Nature Search

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions

The tumor suppressor RAD51C is mutated in ovarian cancers. Through variant analysis the authors identify a mutation cluster in the RAD51C Walker B region important for the repair of DNA double-strand breaks and replicative damage. By identifying Walker B separation-of-function alleles, they show that these activities can be uncoupled.

Hayley L. Rein
Yashpal Rawal
Kara A. Bernstein

ResearchOpen Access16 Jul 2025

Nature Communications

Volume: 16, P: 1-13

Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission

NSF hydrolyzes ATP to disassemble SNARE complexes. Here, the authors find NSF colocalizes with syntaxin nanodomains, reveal disassembly of syntaxin oligomers and other pre-fusion cis-SNARE complexes by NSF, and show how sequential hydrolysis drives disassembly.

K. Ian White
Yousuf A. Khan
Axel T. Brunger

ResearchOpen Access24 Sept 2025

Nature Communications

Volume: 16, P: 1-22

Naturally occurring respiratory deficient Candida slooffii strains resemble petite mutants

HELEN ARTHUR
K. WATSON
G. D. CLARK-WALKER

Research01 Feb 1978

Nature

Volume: 271, P: 750-752

Current-induced magnetic domain wall motion below intrinsic threshold triggered by Walker breakdown

Current-induced magnetic domain wall motion can be triggered by an applied magnetic field, and its motion is described by the vector sum of the velocities imparted by current and magnetic field driving terms.

T. Koyama
K. Ueda
T. Ono

Research09 Sept 2012

Nature Nanotechnology

Volume: 7, P: 635-639

Quantifying the impact of hair and skin characteristics on fNIRS signal quality for enhanced inclusivity

Yücel et al. examine how skin and hair characteristics impact functional near-infrared spectroscopy (fNIRS) signal quality and provide recommendations for inclusive use of fNIRS.

Meryem A. Yücel
Jessica E. Anderson
David A. Boas

Research02 Sept 2025

Nature Human Behaviour

P: 1-18

The adult ORLAU Swivel Walker—Ambulation for paraplegic and tetraplegic patients

I R Farmer
R Poiner
J H Patrick

Research01 Aug 1982

Spinal Cord

Volume: 20, P: 248-254

Research in Industrial Laboratories ¹

R. F. BACON
C. E. K. MEES
W. R. WHITNEY

Research08 Feb 1917

Nature

Volume: 98, P: 458-461

Development of a genetic priority score to predict drug side effects using human genetic evidence

Here the authors develop a genetic priority score to predict side effects by integrating multiple lines of genetic evidence. By applying this score, they provide evidence of known side effects and suggest ones with no clinical trial evidence.

Áine Duffy
Robert Chen
Ron Do

ResearchOpen Access30 Sept 2025

Nature Communications

Volume: 16, P: 1-12

Perceiving intimidation through kinematic cues in men’s gait

K. McCarty
C. Leslie
P. L. Cornelissen

ResearchOpen Access29 Sept 2025

Scientific Reports

Volume: 15, P: 1-13

Desmond Greer Walker Award. Enamel mottling in a non-fluoride community since the advent of fluoride toothpastes

K J Weeks

Research20 Oct 1990

British Dental Journal

Volume: 169, P: 258-260

National identity predicts public health support during a global pandemic

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Jay J. Van Bavel
Aleksandra Cichocka
Paulo S. Boggio

ResearchOpen Access26 Jan 2022

Nature Communications

Volume: 13, P: 1-14

Walker-like domain wall breakdown in layered antiferromagnets driven by staggered spin–orbit fields

Antiferromagnetic systems are becoming an appealing alternative for spintronic-based devices due to the more rapid magnetisation dynamics when compared to their ferromagnetic counterparts. Here, using spin dynamic simulations, the authors demonstrate that the motion of domain walls can achieve supermagnonic speeds in an antiferromagnetic system by means of generation of additional domain wall pairs.

Rubén M. Otxoa
P. E. Roy
J. Wunderlich

ResearchOpen Access29 Oct 2020

Communications Physics

Volume: 3, P: 1-9

Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH

Cryo-EM illuminates atomic binding details and far-ranging conformational effects of the inhibitor targocil-II on wall teichoic acid ABC transporter TarGH, a virulence target from the antibiotic resistant, often hospital acquired pathogen S. aureus.

