Search

Neurons deploy diverse adaptive strategies to ensure survival and neurotransmission amid cellular stress. Here authors show that stressed dopaminergic neurons actively induce a state of transmissive dormancy and appear to prioritize viability over functionality.

A significant challenge remains in preparing high-quality, large-area tin-lead mixed narrow-bandgap perovskite films for all-perovskite tandem solar modules. Here, the authors introduce pyridine to facilitate crystallization process, achieving maximum efficiency of 22.0% for 10.4 cm² mini-modules.

Fungal diseases threaten crops worldwide. By resolving the cryo-EM structure of fungal succinate dehydrogenase, researchers designed an inhibitor with broad antifungal activity, strong field performance, and reduced environmental toxicity.

Developing high-current-density catalysts is key to efficient water splitting. Here, the authors report a single-atom Ru-doped amorphous Ni–Mo oxide that dynamically self-reconstructs to retain high activity at industrial current densities in an anion-exchange membrane water electrolyzer.

A brain–heart–eye axis is generated through integration of multi-omics and multi-organ data from UKBB, BLSA, FinnGen and PGC, revealing phenotypic landscapes and genetic arcitectures of disease.

Direct human actions such as hunting and bird deterrence at aquaculture sites kill up to 10% of the populations of some shorebird species migrating along China’s coast each year, suggesting that this direct mortality is an overlooked threat to migratory populations.

Polar skyrmions are nanoscale topological structures of electric polarizations. Their collective modes, dubbed as “skyrons”, are discovered by the terahertz-field-excitation, femtosecond x-ray diffraction measurements and advanced modeling.

‘Ultrathin’ gold interlayers are shown to form nanoparticles that balance optical losses and electrical contact, enabling efficient perovskite–perovskite integration for scalable and durable triple-junction photovoltaics.

The triple synergy of oxygen, proton, and electron supply is crucial for hydrogen peroxide photosynthesis. Here, the authors report a squaric-acid zwitterionic covalent organic framework that achieves this synergy, boosting hydrogen peroxide yield and enabling solar-driven continuous-flow production.

Electrocatalytic co-reduction of CO₂ and nitrate to synthesize urea is a sustainable and promising option to the alternative conventional Bosch-Meiser. Here, the authors report a CeO_x-integrated diatomic electrocatalyst overcomes the traditional trade-off between urea yield and Faradaic efficiency.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

This study discovers human SERF2 as a key partner in stress granule formation by binding specific RNA G-quadruplexes. SERF2 and these RNAs provide a detailed structural model of protein-RNA interactions driving liquid-liquid phase separation in condensates.

Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

Yin–yang haplotypes are stretches of DNA that differ at multiple markers and exhibit two disparate forms. Here, the authors identify a pair of 284-nucleotide-long yin–yang haplotypes that encompass the gephyringene, and show that these human-specific haplotypes evolved rapidly and bear functional implications.

Mesothelioma is a highly lethal cancer that remains challenging to diagnose. Here, the authors curate a histomorphological atlas of resected mesothelioma and map it using self-supervised AI endorsed by human pathological assessment, revealing patterns that generate highly interpretable predictions.

Developing efficient catalysts that resolve the activity-stability trade-off remains challenging for hydrogen production. Here, the authors report a steam-assisted, machine-learning-screened synthesis of self-healing Ru/TiMnO_x electrodes that resolve this challenge.

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

An algorithm for proteoform identification with top-down mass spectra is proposed, and a pipeline is developed for generating simulated top-down spectra on the basis of input protein sequences with modifications.

Single-atom catalysts, particularly metal/nitrogen-doped carbons, have become a versatile platform for fine-tuning electronic interactions with reactants and controlling thermodynamic selectivity. Here, the authors show that the catalytic ozonation activity of single-atomic Co–N₄ sites can be electronically modulated by adjusting the density of Co nanoparticles on the carbon matrix.

The International Brain Laboratory presents a brain-wide electrophysiological map obtained from pooling data from 12 laboratories that performed the same standardized perceptual decision-making task in mice.

