Nature Search

NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation

Rapid detection of diverse biomarkers is crucial for public health. Here, the authors develop NAPTUNE, a versatile platform that identifies multiple nucleic acids and proteins targets within 45 minutes using a nuclease cascade.

Tao Hu
Xinxin Ke
Chunyi Hu
ResearchOpen Access04 Feb 2025
Nature Communications

Volume: 16, P: 1-16
Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp³)–H bonds

Direct remote C–H functionalization of aliphatic alcohols via alkoxy radicals is largely unexplored. Here, the authors report the C(sp³)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy radicals formed with a hypervalent iodine reagent.

Xinxin Wu
Hong Zhang
Chen Zhu
ResearchOpen Access21 Aug 2018
Nature Communications

Volume: 9, P: 1-8
Zeolite-confined Cu single-atom clusters stably catalyse CO to acetate at 1 A cm⁻² beyond 1,000 h

A zeolite-confined Cu single-atom cluster was developed for the electrochemical CO reduction application, which can achieve stable CO-to-acetate conversion at an industrial current density of 1 A cm⁻² at 2.7 V with a high acetate Faraday efficiency for over 1,000 h at atmospheric pressure.

Yan Wen
Changhong Zhan
Xiaoqing Huang
Research17 Mar 2025
Nature Nanotechnology

Volume: 20, P: 656-663
Standard operating procedure combined with comprehensive quality control system for multiple LC-MS platforms urinary proteomics

Urinary proteomics offers sensitive, non-invasive biomarkers, but cross-platform LC-MS data comparability requires investigation. Here, the authors evaluate 20 LC-MS platforms, developing MSCohort, a QC system with 81 metrics, and a unified SOP, paving the way for precision medicine research.

Xiang Liu
Haidan Sun
Yinghua Zhao
ResearchOpen Access26 Jan 2025
Nature Communications

Volume: 16, P: 1-18
Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish

Cytosine base editing is crucial for modeling human diseases in zebrafish. Here, the authors present zevoCDA1 and zevoCDA1-198, optimized editors that improve editing efficiency and precision, allowing zebrafish modeling for disease-related mutations which were previously limited by DNA sequence contexts.

Yu Zhang
Yang Liu
Yanmei Liu
ResearchOpen Access04 Nov 2024
Nature Communications

Volume: 15, P: 1-10
Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer

The progression from biliary tract intraepithelial neoplasia (BilIN) to gallbladder carcinoma (GBC) remains unclear. Here the authors use genomics to analyze coexisting GBC lesions, low-grade and high-grade BilINs, revealing two distinct evolutionary paths for GBC development.

Jianzhen Lin
Xinxin Peng
Han Liang
ResearchOpen Access06 Aug 2021
Nature Communications

Volume: 12, P: 1-11
High-throughput volumetric mapping of synaptic transmission

Bessel-droplet two-photon fluorescence microscopy offers high-contrast and high-resolution volumetric imaging in vivo and can be used for high-throughput mapping of functional synaptic organization in the mouse brain.

Wei Chen
Xinxin Ge
Na Ji
Research19 Jun 2024
Nature Methods

Volume: 21, P: 1298-1305
Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease

Zihan Li
Xinxin Miao
Min Wang
ResearchOpen Access24 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1-9
Aging associated immunosenescence in rheumatoid arthritis identified by machine learning and single cell profiling

Xinxin Ji
Lingyun Li
Hui Cheng
ResearchOpen Access23 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Fabrication of perovskite solar cells in ambient air by blocking perovskite hydration with guanabenz acetate salt

The fabrication of perovskite solar cells in ambient air is of interest, but the materials are unstable in the presence of moisture. Yan et al. show that guanabenz acetate salt eliminates vacancy defects that trigger perovskite degradation, enabling 25% efficiency devices to be fabricated in air.

Luyao Yan
Hao Huang
Meicheng Li
Research28 Sept 2023
Nature Energy

Volume: 8, P: 1158-1167
Reprogramming tumour-associated macrophages to outcompete cancer cells

In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1 signalling in MYC-overexpressing cancer cells through cell competition, serving as an innate immune defence mechanism to slow tumour growth.

