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A special class of topological Weyl semimetal state is predicted without respecting Lorentz symmetry. Here, Jianget al. report direct visualization of the unique surface Fermi arcs of MoTe₂, confirming its type-II topological Weyl semimetal nature.

The conventional approach with applying self-assembled monolayer suffers from limited interface coverage and weaker dipole interactions. Here, authors employ ferroelectric molecule to construct a dipole layer, achieving certified efficiency of 25.36% for inverted perovskite solar cells.

Electrolytic water splitting requires high electrical energy consumption. Here, the authors report a new type of electrolyser that thanks to palladium-doped titania nanotubes oxidizes bio-alcohols, resulting in energy-convenient hydrogen generation as well as valuable chemical production.

Stretchable elastic materials with high strength, toughness, and good ionic conductivity are desirable for flexible electronics but attaining all of these properties simultaneously remains challenging. Here, the authors report a family of ionically conductive elastomers without compromise between mechanical properties and ionic conductivity by introducing a multiple network elastomer architecture into a low T_g polymer.

Multiple resonance (MR) emitters with narrowband luminescence typically suffer from inadequate frontier molecular orbital levels. Here, authors incorporate cyano motifs at peripheral sites of the MR backbone to adjust the energy levels, realizing device efficiency of over 23% for stable devices.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Hosseinzadeh et al. demonstrate use of a publicly accessible automated machine learning platform to differentiate between a common benign tumor and malignant transformation of it within the paranasal sinuses. This AI algorithm beat prior human prediction, and showed that physicians with no coding background can effectively utilize this tool.

Solitons may develop when strain forms at line defects separating commensurate domains in misaligned or lattice-mismatched van der Waals heterostructures. Here, the authors use atomic-force microscopy and nano-infrared spectroscopy to image solitons in thin hBN crystals in the form of long-range periodic superstructures, creating sub-surface hexagonal networks with periods of a few hundred nanometers.

The detection and modelling of nine X-ray quasi-periodic eruptions from a nearby tidal disruption event shows that these eruptions arise in accretion disks around massive black holes, left behind by tidally disrupted stars, and that an orbiting body colliding with this disk is a plausible explanation for the X-ray variability.

Fracture behaviours in multilayer h-BN, involving interlayer-friction toughening and edge-reconstruction embrittlement, are identified through in situ experiments and theoretical analyses.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

MRI data from more than 100 studies have been aggregated to yield new insights about brain development and ageing, and create an interactive open resource for comparison of brain structures throughout the human lifespan, including those associated with neurological and psychiatric disorders.

Magnetic reconnection is a fundamental energy release process taking place in various astrophysical environments, but it is difficult to observe it directly. Here, the authors provide evidence of three-dimensional magnetic reconnection in a solar eruption using combined perspectives of two spacecraft.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

Two types of amyloid-β protein (1–42) (Aβ₄₂) fibrils are known to form in the insoluble fraction of diseased human brains. Now, another type of Aβ₄₂ fibril (type III) has been identified in the soluble fraction of Alzheimer’s disease brain using cryo-electron microscopy. These studies also reveal differences in ligand–fibril interactions between fibril types.

Water scarcity is a global issue that demands urgent resolution, but current approaches are inadequate. Now a metre-scale atmospheric water harvester, featuring a hygroscopic origami hydrogel panel and a window-like glass chamber, demonstrates exceptional efficiency in extracting water from air, even in extremely arid conditions.

Pressure-induced modulation of interlayer coupling and elastic constant in two-dimensional layered materials is quantitatively described through a unified chain model, offering insights into the tunable mechanical behaviors under extreme conditions.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Surface Fermi arcs (SFAs) are characteristic features of a topological Weyl semimetal but there is no easy way to manipulate them so far. Here, the authors report manipulation of the shape, size and connections of SFAs in a Weyl semimetal NbAs, leading to an unusual topological Lifshitz transition.

