Nature Search

Nature of the Scrapie Agent: Self-replication and Scrapie

J. S. GRIFFITH
Research02 Sept 1967
Nature

Volume: 215, P: 1043-1044
John Jacob Wasmuth (1946–1995)

Nancy S. Wexler
Comments & Opinion01 Feb 1996
Nature Genetics

Volume: 12, P: 119-120
National traditions and the emergence of genetics: the French example

Jean Gayon
Richard M. Burian
Reviews01 Feb 2004
Nature Reviews Genetics

Volume: 5, P: 150-156
WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2

Inhibitors of the protein kinase Wee1 are promising drugs for cancer therapy. Here, the authors show that these drugs activate the integrated stress response via GCN2, synergising with mRNA translation defects. They suggest strategies such as PROTACs or ISR inhibitors to improve WEE1 mediated toxicity.

Jordan C. J. Wilson
JiaYi Zhu
Stephen P. Jackson
ResearchOpen Access09 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Naturally occurring antibodies devoid of light chains

C. Hamers-Casterman
T. Atarhouch
R. Hammers
Research03 Jun 1993
Nature

Volume: 363, P: 446-448
National identity predicts public health support during a global pandemic

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Jay J. Van Bavel
Aleksandra Cichocka
Paulo S. Boggio
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-14
A clonally expanded nodal T-cell population diagnosed as T-cell lymphoma after CAR-T therapy

Secondary malignancies and chimeric antigen receptor (CAR)-T-derived malignant T cell transformation have been reported after CAR-T therapy. Here, the authors describe a patient with diffuse large B-cell lymphoma (DLBCL) who developed new lymphadenopathy 2.5 years after CAR-T in the context of COVID-19 infection with histopathologic features consistent with T-cell lymphoma (TCL).

Katie Maurer
Jackson A. Weir
Caron Jacobson
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-9
Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspring

The treatment potential of psilocybin for postpartum depression was investigated in a preclinical mouse model. Here the authors show both acute and long-term effects of psilocybin in mothers and their offspring who were exposed via lactation.

Cassandra J. Hatzipantelis
Min Liu
Danielle S. Stolzenberg
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-15
How Repressor Molecules Function

MARK S. BRETSCHER
Research10 Feb 1968
Nature

Volume: 217, P: 509-511
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations

Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

Boya Guo
Yanwei Cai
Burcu F. Darst
ResearchOpen Access01 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Measuring the semantic priming effect across many languages

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Erin M. Buchanan
Kelly Cuccolo
Savannah C. Lewis
Research24 Sept 2025
Nature Human Behaviour

P: 1-20
Phages with a broad host range are common across ecosystems

Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.

Amaury Bignaud
Devon E. Conti
Martial Marbouty
Research19 Sept 2025
Nature Microbiology

Volume: 10, P: 2537-2549
LRP8 is a receptor for tick-borne encephalitis virus

LRP8, an apolipoprotein E and reelin receptor with high expression in the brain, is a receptor for tick-borne encephalitis virus.

Eva Mittler
Alexandra L. Tse
Sara Gredmark-Russ
Research24 Sept 2025
Nature

P: 1-8
RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity

Cell state plasticity of neuroblastoma cells is linked to therapy resistance. Here, the authors develop a transcriptomic and epigenetic map of indisulam (RBM39 degrader) resistant neuroblastoma, demonstrating bidirectional cell state switching accompanied by increased NK cell activity, which they therapeutically enhance by the addition of an anti-GD2 antibody.

Shivendra Singh
Jie Fang
Jun Yang
ResearchOpen Access17 Sept 2025
Nature Communications

Volume: 16, P: 1-26
Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes

Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.

Darshana Gupta
Constantinos Patinios
Chase L. Beisel
ResearchOpen Access04 Sept 2025
Nature Biotechnology

P: 1-12
Comparison of imaging based single-cell resolution spatial transcriptomics profiling platforms using formalin-fixed paraffin-embedded tumor samples

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

Nejla Ozirmak Lermi
Max Molina Ayala
Luisa M. Solis Soto
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-16
STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor

Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling.

Bao-cun Zhang
Alice Pedersen
Søren R. Paludan
Research19 Sept 2025
Nature Immunology

P: 1-15
Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease

Asymmetrical distribution of tau pathology in Alzheimer’s disease is linked to asymmetrical amyloid-beta deposition, not reduced brain connectivity, suggesting regional vulnerability plays a key role in determining the distribution of tau pathology.

