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Here the authors propose an evaporation-driven approach to print various nanomaterials on porous substrates, allowing for high-throughput roll-to-roll and spatially programmable fabrication of functional nanomaterial films.

MnBi₂Te₄ has an appealing combination of topological bands and magnetic ordering. While chemical doping with Sb can be used to tune these properties, it typically comes with an increase in defect density. Here, Chen, Wang, Li, Duan, and coauthors demonstrate a defect engineering approach that preserves the topological and magnetic properties of Mn(Bi_1-xSb_x)₂Te₄.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

The exact mechanism for superconductivity in iron-based superconductors remains elusive, but is thought to involve complex interactions between many orbitals. Using angle-resolved photoelectron spectroscopy, Liuet al. report the electronic structure of the single-layer parent compound FeSe.

Long-lasting oxygen catalysts are crucial for rechargeable zinc-air batteries. Here, the authors report that placing tungsten atoms next to iron atoms within N₄ units creates durable Fe-N₄/W-N₄ diatomic sites, enabling a zinc-air battery to cycle reliably for more than 10,000 h.

This work proposes a wet-chemical etching assisted aberration-enhanced single-pulsed femtosecond laser nanolithography, named “WEALTH”, for manufacturing small-size, large-area, deep holey nanostructures, promising for emerging nanophotonic devices.

Ginzburg–Landau theory provides a powerful framework for describing the behaviour of conventional superconductors without detailed microscopic information about them. Bao et al.construct a similar framework for describing spin superconductivity, a recently proposed analogue of conventional superconductivity.

Xue et al. report self-powered photoelectrochemical photodetectors based on CuOx decorated AlGaN nanowires with staggered energy band structure. High-energy photons can be absorbed by CuOx to trigger the multiexciton generation effect, enabling an external quantum efficiency of 131.5% at 255 nm.

Certain chiral macroions have previously been shown to self-assemble into spherical structures. Here, the authors observe self-sorting of racemic macroions into enantiomeric ‘blackberry’-shaped structures, and furthermore show that the addition of chiral co-anions allows the formation of a single enantiomer.

Hydrogel materials have emerged as versatile platforms for biomedical applications. Here this group reports an mRNA lipid nanoparticle-incorporated microgel matrix for immune cell recruitment/antigen expression and presentation/cellular interaction thereby eliciting antitumor efficacy with a single dose.

Mixed matrix membranes capable of breaking the permeability-selectivity trade-off suffer from the inefficient and disconnected bulky transport channels as well as low compatibility between nanomaterials and polymers. Here the authors propose an original photothermally triggered in-situ gelation approach to elaborate a nanofiber-interwoven gel membranes with tunable 3D-interconnected ultrafast transport channels for highly-selective CO₂ separation.

Tissue-specific mRNA or gene editing machinery delivery is achieved with lipid nanoparticles containing peptides with specific sequences, which tune the protein corona of the particles by mechanical optimization of peptide–protein binding affinities.

Parity-time symmetry breaking and related non-Hermitian phenomena, such as high-order exceptional points, have attracted significant interest across various experimental platforms. Here the authors demonstrate a third-order exceptional point induced by parity-time symmetry breaking in a dissipative trapped ion.

Catenanes can exhibit chirality even when their component rings are achiral. Here an isostructural desymmetrization strategy is developed, demonstrating that two achiral rings, each featuring two mirror planes and a two-fold axis of symmetry, can form a catenane with tuneable mechanical chirality.

2D nonlayered materials exhibit interesting properties for catalysis, nanoelectronics and spintronics applications, but their growth is still challenging. Here, the authors report a theoretical model and an experimental strategy to synthesize various 2D nonlayered transition metal oxides with room-temperature magnetic properties.

Bacterial heterodimeric tryptophan-containing diketopiperazines (HTDKPs) are bioactive natural products that are difficult to access chemically. Here, the authors identify a family of three related HTDKP-forming cytochrome P450s and engineer key amino acid residues to produce distinct diketopiperazines frameworks.

Relating the degree of network crosslinking as a descriptor to the desalination performance of crosslinked polymer membranes remains challenging. Here, the authors introduce a parameter based on distinct amide bonds per unit mass of polyamide, to unravel the relationship between the crosslinked networks of polyamide membranes and their desalination performance.

Here, the authors show that TRIM28-mediated SUMOylation of SARS-CoV-2 NP is critical for its liquid-liquid phase separation (LLPS) property and subsequent inhibition of innate antiviral immunity. The peptide NSIP-III is applied to unleash such connection by interfering TRIM28 and NP interaction.

Electron beam lithography (EBL) is renowned to provide fabrication resolution in the deep nanometer scale but their incapability of arbitrary 3D nanofabrication poses a major limitation to the technique. Here, the authors demonstrate a manufacturing technique of functional 3d nanostructures at a resolution of sub-15 nm using voltage-regulated 3d EBL.

G protein-coupled receptors are a large family of signalling proteins that mediate cellular responses primarily via G proteins or arrestins, and they are targets of one-third of the current clinically used drugs; here, an active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin-1 is determined, revealing unique structural features that may constitute essential elements for arrestin-biased signalling.

Topological kink modes are peculiar edge excitations that take place at domain boundaries of magnetic fields inside homogeneous materials. Here, the authors experimentally observe kink magnetoplasmons in a 2D electron gas using custom-shaped strong permanent magnets on top of a GaAs/AlGaAs heterojunction.

RNA polymerase II (Pol II) transcription factories play a central role in gene expression and 3D chromatin organization. Here, the authors demonstrate that RUVBL2 directly regulates Pol II clustering at active gene promoters.

