. Hickson
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 868-876
  • Tau aggregation, a hallmark of Alzheimer’s disease, disrupts neuron structure. Aging weakens chaperone defenses like Hsp90. This study designs β-Hsp90, a small peptide mimicking Hsp90, to prevent Tau aggregation, offering promise for new amyloid disease drugs.

    • Davide Di Lorenzo
    • Nicolo Bisi
    • Sandrine Ongeri
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • To celebrate the journal’s 25th anniversary, we asked 13 researchers to offer a glimpse of what their research field might look like in 2050. They consider how technological breakthroughs — for example, artificial intelligence-powered virtual cells — could transform our understanding of how molecules, organelles and cells behave in different contexts, revolutionize therapies and enable the design of resilient crops.

    • Monther Abu-Remaileh
    • Chii Jou Chan
    • Jan J. Żylicz
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 735-740
  • Four-coordinate cobalt(II) complexes possess high energy barriers toward inversion of the magnetic moment, but not the magnetic bistability needed for magnetic data storage. Here, the authors report an air-stable radical-bridged binuclear cobalt(II) complex with improved magnetic properties.

    • David Hunger
    • Julia Netz
    • Joris van Slageren
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • TRPC3 regulates neuronal excitability via its constitutive activity. Using MD simulations and patch clamp techniques, Clarke et al. show that PIP2 controls TRPC3 via a salt bridge formed between the TRP helix and the S4-S5 linker, affecting both stimulated and constitutive TRPC3 activities.

    • Amy Clarke
    • Julia Skerjanz
    • Oleksandra Tiapko
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

    • Yilan Wu
    • Bo Qian
    • Bin Sheng
    Research
    Nature Medicine
    P: 1-10
  • The main protease, a key enzyme of SARS-CoV-2, can protect itself from oxidative damage. Here, Reinke, Schubert, and colleagues used XFEL radiation to image the enzyme, revealing the disulfide and NOS/SONOS bonds that form in response to oxygen.

    • Patrick Y. A. Reinke
    • Robin Schubert
    • Thomas J. Lane
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10
  • Proteins SegA and SegB are important for chromosome segregation and organization in archaea of the order Sulfolobales, but mechanisms are unclear. Here, Kabli et al. uncover patterns and mechanisms that the SegAB system employs to link chromosome organization to genome segregation.

    • Azhar F. Kabli
    • Irene W. Ng
    • Daniela Barillà
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21
  • Telomeric entanglements arising from stalled telomeric replication forks can cause mitotic catastrophe in dividing cells. Here, the authors show that resolution of such entanglements in fission yeast requires rapid exposure of the DNA to the cytoplasm during anaphase.

    • Rishi Kumar Nageshan
    • Raquel Ortega
    • Julia Promisel Cooper
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121
  • Drivers of viral evolution in SARS-CoV-2 are insufficiently understood. In this study, the authors show how a key SARS-CoV-2 mutation, NSP4 T492I, is potentially responsible for accelerating genome evolution to develop adaptive variants (e.g. Omicron).

    • Xiaoyuan Lin
    • Zhou Sha
    • Zhenglin Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Plant functional diversity is highly dynamic over time, driven by seasonal cycles and wet–dry periods and varying across biomes, based on an analysis of over 4,000 hyperspectral satellite scenes at the global scale.

    • Daniel Mederer
    • Teja Kattenborn
    • Hannes Feilhauer
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 6, P: 1-9
  • Foundation models enable rapid adaptation to various downstream tasks and are hence about to become a new paradigm in biomedicine. Here, the authors develop LLaVA-Rad, a small AI that bests larger models in chest X-ray interpretation, and CheXprompt, a radiologist-aligned factuality metric, to enable scalable, privacy-preserving image analysis.

    • Juan Manuel Zambrano Chaves
    • Shih-Cheng Huang
    • Hoifung Poon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • The authors reveal that probenecid, an FDA-approved drug, uniquely modulates TRPV2 through an intracellular pocket. Probenecid drives the channel into an activated conformation, providing insights into potential therapeutic applications.

    • Julia A. Rocereta
    • Toni Sturhahn
    • Vera Moiseenkova-Bell
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1019-1029
  • The mechanical properties of central nervous system (CNS) scar tissue are considered to contribute to axon regeneration failure. Here, the authors identify members of the small leucine-rich proteoglycan family as modulators of the inhibitory viscoelastic response of CNS lesions.

    • Julia Kolb
    • Vasiliki Tsata
    • Daniel Wehner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-23
  • Characterisation of monoclonal antibodies against SARS-CoV-2 are useful for potential therapeutics or to understand more about the immune response to this virus. Here the authors characterise a monoclonal antibody that has a broad range of reactivity against SARS-CoV-2 variants and measure how it binds to its specific target region of the receptor binding domain.

    • Leire de Campos-Mata
    • Benjamin Trinité
    • Giuliana Magri
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13
  • An atlas study of adipose tissue in people with obesity undergoing weight loss and their lean counterparts reveals that weight loss reduces cell senescence but cannot reverse all the metabolic problems caused by obesity.

