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Developing high-current-density catalysts is key to efficient water splitting. Here, the authors report a single-atom Ru-doped amorphous Ni–Mo oxide that dynamically self-reconstructs to retain high activity at industrial current densities in an anion-exchange membrane water electrolyzer.

Electrochemical CO_x reduction to multi-carbon products is hindered by low energy efficiency, in part due to sluggish ion transport across charge-selective membranes used in electrolysers. Here the authors use a porous, non-charge-selective separator that enhances ion transport and improves performance for CO electrolysis.

Proteins in the fungal plasma membrane are key antifungal targets but their native structure and spatial distribution are poorly understood. Here, Jiang et al. use proteomics and cryo-electron tomography to investigate the organisation of membrane proteins in the fungal plasma membrane and how this is affected by antifungal drugs.

A sustainable two-step strategy for oxime synthesis in a neutral KHCO₃ medium is reported. Free-state NH₂OH is initially synthesized via nitrite electroreduction over a Ketjen-black-supported iron phthalocyanine catalyst, followed by a chemical aldehyde or ketone oximation using the electrochemically synthesized NH₂OH.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

The use of Cu catalysts for the CO₂ reduction reaction is hindered by their poor stability. The authors find that traces dissolved oxygen in the electrolyte results in Cu dissolution/reconstruction and report an in-situ passivation strategy to prevent oxygen adsorption in high stability.

Environmental and genetic factors affect the pathogenesis of inflammatory bowel disease (IBD). Here the authors show a loss of function Adenosine deaminases acting on RNA 1 (ADAR) variant that results in accumulation of dsRNA which is sensed by MDA5 and promotes bowel inflammation.

Control of liquid-based materials is important for developing materials based on these, but topological flexibility is limited. Here, the authors report a method for digital fabrication of slippery objects with solid-liquid composite interfaces and geometric design freedom.

Current propylene oxide production relays on H₂O₂ generated by the energy-intensive anthraquinone processes. Here, an unassisted H₂O₂ production system is integrated with modified titanium silicalite-1 to realize continuous propylene oxide production without external energy input.

Hexopyranose cleavage is a crucial step in carbon metabolism. Here the authors report the discovery and characterization of metalloenzyme Art22, which is involved in the sugar moiety modification of aurantinin B, an antibacterial agent from Bacillus.

Electrolyte design faces challenges of balancing stability at both electrodes. Here, authors present an electrolyte design strategy to direct distinct solvent molecules to negative and positive electrodes respectively, achieving good stability in initially anode-free sodium metal batteries.

Humic substance boost lake denitrification and reduce N₂O emissions via extracellular electron transfer by stimulating bacterial outer membrane cytochrome and nosZII-type N₂O reducers, thereby aiding eutrophication and climate impact mitigation.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

Gastrointestinal motility disorders affect over 20% of the population, yet current therapies provide limited relief. Here, the authors show that in a swine model a closed-loop GI neuroprosthesis restores peristalsis and enhances metabolic responses via targeted electrical and chemical stimulation

A self-assembly perovskite strategy is reported that can integrate optoelectronic arrays with arbitrary non-developable structures, enabling structural manipulations of photodiode arrays with micrometre precision.

Motion tracking systems for virtual reality are challenged in tracking and feedback capabilities. Here, the authors report a wearable sensor-haptic network capturing full-body motion and delivering real-time bidirectional feedback, while deep learning integration enables low-latency, accurate classification.

Rudensky and colleagues demonstrate a context-dependent differential requirement for Foxp3 for T_reg cell transcriptional and functional programs.

Anti-cancer drugs could independently promote TB progression. Here, the authors show using mouse models, that anti-cancer drug treatments could induce delayed Mtb-specific T cell responses, followed by G-CSF dependent neutrophil manifestation in the lungs, leading to TB exacerbation.

Nitrogen promotes wheat’s recovery after drought stress through the TaSnRK2.10-TaNLP7 module. This breakthrough connects drought-stress signalling with nitrate response pathways, providing a genetic framework for developing climate-resilient crops.

Stereoisomers can exhibit distinct chemical behaviors despite identical formulas. Here, the authors reveal how geometric isomers of electrolyte additives tailor solvation and interphasial chemistry, enhancing Zn-ion kinetics and long-term stability in aqueous zinc metal batteries.

The intrinsic instability of wide-bandgap perovskite solar cells is predominantly attributed to the vacancy defects caused by multiple ion migration. Here, authors incorporate an ether ring supramolecule into perovskites and achieve an efficiency of over 28% for all-perovskite tandem solar cells.

Down Syndrome is a common genetic cause of intellectual disability and is associated with altered fetal neurodevelopment. Here, the authors identify altered expression dynamics of lineage commitment genes and de-repression of transposable elements in DS neural progenitor cells.

Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propose a role for KLHL17 in protein homeostasis by mitigating inflammation.

Weak NO adsorption, slow water dissociation, and sluggish hydrogenation hinder neutral-media NH₃ electrosynthesis from low-concentration NO. Here, the authors report an electron-donating motif modulating a NO-affinitive catalyst to create dual active sites, thus facilitating NO-to-NH₃ conversion.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Additives used in the charge transport layers of perovskite solar cells contribute to device degradation during operation. Now Kim et al. report a non-volatile, solid-state additive—4-(N-carbazolyl)pyridine—that enhances the thermal and operational stability of the devices.

