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Showing 1–50 of 1004 results
Advanced filters: Author: T. Z. Guo Clear advanced filters
  • CRISPR/Cas13a is a promising tool for RNA detection but often requires pre-amplification steps. Here, the authors present CRISPR Anti-tag Mediated Room-temperature RNA Detection (CARRD) using a single Cas13a and an anti-tag hairpin for sensitive HIV and HCV testing without pre-amplification.

    • Jeong Moon
    • Jiongyu Zhang
    • Changchun Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

    • Daya Guo
    • Dejian Yang
    • Zhen Zhang
    ResearchOpen Access
    Nature
    Volume: 645, P: 633-638
  • Resolution of G4s has been suggested to be required for efficient DNA replication. Here, the authors show that the nuclease DNA2 and the DNA repair complex MutSα (MSH2-MSH6) are required to remove G4 stabilized by environmental compounds to allow efficient telomere replication.

    • Anthony Fernandez
    • Tingting Zhou
    • Binghui Shen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Multi-omics can be used to characterise tumour and immune cell populations. Here the authors use multi-omics to characterise CLL blood and tissue samples and use prediction models for CLL TCR specificity and implicate interactions between galectin-9 and TIM3 as involved in CLL immune escape and propose galectin-9 as a possible immunotherapy target.

    • L. Llaó-Cid
    • JKL Wong
    • M. Seiffert
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22
  • Here the authors use a range of approaches to examine the interplay between genetic variants linked to risk for polygenic skin diseases and transcription factors (TFs) important for skin homeostasis. The findings implicate dysregulated binding of specific TF families in risk for diverse skin diseases.

    • Douglas F. Porter
    • Robin M. Meyers
    • Paul A. Khavari
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-28
  • Current bacterial sgRNA activity models struggle with accurate predictions and generalizations. Here the authors report crisprHAL, a machine learning architecture that can be trained on existing datasets, and shows good sgRNA activity prediction accuracy can generalize predictions to different bacteria.

    • Dalton T. Ham
    • Tyler S. Browne
    • David R. Edgell
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • Alkaline-earth phenoxides show promise as optical cycling centres; however, their properties when connected to larger structures is unclear. Now it has been shown that their optical cycling remains efficient despite increasing molecular complexity, enabling the scaling of laser-coolable molecules toward larger structures and surface-bound quantum systems.

    • Guanming Lao
    • Taras Khvorost
    • Wesley C. Campbell
    Research
    Nature Chemistry
    P: 1-8
  • Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

    • Boya Guo
    • Yanwei Cai
    • Burcu F. Darst
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Cationic polymers conventionally kill bacteria via physical membrane disruptions. Here, the authors report the development of carbon acid cationic polymers that show potent activity against multidrug-resistant strains in murine infection models and prevent bovine mastitis, and present evidence that these polymers translocate across bacterial membrane aided by N-heterocyclic carbene.

    • Chong Hui Koh
    • Mallikharjuna Rao Lambu
    • Mary B. Chan-Park
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Transcriptomic and proteomic analyses of cells and matrix along the fibrotic trajectory in mouse lung identified PI16 as an anti-fibrotic factor with potential for therapeutic application in humans.

    • Jason L. Guo
    • Michelle Griffin
    • Michael T. Longaker
    Research
    Nature
    Volume: 641, P: 993-1004
  • The management of ulcerative colitis (UC) remains challenging due to the complexity of its etiology. Here, the authors establish that argininosuccinate synthetase 1 (ASS1) and its metabolite arginine are pivotal inducers of UC, through the triggering of mTOR and iNOS activation, and the induction of gut microbiota dysbiosis by metabolomics and proteomics. Inhibition of ASS1 by C-01 provides a viable strategy for the treatment of UC.

    • Shijia Liu
    • Haijian Sun
    • Wei Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22
  • The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature Physics
    Volume: 19, P: 237-253
  • Identifying genes involved in MYC-driven lymphoma reveals therapeutic vulnerabilities. Here, the authors show by using CRISPR knockout screens in primary cells in vivo that the GATOR1 complex suppresses MYC-driven lymphomagenesis, and that GATOR1-deficient lymphomas are sensitive to mTOR inhibitors.

    • Margaret A. Potts
    • Shinsuke Mizutani
    • Marco J. Herold
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

    • Zhishan Chen
    • Xingyi Guo
    • Wei Zheng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17
  • Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb−1.

    • G. Aad
    • B. Abbott
    • L. Zwalinski
    ResearchOpen Access
    Nature
    Volume: 633, P: 542-547
  • While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

    • M. Ablikim
    • M. N. Achasov
    • J. Zu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

    • Nora I. Strom
    • Zachary F. Gerring
    • Manuel Mattheisen
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1389-1401
  • A stable plasma state with a high ratio of plasma to magnetic pressures is likely to be a key requirement for any future magnetic fusion reactor. Here, the authors create such a plasma using a field reversed configuration and active plasma boundary control and demonstrate its stability.

    • H. Y. Guo
    • M. W. Binderbauer
    • E. Trask
    Research
    Nature Communications
    Volume: 6, P: 1-6
  • The precise control of interfacial bonding between engineering materials and biological tissues is essential for in vivo uses but remains elusive. Here, the authors report an interface-enhanced strategy by spatial and temporal anchoring of magnetic nanostickers for controlled bioadhesive properties.

