Nature Search

Sea-level rise at the end of the last deglaciation dominated by North American ice sheets

The melting of the last remnants of the North American ice sheets in the early Holocene led to 14 m of global sea-level rise, higher than prior estimates, according to proxy constraints from the Mississippi Delta and other localities.

Udita Mukherjee
Lael Vetter
Torbjörn E. Törnqvist
Research09 Oct 2025
Nature Geoscience

P: 1-7
Structural basis for mTORC1 activation on the lysosomal membrane

Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and RAPTOR, culminating in mTOR–membrane engagement and full enzyme activation.

Zhicheng Cui
Alessandra Esposito
James H. Hurley
ResearchOpen Access17 Sept 2025
Nature

P: 1-8
Author Correction: Exome analysis links kidney malformations to developmental disorders and reveals causal genes

Hila Milo Rasouly
Sarath Babu Krishna Murthy
Ali G. Gharavi
Amendments and CorrectionsOpen Access09 Oct 2025
Nature Communications

Volume: 16, P: 1-2
Championing queer scientists of colour: ‘I don’t think we’ve scratched the surface on systemic exclusion’

Arachnologist Lauren Esposito develops community platforms to share LGBTQ+ voices and wants to shed light on the overlooked intersectional barriers affecting queer people of colour.

Grey Enticknap
Comments & Opinion16 Jan 2025
Nature
Photon number statistics uncover the fluctuations in non-equilibrium lattice dynamics

Fluctuations of atomic positions are related to several materials properties. Here the authors measure the photon number statistics via a non-equilibrium optical experiment and provide a quantum description of the interaction between photonic and phononic fields to reveal lattice dynamics fluctuations in quartz.

Martina Esposito
Kelvin Titimbo
Daniele Fausti
ResearchOpen Access22 Dec 2015
Nature Communications

Volume: 6, P: 1-7
Evolutionary history of ponerine ants highlights how the timing of dispersal events shapes modern biodiversity

The diversity of ponerine ants varies widely across the globe. This study finds that the origin and early colonization in Gondwana’s tropical regions mainly shaped this distribution, while differences in diversification and dispersal have balanced regional diversity over time.

Maël Doré
Marek L. Borowiec
Bonnie B. Blaimer
ResearchOpen Access16 Sept 2025
Nature Communications

Volume: 16, P: 1-17
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas

Antonio De Luca
Alfonso Baldi
Antonio Giordano
Research01 Aug 1997
Nature Medicine

Volume: 3, P: 913-916
Exome analysis links kidney malformations to developmental disorders and reveals causal genes

The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, along with 38 candidate genes, providing evidence for shared genetics with other developmental disorders.

Hila Milo Rasouly
Sarath Babu Krishna Murthy
Ali G. Gharavi
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease

C J North
C S Venter
J C Jerling
Research18 Feb 2009
European Journal of Clinical Nutrition

Volume: 63, P: 921-933
Effect on Leukæmic Cells of Ribonucleic Acid extracted from Calf's Spleen

S. ESPOSITO
Research05 Sept 1964
Nature

Volume: 203, P: 1078-1079
Histopathology-based protein multiplex generation using deep learning

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

Sonali Andani
Boqi Chen
Gunnar Rätsch
ResearchOpen Access04 Aug 2025
Nature Machine Intelligence

Volume: 7, P: 1292-1307
Comparison of white pock (h) mutants of monkeypox virus with parental monkeypox and with variola-like viruses isolated from animals

K. R. Dumbell
L. C. Archard
Research03 Jul 1980
Nature

Volume: 286, P: 29-32
‘Web of Science’ to be sold to private-equity firms

Thomson Reuters divests intellectual-property and science division in US$3.55-billion deal.

Declan Butler
News12 Jul 2016
Nature
Microencapsulated genetically engineered live E. coli DH5 cells administered orally to maintain normal plasma urea level in uremic rats

S. Prakash
T.M.S. Chang
Research01 Aug 1996
Nature Medicine

Volume: 2, P: 883-887
Construction of a mouse yeast artificial chromosome library in a recombination–deficient strain of yeast

F. L. Chartier
J. T. Keer
S. D. M. Brown
Research01 May 1992
Nature Genetics

Volume: 1, P: 132-136
Relationship of Adrenocortical Insufficiency to Spontaneous Regression in Mammary Tumours induced in Rats by Oral Administration of Dimethylbenzanthracene

STRETTON YOUNG
JANET E. HELFENSTEIN
ROSEMARY A. BAKER
Research05 Sept 1964
Nature

Volume: 203, P: 1079-1080
The pro-oncogenic noncanonical activity of a RAS•GTP:RanGAP1 complex facilitates nuclear protein export

Tripathi et al. identify a noncanonical RAS•GTP activity that increases XPO1-dependent export of nuclear proteins into the cytoplasm. This depends on a RAS–RanGAP1 complex, and this export function contributes to RAS oncogenic activity.

