Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–50 of 4464 results
Advanced filters: Author: Sarah J Short Clear advanced filters
  • UCHL5 is a deubiquitinating enzyme that cleaves Lys-48-linked polyubiquitin chains. Here, the authors discover through in-vivo CRISPR-Cas9 screens that Uchl5 is involved in immune evasion and modulation of extracellular matrix deposition in head and neck squamous cell carcinoma.

    • Cong Fu
    • Robert Saddawi-Konefka
    • Robert T. Manguso
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • This study discovers human SERF2 as a key partner in stress granule formation by binding specific RNA G-quadruplexes. SERF2 and these RNAs provide a detailed structural model of protein-RNA interactions driving liquid-liquid phase separation in condensates.

    • Bikash R. Sahoo
    • Xiexiong Deng
    • James C. A. Bardwell
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22
  • Understanding the mechanisms behind clinical immunity to malaria is crucial for developing effective interventions. Here, the authors demonstrate that clinical immunity to Plasmodium vivax develops rapidly after a single controlled human malaria infection, reducing inflammatory responses and protecting against symptoms, while not significantly affecting parasite load.

    • Mimi M. Hou
    • Adam C. Harding
    • Angela M. Minassian
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Prime editing is a CRISPR methodology whose efficiency declines with distance from the target sequence. Here the authors demonstrate prime editing with prolonged editing window, proPE, which extends the editing distance, enabling the use of prime editing for therapeutic interventions.

    • Sarah Laura Krausz
    • Dorottya Anna Simon
    • Ervin Welker
    ResearchOpen Access
    Nature Catalysis
    P: 1-17
  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768
  • Advances have been made in thin-film piezoelectrics; however, the linearity of electric-field-induced strain with frequency and temperature still requires improvement. Here, by growing interlocked monoclinic and tetragonal polar nanoregions in (K,Na)NbO3 thin films, highly linear strains of up to 1.1% are reported at frequencies up to 105 Hz.

    • Yue-Yu-Shan Cheng
    • Xiaoming Shi
    • Jing-Feng Li
    Research
    Nature Materials
    P: 1-7
  • In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

    • Erin M. Buchanan
    • Kelly Cuccolo
    • Savannah C. Lewis
    Research
    Nature Human Behaviour
    P: 1-20
  • A post hoc analysis of a multicentre, randomised trial showed that prediabetes remission is possible without total weight loss—providing weight is distributed to subcutaneous deposits as opposed to visceral ones.

    • Arvid Sandforth
    • Elsa Vazquez Arreola
    • Reiner Jumpertz von Schwartzenberg
    ResearchOpen Access
    Nature Medicine
    P: 1-11
  • Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly synthesized proteins in diverse bacteria, including ESKAPE pathogens. The substrate polyspecificity of the aaRS mutants enables pulse-chase BONCAT and differential tagging of temporally distinct nascent proteomes in cells.

    • Conor Loynd
    • Soumya Jyoti Singha Roy
    • Abhishek Chatterjee
    Research
    Nature Chemical Biology
    P: 1-10
  • Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity and offering new perspectives for targeting lineage plasticity.

    • Abbie S. Ireland
    • Daniel A. Xie
    • Trudy G. Oliver
    ResearchOpen Access
    Nature
    P: 1-11
  • Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

    • Sarah Cherkaoui
    • Christina S. Turn
    • Raphael J. Morscher
    ResearchOpen Access
    Nature
    P: 1-9
  • ChatGPT provides a way of teaching people about climate change. This research reveals that conversations between climate sceptics and ChatGPT reduced climate scepticism, but these effects are modest, inconsistent across studies and prone to decay over time.

    • Matthew J. Hornsey
    • Samuel Pearson
    • Saphira Rekker
    Research
    Nature Climate Change
    P: 1-7
  • Iridoids are terpenoid metabolites found in thousands of plants. Using single-cell transcriptomics, the authors discovered an unexpected enzyme that has been neofunctionalized to catalyse the cyclization required to form the iridoid scaffold.

    • Maite Colinas
    • Chloée Tymen
    • Sarah E. O’Connor
    ResearchOpen Access
    Nature Plants
    P: 1-13
  • TCR-TRANSLATE, a deep learning framework adapting machine translation to immune design, demonstrates the successful generation of a functional T cell receptor sequence for a cancer epitope from the target sequence alone.

