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Border and colleagues present FUSION, an open-source, web-based platform designed to integrate spatial omics with histological context. FUSION enables intuitive, interactive exploration of cellular and tissue-level features across diverse organs and assay types.

Baseline conditions- Blacks/Males ingesting a “Typical American Diet” exhibited lower urinary tumor necrosis factor-α (TNF-α) levels than Whites/Females, likely contributing to higher Na⁺ - K⁺ -2Cl^- cotransporter type 2 (NKCC2) activity as previously suggested for Black vs White individuals. Higher urinary TNF-α in Females may be required to suppress inherently higher NKCC2 activity to maintain homeostasis. After randomization- Urinary TNF-α increased only for those on the high sodium & control diet, an effect which appeared to be attenuated for those on the Dietary Approaches to Stop Hypertension (DASH) diet.

By investigating the paradoxical retention of a photolyase gene in a light-deprived blind cavefish, the authors reveal a novel light-independent function for CPD photolyase in the repair of oxidative stress-induced DNA damage

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Whole-genome sequences and field experiments focusing on the global invasive forage crop, Trifolium repens, show high levels of genetic variation across continents and parallel signatures of selection in five haploblocks.

Hepatitis B virus is an almost uniquely human-tropic pathogen for which model systems are scarce. Here, the authors determine key residues within the HBV receptor that form a barrier in the HBV life cycle in primates and identify marmosets as a model candidate for infection with simian-tropic HBV.

Phylogenetic and functional analyses suggest that viral histones were acquired from early eukaryotes during eukaryogenesis and that nucleosome evolution proceeded through histone repeat intermediates.

The Connectome Annotation Versioning Engine (CAVE) is a platform for proofreading, annotating and analyzing datasets reaching the petascale. Currently, CAVE is used for electron microscopy datasets, but it can potentially be used for other large-scale datasets.

The authors present a soft metalens (SML) with tungsten-gel composite for ultra-broadband transcranial focus, significantly enhancing intracranial sound pressure and spatial resolution. This breakthrough advances underwater sonar, medical ultrasound imaging, and non-invasive detection for energy transmission.

Authors report on nanofacet engineering of wafer‐scalable InAs nanowires enabling the operation of THz photodetectors in direct or integrating sampling mode, with performance comparable to commercial InP technology.

A new tool based on generative machine learning called FlowER uses flow matching to model reactions as the redistribution of electrons between reactants and products, enabling the enforcement of mass conservation in reaction prediction.

The mechanisms underlying plant phenological shifts are debated. Here, based on phenological observations and ecosystem flux and climate data, Gu and colleagues provide evidence that warming-enhanced photosynthesis in a growing season contributes to earlier spring phenology in the following year in temperate and boreal forests.

Spiracles are tubes that connect the buccopharyngeal cavity with the surface of the skull and are found in many early-diverging fish lineages. Here the authors provide evidence that polypterid fishes use their spiracles to breathe air, and suggest that stem tetrapods may have used them similarly.

Proliferative and effector functions of T cells are determined by T cell receptor signalling and modulated by activator and inhibitory co-receptors. Authors report here that the G-protein-coupled receptor GPR171 functions as a co-inhibitor of T cell signalling and might serve as a target for cancer immunotherapy.

Pacific sub-decadal sea surface temperature (SST) variations have dominantly driven Antarctic atmospheric circulation changes through tropical–polar teleconnections and contributed to recent rapid Antarctic sea ice extent (SIE) decline trends and Southern Ocean subsurface warming.

The photoresponse of graphene-based photodetectors is dominated by photovoltaic and photothermoelectric effects. Here, the authors leverage strongly localised plasmonic heating of graphene carriers to detect a second photothermoelectric effect occurring across a homogeneous channel in the presence of an electronic temperature gradient.

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

The authors systematically study biological influences on the human plasma proteome in a large cohort, thereby revealing causal associations between plasma proteins and modifiable risk factors for protein–disease associations.

Ultracold ensembles are promising sources for precision measurements when their quantum state can precisely be prepared. Here the authors achieve a quantum state engineering of Bose-Einstein condensates in space using NASA’s Cold Atom Lab aboard the International Space Station making a step forward towards space quantum sensing.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

The specifics of the pediatric immune response that gives rise to antibodies capable of neutralising diverse HIV-1 strains is not fully understood. Here the authors characterise the immune environment of Simian-HIV infected paediatric macaques and link to antibody neutralisation induction.

Distributions of the multivalent element Europium are used to recover the partial pressure of oxygen from basaltic mantle melt inclusions trapped in plagioclase crystals, suggesting Earth’s mantle is reduced by partial melting.

Recombination requires DNA break formation by SPO11, following which SPO11 is thought to be released. Here, the authors show that meiotic hotspots retain SPO11 through a recombination intermediate dependent on the methyltransferase PRDM9, and that the ATM kinase governs the release of SPO11.

