Sulfoximines and sulfonimidoyl groups have recently emerged as powerful pharmacophores, however, their synthesis and incorporation into complex molecules is typically limited by long synthetic routes and the need to control stereogenic S-centres. Now, a stereospecific SNAr approach has been developed for the synthesis of α-(hetero)arylation of sulfonimidoyl motifs.
- Zachary P. Shultz
- Thomas Scattolin
- Justin M. Lopchuk
