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Salmonella is a significant cause of gastrointestinal infection and asymptomatic carriage can contribute to transmission. Here, the authors investigate the prevalence of asymptomatic carriage of Salmonella in Yulin, China through occupational health screening and find that carriage was higher in food workers.

Cellular and molecular heterogeneity contributes to the insufficient immunogenicity of glioblastoma (GBM), ultimately leading to limited immune cell infiltration. Here this group reports a GBM therapeutic strategy by activating endogenous cGAS-STING signaling pathway by modulating mitochondrial electron transport chain thereby augmenting the immune responsiveness of GBM.

Communication between room-temperature and cryogenic environments is a bottleneck to the scaling of cryogenic devices. Here, the authors introduce a technique for in situ writing and erasing of circuits at low temperatures, enabling reversible construction of patterns without a photoresist.

Liver proteome dysregulation contributes to the development of alcohol-associated liver disease (ALD), a major global health challenge. Here, the authors develop an approach to specifically identify the liver nascent proteome under various physiological and pathological conditions, revealing key regulators involved in hepatic steatosis.

Despite initial treatment with surgical resection, glioblastoma multiforme (GBM) frequently recurs. Here the authors report the design of an immunostimulatory autolysing Salmonella based-nanocapsule delivery system, promoting anti-tumor immune responses and preventing postoperative relapse in preclinical GBM models.

The role of FGF21 in HFpEF is not fully understood. Here, the authors show that circulating levels of FGF21 are elevated in patients with HFpEF and that it protects against HFpEF by triggering multiorgan crosstalk among the liver, adipose tissue, and the heart, suggesting that FGF21 could be a promising therapeutic target for treating HFpEF.

Ultrasound examination significantly relies on manual operation, which has significant downsides. The authors present UltraBot, a carotid ultrasound robot capable of automated scanning, measurement, and plaque screening, and build an embodied foundation model using deep learning for intelligent, high-precision ultrasound.

Traditional cultured meat scaffolds employ animal-derived biomaterials or intricate manufacturing, but plant-based scaffolds offer an appealing alternative. Here the authors present a simple shortcut method to transform common vegetables into edible bioscaffolds via autoclaving, which mimics meat stiffness and microstructure.

Polyamines are essential metabolites linked to aging, cancer, and Parkinson’s disease. Here, authors develop a live-cell polyamine reporter and use a genome-wide CRISPR screen to uncover a link between mitochondrial respiration and polyamine import.

Calmodulin (CaM) activates target proteins to regulate a variety of cellular processes. Here, the authors report that CaM–target binding is disturbed by a fungal effector PdCDIE1, leading to ROS-dependent plant cell death.

By engineering the eukaryotic-derived Fanzor2-ωRNA system, Wei, Gao, Pan, Li and Chen developed a compact genome editor enNlovFz2, which demonstrated efficient genome-editing activity in vitro and in vivo, with a broad target-adjacent motif scope.

Electrolyzers operating efficiently at industrial current densities offer promise but face challenges for practical NO_x⁻ -to-ammonia conversion. Here, the authors report a full runner electrolyzer stack that enhances mass transfer in porous electrodes for NO_x⁻ reduction at high current densities.

“Due to the inherent disorder and fluidity of water, machining of water through laser cutting is challenging. Here, authors report a strategy through laser cutting to realize the machining of nanoparticle encased water pancakes with the depth of water at sub-millimeter level.”

This study reveals functional heterogeneity at the level of exocytosis among β cells and identifies a subpopulation of β cells that make a disproportionally large contribution to insulin release from mouse islets.

As a promising large-scale energy storage device, aqueous redox flow batteries face challenges with water splitting. Here, authors present polyoxometalate anolyte with a low redox potential which exhibits dynamic pH value changes during charging and discharging.

Mechanically rigid and geometrically stable nano-scaffolds decrease intermembrane spacing at the immunological synapse, leading to the exclusion of tyrosine phosphatase CD45 protein and enhancement of T-cell signalling.

Safe electrolytes for wide temperature applications of lithium metal batteries are highly demanded. Here, authors develop an ether-based electrolyte with 1,3,5-trioxane additive which renders thermoresponsivity, enabling lithium metal batteries in the range of −60 to 60 °C.