A three-dimensional metal stamp can be used to selectively exfoliate two-dimensional materials, allowing the remaining material to be patterned into two-dimensional arrays without leaving chemical or polymer residues.

Observations of γ-rays with energies up to 1.4 PeV find that 12 sources in the Galaxy are PeVatrons, one of which is the Crab Nebula.

Erbium-doped lead magnesium niobium titanate ceramics demonstrate ultrahigh strain and piezoelectric coefficients under low electric fields, setting a benchmark for piezoelectric materials and offering versatile applications in precision actuators and sensors.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

It is extremely difficult to separate tritium from radioactively contaminated water. Here the authors introduce catalytic hydrogen isotope exchange to water distillation, realizing excellent detritiation performance.

Cancer patients suffer from dysgeusia. Here, the authors propose a gustatory interface for operative assessment and taste decoding, offering potential to improve the quality of life of individuals suffering from tongue cancer.

Cancer cells exploit altered metabolic pathways to dynamically regulate epigenetic methylations. Here, the authors show the canonical metabolic and nonmetabolic functions of PRPS2 in enhancing ATP utilization and SAM biosynthesis, promoting RNA m⁶A methylation for lung tumorigenesis and metastasis.

Electrophilic halogenation approaches often suffer from low reactivity and chemoselectivity when it comes to complex compounds. Now a class of halogenating reagents based on anomeric amides that can halogenate complex bioactive molecules with diverse functional groups and heterocycles has been developed. The higher reactivity of these anomeric amide reagents is attributed to the energy stored in the pyramidalized nitrogen.

Intercalation — a cornerstone of materials science with wide-ranging applications — has now been demonstrated in a superatomic crystal. A redox-active tetracyanoethylene guest was inserted into the lattice of a material consisting of alternate layers of {Co₆Te₈} clusters and C₆₀ fullerenes, leading to a single-crystal-to-single-crystal transformation that significantly modulates the material's optical and electrical transport properties.

We find that 2D–3D perovskitoid passivation applied to perovskite solar cells impedes cation migration and decreases carrier recombination at the interface, providing enhanced operating stability at elevated temperatures and increased power conversion efficiencies.

Alternating copolymerization of cyclic anhydrides and epoxides is an interesting platform for the synthesis of polyesters from renewable resources, but the near irreversibility of the copolymerization makes it challenging to develop chemically recyclable polyesters with easy-to-tune structure. Here, the authors develop a recyclable polyester library from alternating copolymerization of aldehyde and cyclic anhydride.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Exploring low-cost, efficient catalysts to replace platinum is crucial for electrocatalytic hydrogen generation. Here, the authors report a termination-acidity strategy that boosts the activity of molybdenum carbides, achieving a low overpotential and sustaining hydrogen generation for over 200 h.

Allele-preferential transcription factor binding can influence pancreatic ductal adenocarcinoma risk loci function. Here, the authors show allele-specific JunB and JunD binding at chr1p36.33 and propose a role for KLHL17 in protein homeostasis by mitigating inflammation.

Heusler compounds have been predicted to host topological order with other emergent properties, which yet awaits for experimental evidence. Here, Liu et al. report a direct observation of topological surface states on half-Heusler compounds LnPtBi.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Landau-Zener transitions near an avoided level crossing are a broadly relevant concept in quantum systems. Here the authors use a superconducting flux qubit to shed new light on the role of the environment in Landau-Zener tunneling by observing a crossover between weak and strong coupling.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Chromatin interactions and genome architecture are key regulators of gene expression. Here the authors present Bridge-Linker-Hi-C to map active chromatin loops and enhancer-promoter interactions.

The anisotropic electrical and optical response of materials has allowed for the development of variety of sensors, memories and other interesting devices. Here, Qi et al turn their attention to the van der Waals antiferromagnetic insulator CrPS₄, and demonstrate a very large, electrically tunable anisotropy in magnon transport, and present a multibit read-only memory based on this anisotropy.