Construction of chiral nanostructures is impeded by the entropic barrier of dissymmetric blocks. Here, the authors report a dynamic assembly/disassembly strategy to yield single-unit organometallic helices for enantioselective amyloid inhibition.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Radiation-induced malignantly transformed cells undergo multi-scale 3D genome reorganization. TP63 acts as a key mediator, creating accessible chromatin sites that form tumour-specific loops activating the MYC oncogene during malignant transformation.

Cell state plasticity of neuroblastoma cells is linked to therapy resistance. Here, the authors develop a transcriptomic and epigenetic map of indisulam (RBM39 degrader) resistant neuroblastoma, demonstrating bidirectional cell state switching accompanied by increased NK cell activity, which they therapeutically enhance by the addition of an anti-GD2 antibody.

Children can learn language from very little experience, and explaining this ability has been a major challenge in cognitive science. Here, the authors combine the flexible representations of neural networks with the structured learning biases of Bayesian models to help explain rapid language learning.

Zaman, Yang and Huang et al. demonstrate MDK’s suppressive effect on amyloid-β and its impact on amyloid burden and microglial activation in Alzheimer disease mice, highlighting its protective role in pathogenesis.

Jian Ma et al. present HuDiff, a diffusion-based deep learning framework that humanizes antibodies and nanobodies (a small type of antibody) without templates. The model achieves improved humanness while preserving or enhancing binding strength, and the authors show promising results in virus neutralization experiments.

Brain-wide recordings in mice reveal that prior expectations are distributed through recurrent loops across all levels of cortical and subcortical processing.

Cross-linkable co-SAMs improve hole-selective SAM stability, preventing defects and thermal degredation in perovskite solar cells, enabling 26.92% efficiency with high heat durability, and guiding the design of more efficient and durable solar cells.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

A coherent 909-Hz quasi-periodic oscillation was potentially detected in GRB 230307A, the second brightest gamma-ray burst to date, indicating that a millisecond magnetar formed after the merger powered the burst.

Integrating computational methods with brain-based data presents a path to precision psychiatry by capturing individual neurobiological variation, improving diagnosis, prognosis, and personalized care. This Viewpoint highlights advances in normative and foundation models, the importance of clinically grounded principles, and the role of robust measurement and interpretability in progressing mental health care.

Mechanisms for generating spin-polarized currents may be helpful for applications. Now one such mechanism that uses the unusual Landau-level spectrum of WSe₂ under a strong magnetic field is demonstrated.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

Lipid nanoparticles (LNPs) are a versatile class of clinically approved drug delivery vehicles, particularly for nucleic acid cargoes, but they often suffer from instability issues. Here, the authors report that the room temperature stability of small interfering RNA LNPs formulated with unsaturated ionizable lipids can be improved by inclusion of mildly acidic, antioxidant-containing buffers.

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

Advances in organoid culture have enabled the modelling of many aspects of organs in vitro, transforming experimental biology. This Review provides a comprehensive overview of the current and emerging liver and pancreas organoid technologies and discusses current limitations and future directions.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Gut bacteria digest dietary fiber and release molecules as energy for the host. Here, Yu et al. find that the ability of certain gut bacteria to digest different fibers influences host consumption of food containing these fibers.

Dioxythiophene-based polymers effectively convert electric potential into optical readouts. Here, the authors used such polymers to optically record bioelectric signals with microvolt sensitivity and sub-millisecond temporal resolution, highlighting their potential in optical bioelectronics.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

Non-invasive optical imaging tools for early detection of anti-tumor immune responses are essential for precision cancer immunotherapy. Here, the authors report a rare-earth-based NIR-II fluorescence ratiometric nanoprobe (DCGA) for in vivo real-time, precise, and non-invasive visualization of granzyme B activity for early prediction of immunotherapy efficacy.

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Olfactory perception of food-derived odors influences feeding behavior, but the underlying neural pathways remain unclear. Here, the authors show that prolonged exposure to food odor suppresses food intake and body weight gain by activating an olfactory bulb–hypothalamus circuit.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.