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Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function.

The proton-sensing GPCRs detect extracellular low pH and regulate diverse physiological responses. Here, the authors report cryo-EM structures of GPR4, which provide insight into the structural features of proton sensing mechanism.

This work presents a strategy for synthesizing and assembling megabase-scale DNA, along with a delivery method for introducing the synthetic DNA into mouse embryos, offering a valuable tool for investigating de novo epigenetic regulation.

Early and accurate clinical assessment of disease severity in COVID-19 patients is essential for planning the allocation of scarce hospital resources. An explainable machine learning tool trained on blood sample data from 485 patients from Wuhan selected three biomarkers for predicting mortality of individual patients with high accuracy.

This study reveals the mechanisms connecting DNA methylation and totipotent gene expression in somatic cell reprogramming. SUVH-SDJ-AHL complex binds to CHH-hypermethylation regions and interacts with LEC2, establishing a feed forward loop to activate totipotency-regulating genes.

Cao et al. report an A-site co-doping strategy by substituting Cs+ cation by alkali metals for perovskite quantum wires embedded in nanoporous alumina template, stabilising the crystal structure and enabling high-colour purity LEDs spanning from blue to green spectral region.

Molecular ferroelectric crystals hold promise in data storage applications, yet their preparations by maximizing molecular polarization are challenging. Here, Youet al. report quinuclidinium periodate with six rotation axes and grow them in macroscopic ferroelectric thin films via a solution process.

In the OptiTROP-Breast01 phase 3 trial, patients with metastatic triple-negative breast cancer who received the TROP2-targeted antibody–drug conjugate sacituzumab tirumotecan experienced longer progression-free survival than patients treated with chemotherapy.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

Although the hetero-Diels–Alder reaction is a staple of organic chemistry, catalytic asymmetric versions of the inverse-electron demand variant often require specially engineered substrates for the reaction to work. Here the authors cyclize non-activated alkenes with α,β-unsaturated ketones or aldehydes to form chiral fused heterocycles using a chiral phosphoric acid catalyst.

A millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism is developed for general applications in electrotherapy and specific uses in temporary cardiac pacing.

Variational autoregressive networks have been employed in the study of equilibrium statistical mechanics, chemical reaction networks and quantum many-body systems. Using these tools, Tang et al. develop a general approach to nonequilibrium statistical mechanics problems, such as dynamical phase transitions.

Quintulene, a quintuple non-graphitic cycloarene, is challenging to synthesize. Here, the authors synthesize and characterize the cone-shaped extended quintulene and its bilayer dimer, and disclose its dimerization as an entropy-driven, second-order reaction with a substantial activation energy.

Here, the authors unveiled a ‘super-silencer’ and its mechanisms of action. They revealed that a combined treatment of an enhancer of zeste homolog 2 inhibitor and a repressor element 1-silencing transcription factor inhibitor can disrupt super-silencers, potentially leading to cancer ablation.

Evidence of quantum phase transitions is normally difficult to be detected. Here, Liu and Wang et al. report divergent critical exponent in ultrathin Pb films with superconducting fluctuations and spin-orbit interaction, indicating an anomalous quantum Griffiths singularity of superconductor-metal transition.

Gold nanoclusters show promise as photothermal materials, but are often thermally unstable. Here ligand engineering is used to integrate molecular rotors with gold nanoclusters to dissipate thermal energy and improve photothermal therapy performance.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Comprehensive molecular characterisations could shed light on the high heterogeneity and poor prognosis of gliomas. Here, the authors perform proteomic profiling of 188 glioma patients, revealing immune and metabolic neuron-related subgroups as well as metabolic biomarkers linked to prognosis.

Seed dormancy is the preferred trait in rice production as it can prevent preharvest sprouting. Here, the authors report that MODD (mediator of OsbZIP46 deactivation and degradation) negatively regulates seed dormancy by inhibiting the transcriptional activity of ABSCISIC ACID INSENSITIVES (ABIs).

