Search

Cortical microtubules (MTs) in Apicomplexa are specialized MTs involved in maintaining the parasite’s shape and are, as such, unusually stable. Here, cryo-EM analysis of cortical MTs from Toxoplasma gondii offers insight into the mechanism of their stabilization by three bona fide microtubule inner proteins.

Light-driven approaches could lower the carbon footprint of chemical production. Here the authors use the perovskite oxide LaMn_1−xCu_xO₃ as a photocatalyst to convert ethane to ethylene and hydrogen.

The authors propose that screw or edge dislocations can trap Majorana zero modes in the absence of an external magnetic field. They predict that the Majoranas will appear as second-order topological modes on the four corners of an embedded 2D subsystem defined by the cutting plane of the dislocation.

Dong et al. demonstrate that targeting arginine N-methyltransferase 9 (PRMT9) inhibits cancer stem cells in the context of acute myeloid leukemia via type I interferon-associated immunity. Furthermore, they show that PRMT9 inhibition synergizes with anti-programmed cell death protein 1.

Conventional alkaline and neutral CO₂-to-CH₄ systems suffer carbon loss, and recovering the lost carbon requires input energy exceeding the heating value of CH₄. Here, the authors report a chelating strategy to obtain Cu-N/O single sites decorated Cu clusters, which enables energy- and carbon-efficient CH₄ electroproduction in an acidic system.

Dielectric capacitors known for high-power density and fast charging/discharging suffer from thermal stability and failure at high temperatures. Here, a metadielectric strategy is used to fabricate thermally stable high temperature film capacitors.

Crystal facets are known to be important in traditional heterogeneous catalysis, yet this effect has not been studied in plasmon-assisted catalysis. Here, the authors investigate the impact facets have on CO₂ reduction using plasmonic Au NPs.

Tandem electrocatalysts are developed for acidic CO₂ electroreduction. The catalyst contains planar-copper for CO₂ reduction to CO, and a dual-copper-active-site layer for CO reduction to C₂₊ products. An ethanol Faradaic efficiency of 46% and a C₂₊ Faradaic efficiency of 91% are achieved in acidic electrolyte at 150 mA cm⁻².

Manipulating the carbon-carbon coupling pathway in CO₂ electroreduction is vital yet challenging. Here, by studying two model copper-based catalysts with distinct ethylene and ethanol selectivity, authors investigate the mechanistic origins for symmetric and asymmetric carbon-carbon coupling.

Reconstructing transcriptome-wide spatially-resolved gene expressions requires modelling nonlinear patterns and spatial structures in RNA profiling data. Here, authors introduce a graph-guided neural hierarchical tensor decomposition model that incorporates spatial and functional relations for the task.

Post transcriptional modifications to RNA may be important in the function of NK cells but this is not fully known. Here the authors show that m⁶A-methyltransferase METTL3 deletion in NK cells leads to reduced function and protection against tumour challenge through suppressing response to IL-15.

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Despite overall warming, many regions in the Northern Hemisphere have been cooling in autumn. This cooling resulted in an increasing release of net CO₂ 2004–2018 as primary production decreased more than respiration in cooling and respiration increased more than production in warming areas.

FOXM1 is a known transcription factor which promotes cell proliferation in cancer cells. Here, the authors show that FOXM1 is required for the maintenance of quiescence and self-renewal of leukemia stem cells in MLL-AF9-rearranged acute myeloid leukemia patient and mouse models.

Ginkgo is one of the living fossils from the plant kingdom. Here, authors conduct population genomics analyses to reveal its refugia and demographic history, and provide evidence of multiple anthropogenic introductions of ginkgo from eastern China into different continents.

Covalent organic frameworks offer a highly tunable class of materials for a range of applications, although their dynamic structural transformations are challenging to analyse. Now single-crystal X-ray diffraction is shown to demonstrate single-crystal-to-single-crystal transformations of the imine linkages, showing a well-defined interpenetrating topology and affording structures that have high positive thermal expansion and anhydrous proton-conduction properties.

PIK3CA is a commonly mutated cancer-associated gene, making it an attractive therapeutic target. Here, the authors report the results of a first-in-human phase Ia trial to assess the safety and recommended phase II dose of CYH33, a PI3Kα inhibitor, in patients with advanced solid tumors.

Delivery and fluidity of cancer nanoparticle vaccines alters efficiency and immune priming. Here the authors show a sonosensitive nanovaccine which depending on fluidity of the vaccine improves vaccine targeting and subsequent anti-tumour immune responses.

The hyperproliferation of vascular smooth muscle cells underlies many vascular diseases. Here Xieet al. show that the splicing factor SRSF1 is an endogenous stimulator of human and mouse aortic smooth muscle cell proliferation via the Δ133p53/EGR1/KLF5 signalling axis, identifying potential therapeutic targets for vascular proliferative disorders.

A moiré potential may play a role in determining the magnetic properties of a two-dimensional homo or heterostructure. Now, non-collinear spin structures are observed in twisted double bilayer CrI₃, providing a platform to engineer unusual magnetic textures.

Controlling the crystallization of perovskites is not trivial. Here Wang et al. develop a close-space annealing to improve the structural and optoelectronic quality of perovskite films with different chemical compositions, leading to over 25% efficiency in all-perovskite tandem solar cells.

Rui Chen and colleagues identify mutations in NMNAT1 as a new cause of Leber congenital amaurosis. They further show that all examined individuals with NMNAT1 mutations have macular colobomas, a condition marked by severe degeneration of the central retina.

Yao and Gong et al. identify WD40 repeat-containing protein 6 (WDR6) to be upregulated in the liver of insulin-resistant mice. WDR6 contributes to promoting hepatic de novo lipogenesis during insulin resistance by upregulation of fatty acid synthase, and the authors identify a small molecule to inhibit this effect of WDR6 and reduce hepatic steatosis.

A draft genome sequence of the hornwort Anthoceros augustus confirms the phylogenetic relationships among the three clades of bryophytes and provides insight into the unique characteristics of hornworts and their adaptations to live on land.

While there has been evidence of strong carrier multiplication effects in halide perovskites, studies in actual solar cells are lacking. Here, the authors demonstrate such effects with a low threshold of 2E_g and a high efficiency of 99.4%, realizing unbiased internal quantum efficiency up to 160%.

Gold nanoclusters show promise as photothermal materials, but are often thermally unstable. Here ligand engineering is used to integrate molecular rotors with gold nanoclusters to dissipate thermal energy and improve photothermal therapy performance.

Metal borides/borates are promising candidates to become high-performance alkaline oxygen evolution reaction catalysts. This study reports an in-situ phase composition modulation approach to fabricate boride/borate-based catalysts.

Polymer dielectrics face huge challenges in the harsh environments of emergent applications. Now, increased energy storage of polymer dielectrics at temperatures up to 250 °C by designing tailored combinations of structural units is reported.

The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.

A sequencing chemistry that separates nucleotide identification from nucleotide incorporation achieves high accuracy.