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

The insertion of thin layers of cobalt can stabilize β-tungsten under back-end-of-line thermal constraints, allowing a 64-kb spin–orbit torque magnetic random-access memory to be fabricated that offers a spin–orbit torque switching of 1 ns, data retention of more than 10 years and a tunnelling magnetoresistance of 146%.

The role of lysine crotonylation (Kcr) in MASLD pathogenesis remains unclear. Here, the authors identify a PCAF/SIRT7-IDH1 Kcr axis that ameliorates hepatic steatosis by boosting TCA cycle activity, uncovering a new mechanism and therapeutic target for MASLD.

Si-based hydrogen generation via hydrolysis/methanolysis faces reactivity challenges. Here, zintl-phase alkali–Si alloys, featuring discrete Si clusters with unpaired electrons, efficiently lower activation barriers, enabling high-yield, low-temperature H₂ release.

Recently, anti-resonant hollow-core fibers have emerged as an important medium for high-power laser delivery. Here, authors demonstrate a highly efficient, all-fiber delivery of 2 kW laser over 2.45 km, using a self-fabricated AR-HCF with a record low transmission loss of 0.168 dB/km at 1080 nm.

This study reports widespread loss of mountain vegetation worldwide from 2000 to 2020, with ∼89% attributable to human expansion, primarily agriculture. Over half of this loss occurred within protected areas and other biodiversity-rich areas, threatening conservation efforts.

An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment of myeloid-derived suppressor cells and reinvigorating CD8⁺ T cell activation.

Kim, Park, and colleagues present near-infrared long-lifetime upconversion nanoparticles combined with time-gated detection. These nanoparticles allow for improved performance of luminescence-based biosensing for sensitive and accurate microRNA analysis in cancer diagnostics.

This study introduces WtCoxG, an efficient genetic analysis method for time-to-event data, which improves statistical power by addressing case ascertainment and leveraging external allele frequency information.

Cancer stem-like cells contribute to tumor growth and therapy resistance in glioblastoma. Here, authors identify that DHRS13 inhibition promotes differentiation of glioma stem-like cells by activating retinoic acid signaling and induces cell death through mitochondrial reactive oxygen species-driven mitophagy.

GBA, a major gene for Parkinson’s disease and dementia with Lewy bodies, is associated with increased risk of developing dementia. Here, we demonstrate that GBA mutations in mice contribute to cognitive deficits through α-synuclein-independent mechanisms that impact synaptic vesicle endocytosis.

Authors develop a quantitative super-resolution proximity labeling technique utilizing stable isotope-coded probes (ICAX). ICAX characterizes the dynamics of the proteome within the mitochondrial intracristal space.

The authors report a study increasing hydrogen peroxide electrosynthesis kinetics over a Ni(OH)₂/CNT material. They show that the catalyst enhances H₂O dissociation and proton transfer in neutral media.

Hereditary deafness lacks effective biological treatments. Here, the authors develop a base editing therapy that corrects a common MPZL2 deafness gene mutation in a humanized mouse model and restores hearing, highlighting base editing as a potential treatment for hereditary deafness.

Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in type 2 alveolar epithelial (AT2) cells is thought to aggravate alveolar inflammation in acute lung injury. Here, the authors show that the mtLCFAO rate limiting enzyme CPT1a is decreased in AT2 cells in acute respiratory distress syndrome, highlighting the role of mtLCFAO in immunometabolism in this context.

Depletion of a transcriptional factor ZBTB11 using molecular glue degraders can overcome oxidative-phosphorylation-mediated KRAS inhibitor resistance in pancreatic ductal adenocarcinoma with low acute neurotoxicity.

Wang et al. show that pregnane X receptor (PXR), a well-known DNA-binding nuclear receptor, has mRNA stabilization functions when in the cytoplasm, thus unveiling a noncanonical perspective to understand and target PXR as an RNA-binding protein.

The sensitivity of mesothelioma to the treatment of immune checkpoint blockade remains elusive. Here this group reports a double blind, placebo-controlled, randomized phase III trial of PD1 inhibitor (Nivolumab) on 332 patients with relapsed mesothelioma, and to uncover determinants of efficacy.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Fang et al. demonstrate that OsHSFA4d enhances thermotolerance by activating HSP101 and promoting CslF6 expression, which suppresses disease resistance. It is phosphorylated by OsCDPK24/28, increasing its DNA binding ability under heat stress. This trade-off mechanism of abiotic/biotic stress may broadly exist in plant kingdom.

The DNA modification N⁶-methyladenine regulates gene expression during mouse trophoblast development by depositing at the boundaries of active chromatin and preventing its spread by antagonizing the chromatin organizer SATB1.

Cytotoxic T lymphocytes targeting ancestral SARS-CoV-2 recognise variants of concern, but deep molecular understanding of why these responses are conserved is hampered by the populational variability due to HLA-restriction. Here authors identify an HLA-C-restricted conserved immunodominant SARS-CoV-2 nucleocapsid epitope in COVID-19 convalescent donors from early waves of the pandemic and provide structural bases for its recognition by the T cell receptor.