Brajendra K. Tripathi
Nicole H. Hirsh
Douglas R. Lowy
ResearchOpen Access11 Nov 2024
Nature Cancer

Volume: 5, P: 1902-1918
Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia

The molecular mechanisms underlying drug resistance in relapsed or refractory (rr) acute myeloid leukemia (AML) remain to be explored. Here, the use of bulk and single cell multi-omics and ex vivo drug profiling for 21 rrAML patients reveals mechanisms of resistance to the Bcl-2 inhibitor venetoclax and treatment vulnerabilities.

Rebekka Wegmann
Ximena Bonilla
Alexandre P. A. Theocharides
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-18
Feasibility of multiomics tumor profiling for guiding treatment of melanoma

In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

Nicola Miglino
Nora C. Toussaint
Andreas Wicki
ResearchOpen Access27 May 2025
Nature Medicine

Volume: 31, P: 2430-2441
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia

Multidrug resistance of the opportunistic pathogen Stenotrophomonas maltophilia is an increasing problem. Here, analyzing strains from 22 countries, the authors show that the S. maltophilia complex is divided into 23 monophyletic lineages and find evidence for intra-hospital transmission.

Matthias I. Gröschel
Conor J. Meehan
Thomas A. Kohl
ResearchOpen Access27 Apr 2020
Nature Communications

Volume: 11, P: 1-12
Leveraging RAS-mSIN1 interaction to selectively inhibit mTORC2 employing competitive RAS binding peptide: implications in breast cancer metastasis

Javed Miyan
Narayan Kumar
Smrati Bhadauria
Research23 Aug 2025
Oncogene

Volume: 44, P: 3909-3923
Resolution of recombination intermediates generated during yeast mating type switching

Amar J. S. Klar
Jeffrey N. Strathern
Research30 Aug 1984
Nature

Volume: 310, P: 744-748
Interactions between Active Sodium Transport and Active Amino-acid Transport in Isolated Rabbit Ileum

STANLEY G. SCHULTZ
RALPH ZALUSKY
Research16 Jan 1965
Nature

Volume: 205, P: 292-294
ROCK-dependent mechanotransduction of macroscale forces drives fibrosis in degenerative spinal disease

In human spinal ligament tissue exposed to high stress, fibrotic regions displaying elevated Rho-associated kinase signalling and an increased density of myofibroblasts expressing smooth muscle actin α contribute to degenerative spinal disease.

Muhamed Hadzipasic
Margaret S. Sten
Ganesh M. Shankar
Research29 May 2025
Nature Biomedical Engineering

P: 1-14
Correction: Corrigendum: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

Joonseok Cho
Yujian Zhang
Naohiro Terada
Amendments and CorrectionsOpen Access18 Aug 2017
Nature Communications

P: 1-4
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Andreas Meyer-Lindenberg
Robert S. Miletich
Karen Faith Berman
Research28 Jan 2002
Nature Neuroscience

Volume: 5, P: 267-271
Publisher Correction: Feasibility of multiomics tumor profiling for guiding treatment of melanoma

Nicola Miglino
Nora C. Toussaint
Andreas Wicki
Amendments and CorrectionsOpen Access01 Aug 2025
Nature Medicine

Volume: 31, P: 2817-2818
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

Genome-wide association analyses identify 30 risk loci for IgA nephropathy. Functional annotations of putative causal genes converge on inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.

Krzysztof Kiryluk
Elena Sanchez-Rodriguez
Ali G. Gharavi
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1091-1105
Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

Esposito et al. report a role for bone vascular niche E-selectin in promoting mesenchymal–epithelial transition and Wnt signalling in breast cancer cells, thereby enhancing bone metastasis.

Mark Esposito
Nandini Mondal
Yibin Kang
Research15 Apr 2019
Nature Cell Biology

Volume: 21, P: 627-639
Management of boys with nonpalpable undescended testis

During the past 15 years, there has been extensive international research in boys with nonpalpable testis. However, the question of what the gold-standard treatment for this disorder should be still remains. This Review assesses the current data on this disorder.

Ciro Esposito
Anthony A Caldamone
Alaa El-Ghoneimi
Reviews15 Apr 2008
Nature Clinical Practice Urology

Volume: 5, P: 252-260
What is the optimal laparoscopic antireflux procedure for children with gastroesophageal reflux disease?

Donald Liu
Irving Waxman
Comments & Opinion01 Jan 2007
Nature Clinical Practice Gastroenterology & Hepatology

Volume: 4, P: 14-15
Simian virus-40 large-T antigen binds p53 in human mesotheliomas

Michele Carbone
Paola Rizzo
Harvey I. Pass
Research01 Aug 1997
Nature Medicine

Volume: 3, P: 908-912
Dust reveals ancient origin for Saturn's rings

Data from the Cassini spacecraft suggest rings formed 4.4 billion years ago.

