Editing and class switch recombination, two processes in the development of B cells, are thought to be separated in the bone marrow and spleen, respectively. Errors in either of these processes can initiate chromosomal translocations, including those of B cell lymphomas, but collaboration between them may also initiate translocations. Here it is shown that both editing and class switch recombination can occur in peripheral B cells, offering insights into the origin of the translocations observed in certain B cell lymphomas.
- Jing H. Wang
- Monica Gostissa
- Frederick W. Alt
