Nature Search

Analysis wheat wild relatives Thinopyrum intermedium and Roegneria kamoji genomes reveal different polyploid evolution paths

Thinopyrum intermedium and Roegneria kamoji are wheat relatives commonly used in distant hybridization breeding program. Here, the authors report the genome assemblies of the two species and reveal their phylogenetic relationship and genome compositions.

Silong Sun
Naixiu Che
Lingrang Kong
ResearchOpen Access18 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger

The ClC-3 chloride/proton exchanger is both physiologically and pathologically critical. Here, authors determined the structures of wildtype and disease-causing I607T mutant of ClC-3 in the apo and adenine nucleotides bounded states, which lays the structural basis of adenine nucleotides regulation in ClC-3.

Yangzhuoqun Wan
Shuangshuang Guo
Fan Yang
ResearchOpen Access06 Aug 2024
Nature Communications

Volume: 15, P: 1-13
Author Correction: Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb

Shuangshuang Ma
Min Chen
Hailan Hu
Amendments and CorrectionsOpen Access06 Nov 2023
Nature

Volume: 623, P: E11
The analysis of learning investment effect for artificial intelligence English translation model based on deep neural network

Yan Zhang
Shuangshuang Lyu
ResearchOpen Access19 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Bridging the knowledge-action divide: environmental awareness and low-carbon behaviors of Chinese university students

Shali Wang
William Mbanyele
Shuangshuang Fan
ResearchOpen Access01 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-19
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation

The mechanisms regulating protein lactylation, a post-translational modification, are not fully understood. Here, the authors discover that Histone deacetylase 6 (HDAC6) acts as the primary lactyltransferase for α-tubulin, regulating microtubule dynamics.

Shuangshuang Sun
Zhe Xu
Lei Li
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-14
Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb

The discrepancy between the short half-life of ketamine and its long-lasting effects is due to ketamine being trapped in NMDA receptors, and its release depends on neural activity in the lateral habenula.

Shuangshuang Ma
Min Chen
Hailan Hu
ResearchOpen Access18 Oct 2023
Nature

Volume: 622, P: 802-809
Estrogen receptor beta in lateral habenula mediates antidepressant effects of estrogen in postpartum-hormone-withdrawal-induced depression

Chenchi Duan
Shuangshuang Ma
He-Feng Huang
ResearchOpen Access05 Sept 2025
Molecular Psychiatry

P: 1-13
Cloning of wheat keto-acyl thiolase 2B reveals a role of jasmonic acid in grain weight determination

It has been reported that several phytohormones are involved in the regulation of grain weight, but the role of jasmonic acids (JA) remains elusive. Here, via bulked segregant analysis (BSA)-based cloning, the authors show keto-acyl thiolase 2B involved in β-oxidation during JA synthesis is a positive regulator of wheat grain weight.

Yun Chen
Yan Yan
Jin-Ying Gou
ResearchOpen Access08 Dec 2020
Nature Communications

Volume: 11, P: 1-11
Neutrophil activation and clonal CAR-T re-expansion underpinning cytokine release syndrome during ciltacabtagene autoleucel therapy in multiple myeloma

Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment of hematological cancers, however, immune related adverse effects, such as cytokine release syndrome (CRS) may limit therapeutic success. Here authors show that CRS is preceded by a latent stage, characterized by neutrophil activation and distinct cytokine signatures, and that CAR-T re-expansion might associate with severe CRS.

Shuangshuang Yang
Jie Xu
Sai-Juan Chen
ResearchOpen Access08 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Perovskite/silicon tandem solar cells with bilayer interface passivation

A power conversion efficiency of 33.89% is achieved in perovskite/silicon tandem solar cells by using a bilayer passivation strategy to enhance electron extraction and suppress recombination.

Jiang Liu
Yongcai He
Xixiang Xu
Research05 Sept 2024
Nature

Volume: 635, P: 596-603
Establishment of human gastrulating stem cells with the capacity of stable differentiation into multiple gastrulating cell types

Mingqian Huang
Mengqi Chen
Jiahao Sha
Research06 Aug 2025
Cell Research

Volume: 35, P: 719-734
Pollen tube emergence is mediated by ovary-expressed ALCATRAZ in cucumber

Pollen tube growth is guided towards ovules. Here the authors show that a bHLH transcriptional factor CsALC functions in pollen tube emergence towards ovules to regulate female fertility in cucumber and promotes the expression of two rapid alkalinization factors CsRALF4/19 in the ovary.

Zhihua Cheng
Xiaofeng Liu
Xiaolan Zhang
ResearchOpen Access17 Jan 2023
Nature Communications

Volume: 14, P: 1-15
Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here, Jiang et al. show that infected macrophages exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates that promote intracellular replication and virulence of S. Typhimurium.

Lingyan Jiang
Peisheng Wang
Lei Wang
ResearchOpen Access09 Feb 2021
Nature Communications

Volume: 12, P: 1-18
H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots

Polycomb Group complexes maintain gene repression through the incorporation of H2AK121ub and H3K27me3. Here, the authors show that H2AK121ub marks less accessible but transcriptionally permissive chromatin, while H3K27me3 enforces a repressed transcriptionally less-permissive state.

Xiaochang Yin
Francisco J. Romero-Campero
Yue Zhou
ResearchOpen Access12 Jan 2021
Nature Communications

Volume: 12, P: 1-12
Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

The rapid antidepressant activity of ketamine results from reversal of increased burst firing and synchronization in the lateral habenula in rat and mouse models of depression.

