Nature Search

Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy

Ischemic injury and reperfusion injury collectively determine total infarct size, a major prognostic factor, following myocardial infarction (MI). Here, Lv et al. develop a hydrogel system utilizing different parts of Glycyrrhiza and apply plant-based photosynthetic mechanisms to treat both ischemic and reperfusion injury in MI.

YongBo Lv
Dashuai Zhu
Juan Wang
ResearchOpen Access18 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Foot-and-mouth disease virus antigenic landscape and reduced immunogenicity elucidated in atomic detail

Foot-and-mouth disease vaccine efficacy is reduced when full virion 146S dissociates into pentameric 12S subunit. Here, the authors elucidate the molecular basis of this compromised immunogenicity by comparing antigenicity, humoral immunogenicity and structures of 146S and 12S particles.

Haozhou Li
Pan Liu
Shiqi Sun
ResearchOpen Access10 Oct 2024
Nature Communications

Volume: 15, P: 1-13
Probing the anomalous Hall transport and magnetic reversal of quasi-two-dimensional antiferromagnet Co_1/3NbS₂

The quasi-two-dimensional antiferromagnet Co_1/3NbS₂ was recently reported to have a significant anomalous Hall effect. However, its controversial spin configuration has presented challenges in understanding the physical mechanism behind the AHE. Here, through an array of experimental probes, Gu, Peng and coauthors verify an intrinsic k-space Berry curvature as origin of the spontaneous Hall effect, and elucidate the domain-related magnetic reversal behaviours.

Pingfan Gu
Yuxuan Peng
Yu Ye
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-9
Disruption of TEX38 impairs sperm morphogenesis and the migration of sperm into the oviduct

TEX38, essential for sperm function in mice, interacts with ARRDC5 to regulate spermiogenesis, sperm migration and egg binding, suggesting that this interaction could be a target for male infertility treatment and contraception

Lu Yuan
Tingting Ge
Ying Zheng
ResearchOpen Access09 Aug 2025
Communications Biology

Volume: 8, P: 1-20
Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

Targeted delivery of mRNA using lipid nanoparticles is currently a challenge. Here, the authors examine the composition of LNPs and report changes to the standard formulation can address issues with liver accumulation and allow for increased tissue specific targeting.

Kexin Su
Lu Shi
Shuai Liu
ResearchOpen Access05 Jul 2024
Nature Communications

Volume: 15, P: 1-12
Greenhouse gas consequences of the China dual credit policy

China issued the Dual Credit policy to improve vehicle efficiency and accelerate new energy vehicle adoption. Here the authors show that the total Greenhouse gas emissions (GHGs) of the Chinese passenger vehicle fleet are expected to peak in 2032 and a significant reduction in GHG emissions is possible by optimizing the Dual Credit policy.

Xin He
Shiqi Ou
Michael Wang
ResearchOpen Access15 Oct 2020
Nature Communications

Volume: 11, P: 1-10
A decade of educational robotics: trends and SDG contributions

Shiqi Lu
Zalik Nuryana
Muhammad Nazir Alias
ResearchOpen Access20 Aug 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-16
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

Peixiang Zheng
Zhiqiang Hu
Daqian Xu
Research25 Apr 2025
Nature Chemical Biology

Volume: 21, P: 1420-1432
ADSL promotes autophagy and tumor growth through fumarate-mediated Beclin1 dimethylation

Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate lyase (ADSL) binds to Beclin1 upon lipid deprivation. ADSL-produced fumarate increases Beclin1 K117 dimethylation by inhibiting lysine demethylase 8 activity, resulting in disrupted binding of BCL-2 to Beclin1, enhanced autophagy and liver tumor growth.

