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The study reveals a nanobody that blocks LGR4 to activate fat browning and combat obesity, offering structural insights and a potential strategy for weight loss therapy.

Preserving anal function in advanced-stage colorectal cancer (CRC) treatment remains challenging. Here this group reports a hydrospongel consists of cellulose nanofibers crosslinked with Fe₃O₄@PDA nanoparticles which enables delivery of 5-FU to the tumor site thereby achieving CRC chemotherapy.

Stereoisomers can exhibit distinct chemical behaviors despite identical formulas. Here, the authors reveal how geometric isomers of electrolyte additives tailor solvation and interphasial chemistry, enhancing Zn-ion kinetics and long-term stability in aqueous zinc metal batteries.

Developing strategies for reducing carbon emissions in municipal solid waste management is essential to achieve the net-zero target. Here the authors systematically assess strategy options of different countries for achieving net-zero municipal solid waste management.

Fungal diseases threaten crops worldwide. By resolving the cryo-EM structure of fungal succinate dehydrogenase, researchers designed an inhibitor with broad antifungal activity, strong field performance, and reduced environmental toxicity.

Zhu, Fu, Zhu, Li and colleagues found that the key DNA repair enzyme poly(ADP-ribose) polymerase 1 promotes transcriptional restart after DNA damage through PARylating and stabilizing AFF1 by preventing its ubiquitylation by the E3 ligase Siah1.

CAD, a de novo pyrimidine synthesis pathway enzyme, is known to promote chemotherapy resistance. Here, the authors shed light into this mechanism of chemoresistance, showing that chemotherapeutic drugs can promote the degradation of CAD following cleavage by activated caspase-3 on its Asp1371 residue.

Optimizing the crystallization of the active materials in organic solar cells is challenging. Fu et al. use an acenaphthene additive to induce a two-step crystallization of the non-fullerene acceptor, achieving a certified 20.5% power conversion efficiency.

The FDA-approved nanodrug ferumoxytol can relieve reactive oxygen species in haematopoietic stem cells, facilitating their post-injury regeneration.

A cost-effective all-in-one halide cathode material with high energy density and exceptional cycling stability can be used to achieve energy-dense, durable cathodes for the next generation of all-solid-state batteries.

Li et al. show that the inner nuclear membrane protein LEMD3 organizes 3D chromatin architecture by anchoring heterochromatin at the nuclear periphery to maintain vascular smooth muscle cell contractile identity.

China’s rapid e-commerce growth has driven a 12-fold surge in express delivery, yet cross-regional emissions and health impacts remain poorly quantified. Road transport emitted 23.9-Mt CO₂-equivalent and caused approximately 5,100 premature deaths in 2021, revealing stark transit-region health inequities and guiding sustainable logistics pathways.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Molecular electronics holds promise for building memristor at nanoscales for in-memory computing. Li et al. design tailored foldamers with furan-benzene and thiophene-benzene stacking to achieve voltage triggered quantum interference switching for potential random number generator application.

Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating ferroptosis sensitivity, tumour development and chemoradiotherapy efficacy.

Radiative cooling is an emerging technology for cooling with reduced energy consumption. Here the authors present photoluminescent composites that combine subambient cooling with aesthetic colour, hydrophobicity and durability.

The mechanisms underlying differential chemotherapeutic response to 5-fluorouracil are not fully known. Here, the authors show that ABDH5 regulates sensitivity to 5-fluorouracil in colorectal cancer by regulating lysosome function.

VCP/p97 is identified as a co-factor to the fusion oncoprotein ASPSCR1::TFE3. They co-localize on chromatin, co-dependent for enhancer looping and transcriptional regulation in alveolar soft part sarcomas and Xp11- rearranged renal cell carcinomas.

By hierarchically assembling single-atom catalysts within the nanopores of ceramic membranes, this cross-scale strategy achieves rapid pollutant removal and exceptional permeability, providing a highly effective platform for advanced wastewater treatment.

AI models for drug discovery often struggle with real-world, incomplete data. Here, the authors present OmniMol, a framework using hypergraphs to improve predictions of molecular properties, addressing challenges of imperfect data annotation and enhancing model explainability.

