Search

BamA is the catalytic core of the BAM complex, which inserts proteins into bacterial outer membranes. Here, the authors show that hinge flexibility between BamA’s β-barrel and POTRA domains is vital, demonstrating how evolution has fine-tuned the BamA sequence and structure for function.

Chemotherapy is commonly used for the treatment of cancer but resistance often occurs. Here, the authors identify mitochondrial DLAT as driver of chemotherapy resistance via interaction with (MTHFD2) and develop a decoy peptide which blocks this interaction, restoring sensitivity to chemotherapy.

Dietary cysteine enhances intestinal stem cell-mediated intestinal repair following injury by promoting CD8 T cell-regenerative immune responses.

Chemical doping allows for boosting the conductivity in conjugated polymers but the relationship between doping and the polymers’ complex, multiscale morphology remains elusive. Here the authors report that supramolecular chirality, which up to now had not been considered a parameter relevant to doping, significantly boosts the underpinning redox reaction in conjugated polymer thin films.

Mendelian randomization (MR) identifies causal relationships from observational data but has increased error rates when the genetic variants used as instruments come from a single region, a typical scenario when assessing molecular traits like protein or metabolite levels as risk factors. Here the authors introduce a single-region pleiotropy-robust MR method, validating the method on three ground truth sources, showing its capability to identify disease-causing molecular traits.

Microporous polymer membranes are promising for gas separation but are prone to aging, reducing performance. Here the authors use a defluorination-induced crosslinking method on aryl-ether-free aromatic polymers, forming a membrane for CO₂ separation.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Mt Fuji’s freshwater springs were believed to be fed exclusively by shallow groundwater aquifers. Using a newly developed combination of tracer techniques, this study finds widespread vertical exchange between shallow and deeper aquifers and shows evidence of a substantial deep groundwater contribution to the springs.

The XRISM Resolve spectrum of the galactic neutron star X-ray binary, GX 13+1, reveals one of the densest winds ever seen in absorption lines.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Nanobubbles in liquid phase are puzzling, because their internal pressure is estimated to be unphysically large. Here, Shin et al. visualize the dynamics of nanobubbles in water encapsulated by graphene membrane and show fast gas diffusion through ultrathin water layer between two coalescing bubbles.

Cytotoxic T lymphocytes targeting ancestral SARS-CoV-2 recognise variants of concern, but deep molecular understanding of why these responses are conserved is hampered by the populational variability due to HLA-restriction. Here authors identify an HLA-C-restricted conserved immunodominant SARS-CoV-2 nucleocapsid epitope in COVID-19 convalescent donors from early waves of the pandemic and provide structural bases for its recognition by the T cell receptor.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Soft electronic probes for measuring neural activity can be made scalably in an initially planar form and turned into various three-dimensional geometries through a controlled rolling method.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Cellular forces shaping cells and tissues during development are well understood, but their dynamic material properties less so. Here, the authors use Brillouin microscopy to map cell material properties in developing fruit fly embryos, revealing dynamic, fate-specific modulation.

Current industrial methods of ethylene glycol production generate substantial CO₂ emissions. Here electrocatalytic ethylene-to-ethylene glycol conversion is coupled to electrochemical CO₂ capture, decreasing carbon intensity by an order of magnitude.

Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA-lipid nanoparticles while enabling high RNA expression.

Controlling nanoscale colloidal crystallization is not straightforward. Such control is now achieved by leveraging a metastable liquid phase of charged nanocrystals.

Twisted bilayer metal-organic frameworks produce dodecagonal quasiperiodic moiré patterns with tunable length scales. Here the authors show that isoreticular ligand design enables control over aperiodic order in porous materials.

HCMV rearranges the host cell to produce infectious virus but molecular details are still unclear. Here, the authors analyze the transcriptome of infected cells and show that HCMV turns on dormant neuronal genes through chromatin manipulation to achieve this goal.

Here the authors reveal via whole genome sequencing of an East Asian AD cohort a common variant locus (APCDD1), rare noncoding variants in excitatory neurons, and short tandem repeat expansions, suggesting a cumulative effects model for Alzheimer’s risk.

Bioenergetic capacity, the ability to maintain energy balance under stress, can be monitored using blood acylcarnitine profiles. Improving this capacity may slow Alzheimer’s disease progression.

Trafficking from endosomes to the trans-Golgi network requires recognition of vesicle tethers during membrane docking. Here, the authors identify a complex localised to AP-1 generated vesicles containing WDR11, C17orf75 and FAM91A, which together with TBC1D23 facilitates vesicle capture on Golgi membranes

Lactobacilli are a principal microbial constituent in the human uterine cervix and vagina. Here, authors identify the stem cells in the human uterine cervix and the role of Lactobacilli metabolite in cervical stem cells and cervical cancers.

Human RIF1 protein protects cells from DNA replication stress, through mechanisms that remain uncertain. Here the authors demonstrate that the RIF1-Long isoform interacts with BRCA1 upon extended replication stress, enabling RAD51-dependent repair of broken replication forks.

Benefits of breastfeeding are well established, but a comprehensive study about its impacts on hospitalizations is lacking. Here, the authors use Korean nationwide birth cohort data (n = 1,608,540) and find that breastfeeding for at least 6 months was associated with a lower risk for subsequent hospital admissions.

Climate model simulations suggest that both anthropogenic aerosols and tropical ocean warming have contributed to reduced precipitation over the southwestern United States in recent decades, thus making the current drought more likely than previously thought.

Electrified reactive capture converts CO₂ from carbonate solutions but suffers from low Faradaic efficiency. Here, the authors report a templated synthesis with defined pores and Ni single atoms to accumulate CO₂, achieving 46% energy efficiency to syngas at 300 mA/cm²

A non-contact wearable device that defines and modulates a microclimate adjacent to the skin can measure incoming and outgoing streams of vapourized substances, offering valuable insights into physiological health, wound healing and environmental exposures.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.