Lei Wang
Runze Shi
Daqian Xu
Research29 Jan 2025
Nature Chemical Biology

Volume: 21, P: 894-905
Facilitating alkaline hydrogen evolution kinetics via interfacial modulation of hydrogen-bond networks by porous amine cages

Modulating the electrochemical interface at the atomic level is challenging due to the lack of efficient interfacial regulators. Here, the authors report using a porous amine cage as an interfacial modifier to enhance alkaline hydrogen evolution reaction kinetics by facilitating charge transfer.

Shiqi Zhou
Wei Cao
Jiayin Yuan
ResearchOpen Access21 Feb 2025
Nature Communications

Volume: 16, P: 1-12
Chiral medium-sized rings beyond central chirality

Chiral medium-sized rings (MSRs) beyond central chirality, with unique rigid–flexible features, show broad potential. This Review highlights progress in the enantioselective synthesis of axial, inherent and planar chiral MSRs, and it critically assesses key synthetic strategies.

Shiqi Jia
Yudong Hao
Yu Lan
Reviews14 Jul 2025
Nature Reviews Chemistry

Volume: 9, P: 617-633
Examining the role of compression in influencing AI-generated image authenticity

Xiaohan Fang
Peilin Chen
Shiqi Wang
ResearchOpen Access09 Apr 2025
Scientific Reports

Volume: 15, P: 1-19
Warm metalworking for plastic manufacturing in brittle semiconductors

The authors show that bulk brittle semiconductors can be plastically manufactured like metals by warm metalworking into free-standing, metre-scale films with decent physical properties.

Zhiqiang Gao
Shiqi Yang
Xun Shi
Research28 Apr 2025
Nature Materials

Volume: 24, P: 1538-1544
An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs

Orally administrable and glucose-responsive worm-like micelles have been developed to protect insulin in the gastrointestinal tract, enhance its intestinal absorption, accumulate in the liver and enable efficient and safe blood-glucose management.

Kangfan Ji
Xiangqian Wei
Zhen Gu
Research02 Sept 2024
Nature Nanotechnology

Volume: 19, P: 1880-1891
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Type 2 diabetes (T2D) is characterized by pancreatic beta-cell failure. Here, the authors show restoration of Phosphatidylinositol transfer protein alpha (PITPNA), a mediator of PtdIns-4-phosphate synthesis in the trans-Golgi network, in human T2D islets reverses impaired insulin granule maturation, exocytosis, and ER stress.

Yu-Te Yeh
Chandan Sona
Matthew N. Poy
ResearchOpen Access17 Jul 2023
Nature Communications

Volume: 14, P: 1-19
A deep learning approach to stress recognition through multimodal physiological signal image transformation

Shiqi Yang
Yuan Gao
Zhushanying Zhang
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Machine learning model to project the impact of COVID-19 on US motor gasoline demand

The COVID 19 pandemic and consequent lockdown has had a substantial impact on mobility and therefore fuel demand and it is not clear when demand will recover. Ou et al. use a machine learning model that integrates health recovery scenarios to project the near-term future of gasoline demand.

Shiqi Ou
Xin He
Jessey Bouchard
Research17 Jul 2020
Nature Energy

Volume: 5, P: 666-673
Identification of recurrent USP48 and BRAF mutations in Cushing’s disease

In this study the authors report USP48 and BRAF are frequently mutated in USP8 wild-type corticotroph adenomas, and cause Cushing’s disease mainly through promoting the promoter activity of POMC. Inhibition of BRAF may be a promising therapeutic strategy for the treatment of patients with BRAF-mutated corticotroph adenomas.

Jianhua Chen
Xuemin Jian
Yongyong Shi
ResearchOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-9
Simultaneously achieving giant piezoelectricity and record coercive field enhancement in relaxor-based ferroelectric crystals

High-drive electromechanical applications require ferroelectrics accounting for a large coercive field and high piezoelectricity simultaneously but it is still a challenge. Here, the authors demonstrate it in a relaxor-based ferroelectric crystal.