Toomas Erik Anijärv
Rik Ossenkoppele
Oskar Hansson
ResearchOpen Access05 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Astronomical tuning of the Aptian stage and its implications for age recalibrations and paleoclimatic events

The Early Cretaceous Aptian stage represents an interval of major dramatic climate changes, but there is no consensus on its lower boundary age. Here, the authors present an astro-chronological framework that offers new age constraints on the onset and duration of Aptian ocean anoxic events and the ‘cold snap’, among other significant climatic events.

C. G. Leandro
J. F. Savian
R. I. F. Trindade
ResearchOpen Access26 May 2022
Nature Communications

Volume: 13, P: 1-12
Abnormal Haem Binding and Globin SH Group Blockade in Unstable Haemoglobins

H. S. JACOB
M. C. BRAIN
H. LEHMANN
Research29 Jun 1968
Nature

Volume: 218, P: 1214-1217
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Evaluation of prostate cancer pathology reports generated by ChatGPT to enhance patient comprehension

Narmina Khanmammadova
Rafael Gevorkyan
David I. Lee
ResearchOpen Access02 Oct 2025
Scientific Reports

Volume: 15, P: 1-7
Stabilizing effect of amino acids on protein and colloidal dispersions

Amino acids possess a new and broad colloidal property: they stabilize patchy nanoscale colloids, such as proteins, by adsorbing onto their surfaces through weak interactions.

Ting Mao
Xufeng Xu
Francesco Stellacci
ResearchOpen Access10 Sept 2025
Nature

Volume: 645, P: 915-921
Nucleotide sequence of the origin of replication in bacteriophage ΦX174 RF DNA

S. A. Langeveld
A. D. M. van Mansfeld
P. J. Weisbeek
Research02 Feb 1978
Nature

Volume: 271, P: 417-420
A fluorescent-protein spin qubit

An optically addressable fluorescent-protein spin qubit is realized using enhanced yellow fluorescent protein; the qubit can be coherently controlled at liquid-nitrogen temperatures and the spin detected at room temperature in cells.

Jacob S. Feder
Benjamin S. Soloway
Peter C. Maurer
ResearchOpen Access20 Aug 2025
Nature

Volume: 645, P: 73-79
Drug Resistance and its Transfer in Salmonella typhimurium

E. S. ANDERSON
M. J. LEWIS
Research08 May 1965
Nature

Volume: 206, P: 579-583
ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche

Therapeutic checkpoint for acute myeloid leukemia requires further investigations. The authors here identify ST2⁺ Treg cells facilitate AML growth by inducing CD8⁺ T cell depletion and exhaustion, while targeting ST2 by antibodies depletes ST2⁺ Treg cells and improves AML prognosis.

Hua Jiang
Denggang Fu
Sophie Paczesny
ResearchOpen Access21 Jul 2025
Nature Communications

Volume: 16, P: 1-26
An Unstable Intermediate Carrying Information from Genes to Ribosomes for Protein Synthesis

S. BRENNER
F. JACOB
M. MESELSON
Research13 May 1961
Nature

Volume: 190, P: 576-581
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape

Preventing endosomal damage sensing or using lipids that create reparable endosomal holes reduces inflammation caused by RNA-lipid nanoparticles while enabling high RNA expression.

Serena Omo-Lamai
Yufei Wang
Jacob S. Brenner
Research11 Aug 2025
Nature Nanotechnology

Volume: 20, P: 1285-1297
Widespread photosynthesis reaction centre barrel proteins are necessary for haloarchaeal cell division

Photosynthesis reaction centre barrel proteins are important components of the FtsZ-based cell division apparatus in Haloferax volcanii and other archaea.

Shan Zhao
Kira S. Makarova
Shishen Du
Research04 Mar 2024
Nature Microbiology

Volume: 9, P: 712-726
Thermodynamics-inspired high-entropy oxide synthesis

By controlling oxygen partial pressure, this study coerces Mn and Fe into divalent states, stabilizing seven new high-entropy rock salt oxides, and introduces oxygen chemical potential as a key design axis for predictive synthesis.