Xian Zhang
Shun Li
Ming O. Li
Research28 Jun 2023
Nature

Volume: 619, P: 616-623
FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism

Saccharomyces cerevisiae is a model organism to study proteins involved in neurodegeneration. Here, the authors performed a yeast genome-wide synthetic genetic interaction array (SGA) to screen for toxicity modifiers of Aβ42 and identify riboflavin kinase and its metabolic product flavin mononucleotide as modulators that alleviate cellular Aβ42 toxicity, which is supported by further experimental analyses.

Xin Chen
Boyang Ji
Dina Petranovic
ResearchOpen Access13 Feb 2020
Nature Communications

Volume: 11, P: 1-16
In situ formation of ZnO_x species for efficient propane dehydrogenation

Propene is obtained through propane dehydrogenation using catalysts that are toxic, expensive or demanding to regenerate with ecologically harmful compounds, but the ZnO-based alternative reported here is cheap, clean and scalable.

Dan Zhao
Xinxin Tian
Evgenii V. Kondratenko
ResearchOpen Access10 Nov 2021
Nature

Volume: 599, P: 234-238
Development and validation of a novel endoplasmic reticulum stress-related lncRNAs signature in osteosarcoma

Peichuan Xu
Jinghong Yuan
Xigao Cheng
ResearchOpen Access26 Oct 2024
Scientific Reports

Volume: 14, P: 1-18
Dynamical topology of chiral and nonreciprocal state transfers in a non-Hermitian quantum system

The complex energy surface of a non-Hermitian system is not single-valued, and windings around its so-called exceptional branching points lead to the chiral and non-reciprocal transfer of eigenstates. Here, the authors experimentally demonstrate such topological state transfers in trapped ion systems, which are being established as promising platforms for quantum simulation.

Pengfei Lu
Yang Liu
Le Luo
ResearchOpen Access07 Mar 2025
Communications Physics

Volume: 8, P: 1-11
Precise control of embolic stroke with magnetized red blood cells in mice

SIMPLE and SIMPLeR are proposed as models for embolism, the latter reversibly manipulating magnetized red blood cells to occlude cerebral vessels. Both methods induce age-dependent micro-hemorrhage transformation, with microglia/macrophage depletion preventing hemorrhage transformation.

Yuxiao Jin
Peijun Shi
Jie-Min Jia
ResearchOpen Access16 Feb 2022
Communications Biology

Volume: 5, P: 1-12
CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Yiru Long
Jianhua Sun
Likun Gong
ResearchOpen Access01 Feb 2022
Cell Discovery

Volume: 8, P: 1-16
Association between the stress hyperglycemia ratio and mortality in patients with acute ischemic stroke

Yaxin Zhang
Xinxin Yin
Guangdong Wang
ResearchOpen Access06 Sept 2024
Scientific Reports

Volume: 14, P: 1-10
Determinants of survival after first relapse of acute lymphoblastic leukemia: a Children’s Oncology Group study

Susan R. Rheingold
Deepa Bhojwani
Mignon L. Loh
ResearchOpen Access11 Sept 2024
Leukemia

Volume: 38, P: 2382-2394
Geospatial characterization of rural settlements and potential targets for revitalization by geoinformation technology

Yixuan Liu
Xinxin Ke
Xiaoting Zhou
ResearchOpen Access19 May 2022
Scientific Reports

Volume: 12, P: 1-16
Large-scale fully printed “Lego Bricks” type wearable sweat sensor for physical activity monitoring

Wenhui Ji
Huanzhuan Liu
Fengwei Huo
ResearchOpen Access20 Dec 2023
npj Flexible Electronics

Volume: 7, P: 1-12
Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

This study presents a novel Type I-A CRISPR-Cas3 variant for precise HPV diagnosis. It demonstrates dual activation modes and robustness without stand-alone Cas3 activity, enhancing CRISPR-Cas3 diagnostic applications.