Franco K. K. Li
Shaun C. Peters
Natalie C. J. Strynadka

ResearchOpen Access04 Apr 2025

Nature Communications

Volume: 16, P: 1-14

Changes in the Earth's Moment of Inertia

S. K. RUNCORN

Research28 Nov 1964

Nature

Volume: 204, P: 823-825

Integrated global assessment of the natural forest carbon potential

Analysis of ground-sourced and satellite-derived models reveals a global forest carbon potential of 226 Gt outside agricultural and urban lands, with a difference of only 12% across these modelling approaches.

Lidong Mo
Constantin M. Zohner
Thomas W. Crowther

ResearchOpen Access13 Nov 2023

Nature

Volume: 624, P: 92-101

Induction of cell wall phenolic monomers as part of direct defense response in maize to pink stem borer (Sesamia inferens Walker) and non-insect interactions

P. Lakshmi Soujanya
J. C. Sekhar
Sujay Rakshit

ResearchOpen Access20 Jul 2021

Scientific Reports

Volume: 11, P: 1-10

Failure of systemic ketosis to control cachexia and the growth rate of the Walker 256 carcinosarcoma in rats

K C Fearon
M J Tisdale
K C Calman

Research01 Jul 1985

British Journal of Cancer

Volume: 52, P: 87-92

Optimizing furrow irrigation performance with WinSRFR software through field experiments and simulations in sunflower cultivation

Ajita Gupta
K. V. Ramana Rao
R. K. Singh

ResearchOpen Access30 Sept 2025

Scientific Reports

Volume: 15, P: 1-23

Regulation of atmospheric circulation controlling the tropical Pacific precipitation change in response to CO₂ increases

The response of tropical precipitation to warming is key for understanding global weather and climate variability. Here the authors use model simulations to show that regional scale circulation shapes the spatial pattern of the tropical Pacific precipitation response to CO₂.

Byung-Ju Sohn
Sang-Wook Yeh
William K. M. Lau

ResearchOpen Access07 Mar 2019

Nature Communications

Volume: 10, P: 1-8

Chromosomal and Nuclear Location of Mouse Satellite DNA in Individual Cells

K. W. JONES

Research07 Mar 1970

Nature

Volume: 225, P: 912-915

Prostaglandin E production and hypercalcaemia in rats bearing the Walker carcinosarcoma

H W Seyberth
G Bonsch
R Mrongovius

Research01 Sept 1980

British Journal of Cancer

Volume: 42, P: 455-461

DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Francisco Gimeno-Valiente
Carla Castignani
Nnennaya Kanu

ResearchOpen Access10 Sept 2025

Nature Genetics

Volume: 57, P: 2226-2237

Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Tsuyoshi Iizuka
Takazo Shibuya
Hisayoshi Yurimoto

Research10 Sept 2025

Nature

Volume: 646, P: 62-67

SNARE disassembly requires Sec18/NSF side loading

Khan et al. show that Sec18 uses both D1 and D2 AAA+ rings cooperatively, opening them laterally for SNARE substrate loading and for subsequent release of SNAREs.

Yousuf A. Khan
K. Ian White
Axel T. Brunger

ResearchOpen Access02 Jul 2025

Nature Structural & Molecular Biology

Volume: 32, P: 1708-1720

Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev

ResearchOpen Access07 Aug 2025

Nature Communications

Volume: 16, P: 1-19

Stronger and prolonged El Niño-Southern Oscillation in the Early Eocene warmth

Early Eocene ENSO had stronger amplitude and longer periodicity than present, driven primarily by tectonic changes, but high atmospheric CO₂ levels offset tectonic influence on the ENSO amplitude through altered ocean-atmospheric interaction.

S. Abhik
Dietmar Dommenget
Ayako Abe-Ouchi

ResearchOpen Access30 Apr 2025

Nature Communications

Volume: 16, P: 1-13

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Negative selection removes deleterious genetic variation, and can influence genetic architectures and evolution of complex traits. Here, the authors analyze data from 25 UK Biobank diseases and complex traits, and quantify frequency-dependent genetic architectures which suggests actions of negative selection.