Saeed S. I. Almishal
Matthew Furst
Jon-Paul Maria
ResearchOpen Access02 Sept 2025
Nature Communications

Volume: 16, P: 1-9
Impact of tongue fat volume on obstructive sleep apnea in non-obese patients

Michael I. Orestes
Kenneth R. Feehs
Lilit Garibyan
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-10
Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

P. BROOKES
P. D. LAWLEY
Research23 May 1964
Nature

Volume: 202, P: 781-784
Inheritance of an Increased Sodium Pump in Human Red Cells

J. S. WILEY
Research01 Mar 1969
Nature

Volume: 221, P: 1222-1224
Selective Alterations of Mammalian Messenger-RNA Synthesis: Evidence for Differential Action of Hormones on Gene Transcription

CHEV KIDSON
K. S. KIRBY
Research08 Aug 1964
Nature

Volume: 203, P: 599-603
Transfer of a Neomycin–Kanamycin Resistance Determinant by the F Factor of Escherichia coli K12

E. S. ANDERSON
JUNE N. MAYHEW
N. D. F. GRINDLEY
Research26 Apr 1969
Nature

Volume: 222, P: 349-351
Influence of the Δ Transfer Factor on the Phage Sensitivity of Salmonellae

E. S. ANDERSON
Research19 Nov 1966
Nature

Volume: 212, P: 795-799
Volcanic earthquakes at Pavlof Volcano correlated with the solid earth tide

S. R. McNutt
R. J. Beavan
Research17 Dec 1981
Nature

Volume: 294, P: 615-618
Lower Dentition of Kenyapithecus africanus

L. S. B. LEAKEY
Research02 Mar 1968
Nature

Volume: 217, P: 827-830
Poly(A) polymerase and poly(A)-specific mRNA binding protein are antigenically related

KATHLEEN M. ROSE
SAMSON T. JACOB
AJIT KUMAR
Research17 May 1979
Nature

Volume: 279, P: 260-262
Comparison of Zooplankton Biomass Determinations by Indian Ocean Standard Net, Juday Net and Clarke-Bumpus Sampler

D. J. TRANTER
Research22 Jun 1963
Nature

Volume: 198, P: 1179-1180
Histones in Development, Growth and Cancer

JAY S. ROTH
Research01 Aug 1965
Nature

Volume: 207, P: 599-601
In Vitro Stimulation of Amino-Acid Incorporation into Protein by Liver Nuclear RNA

S. H. BARONDES
C. W. DINGMAN
M. B. SPORN
Research13 Oct 1962
Nature

Volume: 196, P: 145-147
The role of climate and population change in global flood exposure and vulnerability

This study explores how climate change and population growth shape flood exposure. By 2100, exposure could rise from 1.6 to 1.9 billion people, driven 21% by climate change and 77% by population growth, with low-income and urban regions most affected.

Justin S. Rogers
Marco P. Maneta
Joshua P. Hacker
ResearchOpen Access03 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Ter, a Function which generates the Ends of the Mature λ Chromosome

S. MOUSSET
R. THOMAS
Research18 Jan 1969
Nature

Volume: 221, P: 242-244
Relationship Between Glutathione Stability and In Vivo Survival of Autologous, Deglycerolized, Resuspended Red Blood Cells

C. ROBERT VALERI
LINDA E. McCALLUM
Research06 Feb 1965
Nature

Volume: 205, P: 561-563
Histopathology-based protein multiplex generation using deep learning

HistoPlexer, a deep learning model, generates multiplexed protein expression maps from H&E images, capturing tumour–immune cell interactions. It outperforms baselines, enhances immune subtyping and survival prediction and offers a cost-effective tool for precision oncology.

Sonali Andani
Boqi Chen
Gunnar Rätsch
ResearchOpen Access04 Aug 2025
Nature Machine Intelligence

Volume: 7, P: 1292-1307
O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism

O-GlcNAc transferase (OGT) mediates antiviral host immune response. Here, the authors identify a catalytic activity-independent function of OGT in restraining influenza A virus replication by translocating to lipid droplets and limiting their accumulation following interaction with viral RNA.

Hong Dong
Chenxi Liang
Haitao Wen
ResearchOpen Access19 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease

Gene editing of hematopoietic stem and progenitor cells offers promise as a curative treatment for chronic granulomatous disease (CGD). Here, the authors develop a D10A Cas9n based gene editing strategy to treat CGD with no detectable off-target activity or chromosomal translocations.

Jonas Holst Wolff
Thomas Wisbech Skov
Jacob Giehm Mikkelsen
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-16

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