Tao Hu
Quanquan Ji
Chunyi Hu
ResearchOpen Access13 Jul 2024
Communications Biology

Volume: 7, P: 1-12
The use of T-DNA insertional mutagenesis to improve cellulase production by the thermophilic fungus Humicola insolens Y1

Xinxin Xu
Jinyang Li
Wei Zhang
ResearchOpen Access10 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
Construction of high-density genetic linkage map and identification of flowering-time QTLs in orchardgrass using SSRs and SLAF-seq

Xinxin Zhao
Linkai Huang
Tongwei Shi
ResearchOpen Access08 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Alterations of the duodenal mucosal microbiome in patients with metabolic dysfunction-associated steatotic liver disease

Mengting Ren
Hanghai Pan
Feng Ji
ResearchOpen Access21 Apr 2024
Scientific Reports

Volume: 14, P: 1-9
An entorhinal-visual cortical circuit regulates depression-like behaviors

Jian Lu
Zhouzhou Zhang
Zengcai V. Guo
Research06 Apr 2022
Molecular Psychiatry

Volume: 27, P: 3807-3820
Correction: An entorhinal-visual cortical circuit regulates depression-like behaviors

Jian Lu
Zhouzhou Zhang
Zengcai V. Guo
Amendments and Corrections26 Apr 2022
Molecular Psychiatry

Volume: 27, P: 3821
Integrative transcriptome and proteome analyses of clear cell renal cell carcinoma develop a prognostic classifier associated with thrombus

Xiaolei Shi
Qingyang Pang
Wei Zhang
ResearchOpen Access16 Jun 2023
Scientific Reports

Volume: 13, P: 1-13
DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR

Ji Geng
Rong Zhang
Zheng-Hong Qin
ResearchOpen Access17 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-15
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus

Chao Peng
Yu Huang
Qiong Shi
ResearchOpen Access23 Feb 2021
Cell Discovery

Volume: 7, P: 1-14
Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children’s Oncology Group

Peter G. Steinherz
Nita L. Seibel
Paul S. Gaynon
Research28 Feb 2019
Leukemia

Volume: 33, P: 2144-2154
Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Ivan Seah
Xinxin Zhao
Xinyi Su
ReviewsOpen Access30 Jan 2020
Eye

Volume: 34, P: 1341-1356

Search

NAPTUNE: nucleic acids and protein biomarkers testing via ultra-sensitive nucleases escalation

Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp³)–H bonds

Zeolite-confined Cu single-atom clusters stably catalyse CO to acetate at 1 A cm⁻² beyond 1,000 h

Standard operating procedure combined with comprehensive quality control system for multiple LC-MS platforms urinary proteomics

Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish

Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer

High-throughput volumetric mapping of synaptic transmission

Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease

Aging associated immunosenescence in rheumatoid arthritis identified by machine learning and single cell profiling

Fabrication of perovskite solar cells in ambient air by blocking perovskite hydration with guanabenz acetate salt

Reprogramming tumour-associated macrophages to outcompete cancer cells

FMN reduces Amyloid-β toxicity in yeast by regulating redox status and cellular metabolism

In situ formation of ZnO_x species for efficient propane dehydrogenation

Development and validation of a novel endoplasmic reticulum stress-related lncRNAs signature in osteosarcoma

Dynamical topology of chiral and nonreciprocal state transfers in a non-Hermitian quantum system

Precise control of embolic stroke with magnetized red blood cells in mice

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

Association between the stress hyperglycemia ratio and mortality in patients with acute ischemic stroke

Determinants of survival after first relapse of acute lymphoblastic leukemia: a Children’s Oncology Group study

Geospatial characterization of rural settlements and potential targets for revitalization by geoinformation technology

Large-scale fully printed “Lego Bricks” type wearable sweat sensor for physical activity monitoring

Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

The use of T-DNA insertional mutagenesis to improve cellulase production by the thermophilic fungus Humicola insolens Y1

Construction of high-density genetic linkage map and identification of flowering-time QTLs in orchardgrass using SSRs and SLAF-seq

Alterations of the duodenal mucosal microbiome in patients with metabolic dysfunction-associated steatotic liver disease

An entorhinal-visual cortical circuit regulates depression-like behaviors

Correction: An entorhinal-visual cortical circuit regulates depression-like behaviors

Integrative transcriptome and proteome analyses of clear cell renal cell carcinoma develop a prognostic classifier associated with thrombus

DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR

The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus

Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children’s Oncology Group

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

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