    • Dhuvarakesh Karthikeyan
    • Sarah N. Bennett
    • Alex Rubinsteyn
    ResearchOpen Access
    Nature Machine Intelligence
    Volume: 7, P: 1494-1509
  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477
  • Enfortumab vedotin (EV) is the current standard treatment for advanced bladder cancer, but resistance typically develops within a year, highlighting the need for new therapies. This study demonstrates that NECTIN4-targeting CAR T cells are effective against bladder cancer, including EV-resistant cells, and their potency can be further enhanced by using rosiglitazone to boost NECTIN4 expression.

    • Kevin Chang
    • Henry M. Delavan
    • Jonathan Chou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • A 12-month multicentre randomized clinical trial finds that replacing added sugar in foods and beverages with sweeteners and sweetness enhancers supports modest weight loss maintenance and alters gut microbiota composition, with no safety concerns identified.

    • Sarah H. Schmitz
    • Louis J. Aronne
    News & Views
    Nature Metabolism
    P: 1-2
  • Observed 730 Myr after the Big Bang, a little red dot is found to anchor an overdensity of eight galaxies and seems to be embedded in a massive host dark matter halo.

    • Jan-Torge Schindler
    • Joseph F. Hennawi
    • Riccardo Nanni
    ResearchOpen Access
    Nature Astronomy
    P: 1-13
  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103
  • This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy and lumbar puncture before and after treatment, is feasible and safe and enabled in-depth translational investigation of safusidenib treatment-induced changes in the tumor, including electrophysiological effects.

    • Katharine J. Drummond
    • Montana Spiteri
    • James R. Whittle
    ResearchOpen Access
    Nature Medicine
    P: 1-13
  • A combination of large-scale phylogenomic analysis, mouse lethality experiments and bacterial growth assays shows that gene loss in the putrescine utilization pathway has enhanced biofilm formation and transmission-related characteristics in the pandemic clone of a bacterial pathogen, Vibrio parahaemolyticus, promoting successive waves of global transmission events.

    • Chao Yang
    • Hongling Qiu
    • Daniel Falush
    Research
    Nature Ecology & Evolution
    P: 1-13
  • A summary of CAR T-cell engineering approaches, including functional screening methods, gene editing and delivery advances, and optimization of metabolic fitness.

    • Tham T. Nguyen
    • Patrick Ho
    • Maik Luu
    Reviews
    Nature Biomedical Engineering
    P: 1-22
  • Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which increases drag and prevents sinking. The pili also enrich microcystin and co-localize with iron-enriched extracellular matrix components, suggesting a vital role in bloom proliferation.

    • John G. Ricca
    • Holly A. Petersen
    • Fengbin Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Intermediate-coverage long-read sequencing in 1,019 diverse humans from the 1000 Genomes Project, representing 26 populations, enables the generation of comprehensive population-scale structural variant catalogues comprising common and rare alleles.

    • Siegfried Schloissnig
    • Samarendra Pani
    • Jan O. Korbel
    ResearchOpen Access
    Nature
    Volume: 644, P: 442-452
  • The role of the tumour microenvironment in the response to immune checkpoint inhibitors in metastatic melanoma remains poorly understood. Here, single cell profiling of metastatic melanoma samples identifies associations of the mature dendritic enriched in immunoregulatory molecules subtype with immunotherapy response.

    • Jiekun Yang
    • Cassia Wang
    • Manolis Kellis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

    • Glennis A. Logsdon
    • Peter Ebert
    • Tobias Marschall
    ResearchOpen Access
    Nature
    Volume: 644, P: 430-441
  • Genetic factors affecting Aedes aegypti susceptibility to dengue virus infection aren’t well studied. Here the authors show that a cytochrome P450 gene, typically linked to cuticle structure and insecticide resistance, influences dengue infection in Aedes aegypti.

    • Sarah H. Merkling
    • Elodie Couderc
    • Louis Lambrechts
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present DNAscent, an AI supported assay for DNA replication stress in human cells using Nanopore sequencing data.

    • Mathew J. K. Jones
    • Subash Kumar Rai
    • Michael A. Boemo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus-like particles to enable CRISPR-based epigenome editing for durable gene silencing in human cells.

    • Da Xu
    • Swen Besselink
    • James K. Nuñez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282
  • The ability to sequence oligonucleotides which consist entirely of artificial bases will facilitate their ongoing development and use. Here authors demonstrate de novo nanopore sequencing of DNA oligomers composed of “P” “Z” “S” and “B” bases with high sequencing accuracy.

    • Christopher A. Thomas
    • Henry Brinkerhoff
    • Andrew H. Laszlo
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Portable robots may assist subjects with disabilities. However, upper limb movements are hard to fine-tune. Here, the authors design a personalized AI intention detection model to decode user’s motion intention from IMU and compression sensors.

    • James Arnold
    • Prabhat Pathak
    • Conor J. Walsh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14