Organic electrode materials offer a versatile and sustainable route for lithium-ion batteries, but their application is hindered by low working voltages and poor cycling stability. Now, it has been shown that dissolving halide electrolytes into organic electrodes effectively tunes the working voltage and enhances the electrochemical performance of all-solid-state batteries.

Transition metal dichalcogenide nanotubes possess symmetry-breaking properties promising for fundamental physics research. Here, the authors report a direct synthesis of crystalline MoS₂ nanotubes exhibiting strong polarization and bulk photovoltaic effects.

Here, the authors structurally and biochemically characterise the YcfA-YcfC enzyme system, crucial for biosynthesis of the anticancer and antimicrobial agent 6-thioguanine.

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney failure. This study shows that prolonged glucagon exacerbates lipid accumulation, promoting renal injury in early DKD, rather than lipid oxidation. Targeting glucagon signaling significantly inhibits DKD progression.

Monolayer amorphous carbon (a-C) has attracted attention due to its structural and electronic properties, but its synthesis has so far required the use of metal substrates. Here, the authors report the Te-assisted growth of large-scale 2D a-C patterns on various insulating substrates, confirming their insulating properties in quantum tunnelling devices.

Efficient exchange of long-chain ligands has been challenging for high-performing perovskite quantum dot photovoltaics. Here, the authors construct alkaline environments for antisolvents to promote their hydrolysis into conductive surface capping, enabling a certified solar cell efficiency of 18.3%.

Li et al. report a high-order spatiotemporal processing vision sensor based on vdW phototransistors, leveraging Triplet-spike-timing dependent plasticity to extract the high-order correlation information, rendering spiking neural network for confusing object classifying and dynamic tracking.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

An alternating current paired photo-electrocatalysis approach, integrating electrochemistry, ligand-to-metal charge transfer photocatalysis and asymmetric nickel catalysis, enables enantioselective C(sp³)–C(sp²) cross-coupling of alcohols. This approach has high catalytic efficiency and stability, achieving up to 99% enantiomeric excess with broad substrate compatibility, and is suitable for late-stage functionalization of complex molecules.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Basalt clasts returned by Chang’e-6 suggest a lunar farside mantle potential temperature that is approximately 100 °C cooler than the nearside mantle, according to a petrologic study combined with thermobarometric modelling and remote sensing data.

Acute lung injury (ALI) carries high mortality with limited treatment. Here, the authors show in mice a brain-lung circuit wherein CRH neurons activation in the paraventricular nucleus of the hypothalamus (PVN) attenuates ALI by limiting neutrophil hyperactivation.

This work presents SCIGEN, a machine learning framework integrating geometric constraints into material generation. The framework enables the discovery of stable quantum material candidates, and the authors synthesize two predicted magnetic materials.

The use of Pt(IV) complexes has been largely limited to chemotherapy. Here, the authors reveal that Pt(IV) complexes photolyze under 365 nm light and generate reactive species, and show that Pt(IV) complexes can act as photoinitiators for fabricating multifunctional hydrogels, and as photocrosslinkers for protein labeling and direct gelatin hydrogelation.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.

Xiangdong Fu and colleagues report characterization of a major rice grain yield QTL at the DEP1 locus.

The authors propose a design strategy of multiscale engineering to boost the polar entropy of BaTiO3-based system, by which the large and flexible polarization change can be offered synchronously, availing superior electrocaloric performance.

Lv, Wang, Lin, Ye et al. report that mTORC2 phosphorylates cGAS to promote its chromatin localization and SWI/SNF recruitment to regulate target gene expression, thereby mediating plasticity and chemoresistance in colorectal cancer.

Polycyclic aromatic hydrocarbons (PAHs), particularly phenanthrene derivatives, are integral to diverse applications owing to their distinctive electronic, optical, and biological properties. Here, the authors develop a visible-light-induced, palladium-catalyzed annulation of aryl halides with terminal alkynes to enable direct access to PAHs under mild conditions.

Radiation-induced malignantly transformed cells undergo multi-scale 3D genome reorganization. TP63 acts as a key mediator, creating accessible chromatin sites that form tumour-specific loops activating the MYC oncogene during malignant transformation.

Chip-Tip is a label-free quantification-based single-cell proteomics workflow for deep single-cell proteomics, which identifies over 5,000 proteins and 40,000 peptides in single HeLa cells.