Liya Yang
Houbing Huang
Gang Liu
ResearchOpen Access04 May 2022
Nature Communications

Volume: 13, P: 1-10
Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether

The recent advances in accelerated polymerization of N-carboxyanhydrides (NCAs) enrich the toolbox to prepare well-defined polypeptide materials. Here the authors use crown ethers to catalyze the polymerization of NCA initiated by conventional primary amine initiators in solvents with low polarity and low hydrogen-bonding ability.

Yingchun Xia
Ziyuan Song
Jianjun Cheng
ResearchOpen Access02 Feb 2021
Nature Communications

Volume: 12, P: 1-8
Author Correction: Identification of recurrent USP48 and BRAF mutations in Cushing’s disease

Jianhua Chen
Xuemin Jian
Yongyong Shi
Amendments and CorrectionsOpen Access23 Aug 2023
Nature Communications

Volume: 14, P: 1
A single-cell transcriptomic landscape of the lungs of patients with COVID-19

Wang et al. analysed post-mortem samples of the lungs of patients with COVID-19 by bulk and single-nucleus RNA sequencing along with proteomics and discovered lung senescence as a feature of COVID-19 pathology.

Si Wang
Xiaohong Yao
Xiu-Wu Bian
Research07 Dec 2021
Nature Cell Biology

Volume: 23, P: 1314-1328
Author Correction: Machine learning model to project the impact of COVID-19 on US motor gasoline demand

Shiqi Ou
Xin He
Jessey Bouchard
Amendments and Corrections08 Oct 2020
Nature Energy

Volume: 5, P: 1051-1052
Biparametric MRI-based radiomics for noninvastive discrimination of benign prostatic hyperplasia nodules (BPH) and prostate cancer nodules: a bio-centric retrospective cohort study

Yangbai Lu
Runqiang Yuan
Yongxin Zhang
ResearchOpen Access03 Jan 2025
Scientific Reports

Volume: 15, P: 1-12
CD7 targeted “off-the-shelf” CAR-T demonstrates robust in vivo expansion and high efficacy in the treatment of patients with relapsed and refractory T cell malignancies

Shiqi Li
Xinxin Wang
Sanbin Wang
Research12 Sept 2023
Leukemia

Volume: 37, P: 2176-2186
Polybutadiene structural effects on dynamic wetting

Sahson D. Raissi
Marc A. Magaña
Joseph Kalman
ResearchOpen Access11 Oct 2024
npj Advanced Manufacturing

Volume: 1, P: 1-9
Functional tissue-engineered bone-like graft made of a fibrin scaffold and TG2 gene-modified EMSCs for bone defect repair

In this study, ectomesenchymal stem cells (EMSCs) were modified with the transglutaminase 2 (TG2) genes and tested for their ability to enhance bone regeneration on fibrin scaffold. In vitro analyses revealed that osteogenic differentiation of the EMSCs on the fibrin scaffold was promoted by TG2 expression. Transplanting fibrin scaffold loaded with TG2 gene-modified EMSC into bone defects on rat skull induced significantly faster bone regeneration compared with non-genetically modified EMSC.

Wentao Shi
Yunduan Que
Naiyan Lu
ResearchOpen Access26 Mar 2021
NPG Asia Materials

Volume: 13, P: 1-18
Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma

Yao Zhao, Yongyong Shi and colleagues performed a genome-wide association study on sporadic pituitary adenoma in the Han Chinese population. They identify three new susceptibility loci.