Fan et al. report a role for PRMT5 in regulating GPX4 stability and ferroptosis sensitivity through arginine methylation, which may be targeted to inhibit tumour development.

Achieving stable and selective chlorine production is of high interest yet challenging. Here the authors report an amorphous CoOxCly catalyst prepared by in situ electrodeposition in acidic saline electrolyte which shows ~100% chlorine evolution selectivity with low overpotential and high stability over 500 h.

The inositol deacylase PGAP1 initiates glycolipid remodeling required for GPI-AP sorting and secretion. Here, authors capture three PGAP1 states in a lipid environment and with products, revealing mechanisms for substrate selectivity and catalysis.

The authors show the dimeric structure of human LYCHOS (lysosomal cholesterol signaling), a fusion of a transporter and a G-protein-coupled receptor-like domain. The study uncovers unique transporter and receptor features and proposes a mechanism to couple cholesterol sensing, transport and signaling.

Sterically hindered unsaturated compounds are challenging substrates for asymmetric hydrogenation. Here, the authors report a palladium/chiral (bis)phosphine catalytic system that hydrogenates a number of hindered N-tosylimines with excellent enantioselectivitites.

Compound 8-1-(3-chlorophenethyl)-3-cyclopentylpyrimidine-2,4,6(1H,3H,5H)-trione was previously reported to be a selective inhibitor of the Ca_V1.3 calcium channel. Now, Huang et al. demonstrate that selectivity towards Ca_V1.3 relative to Ca_V1.2 is dependent on the type of β-subunit and Ca_V1.3 splice variant assayed.

Chen et al. report that the YTHDF family of m⁶A-RNA-binding proteins can be differentially regulated by the post-translational modification O-GlcNAcylation, leading to differential regulation of the YTHDF proteins on translation and phase separation.

The ectoenzyme CD73 is often elevated in tumour environments and targeting this protein is a tumour therapeutic target. Here the authors characterise a therapeutic anti-CD73 antibody cocktail which is more effective than either antibody alone and suggest a molecular mechanism of how this antibody cocktail functions.

The dietary uptake of vitamins B1 and B6 is mainly carried out by SLC19A2/A3 transporters. Here, authors characterized biochemically and structurally the transporters with vitamins B1/B6 and several inhibitory drugs

More sensitive and specific non-invasive biomarkers are desired for early detection of cancer. Here, the authors show a protein signature in the urine that increases sensitivity for colorectal cancer detection when combined with fecal immunochemical tests and corrects diagnosis in some fecal immunochemical tests-negative patients.

Graphene has the high carrier mobility and short photoresponse time required for efficient photodetection, but broad and weak optical absorption are severe drawbacks. Here, the authors show that twisted bilayer graphene with van Hove singularities exhibits a strong light-matter interaction and selectively enhanced photocurrent generation.

Biomimetic membranes can be used for various applications such as sensors and separations. Here, Chen et al. report the assembly of lipid-like peptoids into stable and self-repairing 2D membrane nanomaterials that change in thickness when under external stimuli.

Developing a generalizable method for blocking and rescuing tryptophan (Trp) interactions would enable the gain-of-function manipulation of various Trp-containing proteins but has so far been challenging. Now a genetically encoded N¹-vinyl-caged Trp capable of rapid and bioorthogonal decaging enables site-specific activation of Trp on a protein of interest within living cells.

The applications of human extended pluripotent stem cells (which can form both embryonic and extraembryonic lineages) demand a xeno-free culture condition; here, the authors provide a chemically defined and xeno-free culture system to do so.

Copper catalysts are widely studied for electrochemical CO2 conversion, but their structural changes during reactions require further investigation. Here the authors propose that Cu undergoes transformation through alkali cation-induced cathodic corrosion when exposed to sufficiently negative potentials in the presence of alkali cations in the electrolyte.

Clinically identified mutations in CTCF have been linked to adverse developmental outcomes. Here, the authors explore the regulatory roles of the CTCF^R567W point mutation, by introducing it into both murine models and human embryonic stem cell-derived cortical organoid models.