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High-resolution imaging is essential for quantum simulation and computation in optical lattices and tweezers. Here, authors achieve fast 2.4-microsecond single-atom imaging with 99.4% fidelity and demonstrate number-resolved imaging without parity projection, advancing quantum readout capabilities.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Some features resembling superconductivity at high temperature have been seen under pressure in La₃Ni₂O₇, but a transition to a zero-resistance state has not been observed. Now transport studies demonstrate this transition, along with strange metallicity.

A photodiode with bio-plausible event sensing, filtering and adaptation behaviours to replicate the retinal nanostructure and visual pathway is presented, enabling consistent and high-performance machine vision under extreme lighting.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Tandem catalysts are important in electrocatalysis but suffer from uncontrollable interfaces, limited crystal phases, and complex synthesis. Here, the authors report the facile synthesis of hetero-phase 4H/fcc Au–Cu tandem catalysts with tunable interfaces for ammonia electrosynthesis from nitrate.

Bloch oscillations are a fundamental electron transport phenomenon in condensed matter. Here, the authors experimentally realize spatial Bloch oscillations in a non-Hermitian integrated photonic system using CMOS compatible fabrication processes, contributing to improving the understanding of non-Hermitian transport phenomena.

Neurogenic bladder often occurs after pelvic ganglia injury. Here, the authors designed a fiber-enhanced tissue bandage for injured pelvic ganglia that facilitates the delivery of growth factors essential for ganglia healing.

The instability of contact layers for perovskite solar cells under operating conditions limits the deployment of the technology. Now, Lin et al. develop a Cu–Ni electrode sandwiched between in situ-grown graphene protective layers, enabling solar cells with improved stability under light, humidity and high temperature.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

Puissant and colleagues identify a myeloid-restricted PIK3CG/p110γ–PIK3R5/p101 axis as a therapeutic vulnerability in acute myeloid leukemia and develop a proteolysis-targeting chimera to potently degrade PIK3CG and suppress AML progression.

Post-translational modifications regulate tumorigenesis and cancer therapy sensitivity. Here, the authors show that N-glycosylation defective Interleukin-6 (deNG-IL6) switches downstream signalling pathway from JAK-STAT3 to SRC-YAP axis and lung cancer cells secrete deNG-IL6 to promote metastasis and tyrosine kinase inhibitor resistance.

ATP/ADP translocators in obligate intracellular parasites and plastids facilitate energy parasitism and endosymbiosis by mediating ATP import and ADP export, with their cryo-EM structures and mechanisms revealed, providing insights for drug development against intracellular pathogens.

Molecular assembly is of great importance in many fields. Here, the authors establish a strategy to post-modulate angle-mismatched layer-by-layer materials by fullerene derivatives and achieve a modulation accuracy of up to 5 Å.

This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

Nuclear morphology plays a critical role in regulating gene expression and cell function. Here, Wang et al. report that topography-induced nuclear deformation enhances the secretome of hMSCs, promoting extracellular matrix (ECM) organization and facilitating bone regeneration through matricrine effects.

3D printing of liquid metal is important for the integrated design and manufacturing of flexible electronic devices. Here, Lin et al. demonstrate a liquid metal high internal phase emulsion gel used directly for direct-ink-writing 3D printing and activate the ink conductivity by electrocapillarity method.

Currently, there is a lack of effective drugs for the treatment of pulmonary fibrosis. Here, the authors reveal a novel role of PEAR1 in fibroblast activation and demonstrate that activating PEAR1 by monoclonal antibodies might be a promising therapeutic approach for pulmonary fibrosis.

Two epigenetic regulators—identified in an RNA interference screen in Caenhorhabditis elegans, and conserved in mammals—diminish mitochondrial function and accelerate the age-related deterioration of behaviour.

Here, the authors sample air and surfaces in hospital rooms of COVID-19 patients, detect SARS-CoV-2 RNA in air samples of two of three tested airborne infection isolation rooms, and find surface contamination in 66.7% of tested rooms during the first week of illness and 20% beyond the first week of illness.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Here, Zhang et al. succeed in creating a heavily distorted oxygen deficient film of lanthanum cobaltite. The new phase of LaCoO_2.5 has several unique properties, most notably, a Curie temperature of 284 K, significantly larger than the films from which it was derived.

CAR T cell manufacturing faces significant challenges that impact cell quality and in vivo efficacy. This necessitates reliable cellular characterization methods. Here the authors present a real-time, label-free, microfluidic method that profiles cellular biophysical properties and correlates them to activation state and CAR T potency, facilitating the rapid phenotypic cell assessment during production.

Controlling Li nucleation and growth is crucial to avoid dendrite formation. Here, Li₂S(111)@Cu is used as Li metal electrode substrate, where a substrate-dependent Li nucleation process and a facet-dependent growth mode are identified, enabling dense Li deposition and improved battery performance.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Knowing one’s own behavioral state is important to contextualize sensory cues and identify appropriate future actions. Here the authors show how neurons ascending from the fly motor system convey behavioral state signals to specific brain regions.

Using nanopillars with increased spatial resolution, Shiu et al. identify high perinuclear forces that originate from contractile apical actin filaments that span across the nucleus and are dependent on lamin A and the LINC complex.

Retrotransposons are known to be involved in aging. Here the authors show that the retrotransposon silencer Piwi contributes to germline stem cell loss during aging in Drosophila.

Electronic devices and sensors that can sustain large amounts of mechanical deformability enable new applications. Here, the authors present a new type of highly deformable liquid-state electronic device, taking advantage of the inherent property of the liquid phase.

Incorporating thiophene and furan isomers into covalent organic frameworks tunes their electronic structures, enhances charge separation, and stabilizes reaction intermediates, enabling high photocatalytic H₂O₂ yields in both ethanol and water.

Analysis of 97,691 high-coverage human blood DNA-derived whole-genome sequences enabled simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells, indicating that both inherited and acquired mutations are linked to age-related cancers and coronary heart disease.

Zhao et al. identified a novel E3 ligase RED and its E2 partner UBC32 which mediates ethylene-induced degradation of ethylene receptors ETR3 via the ERAD pathway in Rosa hybrida and Solanum lycopersicum, providing new insights into controlling ethylene response through receptor turnover.

Digital proximity ligation assay (dPLA) can measure proteins and mRNAs in single cells, but is not compatible with cell imaging and cannot quantify rare proteins due to a high dilution factor. Here the authors present an automated microfluidic device that combines live-cell imaging, chemical stimulation, and dPLA in a smaller reaction volume.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.