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In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Most of the available fluorogenic RNA approaches emit visible fluorescence, and there is a need for tools working at longer wavelengths. Here, the authors identify and modulate red fluorescent protein-like fluorophores to bind the fluorogenic RNA Squash, thereby obtaining near-infrared fluorogenic RNA-based tools.

Suraxavir marboxil, an antiviral drug designed to inhibit the polymerase acidic protein of influenza, alleviates symptoms in individuals with influenza faster than placebo in a phase 3 trial conducted in China.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

Ferroelectric RAM is considered a promising candidate on the quest for a universal memory, but the concept is still problem prone. Here, the authors use the ferroelectric photovoltaic effect as a non-destructive read-out method for a new prototype memory, which shows good data retention and fatigue resistance.

High-performance n-type molybdenum disulfide and p-type tungsten diselenide field-effect transistors can be fabricated using single-crystal strontium titanate dielectrics that are transferred onto two-dimensional semiconductors with the help of van der Waals forces.

This Review highlights recent progress in 2D-materials-based computational photodetectors, including neuromorphic vision sensors, computational spectrometers, and miniaturized polarimeters, toward multidimensional optical information perception of light intensity, spectrum, and polarization states.

Using normal and Josephson scanning tunnelling microscopy, chiral kagome superconductivity modulations with corresponding residual Fermi arcs are detected in KV₃Sb₅ and CsV₃Sb₅.

A family of two-dimensional transition metal oxychalcogenides is synthesized from bulk transition metal dichalcogenides by tetrabutylammonium intercalation. The stoichiometry and properties of the two-dimensional transition metal oxychalcogenides can be tuned, enabling high stability and catalytic activity for oxygen evolution in acid.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Water oxidation to triplet oxygen requires a spin polarization process for faster kinetics. Here, the authors show an interface spin pinning effect between ferromagnetic oxides and reconstructed oxyhydroxide surface layer, where the spin ordering in paramagnetic oxyhydroxide catalyst layer can be tuned to improve the intrinsic activity.

Cherenkov detectors are used to detect high energy particles and their performance capabilities depend heavily on the material used. Here, the authors propose use of a Brewster-optics-based angular filter for a detector with increased sensitivity and particle identification capability.

Van der Waals (Cr,Bi)₂Te₃, synthesized by non-equilibrium molecular beam epitaxy, is characterized by magnetotransport measurements and shown to be a semimetallic Weyl ferromagnet, with Fermi surface composed of two Weyl points and no irrelevant electronic states.

Regulated cholesterol transport is essential for the maintenance of cellular cholesterol distribution and homeostasis, but tools to monitor this process are limited. Here, the authors develop a genetically encoded cholesterol biosensor and demonstrate its use for visualising cellular cholesterol distribution in various live cells in real time.

Noble metals typically crystallize with the face-centered cubic structure. Here, the authors report the synthesis of gold nanoribbons in the 4H hexagonal polytype, a previously unreported, metastable phase of gold, and use it to stabilize 4H hexagonal phases of silver, palladium and platinum.

Single-crystal monolayer hexagonal boron nitride is unexpectedly tough owing to its asymmetric lattice structure, which facilitates repeated crack deflection, crack branching and edge swapping, enhancing energy dissipation.

Circumventing linear scaling relationships in multi-step catalytic reactions is meaningful but challenging. Here, the authors report a method to break this scaling relationship in the oxygen evolution reaction through dynamic regulation of the active site in a Ni-Fe molecular complex catalyst.

Subarctic Pacific Ocean sediments and modeling results provide new evidence for precession driving meridional shifts in the North Pacific Subtropical Gyre and modulating the efficiency of heat and water vapor transfer to the Arctic regions.

Pollen is an abundant material; but, currently has limited applications. Here, the authors turn pollen grains into soft microgel by de-esterification of pectin molecules and explore the mechanical and structural changes of the pollen grains using physical and modelling approaches.

Accomplishing complex cognitive tasks such as speech recognition calls for artificial intelligence hardware with high computing precision. John et al. propose deep recurrent neural networks based on optoelectronic transition metal dichalcogenide memristors with high weight precision for in-memory computing.

Water-responsive supercontractile polymer films composed of poly(ethylene oxide) and poly(ethylene glycol)-α-cyclodextrin inclusion complex contract by more than 50% of their original length within seconds after wetting and become soft and stretchable hydrogel thin films that can be used in bioelectronic interfaces.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Bacteria can grow as free living planktonic cells or as part of surface-associated biofilms. Here the authors show, for the opportunistic pathogen Pseudomonas aeruginosa, that cells recently dispersed from biofilms are physiologically different from, and more virulent than, planktonic and biofilm cells.