In the observational ZERO Childhood Cancer Precision Medicine Program PRecISion Medicine for Children with Cancer (PRISM) trial, children with high-risk cancer were treated with molecular tumor board-recommended therapies, resulting in overall clinical response rates that translated into survival benefit after long-term follow-up.

The primary structures of four bovine clathrin light chains have been determined. Light chains LC_a and LC_b are homologous proteins encoded by different genes. In the brain the messenger RNA from these genes undergoes differential splicing to yield proteins having centrally inserted brain-specific sequences. A potentially α-helical region of the clathrin light chains shows homology with intermediate filament proteins.

Analysis of blood pressure data from the Million Veteran Program trans-ethnic cohort identifies common and rare variants, and genetically predicted gene expression across multiple tissues associated with systolic, diastolic and pulse pressure in over 775,000 individuals.

The internal amplification of Low-Gain Avalanche Diode sensors can enhance the signal-to-noise ratio, improving the detection of low-energy X-rays. In this work, the authors demonstrate a single photon counting hybrid pixel detector detecting X-ray energies down to 550 eV, and test it in ptychographic imaging at the Fe L₃-edge.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

In addition to its low-field superconducting state, UTe₂ features a re-entrant superconducting state when high magnetic fields are applied at a particular range of angles. Here, the authors demonstrate that the high-field re-entrant superconducting state survives even when the low-field superconducting state is destroyed by disorder.

Declining Arctic sea ice is increasing polar bear land use. Here, the authors follow 20 different polar bears on land over 3 years and measure daily energy expenditure finding that despite behavioural and diet plasticity the bears are at risk of starvation.

Due to fundamental anatomical and biochemical differences, C₃ and C₄ plant species tend to differ in their biogeography and response to climate change. Here, the authors use global observations and optimality theory to map patterns and temporal trends in C₄ species distribution and the contribution of C₄ plants to global photosynthesis.

The performance of supported metal nanoparticle catalysts can be tailored by metal-support interactions, but their use in catalyst design is still challenging. Here, the authors develop two-dimensional transition metal carbides as platforms for designing intermetallic compound catalysts that are efficient for light alkane dehydrogenations.

Vitamin D deficiency is associated with multiple human pathologic conditions. In a genome-wide association study of 79,366 individuals, Jiang et al. replicate four and identify two new genetic loci for serum levels of 25-hydroxyvitamin D and find evidence for a shared genetic basis with autoimmune diseases.

Resolvins are endogenous lipids with pro-resolving activity. Here the authors find that rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation.

Water-responsive materials with deformations on humidity changes are potentially useful as actuators, but prediction of stress is challenging. Here, the authors show that nanoconfinement of water is important in determining actuation behaviour in silk materials.

Implantable neural microelectrodes are critical to neuroscience research and emerging clinical applications including brain-controlled prostheses. A composite electrode consisting of a carbon fibre core, an insulating polymer coating and a polythiophene-based recording pad has now been developed that shows reduced chronic reactive tissue response in rats compared with existing architectures, owing to its smaller size and improved mechanical compliance with brain tissue.

Plant cell wall consists of multiple components and complex structure. Here, ssNMR was used to investigate the physical interactions between two principle cell wall components, cellulose and xylan, and demonstrate the mechanism for their interactions

miRNAs typically bind to target mRNAs to induce their degradation but when base-pairing between miRNAs and the target RNAs are extended, miRNAs themselves can be degraded. Here, by employing AGO1-CLASH in Drosophila cells, the authors show that RNA sequence in AGO1 mRNA 3′UTR induces decay of miR-999.

Shlien and colleagues report on 300 patients from the SickKids Cancer Sequencing program and identify clinically actionable variants in 56% of the patients by profiling somatic and germline data at multiple clinical time points.

The standard current–phase relation in tunnel Josephson junctions involves a single sinusoidal term, but real junctions are more complicated. The effects of higher Josephson harmonics have now been identified in superconducting qubit devices.

The performance of kesterite solar cells is limited by charge carrier losses, and the underlying mechanisms are unclear. By means of an integrated experimental and modelling framework, Li et al. identify the dominant loss mechanism in charge recombination at grain boundaries.

Inherent limitations on continuously measured quantum systems calls into question whether they could even in principle be used for online learning. Here, the authors experimentally demonstrate a quantum machine learning framework for inference on streaming data of arbitrary length, and provide a theory with criteria for the utility of their algorithm for inference on streaming data.

High-temperature hydrocarbon conversions often face issues like coke buildup and catalyst deactivation. Here, the authors show a general approach: balancing key reaction steps to achieve coke-free processes, exemplified in a 1000-hour coke-free dry reforming of methane process by optimizing C-H activation and C removal steps.