Armin P. Schoech
Daniel M. Jordan
Alkes L. Price

ResearchOpen Access15 Feb 2019

Nature Communications

Volume: 10, P: 1-10

Sources of Error in the Wheat Cylinder Bioassay for Auxin

K. E. COCKSHULL
O. V. S. HEATH

Research26 Jan 1963

Nature

Volume: 197, P: 362-364

Accounting for albedo change to identify climate-positive tree cover restoration

Restoring tree cover is a prominent climate solution but can cause global warming due to changes in albedo. This paper maps albedo and carbon changes from restoring tree cover to highlight where the greatest net climate benefits can be achieved.

Natalia Hasler
Christopher A. Williams
Susan C. Cook-Patton

ResearchOpen Access26 Mar 2024

Nature Communications

Volume: 15, P: 1-11

Observation of topological edge states in parity–time-symmetric quantum walks

Spontaneous parity–time-symmetry breaking and topological edge states are observed in a photonic non-Hermitian system — a quantum walk interferometer.

L. Xiao
X. Zhan
P. Xue

Research31 Jul 2017

Nature Physics

Volume: 13, P: 1117-1123

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos

ResearchOpen Access21 Jul 2025

Nature Medicine

Volume: 31, P: 3151-3168

Remodelling of Rea1 linker domain drives the removal of assembly factors from pre-ribosomal particles

The ribosome maturation factor Rea1 catalyzes essential steps in the production of the large ribosomal subunit. Here, Busselez et al. describe functionally important conformational changes in Rea1.

Johan Busselez
Geraldine Koenig
Helgo Schmidt

ResearchOpen Access27 Nov 2024

Nature Communications

Volume: 15, P: 1-19

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

MCC950, a small-molecule inhibitor of the NLRP3 inflammasome, interacts directly with NLRP3 at the Walker B motif that hydrolyzes ATP, as defined by a protease-susceptibility assay, mutational analysis, and surface plasmon resonance analysis.

Rebecca C. Coll
James R. Hill
Kate Schroder

Research13 May 2019

Nature Chemical Biology

Volume: 15, P: 556-559

Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea

Thermophilic archaea have a minimal double-strand DNA break repair apparatus consisting of the HerA ATPase, NurA nuclease and Mre11–Rad50 complex. Here the authors solve the structure of a hexameric HerA ring from Sulfolobus solfataricus, and provide insight into a novel mechanism of DNA repair.

Neil J. Rzechorzek
John K. Blackwood
Nicholas P. Robinson

Research25 Nov 2014

Nature Communications

Volume: 5, P: 1-15

Eastern equatorial Pacific warming delayed by aerosols and thermostat response to CO₂ increase

The tropical Pacific east–west temperature gradient intensified recently, but climate models do not reproduce this, and they also predict future weakening. This discrepancy is attributed to a competition between long-term weakening and transient strengthening from aerosols and ocean equatorial upwelling.

Ulla K. Heede
Alexey V. Fedorov

Research29 Jul 2021

Nature Climate Change

Volume: 11, P: 696-703

Application of ‘molecular’ theories to the structure of the crystalline state

Jeremy K. Burdett

Research01 May 1979

Nature

Volume: 279, P: 121-125

Early archaeological sites, hominid remains and traces of fire from Chesowanja, Kenya

J. A. J. Gowlett
J. W. K. Harris
B. A. Wood

Research12 Nov 1981

Nature

Volume: 294, P: 125-129

Double Chromosome Reduction in a Tetraploid Solanum

G. E. MARKS
R. K. MCKEE
J. B. HARBORNE

Research23 Oct 1965

Nature

Volume: 208, P: 359-361

Interception reduction from deforestation and forest fire increases large-scale fluvial flooding risk

Forest coverage loss from wildfires and deforestation increases flood risk for large-scale river catchments by reducing interception, according to analysis of data from twenty-one watersheds in Australia.