Zhao Ye
Zhiqiang Li
Yao Zhao
Research01 Jun 2015
Nature Genetics

Volume: 47, P: 793-797
Computable general equilibrium analysis of neutral carbon trading scheme and revenue recycling impacts on income distribution in China

Lingli Qi
Lei Zhao
Yishuai Ren
ResearchOpen Access18 Jan 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-12
Prognostic value and underlying mechanism of autophagy-related genes in bladder cancer

Shiyuan Peng
Shanjin Ma
Weijun Qin
ResearchOpen Access09 Feb 2022
Scientific Reports

Volume: 12, P: 1-12
Multi-analytical investigation into the materials and techniques of paintings on Northern Wei Dynasty (398–494 CE) coffin planks excavated from Shanxi, China

Zhiyong Guo
Shiqi Cai
Liu Liu
ResearchOpen Access11 Oct 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-11
Topologically tuned terahertz confinement in a nonlinear photonic chip

Jiayi Wang
Shiqi Xia
Zhigang Chen
ResearchOpen Access23 May 2022
Light: Science & Applications

Volume: 11, P: 1-8
Cell-free adipose tissue extracts as a novel treatment for rosacea by downregulating TRPV1

Liuyi Zhou
Lulu Chen
Tingting Jin
ResearchOpen Access18 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Regular exercise ameliorates high-fat diet-induced depressive-like behaviors by activating hippocampal neuronal autophagy and enhancing synaptic plasticity

Jialin Wu
Huachong Xu
Xiaoyin Chen
ResearchOpen Access10 Oct 2024
Cell Death & Disease

Volume: 15, P: 1-13
Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Bilan Wang
Shiqi Hu
Xiang Gao
ReviewsOpen Access12 Aug 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-65
BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance

Canfeng Zhang
Liping Chen
Yan Liu
ResearchOpen Access02 Feb 2023
Oncogene

Volume: 42, P: 967-979
Design of plasmonic Ag-TiO₂/H₃PW₁₂O₄₀ composite film with enhanced sunlight photocatalytic activity towards o-chlorophenol degradation

Nan Lu
Yaqi Wang
Xing Yuan
ResearchOpen Access11 Dec 2017
Scientific Reports

Volume: 7, P: 1-17
A direct spino-cortical circuit bypassing the thalamus modulates nociception

Bing Cai
Dan Wu
Xu Zhang
ResearchOpen Access13 Jun 2023
Cell Research

Volume: 33, P: 775-789
Insm1 regulates mTEC development and immune tolerance

Weihua Tao
Zhihuan Ye
Shiqi Jia
Research21 Nov 2023
Cellular & Molecular Immunology

Volume: 20, P: 1472-1486
Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer

Shiqi Ma
Lu Zhang
Bangrong Cao
Research09 Mar 2021
Oncogene

Volume: 40, P: 2596-2609
An Oligocene giant rhino provides insights into Paraceratherium evolution

Deng et al. report a new species of giant rhino, Paraceratherium linxiaense, from specimens of the upper Oligocene Jiaozigou Formation in China with an age of 26.5 Ma. Morphological analysis of the completely preserved skull with articulated mandible and atlas reveals a high level of specialization and the formation of a clade with P. lepidum with close ties to P. bugtiense.

Tao Deng
Xiaokang Lu
Shanqin Chen
ResearchOpen Access17 Jun 2021
Communications Biology

Volume: 4, P: 1-10
Multi-scale guided feature extraction and classification algorithm for hyperspectral images

Shiqi Huang
Ying Lu
Ke Sun
ResearchOpen Access15 Sept 2021
Scientific Reports

Volume: 11, P: 1-13
Metoprolol prevents chronic obstructive sleep apnea-induced atrial fibrillation by inhibiting structural, sympathetic nervous and metabolic remodeling of the atria

Li Sun
Sen Yan
Yue Li
ResearchOpen Access02 Nov 2017
Scientific Reports

Volume: 7, P: 1-13
Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA

Pengliang Chi
Xiang Wang
Dong Deng
Correspondence28 Jun 2024
Cell Research

Volume: 34, P: 743-745
Signaling pathways and targeted therapy for myocardial infarction

Qing Zhang
Lu Wang
Quan Wei
ReviewsOpen Access10 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-38
DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71

Shiqi Xie
Kai Wang
Bing Sun
Correspondence12 Jul 2011
Cell Research

Volume: 21, P: 1271-1275

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