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Colorectal cancer can be difficult to treat due to multiple biological barriers. Here, the authors report an orally delivered microbial–inorganic hybrid that combines electrogenic bacteria with MnO₂ nanoparticles to disrupt tumour metabolism, trigger pyroptosis, remodel immunity, and achieve tumour-targeted therapy.

Genetic background, plasma metabolome and dietary data from 4,215 women and 1,490 men reveal 57 metabolites whose associations with dementia risk vary by APOE4 genotype and other risk variants.

A tunable magnetic nanochains platform (EVGpro) enables tandem enrichment, proteomic, and N-glycoproteomic analysis of extracellular vesicles from ultratrace biofluids. EVGpro identifies N-glycoprotein signatures and two asthenozoospermia subtypes.

SOX2 is known to be oncogenic in squamous cell carcinomas. Here, the authors demonstrate that SOX2 promotes global histone acetylation and reprograms lipid metabolism in esophageal squamous cell carcinoma cells.

Nitrogen-vacancy-centre microscopy and anisotropic magnetoresistance measurements reveal the evidence of magnetism in zigzag graphene nanoribbons embedded in hexagonal boron nitride.

Single-atom catalyst design for methanol steam reforming faces stability and activity hurdles. Here, Cd atoms anchored at anatase-rutile phase interfaces achieve exceptional catalytic efficiency, low CO production, and scalable hydrogen generation.

In this work, authors elucidate the molecular mechanisms by which neonatal meningitis Escherichia coli facilitates bacterial invasion through inducing multiple programmed cell death pathways in brain microvascular endothelial cells.

Despite the ease of fine-tuning their reactivity, high-performance homogeneous photocatalysts competent for acetylene semihydrogenation are scarce. Here the authors introduce an effective cobalt catalyst for the production of polymer-grade ethylene, which is amenable to scale-up in a continuous-flow photoreactor.

Unlike charge currents, pure spin currents do not suffer from joule heating; however, taking advantage of pure spin currents requires the development of pure spin current polarizers. Here, through careful material engineering of LaFeO₃, Chen et al succeed in development a pure spin current polarizer.

Pt-based alloy cathode catalysts in proton exchange membrane fuel cells face persistent challenges, including rapid oxidation and loss of transition metal/Pt. Here, the authors report a covalentization concept in intermetallic L1₀-structure Pt-based alloys to boost stability in fuel cells.

A Fusarium graminearum effector is found to target wheat fumarylacetoacetate hydrolase for 26S proteasomal degradation. The hydrolase enhances resistance to Fusarium head blight by regulating defense genes and amino acid metabolism, offering a genetic target for wheat improvement.

The authors demonstrate voltage-controlled multiferroic magnon torque in BiFeO₃ heterostructures, enabling reconfigurable logic-in-memory devices. This work highlights potential for low-power, scalable magnonics in room-temperature computing.

Beyond its canonical role in translation, lysyl-tRNA synthetase (KRS) stabilizes the prometastatic 67-kDa laminin receptor (67LR) in the plasma membrane. A small-molecule inhibitor of the KRS-67LR interaction modulates the KRS-promoted metastatic potential of 67LR without disrupting the normal function of each protein.

Zhao et al. identify an unexpected role of the nuclear export factor Nxf2 as a partner of Panoramix in mediating piRNA-guided silencing. Nxf2 counteracts Nxf1-centred nuclear RNA transport to prevent the export of transposon transcripts.

Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.

Multi-ancestry fine-mapping of breast cancer susceptibility regions identifies candidate causal variants and prioritizes likely effector genes supported by functional genomic evidence.

This study presents the difference in oxidation potential between metals and carbon as a thermodynamic factor for designing multielement heterostructures. A roll-to-roll carbothermal shock technology is developed to achieve one-step synthesis and continuous manufacturing of the multielement heterostructures.