Yan Yang
Yihui Cui
Hailan Hu
Research15 Feb 2018
Nature

Volume: 554, P: 317-322
A high-performance hydroxide exchange membrane enabled by Cu²⁺-crosslinked chitosan

A Cu²⁺-crosslinked chitosan material with unique 1 nm hexagonal nanochannels is synthesized and applied as a high-performance and alkaline-stable hydroxide exchange membrane.

Meiling Wu
Xin Zhang
Liangbing Hu
Research18 Apr 2022
Nature Nanotechnology

Volume: 17, P: 629-636
TAZ sensitizes EGFR wild-type non-small-cell lung cancer to gefitinib by promoting amphiregulin transcription

Weiwei Yuan
Wei Xu
Jianqing Wu
ResearchOpen Access25 Mar 2019
Cell Death & Disease

Volume: 10, P: 1-11
CCL14 serves as a novel prognostic factor and tumor suppressor of HCC by modulating cell cycle and promoting apoptosis

Mengxuan Zhu
Weiyue Xu
Chunmin Liang
ResearchOpen Access22 Oct 2019
Cell Death & Disease

Volume: 10, P: 1-10
BHX Inhibits the Wnt Signaling Pathway by Suppressing β-catenin Transcription in the Nucleus

Fengxia Ding
Meisa Wang
Zhao Yan
ResearchOpen Access02 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

Increased expression of the potassium channel Kir4.1 on astrocytes in the lateral habenula drives neuronal bursting in rodent models of depression.

Yihui Cui
Yan Yang
Hailan Hu
Research15 Feb 2018
Nature

Volume: 554, P: 323-327
Single cell transcriptome profiling of immune tissues from germ-free and specific pathogen-free piglet

Jinwei Zhang
Chuang Tang
Liangpeng Ge
ResearchOpen Access18 Apr 2025
Scientific Data

Volume: 12, P: 1-10
Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates

Improved glycemic control after transplantation of human pluripotent stem-cell-derived islets for diabetes treatment in non-human primates.

Yuanyuan Du
Zhen Liang
Hongkui Deng
Research03 Feb 2022
Nature Medicine

Volume: 28, P: 272-282
Influence of Roasting Condition on Flavor Profile of Sunflower Seeds: A flavoromics approach

Shuangshuang Guo
Kriskamol Na Jom
Yan Ge
ResearchOpen Access05 Aug 2019
Scientific Reports

Volume: 9, P: 1-10
IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway

Rui Shi
Rong Zhao
Hongbo Wang
ResearchOpen Access22 May 2024
Cancer Gene Therapy

Volume: 31, P: 1221-1236
Transcriptomic analysis reveals the roles of microtubule-related genes and transcription factors in fruit length regulation in cucumber (Cucumis sativus L.)

Li Jiang
Shuangshuang Yan
Xiaolan Zhang
ResearchOpen Access26 Jan 2015
Scientific Reports

Volume: 5, P: 1-11
Genome-wide association study of 29 morphological traits in Aegilops tauschii

Yaxi Liu
Lang Wang
Youliang Zheng
ResearchOpen Access27 Oct 2015
Scientific Reports

Volume: 5, P: 1-12
Role of S-palmitoylation in digestive system diseases

Hanqing Li
Qiuxiang Yuan
Xingsi Qi
ReviewsOpen Access18 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-18
BHX, a novel pyrazoline derivative, inhibits breast cancer cell invasion by reversing the epithelial-mesenchymal transition and down-regulating Wnt/β-catenin signalling

Hanmei Bao
Qing Zhang
Zhao Yan
ResearchOpen Access22 Aug 2017
Scientific Reports

Volume: 7, P: 1-10
Different cucumber CsYUC genes regulate response to abiotic stresses and flower development

Shuangshuang Yan
Gen Che
Xiaolan Zhang
ResearchOpen Access09 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging

Zheyi Dong
Xiaofei Wang
Xiangmei Chen
ResearchOpen Access24 Jan 2025
npj Digital Medicine

Volume: 8, P: 1-14
Combination of Lactobacillus fermentum NS9 and aronia anthocyanidin extract alleviates sodium iodate-induced retina degeneration

Yan Xing
Shan Liang
Feng Jin
ResearchOpen Access24 May 2023
Scientific Reports

Volume: 13, P: 1-12
The role of the S100A8/S100A9 in gastric tumor progression

Shuangshuang Fang
Sijing Du
Wei Wei
ResearchOpen Access09 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model

Jiaqi Liu
Nan Wu
Guixing Qiu
Research14 Jan 2019
Genetics in Medicine

Volume: 21, P: 1548-1558
The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

Shuangshuang Wu
Dongyan Huang
Zuyue Sun
ResearchOpen Access04 Aug 2020
Scientific Reports

Volume: 10, P: 1-16
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction

Ying Zhang
Lihua Sun
Baofeng Yang
ResearchOpen Access01 Mar 2016
Scientific Reports

Volume: 6, P: 1-11
Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer

In this work, a new theranostics based on GdW10@BSA NCs with ultrasmall size, but versatile properties, were fabricated, which possesses not only significant CT/ MR imaging signal enhancement but also remarkable photothermal therapy (PTT)/radiotherapy (RT) therapeutic effects for tumor. Therefore, our work may open an avenue in developing other POM-based multifunctional nanomedicines with better therapeutic outcome and fewer side effects.

Yuan Yong
Liangjun Zhou
Yuliang Zhao
ResearchOpen Access27 May 2016
NPG Asia Materials

Volume: 8, P: e273

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