    • Antonio M. A. Miranda
    • Liam McAllan
    • William R. Scott
    ResearchOpen Access
    Nature
    Volume: 644, P: 769-779
  • Furlan’s team engineered the printing of Gd2Zr2O7 photonic coatings on curved metal surfaces, achieving high reflectivity values that outperform state-of-the-art thermal barrier coatings while having remarkably low density and minimal thickness

    • Alberto Gomez-Gomez
    • Diego Ribas Gomes
    • Kaline P. Furlan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Virus-host protein-protein interactions are fundamental to viral pathogenesis, yet few are structurally resolved. Here, the authors combine cross-linking mass spectrometry, bio-orthogonal labeling and AlphaFold to reveal the structural virus-host interface from intact cells infected with HSV-1.

    • Boris Bogdanow
    • Lars Mühlberg
    • Fan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • The spin–orbit interaction and the two-dimensional honeycomb structure of iridium-based oxides are promising for exotic electronic states. Here, the authors find an iridium oxide with a three-dimensional structure that preserves the features of the honeycomb systems, creating new material possibilities.

    • K. A. Modic
    • Tess E. Smidt
    • James G. Analytis
    Research
    Nature Communications
    Volume: 5, P: 1-6
  • Protein kinase transition between different conformational states is controlled by autophosphorylation. Here, the authors demonstrate that the c-terminal Tyr530 is a de facto c-Src autophosphorylation site  and identify a critical c-terminal palindromic phospho-motif that controls the interplay between substrate and enzyme-acting kinases during autophosphorylation.

    • Hipólito Nicolás Cuesta-Hernández
    • Julia Contreras
    • Iván Plaza-Menacho
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21
  • ESCRT filaments drive the final abscission between two daughter cells but how they physically interact with the membrane is unclear. Using proteomics, the authors show that syndecan-4/syntenin/ALIX couples the ESCRT machinery to the abscission site and thus promotes efficient abscission.

    • Cyril Addi
    • Adrien Presle
    • Arnaud Echard
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • Here they show that the essential sperm calcium channel CatSper is temperature-gated and reversibly inhibited by spermine. This discovery uncovers a key regulatory mechanism of sperm function and highlights the critical role of testicular cooling in male fertility.

    • Dilip K. Swain
    • Citlalli Vergara
    • Polina V. Lishko
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136
  • Traditional catalytic studies typically rely on steady-state conditions, producing time-averaged data that cannot distinguish between active species and spectators. Here, the authors explore CO oxidation on Pt(111) by simultaneously monitoring reaction products, surface intermediates, and catalyst responses in real time.

    • Calley N. Eads
    • Weijia Wang
    • Andrey Shavorskiy
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

    • Loïc Yengo
    • Sailaja Vedantam
    • Joel N. Hirschhorn
    ResearchOpen Access
    Nature
    Volume: 610, P: 704-712
  • Combined single-molecule spectroscopy, hydrogen–deuterium exchange and molecular dynamics approaches reveal that agonist activation of metabotropic glutamate receptors entails population of several intermediary states before G protein coupling.

    • Naomi R. Latorraca
    • Sam Sabaat
    • Ehud Y. Isacoff
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 1433-1443
  • Sarcomas are a group of mesenchymal malignancies which are molecularly heterogeneous. Here, the authors develop an in vivo muscle electroporation system for gene delivery to generate distinct subtypes of orthotopic genetically engineered mouse models of sarcoma, as well as syngeneic allograft models with scalability for preclinical assessment of therapeutics.

    • Roland Imle
    • Daniel Blösel
    • Ana Banito
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Xue et al. visualize how the antibiotic chloramphenicol reshapes the translation landscape and induces ribosome collision in bacterial cells, illuminating its context-dependent action across atomic, molecular and cellular scales.

    • Liang Xue
    • Christian M. T. Spahn
    • Julia Mahamid
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 257-267
  • Manju Kurian and colleagues report heterozygous variants in KMT2B in 27 unrelated individuals with a complex progressive childhood-onset dystonia, often associated with a typical facial appearance. Their findings highlight a clinically recognizable form of dystonia and demonstrate a crucial role for KMT2B in the physiological control of voluntary movement.

    • Esther Meyer
    • Keren J Carss
    • Manju A Kurian
    Research
    Nature Genetics
    Volume: 49, P: 223-237
  • A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early events during cancer development.

    • Andreas Panagopoulos
    • Merula Stout
    • Matthias Altmeyer
    ResearchOpen Access
    Nature
    Volume: 642, P: 785-795
  • A new computer simulation will elucidate whether water is transported through the icy shell of Jupiter’s moon Europa, and where it is sourced from, using multiple surface and interior data from upcoming planetary missions.

    • Elodie Lesage
    • Samuel M. Howell
    • Steven D. Vance
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9