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Commercial lithium-ion batteries still have the issue of the uncontrollable dendritic Li under extreme conditions. Here, authors demonstrate a MXene-configured graphite, enabling homogeneous growth of Li, achieving high-capacity retentions in Ah-level pouch cell at −20 °C and high rates.

The realization of tandem solar cells with industrially textured silicon with pyramid sizes larger than 2 μm remains a significant challenge. Here, the authors create iceberg-like pyramids to facilitate complete coverage of perovskites on substrates, achieving certified device efficiency of 33.15%.

The authors demonstrate standing ceramic circuit boards (S-CCBs) with high-resolution and high aspect-ratio fabricated via sacrificial coating-assisted micro-3D printing, which have both high-density integration and large current-carrying capacity

The histone variant H3.3 is deposited onto pericentric and telomeric heterochromatin by the histone chaperone DAXX. How DAXX selectively recognizes H3.3 over the canonical H3.1 is now revealed by the crystal structure of DAXX in complex with H3.3–H4, along with biochemical and cellular analyses.

Non-invasive monitoring of oxygen levels has implications in a wide range of applications. Here, the authors report that biological imaging beyond 1,500 nm enables in vivo quantitative assessment of oxyhaemoglobin saturation at vascular resolution with high sensitivity.

A power conversion efficiency of 33.89% is achieved in perovskite/silicon tandem solar cells by using a bilayer passivation strategy to enhance electron extraction and suppress recombination.

Tan and colleagues conducted a single-cell multiomic analysis of T cell acute lymphoblastic leukemia and identified a treatment-resistant subpopulation of bone marrow progenitor-like blasts associated with poor outcomes.

West Pacific ferromanganese crust provides new insights to Late Miocene Cooling associated with the increased continental phosphorus weathering.

Assembly of the first Gossypium herbaceum genome and improved Gossypium arboreum and Gossypium hirsutum genomes provide insights into the phylogenetic relationships and origin history of cotton A-genomes.

Hydrogen bonds impact the chemical, physical and biological properties of molecular materials, but are rarely able to induce significant changes in electrical properties. Now a dynamic-to-static transition of hydrogen bonds in an organic–inorganic superlattice has been shown to yield a metal–insulator transition with an on–off ratio of 10⁷ in electrical resistivity.

Dao-Yuan Tan and colleagues present a real-time acoustic sensing system with hierarchical clustering for monitoring large-diameter aqueduct flow states. A 6 km aqueduct case study demonstrated improved water management and infrastructure reliability.

In a randomized phase 3 trial, neoadjuvant anti-PD-1 plus either paclitaxel and cisplatin or nab-paclitaxel and cisplatin elicited a significantly superior pathological complete response rate versus neoadjuvant paclitaxel and cisplatin alone in patients with resectable locally advanced esophageal squamous cell carcinoma.

Surgery is an important part of treatment for gastric adenocarcinoma, however, the consensus on perioperative care is less clear. Here, the authors report the results of a phase II clinical trial investigating neoadjuvant camrelizumab with concurrent chemoradiotherapy, followed by surgery for the treatment of advanced gastric adenocarcinoma.

Yin et al. realize a FeFET based compute-in-memory annealer as an efficient combinatorial optimization solver through algorithm-hardware co-design with a FeFET chip, matrix lossless compression, and a multi-epoch simulated annealing algorithm.

Pachytene Piwi-interacting RNAs (piRNAs) expressed in mammalian germ lines are abundant, but their evolution and function are not fully understood. Here, the authors find that pachytene piRNA loci are hotspots of structural variation, which underlies rapid piRNA birth, divergence, and loss.

Sperm carry diverse RNAs to the zygote. Here the authors employ single molecule long-read sequencing to distinguish intact RNAs from fragmented RNAs, reporting thousands of intact sperm RNA species conserved in mouse and human sperms.

The mechanistic functions of neutrophils in skin inflammation are not fully understood. Here the authors use human psoriasis samples and a mouse model of skin inflammation to study neutrophils and find a CXCR4^hi population of NET-forming, phagocytic neutrophils whose induction depends on the transcription factor CREB1.

Light-induced bubble maneuvering remains challenging in terms of response and functional adaptability due to the single driving mechanism including the Marangoni effect or asymmetrical deformation. Using a photopyroelectric slippery surface (PESS), Liu et al. demonstrate the splitting, merging, and detachment of underwater bubbles with high flexibility and precision.

Antigen pliability and lateral mobility in a Pickering emulsion adjuvant may be a safe and effective strategy to enhance adaptive immunity.

Ducks, one of the most common domestic fowls, originated from mallards. Here, the authors perform whole-genome sequencing of mallards, indigenous-breed ducks, and Pekin ducks, as well as 1026 ducks from a population generated by wild × domestic crosses to identify selection signals and map variants associated with body size and plumage color.

There is an intensive effort in developing multi-shelled metal oxide nanostructures for lithium-ion battery applications. Now, a metal anion-adsorption mechanism, as opposed to the conventional cation adsorption on carbonaceous templates, is demonstrated in the synthesis of vanadium oxide hollow microspheres, which exhibit excellent battery performance.

Different mechanisms for generating antibody diversity have evolved since the emergence of immunoglobulin genes in jawed vertebrates. By sequencing the crocodilian immunoglobulin heavy-chain locus, Chenget al. uncover new insights into the evolutionary origins of adaptive immunity.

Ribosome can mediate piRNA biogenesis from long non-coding RNAs following translation of the short open reading frames. Here the authors show that 80S ribosome also guides piRNA production from 3’ UTR of protein-coding genes after translation of long open reading frames, indicating a general piRNA biogenesis mechanism regardless of their precursor ORF length.

Iron gall chelate (GA-Fe) can promote oxygen reduction reactions and reactive oxygen species generation which causes chemical corrosion. Here, the authors, inspired by this phenomenon, develop a composite nanomedicine for tumour therapy constructed by loading gallate into Fe-engineered and PEGylated mesoporous silica nanocarrier, and show that it inhibits tumour growth.

Luminescent CsPbBr₃ quantum dots can be written into glass using femtosecond laser pulses and thermal annealing, and erased by further femtosecond laser irradiation. The resulting quantum dot patterns could prove useful for data storage, decoration or security purposes.

Long noncoding RNAs have been shown to play a role in cardiovascular disease. Here, the authors identify a lncRNA named CCRR, whose downregulation in failing hearts causes cardiac conduction disturbances by altering the endocytic trafficking of Cx43.

Sun et al. uncover a conserved mechanism by which ribosomes function in defining the position of pachytene piRNA formation on long single-stranded RNAs during spermatogenesis.

Amino acids are required for cell survival and growth. However, the different requirements of amino acid metabolic pathways in normal haematopoiesis and leukaemogenesis have not been explored. Here the authors focus on the transporter of neutral amino acids and show that malignant blood cells rely more on ASCT2-mediated amino acid metabolism than normal cells.

CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.

Evolutionary arms races can drive adaptations in hosts and parasites as well as among competing parasites. A combination of multi-omics and functional tests identifies a set of genes that allow a parasitic wasp to minimize intraspecific competition by inducing hosts to escape before more wasps can parasitize them.

Genome-wide association analyses across individuals of East Asian and European ancestries identify new risk loci for inflammatory bowel diseases. A polygenic risk score derived from the combined datasets shows improved prediction accuracy.