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Degradation of carbon-backbone polymers, which make up most plastics, remains a formidable challenge owing to their strong and inert main-chain C–C bonds. Now it has been shown that aromatization-driven C–C bond cleavage is a viable strategy to endow full degradability into carbon backbones under mild conditions.

By utilizing an AI-accelerated silicon photonic slow-light technology, researchers demonstrate a record 400 Gbps/λ PAM-4 transmission based on pure silicon modulators, paving the way for next-generation optical interconnects in computing centers.

Electrochromic materials are promising for smart windows, though challenges such as slow switching, poor stability, and high power consumption must be addressed. Here, the authors report a dual-cathode electrochromic energy storage device that enhances conductivity and stability.

Inflammatory conditions often affect colorectal cancer patients, and their effect on their ongoing treatment is a pressing medical question. Here authors show that inflammation interferes with local anti-tumour immune response and inhibits response to immune checkpoint blockade therapy via immunosuppressive neutrophil leukocytes.

A 35.7-kb inversion in the DG1 promoter increased DG1 expression in sorghum, inducing double-grain spikelets by restoring fertility to the lower floret. The superior DG1 allele boosted grain number and yield, providing insights for high-yield breeding.

The severe fever with thrombocytopenia syndrome virus (SFTSV, officially named Dabie bandavirus) is a tick-borne human-infecting bunyavirus. Here, the authors report the cryo-EM structure of SFTSV virion, and discuss the mechanisms of viral assembly, membrane fusion and antibody neutralization.

An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment of myeloid-derived suppressor cells and reinvigorating CD8⁺ T cell activation.

Combining hydrogen-atom transfer for prochiral radical formation, organic-dye-modulated single-electron transfer and an engineered thiamine-dependent enzyme, a photobiocatalytic platform is developed for assembling C(sp²)–C(sp³) bonds via benzylic C(sp³)–H and aldehyde C(sp²)–H oxidative cross-coupling under mild conditions.

This study identifies BAG3 as a conserved immune regulator in plants and demonstrates that its cleavage by metacaspase 4 triggers cell death and antiviral defense, offering a potential strategy for engineering virus-resistant crops.

Scattering in the archetypal oxide SrRuO₃ is shown to enhance orbital currents. This counter-intuitive effect establishes a transformative paradigm for energy-efficient spintronic devices.

Ionic-junction devices are difficult to integrate with fiber-shaped tissues like nerves and muscles for applications in implantable bioelectronics due to their large size and bulk structure. Authors realize here easy to implant fiber-shaped iontronics through an integrated opposite charge grafting process, enabling the construction of ionic logic gates and artificial neural pathways.

Nanometric distance metrology is needed in application spanning from nanotechnology to largescale manufacturing. Here, authors used a mutually coherent soliton pulse pair generated in a single microresonator for dual-comb ranging (DCR), achieving record 1-nm precision and reducing power requirements by over 60 dB.

The role of stem Leydig cells in restoration of male fertility after acute injury is not clear. In an acute injury mouse model of testicular torsion, the authors show that Stem Leydig cells can restore testicular immunological homeostasis by mitochondria transfer to macrophages in a TRPM7-mediated manner.

The tumor microenvironment influences the metabolic behavior of cancer cells. Here, using Dual Ribosome Profiling, the authors uncover a cancer-stromal cell interaction under glucose starvation that increases nutrient availability, in response to type I interferon. In addition, in vivo, immune checkpoint blockade triggers metabolic constraints in T cells, reducing their proliferation and cytotoxicity.

In this work, the authors implement a crystalline rank-2 chiral modes by employing non-Hermitian dynamics. They showed the momentum-resolved dynamics and non-Hermitian skin effect associated with the rank-2 chirality both theoretically and experimentally.

The discovery of highly enantioselective catalysts is challenging due to the complex multidimensional chemical space of asymmetric catalysis and inefficient screening methods. Here, the authors report a general strategy for ultra-high-throughput mapping of the chemical space of asymmetric catalysis with a combination of ion mobility-mass spectrometry and a diastereoisomerization strategy and identify enantioselective primary amine organocatalysts using this method.

Chiral antiferromagnets, such as Mn3Pt, host a variety of transport phenomena arising due to the chiral arrangement of the spins. Herein, the authors find two contributions to the anomalous hall effect in Mn3Pt, and through comparison with other chiral antiferromagnets develop a universal scaling law for the anomalous hall effect in chiral antiferromagnets.

The H9N2 avian influenza viruses (AIVs) remain dominant in live poultry markets in China, and H9N2 AIVs with HA-Q226L, PB2-V/K627 and NP-N52 mutations can be transmitted between guinea pigs and between ferrets via direct contact and respiratory droplet.

Targeted delivery to the lower regions of the lung is necessary for the treatment of parenchymal lung injury and disease but is challenging. Here, the authors develop an mRNA delivery platform to treat acute lung injury in mice and demonstrate that it can reach the lower regions of the lung.

In the phase 3 EVER-132-002 trial, patients with HR⁺HER2⁻ metastatic breast cancer from Asia were treated with the Trop-2-directed antibody–drug conjugate sacituzumab govitecan or chemotherapy, and those receiving sacituzumab govitecan experienced prolonged progression-free survival compared with patients treated with chemotherapy.

Producing high-quality 3D refractive index maps from 2D intensity-only measurements is a long-standing objective in computational microscopy, with many applications involving the visualization of cellular and subcellular structures. A new method can reconstruct high-contrast and artefact-free images by employing the neural fields technique, which can learn a continuous 3D representation using a neural network that maps spatial coordinates to the refractive index values.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

The authors here present the diurnal tides of dust within the southern Martian atmosphere. The dust tides imply a fast meridional exchange of heat and materials on Mars and allow water content near the summer pole to be rapidly transported to the middle latitudes in the nighttime which is then lifted by daytime deep convection.