Tae-Ho Kang
Ashish Sharma
Young-Oh Kim

ResearchOpen Access01 Oct 2025

Communications Earth & Environment

Volume: 6, P: 1-9

Localization of a gene for Fukuyama type congenital muscular dystrophy to chromosome 9q31–33

T. Toda
M. Segawa
Y. Nakamura

Research01 Nov 1993

Nature Genetics

Volume: 5, P: 283-286

Coupling chromosome organization to genome segregation in Archaea

Proteins SegA and SegB are important for chromosome segregation and organization in archaea of the order Sulfolobales, but mechanisms are unclear. Here, Kabli et al. uncover patterns and mechanisms that the SegAB system employs to link chromosome organization to genome segregation.

Azhar F. Kabli
Irene W. Ng
Daniela Barillà

ResearchOpen Access22 Jul 2025

Nature Communications

Volume: 16, P: 1-21

Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination

The mediator protein Rad52 promotes Rad51 binding onto RPA-coated DNA to initiate homologous recombination. Here, the authors show that Rad52 sorts Rad51 into monomers and stacks the complex on to the ss-dsDNA junction. The Rad55-Rad57 paralog then promotes extension of the Rad51 filament.

Jaigeeth Deveryshetty
Ayush Mistry
Edwin Antony

ResearchOpen Access21 Jul 2025

Nature Communications

Volume: 16, P: 1-17

Contralateral Effects of Sodium and Potassium on the Electrical Potential in Frog Skin and Toad Bladder

FRED M. SNELL
TUSHAR K. CHOWDHURY

Research03 Jul 1965

Nature

Volume: 207, P: 45-46

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

NADPH oxidase NOX4 has been linked to poor cancer survival. Here the authors show that NOX4 regulates drug resistance in renal cancer carcinoma by regulating PKM2 and that NOX4 activity is allosterically activated by reduced mitochondrial ATP levels thus coupling energy metabolism to drug resistance.

Karthigayan Shanmugasundaram
Bijaya K. Nayak
Karen Block

ResearchOpen Access19 Oct 2017

Nature Communications

Volume: 8, P: 1-16

Greenhouse gases reduce the satellite carrying capacity of low Earth orbit

Satellites have become integral to our everyday life, but space debris threatens the sustainability of low Earth orbital space. Greenhouse gases are complicating the problem, leading to longer orbital retention of defunct satellites and increasing the risk of collision.

William E. Parker
Matthew K. Brown
Richard Linares

ResearchOpen Access10 Mar 2025

Nature Sustainability

Volume: 8, P: 363-372

Structural remodelling of the carbon–phosphorus lyase machinery by a dual ABC ATPase

Here, authors analyse the structural organisation of the large carbon-phosphorus lyase enzyme from bacteria using electron microscopy and discover that it contains two ATP-binding cassette dimers of PhnK and PhnL and opens upon ATP hydrolysis.

Søren K. Amstrup
Sui Ching Ong
Ditlev E. Brodersen

ResearchOpen Access22 Feb 2023

Nature Communications

Volume: 14, P: 1-12

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

Flores et al. show that brain-penetrant eIF2B agonists suppress ISR activation in cellular and mouse models of ALS and reduce ISR biomarkers in humans, enabling further clinical studies of ISR inhibition in individuals with neurological diseases

Brittany N. Flores
Seungyoon B. Yu
Joseph W. Lewcock

ResearchOpen Access18 Aug 2025

Nature Communications

Volume: 16, P: 1-23

Bidirectional pilus processing in the Tad pilus system motor CpaF

The ATPase CpaF from C. crescentus powers pilus dynamics in the bacterial Tad pilus system. Cryo-EM and light microscopy characterisation of CpaF uncovers a mechanism for how CpaF may drive both pilus extension and retraction.

Michael Hohl
Emma J. Banks
Harry H. Low

ResearchOpen Access05 Aug 2024

Nature Communications

Volume: 15, P: 1-15

A Theory of S Gene Structure

K. K. PANDEY

Research20 Oct 1962

Nature

Volume: 196, P: 236-238

Jurassic basin evolution of East Greenland

F. Surlyk

Research13 Jul 1978

Nature

Volume: 274, P: 130-133

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