    • Changshun Hou
    • Junjia Guo
    • Li Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Previous ophthalmic foundation models have struggled to generalize effectively to diverse and rare fundus diseases, restricting their clinical applicability. Here, the authors introduce a vision-language foundation model that demonstrates superior performance in diagnosing both common and rare fundus conditions.

    • Meng Wang
    • Tian Lin
    • Huazhu Fu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • The antiferromagnet CoNb3S6 with chiral crystal lattice has near-zero magnetization, but exhibits a large thermoelectric Nernst effect in zero magnetic field, attributed to topological nodal planes in its electronic structure and magnetic spin-space group symmetries in the ordered state.

    • Nguyen Duy Khanh
    • Susumu Minami
    • Max Hirschberger
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Transposable elements are genetic parasites that have colonised genomes and they express as parts of coding and noncoding RNAs. Here, the authors explore how they are expressed in transcripts in normal human development, and how they alter transcript dynamics.

    • Isaac A. Babarinde
    • Xiuling Fu
    • Andrew P. Hutchins
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-24
  • Ageing is linked to environmental factors. This study shows that although participants gradually adapted to heat over time, cumulative exposure to heatwaves had stable and adverse impacts on ageing, especially among manual workers, rural residents and those with limited air conditioning.

    • Siyi Chen
    • Yufei Liu
    • Cui Guo
    Research
    Nature Climate Change
    Volume: 15, P: 1000-1007
  • A system that undergoes a phase transition at absolute zero is said to exhibit a quantum critical point. Zhou et al. identify the signatures of not one but two quantum critical points in the finite-temperature characteristics of an iron-based superconductor.

    • R. Zhou
    • Z. Li
    • Guo-qing Zheng
    Research
    Nature Communications
    Volume: 4, P: 1-7
  • Although many room temperature phosphorescence host–guest systems with versatile performances have been developed, their photophysical mechanisms remain often unclear. Here the authors reveal that a dynamic coupling process in the excited state is crucial for inducing phosphorescence, where host and guest molecules firstly couple to enhance the intersystem crossing efficiency, and then decouple to transfer excitons to the triplet state of guest.

    • Xin Li
    • Wenlang Li
    • Ben Zhong Tang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

    • Marek Cmero
    • Ke Yuan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • This study found no significant impact of the AQUEDUCT Best Practice Resource Kit on psychiatric hospital admissions for people with dementia, highlighting implementation challenges and the need for further evaluation.

    • M. Orrell
    • L. O’Raw
    • D. Challis
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • The blood-brain barrier (BBB) regulates the extracellular composition of the central nervous system (CNS), but it is not known whether its properties differ across CNS regions. Here, the authors show in mice that the BBB exhibits regional specializations, and that such specializations can be important for the function of specific neural circuits.

    • Marie Blanchette
    • Kaja Bajc
    • Richard Daneman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • Whilst superconductivity usually appears when magnetic order is suppressed, the role of charge is less known. Here, Kawasaki et al. report a charge density wave (CDW) above the superconducting transition induced by an in-plane magnetic field in Bi2Sr2-x La x CuO6, with the CDW onset temperature scaling with the pseudogap temperature.

    • S. Kawasaki
    • Z. Li
    • Guo-qing Zheng
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7
  • Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

    • Yilan Wu
    • Bo Qian
    • Bin Sheng
    Research
    Nature Medicine
    Volume: 31, P: 3404-3413
  • Measurements combined with post-processing of their outcomes can be used to prepare ordered quantum states. It has been shown that they can drive a Nishimori phase transition into a disordered state even in the presence of quantum errors.

    • Edward H. Chen
    • Guo-Yi Zhu
    • Abhinav Kandala
    Research
    Nature Physics
    Volume: 21, P: 161-167
  • The Verwey transition of magnetite is complex due to the coexistence of strong correlations and electron-phonon coupling. Here, the authors use resonant inelastic X-ray scattering to show evidence for magnetic polarons in magnetite and provide insight into the nature of the transition.

    • H. Y. Huang
    • Z. Y. Chen
    • D. J. Huang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-6
  • Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

    • M. Ablikim
    • M. N. Achasov
    • J. Zu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9
  • Crown ethers have been used as strong and selective binders for alkali metals and other cations since their discovery. Here the authors observe crown ether type structures in partially oxidized graphene and through simulations predict that they have similar abilities to selectively bind cations.

    • Junjie Guo
    • Jaekwang Lee
    • Matthew F. Chisholm
    Research
    Nature Communications
    Volume: 5, P: 1-6
  • A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

    • Inna V. Krieger
    • Paridhi Sukheja
    • Case W. McNamara
    Research
    Nature
    Volume: 645, P: 755-763
  • The genetics and clinical consequences of resting heart rate (RHR) remain incompletely understood. Here, the authors discover new genetic variants associated with RHR and find that higher genetically predicted RHR decreases risk of atrial fibrillation and ischemic stroke.

    • Yordi J. van de Vegte
    • Ruben N. Eppinga
    • Pim van der Harst
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21
  • Engineered, bifunctional receptors present antigens and initiate signaling in response to binding to the cognate T cell receptor. Libraries built with SABRs can screen thousands of epitopes for the discovery of T cell target antigens.

    • Alok V. Joglekar
    • Michael T. Leonard
    • David Baltimore
    Research
    Nature Methods
    Volume: 16, P: 191-198