The deacetylase SIRT1 regulates IRF3/IRF7-mediated antiviral interferon signaling. Here the authors show that SIRT1 deactylates the DNA-binding domain resulting in liquid–liquid phase separation of IRF3/IRF7 and that this signaling is inhibited in aging, an effect that can be reversed with a SIRT1 agonist to restore antiviral response.

The electrochemical double layer is a key concept in chemistry, but its properties are hard to probe experimentally. Here, the authors use ambient pressure X-ray photoelectron spectroscopy to probe the electrochemical double layer potential profile at the solid/liquid interface, under polarization conditions.

Sparse labelling and whole-brain imaging are used to reconstruct and classify brain-wide complete morphologies of 1,741 individual neurons in the mouse brain, revealing a dependence on both brain region and transcriptomic profile.

For FRB 121102, 1,652 burst events are detected over 47 days, with a peak burst rate of 122 per hour, a bimodal burst rate energy distribution, and no periodicity or quasi-periodicity.

Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral propagation.

The critical temperature of single-layer FeSe films is much higher than the bulk of other iron-based superconductors, but the mechanism for this is unclear. Adding to the puzzle, Liu et al.show that it is much more difficult to induce superconductivity in a double-layer FeSe film than a single layer.

Here, a draft sequence of the giant panda genome is assembled using next-generation sequencing technology alone. Genome analysis reveals a low divergence rate in comparison with dog and human genomes and insights into panda-specific traits; for example, the giant panda's bamboo diet may be more dependent on its gut microbiome than its own genetic composition.

A South China Sea expedition in 2021 identified a 3.5-km-deep site close to the Equator for a next-generation neutrino telescope: TRIDENT. A large array of advanced detectors will be arrayed on the seabed to probe fundamental physics and explore the extreme Universe.

Tumour hypoxia is an important factor in tumorigenesis and cancer therapy. Here, the authors present a micro oxygenation factory, capable of providing an oxygen supply through photosynthesis, and demonstrate its utility in cancer therapy.

Acid-sensing ion channel 1a (ASIC1a) mediates acidic neuronal necroptosis via recruiting receptor-interacting protein kinase 1 (RIPK1). Here authors show that auto-inhibition of ASICa prevents RIPK1 recruitment and demonstrate that targeting the auto-inhibition has therapeutic potential to prevent acidotoxicity.

There are few reports of ferroelectricity due to symmetry breaking transition in A-site-ordered quadruple perovskites. Here, the authors find one with phase transition from a high-temperature centrosymmetric paraelectric phase to a low-temperature non-centrosymmetric ferroelectric phase in a high pressure synthesized compound.

Near-infrared luminescence is useful for advance applications, but is challenging to achieve through clusteroluminescence. Here, the authors report the use of amine-initiated polyesters for amine-ester clusters with near-infrared emission.

High-resolution angle-resolved photoemission spectroscopy reveals bosonic modes in a SrTiO₃ substrate coupling to electrons in an FeSe overlayer to facilitate high-temperature superconductivity.

Measurements of the inelastic cross section of anti-³He allow the estimation of the transparency of the Milky Way to the propagation of these light antinuclei produced in either cosmic-ray collisions or annihilation of dark-matter particles.

Signatures of an excitonic insulator have been reported in several two-dimensional materials. Here the authors report electronic properties of monolayer ZrTe₂ from ARPES and STM measurements that are consistent with the preformed exciton gas phase, a precursor for the excitonic insulator.

Currently polyamide membranes fabricated by interfacial polymerization are limited by inherently negative charge as well as narrow charge tailoring window restricting the application of these membranes. Here, the authors report a facile ionic liquid-decoupled bulk/interfacial diffusion strategy to fabricate polyamide membranes which can transform on-demand from inherently negative to highly positive and near-neutral charge.

Bi et al. reveal a coordinated function for GATA3 and AP1 in altering enhancer landscapes, thereby promoting a basal/mesenchymal phenotype and endocrine resistance in breast cancer.

The bone morphogenetic protein (BMP) and Smad1 signalling pathway is required for embryogenesis. In this study, Smad1 is shown to be phosphorylated by Atm in response to DNA damage and this results in elevated Smad1 signalling, thus uncovering a new role for this pathway in the DNA damage response.

Water is usually not favorable in high-voltage window aprotic electrolytes. Here the authors discover some lithium titanate hydrates that allow superior power rate and ultralong cycle life in aprotic electrolytes.

The unconventional superconductivity associated with iron pnictide materials has been the subject of intense interest. Using an annealing procedure to control the charge-carrier concentration, the behaviour of an FeSe monolayer deposited on SrTiO₃ is now investigated, and indications of superconductivity at temperatures up to 65 K observed.

The bandgap of 2D molybdenum disulfide can be tuned uniformly, reproducibly and precisely over a large range by using a glass sphere support and changing the diameter of the spheres.

Insight-HXMT detected a double-peaked X-ray burst from Galactic magnetar SGR J1935+2154, consistent with two fast radio bursts (FRBs) observed from the same object within seconds. This coincidence suggests a common physical origin, and gives insight into the mechanism behind the origin of FRBs.

This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

Using spin-entangled baryon–antibaryon pairs, the BESIII Collaboration reports on high-precision measurements of potential charge conjugation and parity (CP)-symmetry-violating effects in hadrons.

Ni et al. report that Snail1 promotes mammary tumour initiation and maintenance independently of its role in EMT. They show that Snail1 forms a complex with HDAC1 and p53 that results in p53 inactivation and degradation, permitting tumour formation.