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While it is possible to synthesize two-dimensional covalent organic frameworks with reversible stacking phases and thus pore sizes, it is challenging because the slipped AA-stacking is the most thermodynamically stable phase. Here, the authors report shape memory 2D covalent organic frameworks with reversible interlayer stacking sequences.

Genetic muscle diseases are difficult to treat due to challenges in delivering gene editors to muscles throughout the body. Here, authors engineer muscle-specific virus-like particles that fuse with skeletal muscle cells to deliver CRISPR tools and restore dystrophin in a DMD model.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Anti-TSLP biologics have shown promise for the clinical treatment of type 2 respiratory disease. Here the authors present a clinical trial of CM326, a monoclonal antibody against TSLP, and show the clinical effects in patients with eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP), who present with type 2-dominant inflammation.

This study proposes a contact-dominated, field-enhanced design for capacitive sensors, achieving high response, strong linearity, and high sensitivity over a broad range, demonstrating great potential for functionalized flexible electronics and artificial intelligence robotic applications

The use of Cu catalysts for the CO₂ reduction reaction is hindered by their poor stability. The authors find that traces dissolved oxygen in the electrolyte results in Cu dissolution/reconstruction and report an in-situ passivation strategy to prevent oxygen adsorption in high stability.

Functional nucleic acids (FNAs) achieve specific target recognition, molecular binding and catalytic activity by folding into defined secondary and tertiary structures. This Review focuses on two major classes of FNAs — aptamers and DNAzymes — and discusses their structural features, production strategies and engineering approaches as well as their clinical applications in diagnostics, targeted therapy and precision medicine.

The authors showcase a method to design negative lumped elements by engineering the effective permittivity within the waveguide, which enables realizations of wideband waveguide metatronics and promises performance enhancement in various fields.

The isolation of a crystalline radical cation carbon(I) species, generated via single-electron transfer between a carbodicarbene and a nitroaromatic compound, is reported. The resulting radical ion pair can mediate various C–O and C–C cross-coupling reactions with electron-deficient arenes bearing a leaving group.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Here, the authors report immunogenicity and safety of AR-MPXV5, a penta-component mRNA vaccine, in naive and simian immunodeficiency virus infected nonhuman primates (NHPs), and demonstrate protection in naïve male NHPs after immunization with two doses of AR-MPXV5.

Li and colleagues report that a septo-enteric polysynaptic circuit that is activated by chronic stress links the brain to the tumor microenvironment to promote colorectal cancer growth.

The authors demonstrate that the response of the flexural vibrations of twisted bilayer graphene can be hysteretic depending on the angle between the lattices of the layers, finding that the quality factors of the vibrations are enhanced compared to untwisted bilayers.

Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD).

Hydrogels are essential for stem cell-based tissue regeneration but struggle with hard tissue repair. The authors report a shell-hardened macroporous hydrogel with spatiotemporally programmed mechanics to enhance stem cell-driven bone regeneration.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

This study reports the development and preclinical evaluation of a humanized citrullinated histone H3 (CitH3) monoclonal antibody that mitigates inflammation, restores macrophage function, and protects against sepsis-induced pulmonary injury.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Deep wound healing faces challenges due to poor drug penetration and uncoordinated repair processes. Here, the authors show that stem cell secretome micromotors actively penetrate wounds, accelerating healing by enhancing tissue regeneration and reducing inflammation across species.

There is a long-standing trade-off between high piezoelectricity and good temperature stability for piezoceramics. Here, authors combine phase boundary engineering and process engineering to relieve this relationship in (Pb, Zr) TiO3 piezoceramics.

IrO2 catalysts typically feature rutile structures with multiple facets. The authors develop an ammonia-induced method to synthesize single-faceted CuO₂ monolayers with the theoretically optimal (101) facet, resulting in high oxygen evolution activity and stability (>10,000 h) in a water electrolyser.

Asian soybean rust (ASR) is a devastating disease of soybean. Here, the author report the identification of an atypical pair of nucleotide-binding leucine-rich repeat (NLR) encoding genes and how they function together to confer broad-spectrum resistance to ASR.

In this study, Qin et al. present a murine-adapted SARS-CoV-2 strain, MASCp36, as a model for studying the pathogenicity, evolution and adaptation of the virus to human and animal hosts.

A high-κ dielectric ceramic, magnesium niobate, can be epitaxially grown on a mica substrate and then transferred to form the gate dielectric in molybdenum disulfide transistors, providing van der Waals interfaces and high robustness to temperature and voltage.

A systematic secondary metabolism transcription factor over-expression approach to evaluate the pharmaceutical potentials of fungi.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

Gao and colleagues report a structure-guided chimeric antigen based on the A35 and M1 antigens of the mpox virus (MPXV) that induces strong MPXV-specific antibody responses and protection against lethal doses of vaccinia virus in mice.

Function and mechanism underlying m⁶A modifications in myoblast differentiation and skeletal muscle regeneration while elucidating the regulatory role of METTL3 in promoting successful myoblast fusion.

The production of higher alcohols is very valuable because of their high volumetric energy density. Now, Sargent, Sinton and co-workers report the design of copper nanoparticles with tailored nanocavities that promote n-propanol formation by the coupling of C2 and C1 intermediates inside the cavity.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Transcription factors are crucial in disease but hard to target with traditional drugs. Here, authors present BlockerSELEX, a strategy to develop inhibitory aptamers that block transcription factor interactions, which disrupts interactions between key proteins, showing potential for new nucleic acid therapies.

STAAR is a powerful rare variant association test that incorporates variant functional categories and complementary functional annotations using a dynamic weighting scheme based on annotation principal components. STAAR accounts for population structure and relatedness and is scalable for analyzing large whole-genome sequencing studies.

The pathological effects of Zika virus (ZIKV) infection on placental trophoblast progenitor cells in early human embryos are not well understood. In this study, using human trophoblast stem cells (hTSCs), Wu et al. show that hTSCs are readily infected by ZIKV, but that there is increasing resistance to the virus as differentiation towards mature lineages proceeds.

This paper presents an imaging-based sensor enabled by differential guided-mode resonance with nanoscale thickness modulation, achieving high sensitivity and expanded dynamic range for medical diagnostics and biochemical sensing.

MetaSTAAR enables functionally informed rare variant association analysis in biobank-scale cohorts using an efficient, sparse matrix approach for summary statistic storage.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

Toxic methylmercury in soil can accumulate in rice grains. Here, the authors use DNA stable-isotope probing and metagenomics to identify soil microbes and pathways potentially involved in methylmercury degradation.