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Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

The synthesis of atom-thin amorphous films remains challenging as their thermodynamically favourable grains are neither two dimensional nor layered. Here a droplet-driven nanoribbon-to-film growth strategy is reported to achieve amorphous metal chalcogenides at the single-layer limit.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Alternating copolymerization of cyclic anhydrides and epoxides is an interesting platform for the synthesis of polyesters from renewable resources, but the near irreversibility of the copolymerization makes it challenging to develop chemically recyclable polyesters with easy-to-tune structure. Here, the authors develop a recyclable polyester library from alternating copolymerization of aldehyde and cyclic anhydride.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

Observations of γ-rays with energies up to 1.4 PeV find that 12 sources in the Galaxy are PeVatrons, one of which is the Crab Nebula.

The exact mechanism for superconductivity in iron-based superconductors remains elusive, but is thought to involve complex interactions between many orbitals. Using angle-resolved photoelectron spectroscopy, Liuet al. report the electronic structure of the single-layer parent compound FeSe.

The development of fast-charging and high-capacity negative electrodes is critical for advanced lithium-ion batteries. Here, authors use a vacancy engineering strategy to develop a layered Prussian blue analogue with competitive rate capability, delivering a specific capacity of 510 mAh g⁻¹ at a specific current of 8 A g⁻¹.

The study of isotopes away from the beta stability valley is crucial for the understanding of nuclear structure, especially for neutron-deficient heavy nuclei. Here, the authors report the observation of the alpha-decay isotope 210-protactinium (Pa), extending the alpha-decay systematics of underexplored regions of the nuclides chart.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Weyl semimetals are interesting because they are characterized by topological invariants, but specific examples discovered to date tend to have complicated band structures with many Weyl points. Here, the authors show that TaIrTe₄ has only four Weyl points, the minimal number required by time-reversal symmetry.

Functional materials that act as bio-sensing media when interfaced with complex bio-matter are attractive for health sciences and bio-engineering. Here, the authors report room temperature enzyme-mediated spontaneous hydrogen transfer between a perovskite quantum material and glucose reactions.

Preparation of a pure Si₄₆ framework in the clathrate-I structure is a challenge. Here, the authors demonstrate the stepwise Ba evacuation process and observe a guest-free Si₄₆ framework from Ba_8-xSi₄₆ using atomic-scale STEM imaging during in-situ heating.

Electrocatalysts for CO₂ reduction are typically prepared and optimized ex situ before the reaction begins, but during reactions they may undergo changes that lower their performance. Here the authors show that active Cu catalysts can be formed on a recoverable basis and removed in situ during the CO₂ reduction reaction, improving the stability of the system.

Absorption in one-port passive systems is known to be bound by causality constraints. Here, authors study reflection and transmission of a two-port system to introduce a generalized causality constraint based on duality symmetry. Experimentally, the broadened bandwidth of their meta-absorbers shows the untapped absorption potential of broadband acoustic metamaterials.

Due to the pulsed nature of X-ray free electron laser (XFEL) instruments the majority of protein crystals, which are injected using continuous jet injection techniques are wasted. Here, the authors present a microfluidic device to deliver aqueous protein crystal laden droplets segmented with an immiscible oil and demonstrate that with this device an approx. 60% reduction in sample waste was achieved for data collection of 3-deoxy-D-manno-octulosonate 8-phosphate synthase crystals at the EuXFEL.

The authors identify feeblin, an inhibitory compound of the proinflammatory TLR7/8/9-IRF5 pathway with therapeutic potential, which acts by binding SLC15A4 via an allosteric mechanism mediating degradation of its signaling partner TASL.

Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

Silver nanoparticles are useful antimicrobial agents in water purification systems. Here the fabrication of silver nanoparticles that include a magnetic layer could lead to improved purification systems as it allows the recovery of the nanoparticles by magnetic fields.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Magnetic skyrmions—topologically stable swirls in the spin structure—have great potential for spintronics devices. Here, the authors find two bound skyrmions with a topological charge of two in bilayer-structured manganite, which can be electrically driven with an exceptionally low current density.