Modern sugarcane cultivars have complicated genome due to interspecific crosses and multiple backcrossing. Here, the authors report the haplotype-resolved, chromosome-level genome assembly of a modern hybrid sugarcane cultivar and reveal the expansion of genes related to sugar accumulation and smut resistance.

A state-of-the-art generative artificial intelligence model of a video game is introduced to allow the support of human creative ideation, with the analysis of user study data highlighting three necessary capabilities, namely, consistency, diversity and persistency.

The new kagome metals can exhibit unconventional electron correlated states beyond recently discovered kagome superconductors AV₃Sb₅. Here, the authors report discovery of superconductivity and intrinsic nematic order in a new titanium-based kagome metal CsTi₃Bi₅ without charge density wave order.

A wide-field wavefront sensor consisting of a microlens array on the native image plane enables observation of atmospheric turbulence over a field of view of 1,100 arcsec at 30 Hz with an 80 cm telescope. With the aid of a neural network, turbulence can be predicted 33 ms in advance.

A precise catalogue of more than 19 million variants from 838 tomato genomes, including 32 new reference-level genome assemblies, advances the understanding of the heritability of complex traits and demonstrates the power of the graph pangenome in crop breeding.

Reactivating adult cardiomyocyte proliferation is key to heart regeneration post-injury. Here, authors show that medium from human iPSC-derived primitive macrophages (hiPM-cm) induces adult cardiomyocyte proliferation and promotes heart regeneration.

The chromosome-level genome of maidenhair fern, a model species representing the major homosporangium ferns, lays the foundation for studies on fern biology, origin of euphyllophytes and seed plant evolution.

This study shows that global warming has led to both earlier and later snowmelt floods in different regions over the past 70 years, challenging the prevailing idea that warming always advances floods and highlighting the complex nature of snowmelt flood timing shifts.

Chen, Yang et al. present DreAM, the drug-elicitable alternative splicing module, which is responsive to risdiplam, to inducibly regulate adeno-associated virus vector-mediated transgene expression. Proof-of-concept applications in cardiomyocytes revealed its potential for future clinical use in improving cardiac recovery after myocardial infarction.

Mitochondrial dynamics in large-scale regeneration remain poorly understood. Here they show that the mitochondrial fusion-fission equilibrium can determine the pluripotency of planarian stem cells and that mitonuclear balance is critical for planarian regeneration.

Structures of human NET in the apo state and bound to meta-iodobenzylguanidine and radafaxine provide insights into the mechanism of substrate recognition and orthosteric inhibition of hNET.

In eukaryotes, the origin recognition complex (ORC) is essential for replication licensing. Here, the authors report that a short motif within the intrinsically disordered region of the yeast Orc2 subunit plays an important role in regulating the licensing process.

Bimetallic zinc and gold porphyrin self-assembled into 2D nanosheets as nanoscale optoelectrodes. This design achieves exceptional photoelectric performance under visible one-photon and near-infrared two-photon excitation, enabling far-field optical modulation of single neurons.

Insulator-metal transitions driven by electronic correlations in oxide heterostructures have been widely studied, usually involving a correlated insulator and a band insulator. Here the authors study all-correlated-insulator heterostructures and observe a thickness-dependent insulator-metal transition.

Recovering resources from wastewater sources is an important sustainable development strategy. Here, authors build an electrochemical resource-recovery anaerobic membrane bioreactor for the simultaneous full recovery of carbon, nitrogen, and phosphorus, while demonstrating membrane fouling mitigation.

MeCP2 mutations can cause Rett syndrome, a severe childhood neurological disorder. Here the authors show that MeCP2 mediates the higher-order assembly of a large splicing complex Rbfox/LASR, which is disrupted in the mouse models of Rett syndrome.

Inorganic two-dimensional atomic crystals exhibit a variety of unusual but practically useful properties. Here, the authors produce an organic counterpart, atomically smooth monolayers of a molecular crystal, and use this organic analogue of graphene in high-performance organic field-effect transistors.