Brillouin scattering microscopy is prone to artefacts and inconsistencies. This Consensus statement provides recommendations for measuring and reporting relevant parameters with the aim of standardizing protocols and improving the comparability of studies.

The decision to form a fruiting body have been studied extensively, however, the mechanical events that trigger the creation of multiple cell layers is poorly understood. Here the authors find M. xanthus cells adjust their reversal frequency to control mechanical stresses that triggers layer formation in the colonies.

Artificial magnetic fields have been meticulously engineered in a 3D acoustic crystal, facilitating the creation of 3D flat bands through Landau quantization of quasiparticles arising from nodal-ring band degeneracies.

While the conversion of CO₂ to high-value products provides a promising means to remove and utilize atmospheric carbon, few materials can do so without wasteful, sacrificial reagents. Here, authors prepare single-atom Co on Bi₃O₄Br nanosheets as CO₂ reduction catalysts using water and light.

Polydimethylsiloxane–gold conductors that are 1.3 μm thick and have controlled morphology of microcracks in the gold film can be used to create breathable and water-resistant electrodes for recording electrocardiogram signals, as well as on-skin pressure sensors and implantable nerve electrodes.

A large-scale pharmacophore model supported by in vitro ligand-binding studies suggests polylactic acid oligomer toxicity in a mouse model is due to the inhibition of matrix metallopeptidase 12.

A method to map the known tranverse photon spin of electromagnetic surface waves over to bulk modes is enabled thanks to bianisotropy.

Two-dimensional superconductors will likely have applications not only in devices, but also in the study of fundamental physics. Here, Wang et al. demonstrate the CVD growth of superconducting NbSe2 on a variety of substrates, making these novel materials increasingly accessible.

Molybdenum sulfides are attractive electrocatalysts for the hydrogen evolution reaction. The polymeric structure of amorphous molybdenum sulfide can now be formulated as a coordination polymer based on [Mo₃S₁₃²⁻] clusters sharing disulfide ligands.

Lattice distortions induced by ripples in two-dimensional molybdenum disulfide can reduce electron–phonon scattering, leading to improved charge carrier mobility and enhanced transistor performance.

A χ⁽²⁾ nonlinear micro-waveguide platform is demonstrated based on the birefringence phase matching for simple and efficient long-wavelength infrared generation, which could trigger new frontiers of MIR integrated nonlinear photonics.

Heterostructures combine the unique properties of each constituent, improving the efficiency and stability of perovskite-based optoelectronic devices, yet the films suffer from poor compositional and structural uniformity. Here, the authors demonstrate a ligand-assisted welding process to fabricate a series of epitaxial 2D and 3D perovskite heterostructures.

Bacterial pathogens can subvert host cell processes through secreted proteins but the precise mechanisms and repertoire of proteins remains unclear. Here the authors report that a bacterial effector protein of Xanthomonas campestris, XopR, undergoes liquid-liquid phase separation to hijack the host cell actin cytoskeleton.

The assembly of the durian genome provides insights into the unique flavor profile of this tropical fruit. Transcriptome and metabolome analyses show that methionine γ-lyase is upregulated and that volatile sulfur compounds are produced during ripening.

The authors present a multiomics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits in Hispanic/Latino populations. They demonstrate how integrating GWAS with omics characterization can advance precision medicine.

A class of core–shell nanoparticles self-assembled from amphiphilic peptides can kill a range of bacteria, yeast and fungus. They are more potent than their unassembled peptide counterparts and can suppress bacterial growth in the brains of rabbits infected with meningitis. These particles, which carry a high number of positive charges, are promising antimicrobial agents.

Multilayers comprising alternating soft and hard layers offer enhanced toughness compared to all-hard structures. Here authors reveal how the hard and soft components in Ruddlesden–Popper perovskites work cooperatively to resist deformation under pressure, informing the design of alternating superlattices for engineering applications.

Topological boundary modes within charge-ordered states have not yet been observed experimentally. Now an in-gap boundary mode, stemming solely from the charge order, is visualized in the topological material Ta₂Se₈I.

Approaches have been devised to increase the discovery rate of intrabodies but often these yield results that aren’t functional in cells. Here the authors engineer and optimise an autonomous and disulphide-free human VH domain for intracellular expression, and they identify several VH domain binders against eIF4E.

The limits of topological protection in photonic systems remain unclear. Here, Gao et al. construct photonic topological edge states and probe their robustness against a variety of defect classes, including some common time-reversal-invariant photonic defects that can break the topological protection.

A Type II Weyl fermion semimetal has been predicted in Mo_xW_1−xTe₂, but it awaits experimental evidence. Here, Belopolski et al. observe a topological Fermi arc in Mo_xW_1−xTe₂, showing it originates from a Type II Weyl fermion and offering a new platform to study novel transport phenomena in Weyl semimetals.