Whether superconductivity coexists or competes with other types of order in unconventional superconductors is a question that has been hotly contested. An ARPES study reported by Yi et al. suggest that superconductivity and spin-density wave orders coexist and compete dynamically in Ba_1−xK_xFe₂As₂.

Ultrashort electron bunches are promising for diffractive imaging measurements of structural dynamics, particularly in small or delicate structures. To this end, McCulloch et al. use a two-colour photoionization process to generate high-coherence ultrafast electron bunches from laser-cooled atoms.

This work develops dye-lanthanide tandem-sensitized perovskite nanocrystals that can harvest a broad range of infrared light, upconvert it to sensitize excitons, and generate multicolor band-edge exciton luminescence

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

It is extremely difficult to separate tritium from radioactively contaminated water. Here the authors introduce catalytic hydrogen isotope exchange to water distillation, realizing excellent detritiation performance.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

The SARS-CoV-2 3CL main protease (3CL M^pro) is a chymotrypsin-like protease that facilitates the production of non-structural proteins, which are essential for viral replication and is therefore of great interest as a drug target. Here, the authors present the 2.30 Å room temperature crystal structure of ligand-free 3CL M^pro and compare it with the earlier determined low-temperature ligand-free and inhibitor-bound crystal structures.

By controlling the flow or composition of liquids, optofluidics provides numerous possibilities for devices, and so has great potential for transformation optics. Here, a multi-mode optofluidic waveguide is presented, which manipulates light to produce controllable chirped focussing and interference.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

The dorsal peduncular area of the mouse brain functions as a network hub that integrates diverse cortical and thalamic inputs to regulate neuroendocrine and autonomic responses.

This study introduces the Cattle Cell Atlas, a single-cell expression resource including 1,793,854 cells from 59 tissues. Integrative analyses leveraging this atlas provide insights into the biology underlying bovine monogenic and complex traits.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Authors demonstrate that Ig-like binders targeting the C-terminal of α-synuclein fibrils block fibrils-induced pathological activities, including neuronal aggregation and neuroinflammation, suggesting potential molecular avenues for future Parkinson’s disease intervention.

Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evolutionary comparisons.

Delocalized radical systems are appealing for controlling stereoselectivity in organic synthesis. Here the authors report on a Co(II)-based enantioselective radical system for the dearomative 1,7-conjugate amination of readily available 4-vinylphenols with aryl azides.

A variational-autoencoder-based diffusion architecture that enables topological controls on the diffusion-based protein structure generation is proposed. As a result, novel folds of mainly beta proteins can be designed with experimental validation.

Human primary monocytes reversibly phase separate into regular, multicellular, multilayered domains on soft matrices with physiological stiffness due to local activation and global inhibition processes that occur during random cell migration.

Origami-based soft robotic manipulators offer compactness, cost-effectiveness, and scalability, but challenges related to stiffness, precision, and dexterity remain. To address these issues, the authors introduce the Micro-X4, a 4-degree-of-freedom origami micromanipulator that is capable of achieving three-dimensional translational motion, along with rotation around the central axis of the moving platform.

Lilies are perennial plants with ornamental flowers and large genomes. The authors assemble genomes of two Liliales species, analyze lily phylogeny, flower and stem development (bulbs in lilies, rhizomes in flame lilies), bulb growth transitions, and colchicine biosynthesis.

Analysis of whole-genome sequencing data from 3,023 human genomes from mainland Southeast Asia identifies high genetic heterogeneity among populations in the region and many unique small and structural variants.

Single-phase high-entropy alloys, such as CrMnFeCoNi, display excellent ductility and fracture toughness. Here, the authors use in situ mechanical loading in an aberration-corrected transmission electron microscope to probe the atomistic to micro-scale mechanisms underlying these properties.

The coexistence of topological and superconducting states in a single layer of FeSe on a SrTiO₃ substrate is reported.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.