Plasmons polaritons, or collective excitations of electrons and electromagnetic fields, have been rarely studied in layered correlated materials. Shiravi et al. report hyperbolic plasmon polaritons in thin flakes of the Kagome metal CsV₃Sb₅ and discuss correlation effects on their formation and tunability.

Studying the electronic structures and spin transitions of synthetic heme analogs is crucial to advancing our understanding of heme enzyme mechanisms. Here the authors show that a Co(II) porphyrin complex undergoes an unexpected spin state transition upon deprotonation of its axial imidazole ligand.

Modulation of surface properties and functions can be achieved through covalent and non-covalent molecular binding, but the lack of responsiveness and requirement for specific binding groups makes spatiotemporal control challenging. Now, it has been shown that adaptive insertion of a hydrophobic anchor into a poly(ethylene glycol) host is an effective non-covalent binding strategy for programmable surface functionalization.

Topological photonic structures enable robust light transport but face coupling challenges. The authors demonstrate transverse spin matching governs the coupling between the topological waveguide and waveguide, achieving 96.3% theoretical and 94.2% experimental transmission efficiencies.

Applications of Cu catalysts at high-temperature is a long-sought goal but limited by their serious deactivation due to low copper’s Tammann temperature. Here, the authors introduce an encapsulation layer to improve thermal stability at 800 °C by reconstructing electronic structure of Cu atoms.

Predictive methods for gastric cancer to try and differentiate between potential treatment response are required. Here the authors use a multiplexed immunohistochemistry method to propose the proximity of tumour infiltrating immune cells as an indicator of likely therapeutic response.

The development of optical information processing depends on the demonstration of silicon-based all-optical circuit components. Here, the authors show a monolithic pulse compressor, compatible with current electronic processing technologies, which is able to function at low power input.

van der Waals materials are usually characterized by a significant out-of-plane optical anisotropy, but in-plane birefringence is also necessary for photonics applications. Here, the authors report the presence of broadband optical anisotropy in a layered material, Ta₂NiS₅, showing in-plane birefringence of ~2 and ~0.5 in the visible and mid-infrared range, respectively.

Intrusive memories are a hallmark symptom of post-traumatic stress disorder (PTSD). This preregistered meta-analysis investigates how experimental techniques alter intrusive memory frequency, intrusion-related distress and symptoms arising from lab-analogue trauma exposure.

RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.

Allylic amination of unactivated alkenes with aliphatic amines is a long-standing synthetic challenge in organic chemistry. This is now accomplished in an oxidant-free, site-selective process by using a combination of a photocatalyst and cobalt complex for the coupling of olefins and alkyl amines with hydrogen evolution.

The crystal structure of LptB2FG, an ABC transporter that extracts LPS from the bacterial inner membrane and transports it to the outer membrane, indicates a transport mechanism distinct from classical ABC transporters.

Gastric cancer can vary in tumour stage and immune cell involvement. Here the authors compare gene expression in immune cell types from the blood and the tumour site from GC patients using single cell and TCR sequencing and show that IL17⁺CD8⁺ T cells have a phenotype related to that seen with exhausted cells.

Phosphorylation of ACSL4 by mitochondria-located metabolic kinase PCK2 is critical to regulating ferroptosis-associated phospholipid remodeling in tumor-repopulating cells that are resistant to chemotherapy and radiotherapy.

Hyperbolic exciton polaritons (HEPs) are anisotropic light-matter excitations with promising applications, but their steady-state observation is challenging. Here, the authors report experimental evidence of HEPs in a van der Waals magnet, CrSBr, via cryogenic infrared near-field microscopy.

Biochemical and structural approaches define how the chaperone TAPBPR interacts with MR1 molecules, including empty and ligand-loaded MR1, and facilitates presentation of metabolite-derived antigen ligands by MR1 complexes.

Soliton molecules have been observed only in the temporal dimension for classical wave optical systems. Here, the authors use scanning tunneling spectroscopy to identify a topological soliton molecule in real space in a quasi-1D charge-ordered phase of indium atomic wires.

The outer membrane (OM) of Gram-negative bacteria is an asymmetric bilayer, with phospholipids in the inner leaflet. Here the authors show that a reduction in OM proteins and the subsequent mislocalization of phospholipids weaken the OM and alter growth rate and cell shape, emphasizing the role of OM proteins in OM stiffness and cell shape.

Emergence of the Omicron BA.1/2 SARS-CoV-2 subvariants led to a wave of infection South Africa. Here, the authors use serological data from a prospective household study to characterise infection rates in the context of diverse immune histories following vaccination and exposure to different variants.

Climate-driven warming affects the reproduction of oviparous ectotherms. Here, authors identify and characterize a VtgR-mediated heat protection mechanism for oocyte development in both mud crabs and zebrafish.

The authors use angle-resolved photoemission spectroscopy (ARPES) and scanning tunneling microscopy (STM) to study the charge density wave (CDW) in the kagome material ScV₆Sn₆. The ARPES data shows minimal changes to the electronic structure in the CDW state, while STM quasiparticle interference measurements imply a strong reconstruction of the electronic structure in the CDW state.

In this study, the authors report a potent neutralizing antibody targeting a conserved epitope within RSV pre-F that shows higher antiviral activity against both RSV-A and -B subgroups in vitro and in small animal models than FDA-approved prophylactic agents.

Adaptive wireless communication over an unprecedented frequency range spanning over 100 GHz can be achieved by a thin-film lithium niobate photonic wireless system, which can process a large flux of information at high speed.

The authors report the inverse effect of chiral-induced spin selectivity in an organic material.