Piwi-interacting RNAs (piRNAs) are vital for genome integrity and fertility. Here the authors reveal that spatial clustering of piRNA genes in Caenorhabditis elegans promotes transcription through phase separation and deSUMOylation, uncovering a SUMOylation-regulated mechanism for piRNA production in heterochromatic genomes.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

m336 is an exceptionally potent germline-like antibody against the emerging MERS-CoV virus. Here, the authors solve the structure of m336 in complex with MERS-CoV receptor-binding domain and use it to reveal a role of junctional and allele-specific residues in the interaction and suggest implications for vaccine development.

Jing et al., perform local injections of lipid nanoparticles carrying synthetic IL-2 and circRNAs encoding IL-2R–TLR4 chimeric receptors and anti-CA9 CARs to target renal tumor macrophages, thereby promoting their antitumorigenic potential in situ.

The site-selective acylation of saccharides without extensive pre-protection of alcohol units has been a longstanding objective in organic synthesis. Here, the authors demonstrate that by simply altering the chirality of N-heterocyclic carbene (NHC) organic catalysts, the site-selectivity of saccharide acylation can be effectively modulated.

This study demonstrated that different types of HC-Pros from potyviruses exhibit varying capacities to inhibit HEN1. This results in distinct levels of autophagic AGO1 degradation, which in turn leads to differences in RNA silencing suppression efficiency.

Bloodstream infections with Candida parapsilosis in allogeneic hematopoietic cell transplantation recipients are associated with heteroresistance to the antifungal micafungin, which can be predicted from genomic features using machine learning.

The authors propose a matrix plainification strategy to eliminate lattice vacancies in the Cu2Se matrix of the Cu2Se/SnSe composites, resulting in obvious improvement in carrier mobility and power factor, obtaining a high figure of merit of 3.3.

By integrating the serum concentration of a broadly neutralizing antibody (bNAb) with its in vitro 80% inhibitory concentration, the PT₈₀ biomarker may be used to guide target levels of bNAbs for effective prevention of HIV-1 acquisition.

This study characterized the substrate binding and transport mechanisms of the plant purine/cytokinin transporter AZG2. Conformational dynamics were examined by determining AZG2 structures in the apo or substrate-bound states under different pH.

In the phase 2 trial NEOSUMMIT-01, perioperative treatment of patients with locally advanced gastric or gastro-esophageal junction adenocarcinoma with anti-PD-1 and SOX/XELOX versus SOX/XELOX alone improved pathological complete response or near-complete response rate.

An annually resolved 3476-year tree-ring record from the Tibetan Plateau reveals severe 20^th century droughts and highlights the interplay between the Asian Monsoon and Westerlies. Droughts are often linked to the collapse of dynasties.

Solar-driven oxidative coupling of methane is a promising approach to synthesize important C₂₊ products, yet poor efficiency limits its application. Now, a TiO₂ membrane loaded with Au nanoclusters, which act as hole acceptors and catalytic centres, achieves high yield and selectivity in C₂₊ production.

Here the authors identify a nuclear short form of IL-18 in cancer cells that can enhance NK cell activation to promote tumor elimination.

A sugar transporter OsSTP28 is identified as a regulator of nitrogen-response tillering and yield formation in rice. Nitrogen supply represses the expression of OsSTP28 to fine turn the level of apoplastic glucose in shoot base, which in turn activates gibberellin catabolism.

This study identifies a kinesin motor at kinetochores that teams up with a key mitotic checkpoint protein to orchestrate proper chromosome movement during plant cell division, revealing a plant-specific mechanism for maintaining genetic integrity.

Nanotwinning strategies are widely recognized for their ability to substantially enhance the mechanical properties of materials. Here diamond with both penetrating and interlocked twins was synthesized, yielding a hardness of 276 GPa, which can be explained by diamond models that feature diverse twin configurations and dimensions.

The physiological significance of low fatty acid synthesis in adipocytes remains unclear. Here, the authors show a protective role of this phenomenon by demonstrating that overproduction of fatty acids increases ROS production and results in adipocyte necroptosis and lipodystrophy.