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Manganese is essential but toxic in excess. Here, the authors report cryo-EM structures of the Mn²⁺ transporter SLC30A10, define its Mn²⁺-binding site, and show how a disease-linked mutation impairs transport, mitochondria and cell viability, advancing understanding of Mn²⁺ homeostasis.

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder characterized by the functional loss of the tumor suppressor gene neurofibromin, that can lead to the development of benign and malignant tumors. Here the authors describe the development of an adeno-associated virus vector for NF1 gene replacement therapy of NF1 related tumors, showing tropism and anti-tumor activity in preclinical models

Solitary fibrous tumors (SFTs) of the central nervous system (CNS) are uncommon mesenchymal neoplasms with limited treatment options. Here, the authors perform a multi-omics analysis of 189 cases of CNS SFTs to identify potential clinical biomarkers and therapeutic targets.

Lu et al. characterize cis-regulatory element dynamics at different stages of colorectal cancer progression and identify a functional variant associated with increased colorectal cancer risk because of selective transcription factor binding.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Drought, fires, and human activities have reversed the accumulation of live biomass carbon in the Northern Hemisphere, with total biomass shifting from a positive to a negative trend around 2016.

STING agonist-based endoplasmic reticulum-targeting molecules can be conjugated directly onto antigens to deliver them to the cross-presentation pathway, improving CD8⁺ T cell responses against tumours and viruses.

The Pacific white shrimp Litopenaeus vannamei is an important aquaculture species and a promising model for crustacean biology. Here, the authors provide a reference genome assembly, and show that gene expansion is involved in the regulation of frequent molting as well as benthic adaptation of the shrimp.

Single-cell transcriptomics of human lung tissue from individuals with tuberculosis identifies signatures of inflammation, apoptosis and senescence affecting immune, epithelial and endothelial cells linked with long-term pulmonary impairment.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Solitary fibrous tumours are mesenchymal tumours with an unpredictable progression and current medical treatments for relapsed SFTs remain ineffective. Here, the authors identified potential therapeutic targets and risk factors for SFTs and created an integrated risk model using 101 patients, and validated in 3 independent cohorts to successfully predict tumour progression.

Employing appropriate catalysts in room-temperature sodium-sulfur batteries can significantly enhance performance. Here, authors utilize natural language processing techniques in conjunction with a binary descriptor to screen preferrable single-atom catalysts to achieve high specific capacity.

It is generally more difficult to modify the buried interfaces compared to top interfaces in tin-lead perovskite subcells. Here, the authors employ a mercapto-functionalized mesoporous silica layer as a superstructure, realizing maximum efficiency of 29.6% for double-junction tandem solar cells.

Cross-ancestry and sex-stratified genome-wide association analyses for 21 amygdala volumetric traits in East Asian and European individuals provide insight into the genetic architectures of amygdala and subnucleus volumes.

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

The acetylene hydrogenation activity and stability of a palladium single-atom catalyst are both controlled by the lowest unoccupied molecular orbital of the oxide support.

Minimizing the non-radiative energy loss without sacrificing the charge collection efficiency is the key to improve the performance of organic solar cells. Here, the authors develop hybrid side chain-based asymmetric small molecule acceptors and achieve maximum power conversion efficiency of 19.76%.

The interplay among hybrid self-assembled monolayers (SAMs) during deposition has not been well studied. Here, authors mix co-adsorbents with carbazole-based SAM material to improve the buried interface, achieving efficiency of 20.67% for wide-bandgap solar cells and 28.94% for all-perovskite tandem devices.

The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.

This study of Chinese endometrioid endometrial carcinomas describes the proteogenomic differences between early-onset and late-onset tumors, finding that SIGLEC10 mutation may contribute to tumorigenesis and progestin resistance in early cases.

Reducing energy loss of sub-cells is critical for high performance tandem organic solar cells. Here, the authors design and synthesize an ultra-narrow bandgap acceptor through replacement of terminal thiophene by selenophene in the central fused ring, achieving efficiency of 19% for tandem cells.

The interactions between tertiary lymphoid structures (TLS) and tumor cell aggregates remain to be investigated. Here, single-cell and spatial transcriptomics reveal the cellular composition, formation, and function of TLS during tumour progression and immunotherapy response in nasopharyngeal carcinoma.

The underlying mechanisms for drug resistance in Acute Myeloid Leukemia (AML) are not completely understood. Here, the authors show that succinate accumulation, associated with succinate dehydrogenase deficiency, impairs the activity of the ubiquitin-conjugating enzyme UBC12 leading to tumor-promoting protein accumulation and drug resistance in AML.

Bacteria have evolved proteinaceous microcompartments (BMCs) to control the passage of metabolites and facilitate catabolism in a micro-environment. Here, Yang et al. apply fluorescence microscopy to characterize the protein-protein interaction and assembly involved in the de novo biogenesis of propanediol-utilization (Pdu) metabolosomes and show that Pdu BMCs undergo a combination of ‘Shell first’ and ‘Cargo first’ assembly.

The modification of small molecule acceptor building block and π−bridge linker is effective to improve photovoltaic performance. Here, the authors replace linear with branched alkyl chains and introduce difluorene-substituted linker to realise all-polymer solar cells with efficiency of 17.24%.

The genome of the tropical blue-petal water lily Nymphaea colorata and the transcriptomes from 19 other Nymphaeales species provide insights into the early evolution of angiosperms.

Non-fullerene organic molecule acceptors have been the hot research subject to drive the efficiency of the organic solar cells higher, but their synthetic costs are high. Here Li et al. design a simplified synthetic route for the state-of-the-art acceptors and bring down their cost by more than 15%.

Constructing an artificial solid electrolyte interphase to protect the lithium metal electrode is promising but challenging. Here, authors report a facile approach to form a layer to simultaneously overcome diffusion and advection-limited ion transport to achieve dendrite-free Li plating/stripping.

Brachyurans, or crabs, are of commercial and ecological importance, but limited genomic resources exist. Here the authors present a chromosome-level genome and expression data for the Chinese mitten crab, to shed light on the biology of this group.

Realizing robust ferromagnetic order in two dimensions is challenging as an underlying crystalline framework is normally required. Now room-temperature ferromagnetism is demonstrated in a two-dimensional honeycomb self-assembly of confined molecules.

Here, the authors apply the Activity-by-Contact (ABC) model to infer enhancer-gene regulation and the effect of associated variants across multiple cancer types, integrating genetic and multi-omics data. Then, they explore the mechanisms associated with ABC regulatory variants in colorectal cancer.

Increased nutrient uptake of cancer cells offers a possible therapeutic target. Here, the authors designed a nanoparticle to deliver phenylboronic-acid-modified cholesterol which reacts in cancer cells to trigger Gaucher disease-like metabolic damage to tumour cells, demonstrating potential application.

Development of tandem organic solar cells has been limited by the choice of near-infrared absorbing materials for the rear cell. Here, the authors report a simple strategy to extend the conjugation length of acceptor Y6 and broaden its absorption range to near-infrared region. A tandem organic solar cell with efficiency of 16.4% was achieved.