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A cell-sorting method leveraging leucine zippers allows for the generation of T cells displaying multiple chimaeric antigen receptors as well as receptors converting inhibitory signals into stimulatory signals.

The ubiquitin ligase APC/C is required for the metaphase-to-anaphase transition in mitosis. Downstream of Cdk1, CUEDC2 is shown to activate the APC/C by mediating the release of the checkpoint protein Mad2 from APC/C.

Pearl inductance in thin films of YBCO enables terahertz superinductance and achieves impedance surpassing the quantum resistance limit, promising advancements in quantum and photonic technologies.

An integrated workflow that uses robotics and machine learning to discover all-natural plastic substitutes with programmable properties is presented.

A metalens array of GaN nanoantennas is used to make a full-colour achromatic light-field camera.

Zhao et al. find that AMPK phosphorylates and activates the mitochondrial Ca²⁺ uniporter in response to low energy status in mitosis, allowing Ca²⁺ entry into mitochondria to boost mitochondrial respiration.

SERS spectroscopy critically relies on the accumulation of analyte molecules in electromagnetic ‘hotspots’. Here, the authors demonstrate plasmonic trimers with central particles that act as chemical traps, enabling the subtyping of lung tumors using fresh tissue samples.

Determining glioma types directly from whole-slide images (WSIs) would be of great diagnostic utility. Here, the authors develop a deep learning model to identify diffuse glioma types from WSIs according to the 2021 WHO classification across multiple cohorts and with interpretable features.

Polaritonic topological transitions of the isofrequency dispersion contour are observed in a graphene/α-MoO₃ heterostructure by tuning the graphene doping level, which enables partial focusing at deep subwavelength.

Genomic amplification of chromosome 3q often encodes proteins that contribute to cancer development. Here the authors identify a non-coding product of the 3q region, the lncRNA PLANE that promotes tumorigenesis through the deregulation of transcriptional corepressor NCOR2 pre-mRNA splicing.

Current vaccines are less efficient in preventing infection. Here, the authors show that an intranasal vaccine (DelNS1-RBD) based on a live attenuated influenza virus induces robust levels of neutralizing antibodies and T cells and prevents replication of SARS-CoV-2 Delta and Omicron variants in respiratory tissues.

Atomically dispersed gold supported by carbon dots amplifies mitochondrial oxidative stress, and leads to irreversible cell damage, inhibiting hepatocellular carcinoma in animal models.

The ChangKang (Heathy Bowel) project was established to collect molecular and clinical information of a thousand Chinese colorectal cancer patients. Here, the authors present the genomic landscape of the ChangKang cohort and find a subgroup of patients defined by abnormal mitochondrial copy numbers.

2D transition metal ditellurides exhibit nontrivial topological phases, but the controlled bottom-up synthesis of these materials is still challenging. Here, the authors report the layer-by-layer growth of large-area bilayer and trilayer 1T’ MoTe2 films, showing thickness-dependent ferroelectricity and nonlinear Hall effect.

Inhaled lipid nanoparticles face several challenges when delivered to the lungs. Here, the authors show “LOOP”-optimized iLNP-HP08^LOOP could withstand shear damage generated during nebulization process and be used to develop mRNA-mediated antibody therapy for treating idiopathic pulmonary fibrosis.

Gorman et al. designed a Lassa virus prefusion-stabilized soluble glycoprotein complex trimer (GPC), with which they identified a Lassa virus-neutralizing nanobody that bound the GPC apex and elicited neutralizing antibody responses in guinea pigs.

FeGe is a Kagome metal that exhibits a very rich array of magnetic and electronic phases. Here, using neutron scattering, Chen et al add to this zoo, by showing the emergence of a spin density wave order.

Cranial sutures separate neighboring skull bones but how osteogenic activity is controlled at cranial sutures remains unclear. Here, authors employ zebrafish to uncover the cellular and transcriptional basis of growth control during suture formation.

Machine learning-assisted robots produce MXene aerogels containing cellulose, gelatin, and glutaraldehyde, fabricating 162 compositions. Inverse design from resulting properties affords tailored compression-stable materials for Joule heating.

Electric cooking and air-to-air heat pump adoption in China advances carbon neutrality and the rural energy transition, with the transformation costs offset by monetized health benefits in most provinces.

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

Leukemia inhibitory factor receptor (LIFR) is frequently downregulated in liver cancer. Here the authors show that loss of LIFR promotes liver tumorigenesis and confers resistance to drug-induced ferroptosis through NF-κB-mediated upregulation of iron-sequestering cytokine LCN2.

Lu et al. show that single-stranded DNA produced as a result of DNA damage may directly activate PprI in Deinococcus species, triggering the DNA damage response.

A genome-wide association study suggests 41 previously unreported loci on top of the 23 known loci that influence the disease risk for lumbar disc herniations. Many of these loci harbour genes implicated in disc structure and inflammation, as well as genes related to the nervous system and nerve function.

Nanoparticles of non-noble metals are useful for many applications but can be prone to sintering or surface oxidation. Here, the authors use a rapid heating-cooling approach to synthesize uniformly distributed nanoparticles in a reduced graphene oxide matrix, and test them as switchable energetic materials.

High-volume, low-cost production of graphene is pivotal for the industrial advance of this 2D material. Here, the authors make use of naturally occurring diatomite as a 3D substrate for graphene growth, obtaining non-planar porous graphene structures after removal of the silica templates.

The molecular target of the antidiabetic medicine metformin is identified as PEN2, a subunit of γ-secretases, and the PEN2–ATP6AP1 axis offers potential targets for screening for metformin substitutes.

The controlled manipulation of the topological phases of electronic materials is a central goal of modern condensed matter research. Here, the authors demonstrate controllable switching between two distinct topological phases in a layered ferromagnet via thermal cycling.

Sequencing of haploid sugarcane, Saccharum spontaneum, allows assembly of a prototypical version of the sugarcane chromosome set. This new reference genome will serve as a resource to accelerate sugarcane improvement.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

The regulation of genetic diversity resulting from polyploidization and its impact on environmental adaptability remain unclear. Here, the authors show that LHP1-mediated epigenetic buffering of subgenome diversity and defense responses confers genome plasticity and adaptability in allopolyploid wheat.

Acidic CO₂ electroreduction suffers poor selectivity for multi-carbon products. Here, the authors report that lengthening the 2-position substituents of benzimidazole-based copper coordination polymer precatalysts retards H⁺ diffusion, reduces Cu-Cu coordination numbers, and promotes C-C coupling.

This study presents the development of nanodrugs based on bacterial-derived outer membrane vesicles for targeted intervention in nerve–cancer crosstalk, which efficiently enhances pancreatic cancer chemotherapy.

Here the authors show that the Koolen-de Vries syndrome associated gene KANSL1 modulates autophagosome-lysosome fusion via transcriptional regulation of autophagosomal gene Syntaxin17, and that 13-cis retinoic acid can reverses mitophagic defects and neurobehavioural abnormalities of mice lacking Kansl1.

Buffalo is an important livestock in Asia. Here, the authors present a comprehensive metagenomic analysis of the microbial communities present in different sites and compartments along the buffalo digestive tract.