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The role of cellular stress responses in ovarian aging remains incompletely understood. In this study, the authors identify NCOA7 as a facilitator of autophagic clearance of stress granules in granulosa cells, conveying protection against ovarian aging. Loss of NCOA7 promotes ovarian aging, whereas its expression via mRNA delivery delays aging.

This article addresses the challenge of training AI models in personalized Internet of Things systems while ensuring data security and privacy. Authors combine federated and meta-learning to improve model training performance, adaptation speed, cost-efficiency, and security against attacks.

This study identifies the compound napabucasin as a promising candidate against refractory Helicobacter pylori infections, demonstrating efficacy compared to standard triple therapy in murine infection models, and probing the mechanism of action.

This study presents a flexible nanoparticle-based strategy for targeted protein degradation, simplifying the design process via intact nanoparticle trafficking routes and self-assembly. It provides knowledge for targeted nanomedicine design.

A paddle-like self-stirring nanoreactor system with spatially isolated multifunctional components is successfully constructed. The rotation–revolution pattern enhances the internal and reverse dual-dynamic diffusion processes, thus effectively boosting the cascade efficiency.

Heterostructures of indium gallium zinc oxide and tungsten diselenide can be used to create phototransistor arrays capable of three-dimensional morphology reconstruction, two-dimensional depth field mapping and multi-view coupling.

The narrow bandgap of near-infrared polymers is a hindrance to their performance improvement. Here, authors present a diffusion interface layer between the channel layer and bulk heterojunction layer of a phototransistor, using solvent vapor annealing as a way of overcoming this barrier.

Surface frustrated Lewis pairs (SFLPs) provide a unique class of active sites that enable efficient gas-phase CO₂ photocatalysis. How to tailor the reactivity of the SFLPs represents a major challenge, which the authors address here by single-site Bi³⁺ ion substitution of the SFLPs.

Rechargeable sodium-chlorine (Na-Cl₂) batteries hold promise for grid energy storage but face challenges of corrosive thionyl chloride (SOCl₂) electrolytes. Here, authors introduce a non-corrosive ester as an alternative, enabling Na-Cl₂ batteries with a wide temperature range from −40 to 80 °C.

Protein expression vectors in cell-free systems mainly rely on double-stranded DNA and single-stranded RNA. Here, authors use circular single-stranded DNA as a programmable vector for gene regulation in a cell-free expression system by identifying its expression pathways.

Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.

Perylene bisimide dyes are high-performance pigments that have red, maroon or black colors, but with typically only weak fluorescence in the solid state. Here, the authors report a series of π-stacked PBI derivatives that show highly efficient deep-red fluorescence in the solid state.

Atropisomers are an important chiral system which are widely present in natural products but atropisomerism bearing a N−N bond remains largely underdeveloped. Here, the authors report an efficient method for the enantioselective synthesis of N−N axially chiral frameworks under mild conditions via a cobalt-catalyzed atroposelective C-H activation/annulation

Synthetic gene networks in mammalian cells are currently limited to either transcription factors or RNA regulators. Here, the authors develop a regulatory approach based on circular single-stranded DNA, which can be used as a conformationally switchable genetic vector in mammalian cells.

Multi-chambered structures have attracted great attention due to their ability to create multifunctional partitions in different chambers. Here, the authors prepared mesoporous silica nanoreactors with hierarchical chambers for catalytic cascades.

Carbon-based single-atom catalysts usually rely on nitrogen co-doping to stabilize the single metal atoms as metal–N₄ moieties. Now, Wei, Yao and colleagues make use of operando techniques to show that under alkaline hydrogen evolution reaction conditions the Co–N₄ active site undergoes structural distortion to a HO–Co–N₂ configuration.

Though low-dimensional (LD) materials are attractive for polarization-type photodetectors, their low anisotropic photocurrent rate hinders widespread application. Here, the authors report an amplification system for enhanced photocurrent in polarization-sensitive LD material-based photodetectors.

Strong and ductile materials with resistance to both corrosion and hydrogen embrittlement remain rare and yet are essential for hydrogen-propelled industries. Here, the authors show that a CoNiV medium-entropy alloy with face-centered cubic structure fulfils all the above criteria.

An introgression platform for transferring genetic variations of Aegilops tauschii to hexaploid wheat is established based on synthetic octoploid wheat. Combined with newly generated genome resources of A. tauschii, it represents a powerful tool for wheat gene discovery and breeding.

An approach using multiple stable isotopes reveals that early tetrapods of the Devonian period were euryhaline animals that inhabited aquatic environments of highly variable salinity.

Zhou et al. show that the generation and maintenance of chronic neuropathic pain after peripheral nerve injury is crucially dependent on the activation of a parabrachial nucleus–nucleus basalis-S1 pathway during non-REM sleep.

Cancer-associated fibroblasts (CAFs) have been implicated in lung cancer chemo-resistance. Here the authors show that a zinc-transporter positive CAF subset is enriched in lung cancer models after chemotherapy and actively transfers zinc to cancer cells, promoting ABCB1-mediated chemo-resistance.

The selective hydrogenation of nitriles to prepare corresponding amines is highly desired in chemistry industry. Here, the authors selectively obtained secondary amines and primary amines over two types of atomically dispersed Pd catalysts supported on the nanodiamond-graphene hybrid support.