Alexandra Witze
News19 Aug 2014
Nature
Integrated multimodal cell atlas of Alzheimer’s disease

The affected cellular populations during Alzheimer’s disease progression remain understudied. Here the authors use a cohort of 84 donors, quantitative neuropathology and multimodal datasets from the BRAIN Initiative. Their pseudoprogression analysis revealed two disease phases.

Mariano I. Gabitto
Kyle J. Travaglini
Ed S. Lein
ResearchOpen Access14 Oct 2024
Nature Neuroscience

Volume: 27, P: 2366-2383
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice

A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional changes and the interaction of ageing and disease.

Kelly Jin
Zizhen Yao
Hongkui Zeng
ResearchOpen Access01 Jan 2025
Nature

Volume: 638, P: 182-196
Taxonomy of Arabian Temnothorax Mayr (Formicidae: Myrmicinae) with description of a new species enhanced by x-ray microtomography

Mostafa R. Sharaf
Abdulrahman S. Aldawood
Francisco Hita Garcia
ResearchOpen Access29 Jul 2019
Scientific Reports

Volume: 9, P: 1-7
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development

The involvement of cell death pathways in the early stage of pancreatic ductal adenocarcinoma (PDAC) development, especially KRAS-dependent acinar-to-ductal metaplasia (ADM), remains to be investigated. Here, the authors find that TAK1 mediates cell survival during ADM transdifferentiation through suppression of apoptosis and necroptosis, which could be targeted for prevention and treatment of PDAC.

Anne T. Schneider
Christiane Koppe
Tom Luedde
ResearchOpen Access19 Feb 2025
Nature Communications

Volume: 16, P: 1-18
Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

Metastatic cells can mimic many of the phenotypic behaviors of embryonic cells. Here, the authors generate a melanoblast-specific transcriptome using a genetically engineered mouse model and identify KDELR3 as a pro-metastasis gene in melanoma.

Kerrie L. Marie
Antonella Sassano
Pravin J. Mishra
ResearchOpen Access16 Jan 2020
Nature Communications

Volume: 11, P: 1-18
A cross-species proteomic map reveals neoteny of human synapse development

A study presents a cross-species proteomic map of synapse development in neocortex and reveals that the human postsynaptic density assembly develops two to three times slower than that in macaques and mice.

Li Wang
Kaifang Pang
Arnold R. Kriegstein
Research13 Sept 2023
Nature

Volume: 622, P: 112-119
Red cell 2,3-diphosphoglycerate concentration in man decreases with age

YVONNE PURCELL
BRANKO BROZOVIĆ
Research11 Oct 1974
Nature

Volume: 251, P: 511-512
Depsides in Sunflower Leaves

A. ZANE
S. H. WENDER
Research01 Jan 1966
Nature

Volume: 209, P: 80-81
Inhibitory Synapses and Inflammation

S. I. FRANKSTEIN
Z. G. BIJASHEVA
L. N. SMOLIN
Research16 Jan 1965
Nature

Volume: 205, P: 294-295
Intense community dynamics in the pre-Roman frontier site of Fermo (ninth–fifth century BCE, Marche, central Italy) inferred from isotopic data

Carmen Esposito
Melania Gigante
Wolfgang Müller
ResearchOpen Access03 Mar 2023
Scientific Reports

Volume: 13, P: 1-14
A Die-back of Cacao Seedlings in Nigeria caused by a Species of Phytophthora

S. R. CHANT
Research28 Dec 1957
Nature

Volume: 180, P: 1494-1495
Metabolic Differences between Starch and Sucrose

SOHAIR AL-NAGDY
D. S. MILLER
JOHN YUDKIN
Research01 Jan 1966
Nature

Volume: 209, P: 81-82
Induction of Mitotic Recombination in Saccharomyces cerevisiae by Ethyl Methane Sulphonate

HENRY T. YOST JUN.
ROY S. CHALEFF
JAMES P. FINERTY
Research05 Aug 1967
Nature

Volume: 215, P: 660-661
A Physiological Effect of Triethanolamine on the Development of Sclerotium rolfsii (Sacc.)

S. LAVEE
Research28 Dec 1957
Nature

Volume: 180, P: 1494
Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate

While cellular stress shuts down translation, how protein degradation occurs with stress is incompletely understood. The authors describe a stress-induced phase separated organelle that mediates ubiquitin-independent degradation in the proteasome.

Daniel C. Carrettiero
Maria C. Almeida
Kenneth S. Kosik
ResearchOpen Access02 Jun 2022
Nature Communications

Volume: 13, P: 1-16

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